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Jie Shen, PhD

Present Title & Affiliation

Primary Appointment

Instructor, Department of Epidemiology, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

* Role of genetic variation of mitochondrial DNA in cancer development

* Metabolomics in cancer research

* Relationship between microRNAs and cancer

Biomarkers of cancer early detection, diagnosis, progression, cancer staging and tumor characterization, treatment  response and survival

* Allelic imbalance of gene expression and cancer

Office Address

The University of Texas MD Anderson Cancer Center
1155 Pressler Street
Department of Epidemiology
Unit Number: 1340
Houston, TX 77030
Phone: (713) 792-3739
Fax: (713) 794-1964

Education & Training

Degree-Granting Education

2006 Tulane University, New Orleans, LA, Post-Doc, Cancer Epidemiology
2004 The University of Texas MD Anderson Cancer Center, Houston, TX, Post-Doc, Cancer Biology
2003 The University of Texas MD Anderson Cancer Center, Houston, TX, PHD, Cancer Biology
1996 Fudan University, Shanghai, China, MA, Microbiology
1991 Fudan University, Shanghai, China, BS, Microbiology

Selected Publications

Peer-Reviewed Original Research Articles

1. Shen J, Hu Q, Schrauder M, Yan L, Wang D, Medico L, Gu Y, Yao S, Zhu Q, Liu B, Qin M, Beckmann MW, Fasching PA, Strick R, Johnson CS, Amtrosone CB, Zhao H, Liu S. Circulating miR-148b and miR-133a as biomarkers for breast cancer detection. Oncotarget 14:5284-94, 7/2014. PMCID: PMCPMC4170614.
2. Shen J, Yan L, Liu S, Ambrosone CB, Zhao H. Plasma metabolomic profiles in breast cancer patients and healthy controls: by race and tumor receptor subtypes. Transl Oncol 6:757-65, 12/2013. PMCID: PMCPMC3890711.
3. McCann SE, Liu S, Wang D, Shen J, Hu Q, Hong CC, Newman VA, Zhao H. Reduction of dietary glycaemic load modifies the expression of microRNA potentially associated with energy balance and cancer pathways in pre-menopausal women. Br J Nutr. e-Pub 5/2012. PMID: 22647265.
4. Shen J, Wang D, Gregory SR, Medico L, Hu Q, Yan L, Odunsi K, Lele SB, Ambrosone CB, Liu S, Zhao H. Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer. Carcinogenesis 33(3):604-12, 3/2012. e-Pub 1/2012. PMCID: PMC3291866.
5. Shen J, Medico L, Zhao H. Allelic imbalance in BRCA1 and BRCA2 gene expression and familial ovarian cancer. Cancer Epidemiol Biomarkers Prev 20(1):50-6, 1/2011. e-Pub 11/2010. PMID: 21119070.
6. Shen J, Platek M, Mahasneh A, Ambrosone CB, Zhao H. Mitochondrial copy number and risk of breast cancer: a pilot study. Mitochondrion 10(1):62-8, 1/2010. e-Pub 9/2009. PMID: 19788937.
7. Zhao H, Shen J, Medico L, Wang D, Ambrosone CB, Liu S. A pilot study of circulating miRNAs as potential biomarkers of early stage breast cancer. PLoS One 5(10):e13735, 2010. e-Pub 10/2010. PMCID: PMC2966402.
8. Zhao H, Shen J, Medico L, Platek M, Ambrosone CB. Length heteroplasmies in human mitochondrial DNA control regions and breast cancer risk. Int J Mol Epidemiol Genet 1(3):184-92, 2010. e-Pub 4/2010. PMCID: PMC3076767.
9. Shen J, DiCioccio R, Odunsi K, Lele SB, Zhao H. Novel genetic variants in miR-191 gene and familial ovarian cancer. BMC Cancer 10:47, 2010. e-Pub 2/2010. PMCID: PMC2831822.
10. Shen J, Ambrosone CB, Zhao H. Novel genetic variants in microRNA genes and familial breast cancer. Int J Cancer 124(5):1178-82, 3/2009. PMID: 19048628.
11. Shen J, Ambrosone CB, DiCioccio RA, Odunsi K, Lele SB, Zhao H. A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis. Carcinogenesis 29(10):1963-6, 10/2008. e-Pub 7/2008. PMID: 18660546.
12. Shen J, Deininger P, Hunt JD, Zhao H. 8-Hydroxy-2'-deoxyguanosine (8-OH-dG) as a potential survival biomarker in patients with nonsmall-cell lung cancer. Cancer 109(3):574-80, 2/2007. PMID: 17154177.
13. Zhao H, Shen J, Deininger P, Hunt JD. Abasic sites and survival in resected patients with non-small cell lung cancer. Cancer Lett 246(1-2):47-53, 2/2007. e-Pub 3/2006. PMID: 16519994.
14. Shen J, Behrens C, Wistuba II, Feng L, Lee JJ, Hong WK, Lotan R. Identification and validation of differences in protein levels in normal, premalignant, and malignant lung cells and tissues using high-throughput Western Array and immunohistochemistry. Cancer Res 66(23):11194-206, 12/2006. PMID: 17145864.
15. Shen J, Deininger PL, Zhao H. Applications of computational algorithm tools to identify functional SNPs in cytokine genes. Cytokine 35(1-2):62-6, 7/2006. e-Pub 8/2006. PMID: 16919468.

Grant & Contract Support

Title: Mitochondrial DNA heteroplasmy and breast cancer risk
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 9/1/2012 - 8/31/2014
Title: Mitochondrial: A novel genetic modifier for breast cancer risk in Caucasian and African American women
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Zhao
Duration: 9/10/2010 - 8/31/2013
Title: MicroRNA: A novel genetic modifier for breast cancer predisposition
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Zhao
Duration: 8/20/2009 - 5/31/2014

Last updated: 11/6/2014