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Jim Klostergaard, Ph.D.

Present Title & Affiliation


Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd
Unit Number: 108
Houston, TX 77030
Room Number: Y8.6077
Phone: (713) 792-8962
Fax: (713) 794-3270

Education & Training

Degree-Granting Education

1976 State University of New York, Buffalo, NY, PHD, Chemistry
1972 University of California, Santa Barbara, CA, MS, Chemistry
1970 University of California, Los Angeles, CA, BS, Chemistry


Academic Appointments

Professor and Biologist, Molecular and Cellular Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, 1/2000-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Auzenne E, Ghosh SC, Khodadadian M, Rivera B, Farquhar D, Price RE, Ravoori M, Kundra V, Freedman RS, Klostergaard J. Hyaluronic acid-paclitaxel: antitumor efficacy against CD44(+) human ovarian carcinoma xenografts. Neoplasia 9:479-86, 2007.
2. Klostergaard J, Bankson J, Yuill W adn Seeney CE. Magnetic vectoring of magnetically-responsive nanoparticles within the murine peritoneum. J Magnetism Magnetic Materials 311:330-335, 2007.
3. Ghosh SC, Auzenne E, Farquhar D and Klostergaard J. N,N-Dimethylsphingosine-Coumarin: Synthesis, Chemical Characterization and Biological Evaluation. Bioconjugate Chem. 18:731-735, 2007.
4. Leroux ME, Auzenne E, Evans R, Hail N Jr, Spohn W, Ghosh SC, Farquhar D, McDonnell T, Klostergaard J. Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells. Prostate 37:1699-717, 2007.
5. Klostergaard J, Leroux ME, Auzenne E, Khodadadian M, Spohn W, Wu JY, Donato NJ. Hyperthermia engages the intrinsic apoptotic pathway by enhancing upstream caspase activation to overcome apoptotic resistance in MCF-7 breast adenocarcinoma cells. J Cell Biochem 98(2):356-69, 5/2006. PMID: 16440323.
6. Klostergaard J, Auzenne E, Ghosh S, Farquhar D, Rivera B, Price RE. Magnetic resonance imaging-based prospective detection of intraperitoneal human ovarian carcinoma xenografts treatment response. Int J Gynecol Cancer 16 Suppl 1:111-7, 2006. PMID: 16515577.

Grant & Contract Support

Title: Effects of nanoparticle size and surface charge on magnetically enhanced tumor extravasation
Funding Source: NanCogenics, Inc.
Role: Principal Investigator
Duration: 9/14/2013 - 3/13/2014
Title: Magnetic Vectoring of Nanoparticle Drug-Carriers for Tumor-Specific Delivery of Chemotherapeutics
Funding Source: National Science Foundation (NSF)
Role: Co-Principal Investigator
Duration: 7/1/2010 - 12/31/2010
Title: Subcellular localization of nanoparticles
Funding Source: NIH/NIGMS
Role: Co-Principal Investigator
Principal Investigator: Mauro Ferarri
Duration: 9/30/2009 - 8/31/2011
Title: Magnetic Localization of Nanoparticle drug Carriers to Ovarian and Breast Carcinoma Xenografts
Funding Source: NanoBioMagnetics, Inc.
Role: Principal Investigator
Duration: 3/1/2008 - 3/1/2011

Last updated: 8/21/2014