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Jing Yang

Present Title & Affiliation

Primary Appointment

Assistant Professor, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Professor, Guangzhou Medical College, NA, China

Education & Training

Degree-Granting Education

2002 Central South University, NA, China, PHD, Medicine
1994 Guangzhou Medical College, NA, China, MS, Medicine
1991 Guangzhou Normal College, NA, China, BS, Science

Postgraduate Training

2004-2008 Research Fellowship, The University of Texas MD Anderson Cancer Center, Houston, TX
2004 Research Fellowship, University of Arkansas for Medical Sciences, Little Rock, AR

Honors and Awards

2009-2014 K99/R00, National Cancer Institute
2008-2010 Scholar Award, American Society of Hematology
2008 Brian D. Novis Research Award, International Myeloma Foundation
2007 Travel Award, 49th American Society of Hematology
2006 Altana Pharma Publication Award, MD Anderson Cancer Center
2003-2004 National Nature Science Foundation of China, National Nature Science Foundation of China
2001 Scholarship of Central South University in China, Central South University in China
2001 Tan Jiazhen-Fudan University Life Science Award in China, Tan Jiazhen-Fudan University

Selected Publications

Peer-Reviewed Original Research Articles

1. Sun L, Zhang L, Qian J, Yang J, Yi Q, Dong W, Wang M. Combination of atiprimod and the proteasome inhibitor bortezomib induces apoptosis of mantle cell lymphoma in vitro and in vivo. Leuk Res 36(3):363-8, 3/2012. e-Pub 10/2011. PMID: 22000823.
2. Yang J, He J, Wang J, Cao Y, Ling J, Qian J, Lu Y, Li H, Zheng Y, Lan Y, Hong S, Matthews J, Starbuck MW, Navone NM, Orlowski RZ, Lin P, Kwak LW, Yi Q. Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma. Leukemia. e-Pub 3/2012. PMID: 22425892.
3. Qian J, Zheng Y, Zheng C, Wang L, Qin H, Hong S, Li H, Lu Y, He J, Yang J, Neelapu S, Kwak LW, Hou J, Yi Q. Active vaccination with Dickkopf-1 induces protective and therapeutic antitumor immunity in murine multiple myeloma. Blood 119(1):161-9, 1/2012. e-Pub 11/2011. PMCID: PMC3251227.
4. Zheng Y, Yang J, Qian J, Zhang L, Lu Y, Li H, Lin H, Lan Y, Liu Z, He J, Hong S, Thomas S, Shah J, Baladandayuthapani V, Kwak LW, Yi Q. Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone. J Mol Med (Berl). e-Pub 12/2011. PMID: 22207485.
5. Cao Y, Lan Y, Qian J, Zheng Y, Hong S, Li H, Wang M, Kwak LW, Lin D, Yang J, Yi Q. Targeting cell surface β2 -microglobulin by pentameric IgM antibodies. Br J Haematol 154(1):111-21, 7/2011. e-Pub 5/2011. PMCID: PMC3111817.
6. Li H, Hong S, QianJ, Zheng Y, Yang J, and Yi Q. Crosstalk between the Bone and Immune systems: Osteoclasts Function as Antigen-Presenting Cells and Activate CD4+ and CD8+ T cells. Blood, 7/2010.
7. Yang J, Yi Q. Killing tumor cells through their surface beta(2)-microglobulin or major histocompatibility complex class I molecules. Cancer, 4/2010.
8. Yang J, Yi Q. Monoclonal antibodies targeting B2/MHC Class I- induced tumor an apoptosis and signaling pathways. Cancer, 4/2010.
9. Qian J, Hong S, Wang S, Zhang L, Sun L, Wang M, Yang J, Kwak LW, Hou J, Yi Q. Myeloma cell line-derived, pooled heat shock proteins as a universal vaccine for immunotherapy of multiple myeloma. Blood, 8/2009. e-Pub 8/2009. PMID: 19654406.
10. Yang J, Cao Y, Hong S, Li H, QianJ, Kwak LW, and Yi Q. Human-like mouse models for testing the efficacy and safety of anti-beta2-microglobulin monoclonal antibodies to treat myeloma. Clin Cancer Res 15(3):951-9, 2/2009. PMCID: PMC2659684.
11. Zheng Y, Cai Z, Wang S, Zhang X, Qian J, Hong S, Li H, Wang M, Yang J and Yi Q. Macrophages Are an Important Component of Myeloma Microenvironment and Protect Myeloma Cells from Chemotherapy Drug-Induced Apoptosis. Blood, 2009.
12. Hong S, Qian J, Yang J, Li H, Kwak LW, Yi Q. Roles of idiotype-specific t cells in myeloma cell growth and survival: Th1 and CTL cells are tumoricidal while Th2 cells promote tumor growth. Cancer Res 68(20):8456-64, 10/2008. PMCID: PMC2575640.
13. Wang M, Zhang L, Han XH, Yang J, Qian J, Hong S, Lin P, Shi Y, Romaguera J, Kwak LW and Yi Q. A severe combined immunodeficient-hu in vivo mouse model of human primary mantle cell lymphoma. Clin Cancer Res 14(7):2154-60, 4/2008. PMID: 18381957.
14. Wang M, Han XH, Zhang L, Yang J, Qian JF, Kwak LW, Romaguera J and Yi Q. Bortezomib is synergistic with rituximab and cyclophosphamide in inducing apoptosis of mantle cell lymphoma cells in vitro and in vivo. Leukemia 22(1):179-85, 1/2008. e-Pub 9/2007. PMID: 17898787.
15. Yang J, Zhang X, Wang J, Qian J, Zhang L, Wang M, Kwak LW, Yi Q. Anti beta2-microglobulin monoclonal antibodies induce apoptosis in myeloma cells by recruiting MHC class I to and excluding growth and survival cytokine receptors from lipid rafts. Blood 110(8):3028-35, 10/2007. e-Pub 7/2007. PMCID: PMC2018676.
16. Qian J, Xie J, Hong S, Yang J, Zhang L, Han X, Wang M, Zhan F, Shaughnessy JD, Epstein J, Kwak LW, Yi Q. Dickkopf-1 (DKK1) is a widely expressed and potent tumor-associated antigen in multiple myeloma. Blood 110(5):1587-94, 9/2007. e-Pub 5/2007. PMCID: PMC1975842.
17. Yang J, Wezeman M, Zhang X, Lin P, Wang M, Qian J, Wan B, Kwak LW, Yu L, Yi Q. Human C-reactive protein binds activating Fcgamma receptors and protects myeloma tumor cells from apoptosis. Cancer Cell 12(3):252-65, 9/2007. PMID: 17785206.
18. Ding L, Li L, Yang J, Zhou S, Li W, Tang M, Shi Y, Yi W, Cao Y. Latent membrane protein 1 encoded by Epstein-Barr virus induces telomerase activity via p16(INK4A)/Rb/E2F1 and JNK signaling pathways. J Med Virol, 8/2007.
19. Wang M, Zhang L, Han X, Yang J, Qian J, Wang S, Hong S, Zhang X, Zhou Y, Romaguera J, and Yi Q. Atiprimod inhibits growth of mantle cell lymphoma in vitro and in vivo and induces apoptosis via activation of the mitochondrial pathway. Blood, 6/2007.
20. Wang S, Hong S, Wezeman M, Qian J, Yang J, and Yi Q. Dendritic cell vaccine but not idiotype-KLH protein vaccine primes therapeutic tumor-specific immunity against multiple myeloma. Front Biosci, 5/2007.
21. Wang S, Hong S, Yang J, Qian J, Zhang X, Shpall E, Kwak LW and Yi Q. Optimizing immunotherapy in multiple myeloma: restoring the function of patient’s monocyte-derived dendritic cells by inhibiting p38 or activating MEK/ERK MAPK and neutralizing interleukin-6 in the progenitor cells. Blood, 12/2006.
22. Yang J, Qian J, Wezeman M, Wang S, Lin P, Wang M, Yaccoby S, Kwak LW, Barlogie B and Yi Q. Targeting b2-microglobulin for induction of tumor apoptosis in human hematological malignancies. Cancer Cell, 10/2006.
23. Wang S, Yang J, Qian J, Wezeman M, Kwak LW and Yi Q. Tumor evasion of the immune system: inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma. Blood, 3/2006.
24. Qian J, Wang S, Yang J, Xie J, Lin P, Freeman ME 3rd and Yi Q. Targeting heat shock proteins for immunotherapy in multiple myeloma: generation of myeloma-specific cytotoxic T lymphocytes using dendritic cells pulsed with tumor-derived gp96. Clin Cancer Res, 12/2005.
25. Ding L, Li L, Yang J, Tao Y, Ye M, Shi Y, Tang M, Yi W, Li X, Gong J, Cao Y. Epstein-Barr virus encoded latent membrane protein 1 modulates nuclear translocation of telomerase reverse transcriptase protein by activating nuclear factor-kappaB p65 in human nasopharyngeal carcinoma cells. Int J Biochem Cell Biol, 8/2005.
26. Song X, Tao Y, Zeng L, Yang J, Tang F, Lee LM, Gong J, Wu Q, Cao Y. Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers. Sci China C Life Sci, 8/2005.
27. Xie J, Qian J, Yang J, Wang S, Freeman ME 3rd and Yi Q, et al. Critical roles of Raf/MEK/ERK and PI3K/AKT signaling and inactivation of p38 MAP Kinase in the differentiation and survival of monocyte-derived immature dendritic cells. Exp Hematol, 5/2005.
28. Yang J, Deng XY, Deng L, Gu H, Fan W and Cao Y. Telomerase activation by Epstein-Barr virus latent membrane protein 1 is associated with c-Myc expression in human nasopharyngeal epithelial cells. J Exp Clin Cancer Res, 8/2004.
29. Yang J, Deng XY, Cao Y. Epstein-Barr Virus LMP1 activates human telomerase transcription via c-Myc expression. China J Virol, 12/2003.
30. Yang J, Deng L, Cao Y. Telomerase activation by Epstein-Barr virus latent membrane 1 is associated with p16INK4a/E2F1 pathway. J Modern Oncol, 12/2003.
31. Yang J, Deng L, Cao Y, et al. Telomerase Activation and p16INK4a Inhibition in the process of human nasopharyngeal epithelial cells escaping from replicative senescence by Epstein-Barr Virus. Shanxi Oncol Med, 11/2003.
32. Deng L, Yang J, Zhao XR, Deng XY, Zeng L, Gu HH, Tang M and Cao Y. Cells in G2/M phase increased in human nasopharyngeal carcinoma cell line by EBV-LMP1 through activation of NF-κB and AP-1. Cell Res, 6/2003.
33. Yang J, Deng L, Song X, Ding L, Deng XY, Yi W and Cao Y. Epstein-Barr virus inhibits P16INK4a expression in human fetal nasopharyngeal epithelial cells escaping from the replicative senenscence. Shi Yan Sheng Wu Xue Bao, 6/2003.
34. Yang J, Deng XY, Cao Y, et al. Epstein-Barr virus LMP1 enhances telomerase activity of nasopharyngeal epithelial cells through NF-B pathway. Prog Biochem & Biophy, 8/2002.
35. Yang J, Tang F, Gu H, Deng X, Weng X, Tang M and Cao Y, et al. Epstein-Barr virus induces human nasopharyngeal epithelial cells to escape from the replicative senescence. Chin Med J (Engl) 115(6):803-9, 6/2002. PMID: 12123541.
36. Yang J, Deng XY, Gu HH, Xia LQ, Yi W and Cao Y. Epstein-Barr virus latent membrane protein 1 activates telomerase of nasopharyngeal epithelial cells. Shi Yan Sheng Wu Xue Bao 34(3):207-11, 9/2001.
37. Yang J, Tang FQ, Gu HH, Deng XY, Weng XX, Tang M and Cao Y. Observation of the biological characterizations of nasopharyngeal epithelial cells by EB virus infection in early phase of immortalization. Shi Yan Sheng Wu Xue Bao. 6/2001.

Book Chapters

1. NA. Signaling pathways mediating dendritic cells dysfunction in cancer. In: Dendritic cells in Cancer. Ed by Shurin M and Salter R, Springer, 2009.
2. Yang J. Cytokines and Growth Factors. In: Signal Transduction. People’s Health Publishing House, China, 2005. ISBN: 7117068035.
3. Yang J. Tissue Culture Technology and Cell Biological Detection. In: Practical Guide to Molecular Biology Operation. People’s Health Publishing House, China: China, 2003. ISBN: 7117056096.

Grant & Contract Support

Title: Novel targets for myeloma bone disease prevention or treatment
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 9/1/2012 - 8/31/2017
 
Title: The role of tumor cell p38 MAPK activity in osteolytic bone lesions in myeloma.
Funding Source: American Society of Hematology (ASH)
Role: Principal Investigator
Duration: 7/1/2012 - 6/30/2015
 
Title: C-reactive protein promotes myeloma cell-mediated bone destruction
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 2010 - 2015
 
Title: Anti-beta2 microglobulin mAbs as a novel therapeutic agent in multiple myeloma
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 9/1/2009 - 8/31/2014
 
Title: Targeting surface b2M for myeloma and bone therapy
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Qing Yi, M.D., Ph.D
Duration: 2009 - 2013

Last updated: 8/5/2013