Skip to Content

'
Jingsong Yuan, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2006 Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS&PUMC), Beijing, China, PHD, Oncology
2001 Tongji Medical University, Wuhan, China, MD, Clinical Medicine

Postgraduate Training

7/2009-5/2010 Postdoctoral Fellow, Cancer Biology, the University of Texas M. D. Anderson Cancer Center, Houston, TX, Dr. Junjie chen
1/2007-6/2009 Postdoctoral Associate, Cancer Biology, Yale University School of Medicine, New Haven, CT, Dr. Junjie chen

Experience/Service

Academic Appointments

Instructor, Department of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 6/2010-11/2011

Other Appointments/Responsibilities

Postdoctoral Fellow, the University of Texas M. D. Anderson Cancer Center, Houston, TX, 7/2009-5/2010
Postdoctoral Associate, Yale University School of Medicine, New Haven, CT, 1/2007-6/2009
Research Associate, the Chinese National Human Genome Center, Beijing, China, 7/2006-1/2007
Research Assistant, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS&PUMC), Beijing, China, 9/2001-7/2006
Chief Class Monitor, Tongji Medical University, Wuhan, China, 1/1997-6/2001

Honors and Awards

2006 Young Investigator Award, the National Cancer Forum for Young Scientists
2002-2005 consecutive Excellent Graduate Awards, CAMS&PUMC
2001 Excellent Graduate Awards, Tongji Medical University
2000 United Laboratories golden Scholarship, Tongji Medical University
1997-2001 consecutive Excellent Student Awards, Tongji Medical University

Selected Publications

Peer-Reviewed Original Research Articles

1. Yuan J, Chen J. FIGNL1-containing protein complex is required for efficient homologous recombination repair. Proc Natl Acad Sci U S A 110(26):10640-5, 6/2013. e-Pub 6/2013. PMCID: PMC3696823.
2. Ling B, Zheng H, Fu G, Yuan J, Shi T, Chen S, Liu Y, Liu Y, Cao Y, Zheng S, Guo S, Han N, Gao Y, Cheng S, Zhang K. Suppression of non-small cell lung cancer proliferation and tumorigenicity by DENND2D. Lung Cancer 79(2):104-10, 2/2013. e-Pub 11/2012. PMID: 23182661.
3. Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J. PTPN14 is required for the density-dependent control of YAP1. Genes Dev 26(17):1959-71, 9/1/2012. PMCID: PMC3435498.
4. Yuan J, Ghosal G, Chen J. The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. Mol Cell 47(3):410-21, 8/2012. e-Pub 6/2012. PMID: 22705370.
5. Ghosal G*, Yuan J*, Chen J. The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1. EMBO Rep 12(6):574-80, 6/2011. e-Pub 4/2011. PMID: 21525954.
6. Yuan J, Chen J. The Role of the Human SWI5-MEI5 Complex in Homologous Recombination Repair. J Biol Chem 286(11):9888-93, 3/2011. e-Pub 1/2011. PMCID: PMC3059048.
7. Yuan J, Adamski R, Chen J. Focus on histone variant H2AX: To be or not to be. FEBS Lett 584(17):3717-24, 9/2010. e-Pub 5/2010. PMID: 20493860.
8. Liu T, Ghosal G, Yuan J, Chen J, Huang J. FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science 329(5992):693-6, 8/2010. e-Pub 7/2010. PMID: 20671156.
9. Zhang Q, Duan L, Xu H, Yuan J, Wu W, Wu Y, Gao Y, Cheng S. [Effects of Rap2b gene on foci formation and wound-healing of NIH3T3 cells]. Wei Sheng Yan Jiu 39(4):403-6, 7/2010. PMID: 20726223.
10. Yuan J, Chen J. MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem 285(2):1097-104, 1/2010. e-Pub 11/2009. PMCID: PMC2801237.
11. Yuan J, Chen J. N terminus of CtIP is critical for homologous recombination mediated double-strand break repair. J Biol Chem 284(46):31746-52, 11/2009. e-Pub 9/2009. PMCID: PMC2797245.
12. Yuan J, Ghosal G, Chen J. The annealing helicase HARP protects stalled replication forks. Genes Dev 23(20):2394-9, 10/2009. e-Pub 9/2009. PMCID: PMC2764499.
13. Fu G, Liu Y, Yuan J, Zheng H, Shi T, Lei W, Xiao T, Gao Y, Cheng S. [Identification and Functional Analysis of A Novel Candidate Oncogene RAP2B in Lung Cancer.]. Zhongguo Fei Ai Za Zhi 12(4):273-6, 4/2009. PMID: 20719111.
14. Fu D, Tian L, Peng Z, Deng W, Yuan J, Ma D, Shi T, Li D, Wang Y. Overexpression of CHMP6 induces cellular oncosis and apoptosis in HeLa cells. Biosci Biotechnol Biochem 73(3):494-501, 3/2009. e-Pub 3/2009. PMID: 19270365.
15. Yuan J, Ma J, Zheng H, Shi T, Sun W, Zhang Q, Lin D, Zhang K, He J, Mao Y, Gao X, Gao P, Han N, Fu G, Xiao T, Gao Y, Ma D, Cheng S. Overexpression of OLC1, cigarette smoke, and human lung tumorigenesis. J Natl Cancer Inst 100(22):1592-605, 11/2008. e-Pub 11/2008. PMID: 19001599.
16. Huen MS, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, Xiao W, Chen J. Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly. Mol Cell Biol 28(19):6104-12, 10/2008. e-Pub 8/2008. PMCID: PMC2547017.
17. Ma J, Gao M, Lu Y, Feng X, Zhang J, Lin D, Xiao T, Hu Z, Yuan J, Su K, Shipley J, Xue J, Gao Y. Gain of 1q25-32, 12q23-24.3, and 17q12-22 facilitates tumorigenesis and progression of human squamous cell lung cancer. J Pathol 210(2):205-13, 10/2006. PMID: 16927450.
18. Ma Y, Lin D, Sun W, Xiao T, Yuan J, Han N, Guo S, Feng X, Su K, Mao Y, Cheng S, Gao Y. Expression of targeting protein for xklp2 associated with both malignant transformation of respiratory epithelium and progression of squamous cell lung cancer. Clin Cancer Res 12(4):1121-7, 2/2006. PMID: 16489064.
19. Xiao T, Ying W, Li L, Hu Z, Ma Y, Jiao L, Ma J, Cai Y, Lin D, Guo S, Han N, Di X, Li M, Zhang D, Su K, Yuan J, Zheng H, Gao M, He J, Shi S, Li W, Xu N, Zhang H, Liu Y, Zhang K, Gao Y, Qian X, Cheng S. An approach to studying lung cancer-related proteins in human blood. Mol Cell Proteomics 4(10):1480-6, 10/2005. e-Pub 6/2005. PMID: 15970581.
20. Hu Z, Lin D, Yuan J, Xiao T, Zhang H, Sun W, Han N, Ma Y, Di X, Gao M, Ma J, Zhang J, Cheng S, Gao Y. Overexpression of osteopontin is associated with more aggressive phenotypes in human non-small cell lung cancer. Clin Cancer Res 11(13):4646-52, 7/2005. PMID: 16000556.
21. Sun W, Zhang K, Zhang X, Lei W, Xiao T, Ma J, Guo S, Shao S, Zhang H, Liu Y, Yuan J, Hu Z, Ma Y, Feng X, Hu S, Zhou J, Cheng S, Gao Y. Identification of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization. Cancer Lett 212(1):83-93, 8/2004. PMID: 15246564.

Abstracts

1. Yuan J, Chen J. Defects of homologous recombination repair in breast cancer: Identification of a novel RAD51-associated protein complex. AACR, 4/2013.
2. Yuan J, Chen J. A Novel Protein Complex Constitutes a Sub-pathway of Homologous Recombination Repair. Keystone Symposium: Genomic Instability and DNA Repair, 3/2013.
3. Ghosal G, Yuan J, Chen J. The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1. Keystone Symposium: Genomic Instability and DNA Repair, 1/2011.
4. Yuan J, Ma J, Zheng H, Shi T, Gao Y, Ma D, Cheng S. OLC1 is a newly discovered oncogene in human lung cancer. 98th AACR Annual Meeting, 4/2007.
5. Yuan J, Zheng H, Shi T, Gao X, Gao P, Fu G, Gao Y, Ma D, Cheng S. Cloning, screening and identification of new genes potentially involved in human lung cancer. Sixth International Symposium on Frontiers in Life Sciences-Molecular basis of disease, prevention and treatment. 9/2006.
6. Yuan J, Zheng H, Cheng S. Cloning and identification of a new candidate oncogene in human lung cancer. The Fourth Life Science Annual Conference, 2006.
7. Yuan J and Cheng S. New challenges in cancer research. New progress in cancer prevention and treatment. Jinan forum, 2006.

Last updated: 2/28/2014