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Jinyun Chen, M.D., Pharm.D., M.S.

Present Title & Affiliation

Primary Appointment

Instructor, Department of Epidemiology, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

My research focuses on genetic risk factors for development of gastrointestinal cancer with emphasis on pancreatic cancer and a genetic disorder known as hereditary nonpolyposis colorectal cancer (Lynch syndrome), as well as predictors of response to chemotherapeutic strategies. To identify early detection and prognostic markers for colorectal and pancreatic cancer, I use a multigenic pathway-based approach which assesses the combined effects of a comprehensive panel of genetic variants in genes that interact in the same pathways (e.g., cell cycle, DNA repair, and apoptosis pathways), as well as genome-wide pathway analysis and network analysis for integration of genotype, mRNA, miRNA, and phenotype data. I also use machine learning analytic tools (i.e. Classification and Regression Tree and Random Forest) to evaluate the influence of high-order gene-gene interactions on development of cancer at an early age.

Research Interests

  • Genetic risk factors for development of gastrointestinal cancer
  • Early detection and prognostic markers for colorectal and pancreatic cancer
  • Multigenic pathways-based approach, genome-wide pathway analysis, and network Analysis for Integration of  genotype, mRNA, miRNA, and phenotype data

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Boulevard
Unit Number: 1365
Houston, TX 77030
Room Number: CPB 7.3562
Phone: 713-563-9671
Fax: 713-563-0999

Education & Training

Degree-Granting Education

2003 Texas A & M University, College Station, TX, MS, Management Information System
1996 Beijing University of Traditional Chinese Medicine, Beijing, China, PHARMD, Pharmacy
1993 Jiangxi University of Traditional Chinese Medicine, Jiangxi, China, MD, Medicine

Postgraduate Training

2004-2009 Postdoctoral Fellow, Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, Marsha L. Frazier

Honors and Awards

2010 Young Investigator Travel Award, 41st Anniversary Meeting of American Pancreatic Association
2007 Best Overall Poster, University of Texas M.D. Anderson Cancer Center, Houston, Texas
2005-2007 Janice David Gordon Memorial Fellowship Award, University of Texas M.D. Anderson Cancer Center, Houston, Texas
2005 Travel Award for the 2nd NCI Epidemiology Leadership Workshop, Boston, MA

Selected Publications

Peer-Reviewed Original Research Articles

1. Wei C, Chen J, Pande M, Lynch PM, Frazier ML. A pilot study comparing protein expression in different segments of the normal colon and rectum and in normal colon versus adenoma in patients with Lynch syndrome. J Cancer Res Clin Oncol 139(7):1241-50, 7/2013. e-Pub 4/2013. PMCID: PMC3708474.
2. Chen N, Balasenthil S, Reuther J, Frayna A, Wang Y, Chandler DS, Abruzzo LV, Rashid A, Rodriguez J, Lozano G, Cao Y, Lokken E, Chen J, Frazier ML, Sahin AA, Wistuba II, Sen S, Lott ST, Killary AM. DEAR1 is a Chromosome 1p35 Tumor Suppressor and Master Regulator of TGFβ-Driven Epithelial-Mesenchymal Transition. Cancer Discov. e-Pub 7/2013. PMID: 23838884.
3. Liu Q, Chen J, Wang J, Amos C, Killary AM, Sen S, Wei C, Frazier ML. Putative tumor suppressor gene SEL1L was downregulated by aberrantly upregulated hsa-mir-155 in human pancreatic ductal adenocarcinoma. Mol Carcinog. e-Pub 5/9/2013. PMID: 23661430.
4. Chen J, Pande M, Huang YJ, Wei C, Amos CI, Talseth-Palmer BA, Meldrum CJ, Chen WV, Gorlov IP, Lynch PM, Scott RJ, Frazier ML. Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients. Carcinogenesis. e-Pub 11/2012. PMID: 23125224.
5. Pande M, Wei C, Chen J, Amos CI, Lynch PM, Lu KH, Lucio LA, Boyd-Rogers SG, Bannon SA, Mork ME, Frazier ML. Cancer spectrum in DNA mismatch repair gene mutation carriers: results from a hospital based Lynch syndrome registry. Fam Cancer 11(3):441-447, 9/2012. PMCID: PMC3475767.
6. Bellows CF, Zhang Y, Chen J, Frazier ML, Kolonin MG. Circulation of progenitor cells in obese and lean colorectal cancer patients. Cancer Epidemiol Biomarkers Prev 20(11):2461-8, 11/2011. e-Pub 9/2011. PMID: 21930958.
7. Chen J, Wu X, Pande M, Amos CI, Killary AM, Sen S, Frazier ML. Susceptibility Locus for Lung Cancer at 15q25.1 is not Associated with Risk of Pancreatic Cancer. Pancreas 40(6):872-5, 8/2011. PMCID: PMC3138891.
8. Liu Q*, Chen J*, Mai B, Amos C, Killary AM, Sen S, Wei C, Frazier ML. A single-nucleotide polymorphism in tumor suppressor gene SEL1L as a predictive and prognostic marker for pancreatic ductal adenocarcinoma in caucasians. Mol Carcinog. e-Pub 6/2011. PMID: 21656579.
9. Balasenthil S, Chen N, Lott ST, Chen J, Carter J, Grizzle WE, Frazier ML, Sen S, Killary AM. A Migration Signature and Plasma Biomarker Panel for Pancreatic Adenocarcinoma. Cancer Prev Res (Phila) 4(1):137-49, 1/2011. e-Pub 11/2010. PMID: 21071578.
10. Chen J, Amos CI, Merriman KW, Wei Q, Sen S, Killary AM, Frazier ML. Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control study. Pancreas 39(1):1-4, 1/2010. PMCID: PMC2796289.
11. Chen J, Etzel CJ, Amos CI, Zhang Q, Viscofsky N, Lindor NM, Lynch PM, Frazier ML. Genetic Variants in The Cell Cycle Control Pathways Contribute to Early Onset Colorectal Cancer in Lynch Syndrome. Cancer Causes Control 20(9):1769-77, 11/2009. e-Pub 8/2009. PMID: 19690970.
12. Wang J, Chen J, Chang P, LeBlanc A, Li D, Abbruzzesse JL, Frazier ML, Killary AM, Sen S. MicroRNAs in Plasma of Pancreatic Ductal Adenocarcinoma Patients as Novel Blood Based Biomarkers of Disease. Cancer Prev Res (Phila) 2(9):807-13, 9/2009. e-Pub 9/2009. PMID: 19723895.
13. Lott ST, Chen N, Chandler DS, Yang Q, Wang L, Rodriguez M, Xie H, Balasenthil S, Buchholz TA, Sahin AA, Chaung K, Zhang B, Olufemi SE, Chen J, Adams H, Band V, El-Naggar AK, Frazier ML, Keyomarsi K, Hunt KK, Sen S, Haffty B, Hewitt SM, Krahe R, Killary AM. DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer. PLoS Med 6(5):e1000068, 5/2009. e-Pub 5/2009. PMCID: PMC2673042.
14. Chen J, Li D, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation. Ann Surg Oncol 16(2):431-9, 2/2009. e-Pub 11/2008. PMID: 19020940.
15. Chen J, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer. Cancer Lett 272(1):32-39, 12/2008. e-Pub 8/2008. PMID: 18694622.
16. Pande M, Amos CI, Osterwisch DR, Chen J, Lynch PM, Broaddus R, Frazier ML. Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome. Cancer Epidemiol Biomarkers Prev 17(9):2393-401, 9/2008. PMCID: PMC3028532.
17. Pande M, Chen J, Amos CI, Lynch PM, Broaddus R, Frazier ML. Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associated risk for colorectal cancer in a caucasian lynch syndrome population. Cancer Epidemiol Biomarkers Prev 16(9):1753-9, 9/2007. PMID: 17855693.
18. Chen J, Li D, Wei C, Sen S, Killary AM, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians. Clin Cancer Res 13(10):3100-4, 5/2007. PMCID: PMC2365501.
19. Chen J, Sen S, Amos CI, Wei C, Jones JS, Lynch P, Frazier ML. Association Between Aurora-A Kinase Polymorphisms and Age of Onset of Hereditary Nonpolyposis Colorectal Cancer in a Caucasian Population. Mol Carcinog 46(4):249-56, 4/2007. PMID: 17219423.
20. Jones JS, Amos CI, Pande M, Gu X, Chen J, Campos IM, Wei Q, Rodriguez-Bigas M, Lynch PM, Frazier ML. DNMT3b Polymorphism and Hereditary Nonpolyposis Colorectal Cancer Age of Onset. Cancer Epidemiol Biomarkers Prev 15(5):886-891, 5/2006. PMID: 16702365.
21. Chen J, Li Q. GYSB Decoction’s effect on immunologic enhancement and Prevention of Leukopenia casued by Chemotherapy. Journal of Chengdu:198-200, 1995.

Invited Articles

1. Chen J, Zhu J, Pande M, Amos J, Frazier ML, Wei C. Modifiers of Expression in Mutations of Mismatch Repair Gene Carriers in Hereditary Non-Polyposis Colorectal Cancer. Current Colorectal Cancer Reports 2:179-184, 2006.

Abstracts

1. Pande M*, Chen J*, Huang YJ, Wei C, Amos CI, Talseth-Palmer B, Meldrum CJ, Chen WV, Gorlov IP, Lynch PM, Scott R, Frazier ML. Cell cycle–related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients. AACR Frontiers in Cancer Prevention Research Conference (#A108), 10/2012.
2. Wei C, Huang Y, Chen J, Pande M, Amos CI, Frazier ML. Genetic variants in 15q25.1 and age of onset of pancreatic cancer. AACR Frontiers in Cancer Prevention Research Conference (#A25), 10/2012.
3. Chen J, Wang J, Balasenthil S, Liu Q, Chen N, Killary AM, Sen S, Frazier ML. A Genomic Pathway Approach to Biomarker Discovery for the Early Detection and Risk Assessment of Pancreatic Cancer, 9/2011.
4. Chen J, Etzel CJ, Amos CI , Zhang Q, Viscofsky N, Lynch PM, Frazier ML. Using tree-model to identify genetic determinant of early onset of Hereditary Nonpolyposis Colorectal Cancer, 2007.
5. Killary AM, Frazier ML, Lott S, Carter J, Stivers D, Chen J, Hwang R, Abbruzzese J, and Sen S. A Functional Genomic Approach to Biomarker Discovery in Pancreatic Cancer, 2006.
6. Chen J and Frazier ML. Association Between Aurora-A Polymorphism and Onset Age of Hereditary Nonpolyposis Colorectal Cancer, 2005.
7. Li D, Liu H, Evans DB, Abbruzzese JL, Chen J, and Frazier ML. Genetic Polymorphisms as Significant Prognosis Factors for Patients with Pancreatic Adenocarcinoma, 2005.
8. Frazier ML, Chen J, Jones JS, Lynch PM, Lindor N, and Amos CI. Influence of SNPs in Cell Cycle Control Genes on Age Associated Risk for Hereditary Nonpolyposis Colorectal Cancer. Breast and Colon Cancer, 2005.
9. Chen J and Frazier ML. Polymorphisms in the DNA Repair Gene XRCC1 and Hereditary Nonpolyposis Colorectal Cancer, 2004.

Grant & Contract Support

Title: Genetic Analysis of Anticipation in Lynch Syndrome
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Co-Investigator
Principal Investigator: Marsha L. Frazier
Duration: 1/1/2011 - 12/31/2013
 
Title: Biomarkers For the Early Detection of Pancreatic Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Ann M. Killary
Duration: 9/28/2004 - 6/30/2015
 
Title: Molecular Genetics of Hereditary Nonpolyposis of Colorectal Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Marsha Frazier
Duration: 6/1/1997 - 4/30/2012

Last updated: 11/20/2012