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Joerg J. Jacoby, Ph.D.

Present Title & Affiliation

Primary Appointment

Instructor, Department of Thoracic/Head and Neck Medical Oncology - Research, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1997 Heinrich Heine University, Duesseldorf, Germany, PHD, Microbiology
1992 Heinrich Heine University, Duesseldorf, Germany, BS/MS, Microbiology, Biophysics and Organic Chemistry

Postgraduate Training

8/1998-8/2002 Research Fellowship, Patholgy, Yale University, New Haven, CT, Xin-Yuan Fu, Ph.D.
11/1997-7/1998 Research Fellowship, Microbiology, Heinrich Heine University, Duesseldorf, Germany, Juergen J. Heinisch, Ph.D.

Selected Publications

Peer-Reviewed Original Research Articles
1. Moh A, Iwamoto Y, Chai GX, Zhang SSM, Kano A, Yang DD, Zhang W, Wang J, Jacoby JJ, Gao B, Flavell RA, Fu XY.. Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery. Lab Invest 87(10):1018-28, 10/2007. e-Pub 7/2007. PMID: 17660847.
2. Poblenz AT, Jacoby JJ, Singh S, Darnay BG.. Inhibition of RANKL-mediated osteoclast differentiation by selective TRAF6 decoy peptides. Biochem Biophys Res Commun 359(3):510-515, 8/2007. e-Pub 5/2007. PMID: 17544369.
3. Kano A, Wolfgang MJ, Gao Q, Jacoby J, Chai GX, Hansen W, Iwamoto Y, Pober JS, Flavell RA, Fu XY. Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. J Exp Med 198(10):1517-25, 11/2003. PMCID: PMC2194113.
4. Jacoby JJ, Kalinowski A, Liu MG, Zhang SS, Gao Q, Chai GX, Ji L, Iwamoto Y, Li E, Schneider M, Russell KS, Fu XY. Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proc Natl Acad Sci U S A 100(22):12929-34, 10/2003. PMID: 14566054.
5. Lorberg A, Schmitz HP, Jacoby JJ, Heinisch JJ. Lrg1p functions as a putative GTPase-activating protein in the Pkc1p-mediated cell integrity pathway in Saccharomyces cerevisiae. Mol Genet Genomics 266(3):514-26, 11/2001. PMID: 11713681.
6. Lorberg A, Jacoby JJ, Schmitz HP, Heinisch JJ. The PH domain of the yeast GEF Rom2p serves an essential function in vivo. Mol Genet Genomics 266(3):505-13, 11/2001. PMID: 11713680.
7. Ehrhard KN, Jacoby JJ, Fu XY, Jahn R, Dohlman HG. Use of G-protein fusions to monitor integral membrane protein-protein interactions in yeast. Nat Biotechnol 18(10):1075-9, 10/2000. PMID: 11017046.
8. Jacoby JJ, Kirchrath L, Gengenbacher U, Heinisch JJ. Characterization of KLBCK1, encoding a MAP kinase kinase kinase of Kluyveromyces lactis. J Mol Biol 288(3):337-52, 5/1999. PMID: 10329146.
9. Jacoby JJ, Nilius SM, Heinisch JJ. A screen for upstream components of the yeast protein kinase C signal transduction pathway identifies the product of the SLG1 gene. Mol Gen Genet 258(1-2):148-55, 4/1998. PMID: 9613583.
10. Heinisch JJ, Muller S, Schluter E, Jacoby J, Rodicio R. Investigation of two yeast genes encoding putative isoenzymes of phosphoglycerate mutase. Yeast 14(3):203-13, 2/1998. PMID: 9544241.
11. Jacoby JJ, Schmitz HP, Heinisch JJ. Mutants affected in the putative diacylglycerol binding site of yeast protein kinase C. FEBS Lett 417(2):219-22, 11/1997. PMID: 9395299.
12. Jacoby JJ, Heinisch JJ. Analysis of a transketolase gene from Kluyveromyces lactis reveals that the yeast enzymes are more related to transketolases of prokaryotic origins than to those of higher eukaryotes. Curr Genet 31(1):15-21, 1997. PMID: 9000376.
13. Jacoby J, Hollenberg CP, Heinisch JJ. Transaldolase mutants in the yeast Kluyveromyces lactis provide evidence that glucose can be metabolized through the pentose phosphate pathway. Mol Microbiol 10(4):867-76, 11/1993. PMID: 7934848.

Grant & Contract Support

Title: HIF-1 in lung cancer and antagonism by PX-478
Funding Source: Lung Cancer Research Foundation
Role: Principal Investigator
Duration: 8/1/2008 - 1/31/2010

Last updated: 3/5/2010