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John DiGiovanni, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Carcinogenesis, Science Park - Research Division, The University of Texas M.D. Anderson Cancer Center, Smithville, TX
Director, Center for Research on Environmental Disease, Science Park - Research Division, The University of Texas M.D. Anderson Cancer Center, Smithville, TX
J. Ralph Meadows Chair in Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Smithville, TX

Education & Training

Degree-Granting Education

1978 University of Washington, School of Medicine, Seattle, WA, PHD, Pharmacology
1974 University of Washington, School of Pharmacy, Seattle, WA, BS, Pharmacy

Postgraduate Training

1978-1980 Postdoctoral Fellow, University of Wisconsin, Madison, WI, R.K. Boutwell, Ph.D., Sc.D.

Selected Publications

Peer-Reviewed Original Research Articles
1. Hursting SC, Perkins SN, Lavigne JA, Beltran L, Haines DC, Hill HL, Alvord G, Barrett C, DiGiovanni J. Urothelial overexpression of insulin-like growth factor-1 increases susceptibility to p-cresidine-induced bladder carcinogenesis in transgenic mice. Mol Carcinog. In Press. PMID: 19415693.
2. Kim DJ, Kataoka K, Sano S, Connolly K, Kiguchi K, DiGiovanni J. Targeted disruption of Bcl-x(L) in mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis. Mol Carcinog. e-Pub 3/2009.
3. Kim DJ, Angel JM, Sano S, DiGiovanni J. Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis. Oncogene 28(7):950-60, 2/2009. PMCID: PMC2645481.
4. Wang G, Carbajal S, Vijg J, DiGiovanni J, Vasquez KM. DNA structure-induced genomic instability in vivo. J Natl Cancer Inst 100(24):1815-7, 12/2008. PMCID: PMC2639325.
5. Moore T, Beltran L, Carbajal S, Strom S, Traag J, Hursting SD, DiGiovanni J. Dietary energy balance modulates signaling through the Akt/mammalian target of rapamycin pathways in multiple epithelial tissues. Cancer Prev Res (Phila Pa) 1(1):65-76, 6/2008. PMID: 19138937.
6. Kataoka K, Kim DJ, Carbajal S, Clifford J, DiGiovanni J. Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis. Carcinogenesis 29(6):1108-14, 6/2008. PMID: 18453544.
7. Moore T, Carbajal S, Beltran L, Perkins SN, Yakar S, Leroith D, Hursting SD, DiGiovanni J. Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels. Cancer Res 68(10):3680-8, 5/2008. PMID: 18483250.
8. Chan KS, Sano S, Kataoka K, Abel E, Carbajal S, Beltran L, Clifford J, Peavey M, Shen J, DiGiovanni J. Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis. Oncogene 27(8):1087-94, 2/2008. PMID: 17700521.
9. Segrelles C, Lu J, Hammann B, Santos M, Moral M, Cascallana JL, Lara MF, Rho O, Carbajal S, Traag J, Beltran L, Martinez-Cruz AB, Garcia-Escudero R, Lorz C, Ruiz S, Bravo A, Paramio JM, DiGiovanni J. Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis. Cancer Res 67(22):10879-88, 11/2007. PMID: 18006833.
10. Kiguchi K, Ruffino L, Kawamoto T, Franco E, Kurakata S, Fujiwara K, Hanai M, Rumi M, DiGiovanni J. Therapeutic effect of CS-706, a specific cyclooxygenase-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice. Mol Cancer Ther 6(6):1709-17, 6/2007. PMID: 17575102.
11. Shen J, Riggs PK, Hensley SC, Schroeder LJ, Traner AR, Kochan KJ, Person MD, DiGiovanni J. Differential expression of multiple anti-apoptotic proteins in epidermis of IGF-1 transgenic mice as revealed by 2-dimensional gel electrophoresis/mass spectrometry analysis. Mol Carcinog 46(5):331-40, 5/2007. PMID: 17330866.
12. Wu Q, Kiguchi K, Kawamoto T, Ajiki T, Traag J, Carbajal S, Ruffino L, Thames H, Wistuba I, Thomas M, Vasquez KM, DiGiovanni J. Therapeutic effect of rapamycin on gallbladder cancer in a transgenic mouse model. Cancer Res 67(8):3794-800, 4/2007. PMID: 17440093.
13. He G, Sung YM, DiGiovanni J, Fischer SM. Thiazolidinediones inhibit insulin-like growth factor-i-induced activation of p70S6 kinase and suppress insulin-like growth factor-I tumor-promoting activity. Cancer Res 66(3):1873-8, 2/2006. PMID: 16452250.
14. Sano S, Chan KS, Kira M, Kataoka K, Takagi S, Tarutani M, Itami S, Kiguchi K, Yokoi M, Sugasawa K, Mori T, Hanaoka F, Takeda J, DiGiovanni J. Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Cancer Res 65(13):5720-9, 7/2005. PMID: 15994947.
15. Sano S, Chan KS, Carbajal S, Clifford J, Peavey M, Kiguchi K, Itami S, Nickoloff BJ, DiGiovanni J. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med 11(1):43-9, 1/2005. PMID: 15592573.

Last updated: 9/25/2009