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Juinn-Lin Liu, Ph.D.

Present Title & Affiliation

Primary Appointment

Instructor, Department of Neuro-Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1990 University of Florida, College of Medicine, Gainesville, FL, PHD, Pathology and Laboratory Medicine
1983 National Taiwan University, Taipei, Taiwan, DVM, Veterinary Medicine

Postgraduate Training

1990-1993 Post-Doctoral Fellow, Case Western Reserve University, Cleveland, OH, Dr. Hsing-Jien Kung

Experience/Service

Academic Appointments

Research Scientist, Department of Neuro-Oncology - Research, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2004-2008
Instructor, Department of Neuro-Oncology - Research, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2000-2004
Research Associate, Department of Neuro-Oncology - Research, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1999-2000
Research Associate, Case Western Reserve University, College of Medicine, Cleveland, OH, 1998-1999
Research Molecular Biologist, Avian Disease & Oncology Lab., US Department of Agriculture, Agricultural Research Station, East Lansng, MI, 1997-1998
Research Associate, Case Western Reserve University, College of Medicine, Cleveland, OH, 1993-1998

Honors and Awards

1997 Travel grant award, 22nd International Herpesvirus Workshop
1997 USDA Fellowship, USDA
1995 Travel Fellowship Award, The Sixth SCBA International Symposium
1979 Bookworm Award, National Taiwan University

Professional Memberships

Society of Neuro-Oncology (SNO), Houston, TX
Member, 2002-present
The United States Department of Agriculture (USDA), Washington, DC
Reviewer Panel, 1997-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Emerling BM, Weinberg F, Liu JL, Mak TW, Chandel NS. PTEN regulates p300-dependent hypoxia-inducible factor I transcriptional activity through Forkhead transcription factor 3a (FOXO3a). Proc Natl Acad Sci 105:2622-7, 2008.
2. Liu JL, Mao Z, LaFortune TA, Alonso MM, Gallick GE, Fueyo J, Yung WK. Cell cycle-dependent nuclear export of PTEN tumor suppressor is regulated by the P13K signaling cascade. Cancer Res 67(22):11054-63, 11/2007. PMID: 18006852.
3. Pelloski CE, Lin E, Zhang L, Yung WKA, Colman H, Liu JL, Woo SY, Heimberger AB, Suki D, Prados M, Chang S, Barker FG, Fuller GN, and Aldape KD.. Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma. Clin Cancer Res 12(13):3935-41, 2006. PMID: 16818690.
4. Liu JL, Sheng X, Hortobagyi ZK, Mao Z, Gallick GE, and Yung WKA.. Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation. Mol Cell Biol 25(14):6211-24, 2005. PMCID: PMC1168816.
5. Lee LF, Liu JL, Cui XP, and Kung HJ. Marek's disease virus latent protein MEQ: delineation of an epitope in the BR1 domain involved in nuclear localization. Virus Genes 27:211-218, 2003.
6. Gomez-Manzano C, Fueyo J, Jiang H, Glass TL, Lee HY, Hu M, Liu JL. Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis. Ann Neurol 53:109-17, 2003.
7. Sheng X, Koul D, Liu JL, Liu TJ, and Yung WKA. Promoter analysis of tumor suppressor gene PTEN: identification of minimum promoter region. Biochem Biophys Res Commun 292:422-6, 2002.
8. Kung HJ, Xia L, Brunovskis P, Li D, Liu JL, Lee LF. Meq: an MDV-specific bZIP transactivator with transforming properties. Curr Top Microbiol 255:245-60, 2001.
9. Liu JL, Hebert MD, Ye Y, Templeton D, Kung HJ, and Matera AG. Cell cycle-dependent localization of CDK2-cyclin E complex in Caja (coiled) bodies. J Cell Science 113:1543-52, 2000.
10. Liu JL, Kung HJ. Marek's disease herpesvirus transforming protein MEQ: a c-Jun analogue with an alternative life style. Virus Genes 21:51-64, 2000.
11. Fujise K, Zhang D, Liu JL, and Yeh ETH. Regulation of apoptosis and cell cycle progression by MCL1-differential role of PCNA. J Biol Chem 275:39458-39465, 2000.
12. Liu JL, Ye Y, Qian Z, Qian Y, Templeton D, Lee LF, and Kung HJ. Functional interactions between the herpesvirus oncoprotein MEQ and cell-cycle regulator CDK2. J Virol 73:4208-4219, 1999.
13. Liu JL, Lin SF, Xia L, Brunovskis P, Li D, Lee LF and Kung HJ. MEQ and v-IL8: Cellular genes in disguise. Acta Virol 43:94-101, 1999.
14. Liu JL, Ye Y, Lee LF, and Kung HJ. Transforming potential of the herpesvirus oncoprotein MEQ: morphological transformation, serum-independent growth, and inhibition of apoptosis. J Virol 72:388-395, 1998.
15. Liu JL, Lee LF, Ye Y, Qian Z, and Kung HJ. The nucleolar and nuclear localization properties of a herpesviral bZIP oncoprotein. MEQ J Virol 71:3188-3196, 1997.
16. Robinson D, Liu JL, Jones D, Brunovskis P, Qian Z et al. Avian leukemias and lymphomas: interplay between retroviruses and herpesviruses. Leukemia 3(11 Suppl):176-178, 1996.
17. Jones D, Lee L, Liu JL, Kung HJ, and Tillotson JK. Marek's disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors. Proc Natl Acad Sci 89:4041-4046, 1992.
18. Liu JL, Klien PA, Moscovici MG and Moscovici C. Monoclonal antibodies recognizing normal and retrovirus-transformed chicken hematopoietic cells. Virology 189:583-591, 1992.
19. Cui Z, Lee LF, Liu JL. Structural analysis and transcriptional mapping of the Marek's disease virus gene encoding pp38, an antigen associated with transformed cells. J Virol 65:6509-6515, 1991.
20. Shien YS, Liu JL. Canine primary intestinal lymphagiectasia: a case report and literature review. J Chinese Soc 9:167-176, 1983.

Invited Articles

1. Kung HJ, Liu JL. Retroviral insertional mutagenesis and oncogenesis. Forty-Seventh annual Meeting of the American College of Veterinary Pathologists.(Seattle, Washington):64-67, 1996.

Book Chapters

1. Kung HJ, Liu JL. Retroviral Oncogenesis. In: Viral Pathogenesis. Ed(s) N. Nathanson. Lippincott-Raven Publishers: Philadelphia, PA, 235-266, 1997.
2. Liu JL, Lee LF, and Kung HJ. Biological properties of the Marek's disease virus latent protein MEQ: subcellular localization and transforming potential. In: Current Research on Marek's Disease. Ed(s) Silva RF, Cheng HH, Coussens PM, Lee LF and Velicer LF. American Association of Avian Pathologists. Kennett Square, PA, 271-277, 1996.

Grant & Contract Support

Title: Analysis of a 10Q Tumor Suppressor Gene.
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: W. K. Alfred Yung, M.D.
Duration: 1/1/2003 - 6/30/2008
 
Title: Identification of AKT-independent signaling pathways involved in nuclear PTEN.
Funding Source: The University of Texas M. D. Anderson Cancer Center
Role: Principal Investigator
Duration: 1/1/2003 - 12/31/2004

Last updated: 8/2/2013