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Kaoru Kiguchi, MD, PhD

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Carcinogenesis, Science Park - Research Division, University of Texas M.D. Anderson Cancer Center, Smithville, TX

Education & Training

Degree-Granting Education

1979 Jikeii University of Medicine, Tokyo, Japan, PHD, Medicine
1974 Jikeii University of Medicine, Tokyo, Japan, MD, Medicine

Postgraduate Training

1983-1986 Fellowship, Division of Biological and Medical Research, Argonne National Laboratory, Argonne, IL, Dr. E. Huberman

Selected Publications

Peer-Reviewed Original Research Articles
1. Kim DJ, Kataoka K, Sano S, Connolly K, Kiguchi K, DiGiovanni J. Targeted disruption of Bcl-x(L) in mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis. Mol Carcinog, 3/2009. PMID: 19309000.
2. Moral M, Segrelles C, Lara MF, Martinez-Cruz AB, Lorz C, Santos M, Garcia-Escudero R, Lu J, Kiguchi K, Buitrago A, Costa C, Saiz C, Rodriguez-Peralto JL, Martinez-Tello FJ, Rodriguez-Pinilla M, Sanchez-Cespedes M, Garin M, Grande T, Bravo A, DiGiovanni J, Paramio JM.. Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma. Cancer Res 69(3):1099-108, 2/2009.
3. Liu B, Xia X, Zhu F, Park E, Carbajal S, Kiguchi K, DiGiovanni J, Fischer SM, Hu Y. IKKalpha is required to maintain skin homeostasis and prevent skin cancer. Cancer Cell 14(3):212-25, 9/2008. PMID: 18772111.
4. Kiguchi K, Ruffino L, Kawamoto T, Franco E, Kurakata S, Fujiwara K, Hanai M, Rumi M, DiGiovanni J. Therapeutic effect of CS-706, a specific COX-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice. Mol Cancer Ther 6(6):1709-17, 6/2007. PMID: 17575102.
5. Wu Q, Kiguchi K, Kawamoto T, Ajiki T, Traag J, Carbajal S, Ruffino L, Thames H, Wistuba I, Thomas M, Vasquez KM, DiGiovanni J. Therapeutic effect of rapamycin on gallbladder cancer in a transgenic mouse model. Cancer Res 6(8):3794-800, 4/2007. PMID: 17440093.
6. Kiguchi K, Ruffino L, Kawamoto T, Ajiki T, Digiovanni J. Chemopreventive and therapeutic efficacy of orally active tyrosine kinase inhibitors in a transgenic mouse model of gallbladder carcinoma. Clin Cancer Res 11(15):5572-80, 8/2005. PMID: 16061875.
7. Sano S, Chan KS, Kira M, Kataoka K, Takagi S, Tarutani M, Itami S, Kiguchi K, Yokoi M, Sugasawa K, Mori T, Hanaoka F, Takeda J, DiGiovanni J. Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Cancer Res 65(13):5720-9, 7/2005. PMID: 15994947.

Book Chapters
1. Kiguchi K, DiGiovanni J. Role of growth factor signaling pathways. In: Biliary Tract and Gallbladder Cancer: Diagnosis & Therapy. Ed(s) CR Thomas, C Fuller. Demos Medical: New York, 19-36, 2009.

Last updated: 10/16/2009