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Karen C. Dwyer

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Stem Cell Transplantation - Research, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Office Address

The University of Texas M. D. Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number: 900
Houston, TX 77030
Room Number: SCRB 1, 3.3015
Phone: 713-563-3322
Fax: 713-563-3364
Email: kcdwyer@mdanderson.org

Education & Training

Degree-Granting Education

2002 University of Wisconsin-Madison, Madison, WI, PHD, Biochemistry
1995 University of Massachusetts at Lowell, Lowell, MA, BS, Biological Sciences

Postgraduate Training

2002-2006 Research Fellowship, Trudeau Institute, Inc., Saranac Lake, NY, Susan Swain

Professional Memberships

American Association of Immunologists
Member, 2002-present
FlowTex: Texas Flow Cytometry Community
Member, 2006-present
International Society for the Advancement of Cytometry
Member, 2008-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Fiegl M, Samudio I, Clise-Dwyer K, Burks JK, Mnjoyan Z, Andreeff M. CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure. Blood 113(7):1504-12, 2/2009. PMCID: PMCPMC2644078.
2. Samudio I, Fiegl M, McQueen T, Clise-Dwyer K, Andreeff M. The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation. Cancer Res 68(13):5198-205, 7/2008. PMCID: PMCPMC2562568.
3. Jones SC, Clise-Dwyer K, Huston G, Dibble J, Eaton S, Haynes L, Swain SL. Impact of post-thymic cellular longevity on the development of age-associated CD4+ T cell defects. J Immunol 180(7):4465-75, 4/2008. PMCID: PMCPMC2366213.
4. Clise-Dwyer K, Huston GE, Buck AL, Duso DK, Swain SL. Environmental and intrinsic factors lead to antigen unresponsiveness in CD4(+) recent thymic emigrants from aged mice. J Immunol 178(3):1321-31, 2/2007. PMID: 17237378.
5. Harless SM, Lentz VM, Sah AP, Hsu BL, Clise-Dwyer K, Hilbert DM, Hayes CE, Cancro MP. Competition for BLyS-mediated signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers. Curr Biol 11(24):1986-9, 12/2001. PMID: 11747827.
6. Amanna IJ, Clise-Dwyer K, Nashold FE, Hoag KA, Hayes CE. Cutting edge: A/WySnJ transitional B cells overexpress the chromosome 15 proapoptotic Blk gene and succumb to premature apoptosis. J Immunol 167(11):6069-72, 12/2001. PMID: 11714762.
7. Clise-Dwyer K, Amanna IJ, Duzeski JL, Nashold FE, Hayes CE. Genetic studies of B-lymphocyte deficiency and mastocytosis in strain A/WySnJ mice. Immunogenetics 53(9):729-35, 12/2001. PMID: 11862404.
8. Hoag KA, Clise-Dwyer K, Lim YH, Nashold FE, Gestwicki J, Cancro MP, Hayes CE. A quantitative-trait locus controlling peripheral B-cell deficiency maps to mouse Chromosome 15. Immunogenetics 51(11):924-9, 9/2000. PMID: 11003386.

Invited Articles
1. Swain S, Clise-Dwyer K, Haynes L. Homeostasis and the age-associated defect of CD4 T cells. Semin Immunol 17(5):370-7, 10/2005. PMID: 15964201.

Grant & Contract Support

Title: The Therapy of CML: Core C - Immunology
Funding Source: NIH/NCI
Role: Core Leader
Principal Investigator: Champlin
Duration: 12/1/2010 - 11/30/2013
 
Title: Translational Development of Novel Vaccine Therapies, Core C - FACS Core
Funding Source: Leukemia and Lymphoma Society
Role: Core Leader
Principal Investigator: Kwak
Duration: 10/1/2008 - 9/30/2009
 
Title: Cancer Center Support Grant (CCSG): Automated Flow Cytometry and Image Analysis Laboratory
Funding Source: NIH/NCI
Role: Core Leader
Principal Investigator: Mendelsohn
Duration: 7/1/2008 - 6/30/2013
 
Title: The Therapy of CML: Core C - Immunology, no-cost extension
Funding Source: NIH/NCI
Role: Core Leader
Principal Investigator: Champlin
Duration: 2/12/2003 - 2/28/2010

Last updated: 8/31/2009