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Keping Xie, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Professor (Tenured), Department of Gastroenterology, Hepat,& Nutr, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Chief, Section of Gastroenterology Research Director, Laboratory for Gastrointestinal Cancer Research, Department of Gastroenterology, Hepat,& Nutr, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number 1466
Houston, TX 77030
Phone: 713-794-5073

Education & Training

Degree-Granting Education

1998 UT M.D. Anderson Cancer Center, Houston, TX, Research Associate, Cancer Metastasis
1982 Zhenjiang Medical College, Zhenjiang, China, MD, Medicine

Selected Publications

Peer-Reviewed Original Research Articles

1. Sun H, Tang H, Xie D, Jia Z, Ma Z, Wei D, Mishra L, Gao Y, Zheng S, Xie K, Peng Z. Krüppel-like Factor 4 Blocks Hepatocellular Carcinoma Dedifferentiation and Progression through Activation of Hepatocyte Nuclear Factor-6. Clin Cancer Res 22(2):502-12, 1/15/2016. e-Pub 9/2/2015. PMCID: PMC4715982.
2. Li F, Hu J, Xie K, He TC. Authentication of experimental materials: A remedy for the reproducibility crisis? Genes Dis 2(4):283, 12/2015. e-Pub 7/7/2015. PMCID: PMC4758512.
3. Xie D, Cui J, Xia T, Jia Z, Wang L, Wei W, Zhu A, Gao Y, Xie K, Quan M. Hippo transducer TAZ promotes epithelial mesenchymal transition and supports pancreatic cancer progression. Oncotarget 6(34):35949-63, 11/3/2015. PMID: 26416426.
4. Quan M, Cui J, Xia T, Jia Z, Xie D, Wei D, Huang S, Huang Q, Zheng S, Xie K. Merlin/NF2 Suppresses Pancreatic Tumor Growth and Metastasis by Attenuating the FOXM1-Mediated Wnt/β-Catenin Signaling. Cancer Res 75(22):4778-89, 11/15/2015. e-Pub 10/19/2015. PMCID: PMC4651817.
5. Xue J, Zhou A, Tan C, Wu Y, Lee HT, Li W, Xie K, Huang S. Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression. J Biol Chem 290(30):18662-70, 7/24/2015. e-Pub 6/17/2015. PMCID: PMC4513123.
6. Xie D, Xie K. Pancreatic cancer stromal biology and therapy. Genes Dis 2(2):133-143, 6/1/2015. PMCID: PMC4476547.
7. Yu G, Zhou A, Xue J, Huang C, Zhang X, Kang SH, Chiu WT, Tan C, Xie K, Wang J, Huang S. FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway. Oncotarget 6(13):11281-94, 5/10/2015. PMCID: PMC4484456.
8. Zhu M, Guo J, Li W, Lu Y, Fu S, Xie X, Xia H, Dong X, Chen Y, Quan M, Zheng S, Xie K, Li M. Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells. Oncotarget 6(14):12196-208, 5/20/2015. PMCID: PMC4494932.
9. Yu G, Fang W, Xia T, Chen Y, Gao Y, Jiao X, Huang S, Wang J, Li Z, Xie K. Metformin potentiates rapamycin and cisplatin in gastric cancer in mice. Oncotarget 6(14):12748-62, 5/20/2015. PMCID: PMC4494971.
10. Lee HT, Xue J, Chou PC, Zhou A, Yang P, Conrad CA, Aldape KD, Priebe W, Patterson C, Sawaya R, Xie K, Huang S. Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells. Oncotarget 6(12):10016-29, 4/30/2015. PMCID: PMC4496337.
11. Yao JC, Phan AT, Hess K, Fogelman D, Jacobs C, Dagohoy C, Leary C, Xie K, Ng CS. Perfusion computed tomography as functional biomarker in randomized run-in study of bevacizumab and everolimus in well-differentiated neuroendocrine tumors. Pancreas 44(2):190-7, 3/2015. PMID: 25426617.
12. Li Z, Jia Z, Gao Y, Xie D, Wei D, Cui J, Mishra L, Huang S, Zhang Y, Xie K. Activation of vitamin D receptor signaling downregulates the expression of nuclear FOXM1 protein and suppresses pancreatic cancer cell stemness. Clin Cancer Res 21(4):844-53, 2/15/2015. e-Pub 12/11/2014. PMCID: PMC4334671.
13. Yu G, Yu W, Jin G, Xu D, Chen Y, Xia T, Yu A, Fang W, Zhang X, Li Z, Xie K. PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma. Mol Cancer 14(1):193, 2015. e-Pub 11/14/2015. PMCID: PMC4650283.
14. Li Z, Guo J, Xie K, Zheng S. Vitamin D receptor signaling and pancreatic cancer cell EMT. Curr Pharm Des 21(10):1262-7, 2015. PMID: 25506892.
15. Shi M, Cui J, Du J, Wei D, Jia Z, Zhang J, Zhu Z, Gao Y, Xie K. A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer. Clin Cancer Res 20(16):4370-80, 8/15/2014. e-Pub 6/19/2014. PMCID: PMC4134726.
16. Li X, Wang Z, Ma Q, Xu Q, Liu H, Duan W, Lei J, Ma J, Wang X, Lv S, Han L, Li W, Guo J, Guo K, Zhang D, Wu E, Xie K. Sonic hedgehog paracrine signaling activates stromal cells to promote perineural invasion in pancreatic cancer. Clin Cancer Res 20(16):4326-38, 8/15/2014. e-Pub 6/19/2014. PMID: 24947933.
17. Li L, Li Z, Kong X, Xie D, Jia Z, Jiang W, Cui J, Du Y, Wei D, Huang S, Xie K. Down-regulation of microRNA-494 via loss of SMAD4 increases FOXM1 and β-catenin signaling in pancreatic ductal adenocarcinoma cells. Gastroenterology 147(2):485-97.e18, 8/2014. e-Pub 5/20/2014. PMID: 24859161.
18. Cui J, Shi M, Xie D, Wei D, Jia Z, Zheng S, Gao Y, Huang S, Xie K. FOXM1 Promotes the Warburg Effect and Pancreatic Cancer Progression via Transactivation of LDHA Expression. Clin Cancer Res. e-Pub 3/14/2014. PMID: 24634381.
19. Huang C, Xie D, Cui J, Li Q, Gao Y, Xie K. FOXM1c Promotes Pancreatic Cancer Epithelial-to-Mesenchymal Transition and Metastasis via Upregulation of Expression of the Urokinase Plasminogen Activator System. Clin Cancer Res 20(6):1477-88, 3/15/2014. e-Pub 1/22/2014. PMCID: PMC3959252.
20. Xie K, Gao A, Li M, Wang X. Printing properties of the red reactive dyes with different number sulfonate groups on cotton fabric. Carbohydr Polym 101:666-70, 1/30/2014. e-Pub 10/7/2013. PMID: 24299824.
21. Shi M, Xie D, Gao Y, Xie K. Targeting MiRNAs for Pancreatic Cancer Therapy. Curr Pharm Des. e-Pub 1/28/2014. PMID: 24479803.
22. Huang C, Du J, Xie K. FOXM1 and its oncogenic signaling in pancreatic cancer pathogenesis. Biochim Biophys Acta 1845(2). e-Pub 1/2014. PMID: 24418574.
23. Cui J, Shi M, Quan M, Xie K. Regulation of EMT by KLF4 in gastrointestinal cancer. Curr Cancer Drug Targets 13(9):986-95, 11/2013. PMID: 24168184.
24. Li L, Du Y, Kong X, Li Z, Jia Z, Cui J, Gao J, Wang G, Xie K. Lamin B1 is a novel therapeutic target of betulinic acid in pancreatic cancer. Clin Cancer Res 19(17):4651-61, 9/2013. e-Pub 7/2013. PMCID: PMC3800003.
25. Shi M, Cui J, Xie K. Signaling of miRNAs-FOXM1 in cancer and potential targeted therapy. Curr Drug Targets 14(10):1192-202, 9/2013. PMID: 23834153.
26. Kong X, Li L, Li Z, Le X, Huang C, Jia Z, Cui J, Huang S, Wang L, Xie K. Dysregulated expression of FOXM1 isoforms drives progression of pancreatic cancer. Cancer Res 73(13):3987-96, 7/2013. e-Pub 4/2013. PMCID: PMC3702645.
27. Guo K, Ma Q, Li J, Wang Z, Shan T, Li W, Xu Q, Xie K. Interaction of the sympathetic nerve with pancreatic cancer cells promotes perineural invasion through the activation of STAT3 signaling. Mol Cancer Ther 12(3):264-73, 3/2013. e-Pub 1/2013. PMID: 23288783.
28. Li D, Wei P, Peng Z, Huang C, Tang H, Jia Z, Cui J, Le X, Huang S, Xie K. The critical role of dysregulated FOXM1-PLAUR signaling in human colon cancer progression and metastasis. Clin Cancer Res 19(1):62-72, 1/2013. e-Pub 11/2012. PMCID: PMC3537853.
29. Huang C, Xie K. Analysis of the potential for pancreatic cancer metastasis in vitro and in vivo. Methods Mol Biol 980:301-19, 2013. PMID: 23359162.
30. Quan M, Wang P, Cui J, Gao Y, Xie K. The roles of FOXM1 in pancreatic stem cells and carcinogenesis. Mol Cancer 12:159, 2013. e-Pub 12/2013. PMCID: PMC3924162.
31. Li Q, Gao Y, Jia Z, Mishra L, Guo K, Li Z, Le X, Wei D, Huang S, Xie K. Dysregulated KLF4 and Vitamin D Receptor Signaling Promotes Hepatocellular Carcinoma Progression. Gastroenterology 143(3):799-810.e1-2, 9/2012. e-Pub 6/2012. PMCID: PMC3653768.
32. Li Q, Jia Z, Wang L, Kong X, Li Q, Guo K, Tan D, Le X, Wei D, Huang S, Mishra L, Xie K. Disruption of klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice. Gastroenterology 142(3):531-42, 3/2012. e-Pub 12/2011. PMID: 22155367.
33. Huang C, Qiu Z, Wang L, Peng Z, Jia Z, Logsdon CD, Le X, Wei D, Huang S, Xie K. A Novel FoxM1-Caveolin Signaling Pathway Promotes Pancreatic Cancer Invasion and Metastasis. Cancer Res 72(3):655-65, 2/2012. e-Pub 12/2011. PMCID: PMC3271134.
34. Huang C, Xie K. Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis. Cytokine Growth Factor Rev 23(1-2):25-35, 2/2012. e-Pub 2/16/2012. PMCID: PMC3307878.
35. Li W, Ma Q, Liu J, Han L, Ma G, Liu H, Shan T, Xie K, Wu E. Hyperglycemia as a mechanism of pancreatic cancer metastasis. Front Biosci 17:1761-74, 2012. e-Pub 1/1/2012. PMID: 22201834.
36. Cui J, Jiang W, Wang S, Wang L, Xie K. Role of Wnt/β-catenin signaling in drug resistance of pancreatic cancer. Curr Pharm Des 18(17):2464-71, 2012. PMID: 22372504.
37. Zhang N, Wei P, Gong A, Chiu WT, Lee HT, Colman H, Huang H, Xue J, Liu M, Wang Y, Sawaya R, Xie K, Yung WK, Medema RH, He X, Huang S. FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell 20(4):427-42, 10/2011. PMCID: PMC3199318.
38. Gao Y, Jia Z, Kong X, Li Q, Chang DZ, Wei D, Le X, Suyun H, Huang S, Wang L, Xie K. Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis. Cancer Res 71(15):5182-93, 8/2011. e-Pub 6/2011. PMCID: PMC3245664.
39. Chiu WT, Lee HT, Huang FJ, Aldape KD, Yao J, Steeg PS, Chou CY, Lu Z, Xie K, Huang S. Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition. Cancer Res 71(14):4932-43, 7/15/2011. e-Pub 5/27/2011. PMID: 21622714.
40. Li D, Peng Z, Tang H, Wei P, Kong X, Yan D, Huang F, Li Q, Le X, Li Q, Xie K. KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis. Clin Cancer Res 17(11):3558-68, 6/1/2011. e-Pub 4/29/2011. PMCID: PMC3107880.
41. Wei D, Wang L, Kanai M, Jia Z, Le X, Li Q, Wang H, Xie K. KLF4a Up-regulation Promotes Cell Cycle Progression and Reduces Survival Time of Patients With Pancreatic Cancer. Gastroenterology 139(6):2135-45, 12/2010. e-Pub 8/2010. PMID: 20727893.
42. Dai B, Pieper RO, Li D, Wei P, Liu M, Woo SY, Aldape KD, Sawaya R, Xie K, Huang S. FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes. Cancer Res 70(7):2951-61, 4/1/2010. e-Pub 3/23/2010. PMCID: PMC2848915.
43. Jia Z, Gao Y, Wang L, Li Q, Zhang J, Le X, Wei D, Yao JC, Chang DZ, Huang S, Xie K. Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity. Cancer Res 70(3):1111-9, 2/2010. e-Pub 1/2010. PMCID: PMC2840649.
44. Hu HT, Ma QY, Zhang D, Shen SG, Han L, Ma YD, Li RF, Xie KP. HIF-1alpha links beta-adrenoceptor agonists and pancreatic cancer cells under normoxic condition. Acta Pharmacol Sin 31(1):102-10, 1/2010. e-Pub 12/28/2009. PMID: 20037603.
45. Li Q, Wei D, Wang L, Wang L, Jia Z, Le X, Gao Y, Huang S, Xie K. Modeling liver metastasis using a tumor cell line derived from an enhanced green fluorescent protein transgenic mouse. Clin Exp Metastasis 27(1):11-8, 2010. e-Pub 10/31/2009. PMID: 19882218.
46. Wang L, Xie K. Nitric oxide and pancreatic cancer pathogenesis, prevention, and treatment. Curr Pharm Des 16(4):421-7, 2010. PMID: 20236070.
47. Hu W, Hofstetter WL, Li H, Zhou Y, He Y, Pataer A, Wang L, Xie K, Swisher SG, Fang B. Putative tumor-suppressive function of kruppel-like factor 4 in primary lung carcinoma. Clin Cancer Res 15(18):5688-95, 9/15/2009. e-Pub 9/8/2009. PMCID: PMC2745510.
48. Zheng Y, Xia Y, Hawke D, Halle M, Tremblay ML, Gao X, Zhou XZ, Aldape K, Cobb MH, Xie K, He J, Lu Z. FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell 35(1):11-25, 7/2009. PMCID: PMC2715139.
49. Li Q, Zhang N, Jia Z, Le X, Dai B, Wei D, Huang S, Tan D, Xie K. Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression. Cancer Res 69(8):3501-9, 4/2009. e-Pub 4/2009. PMID: 19351851.
50. Yu G, Wang J, Chen Y, Wang X, Pan J, Li G, Jia Z, Li Q, Yao JC, Xie K. Overexpression of Phosphorylated Mammalian Target of Rapamycin Predicts Lymph Node Metastasis and Prognosis of Chinese Patients with Gastric Cancer. Clin Cancer Res 15(5):1821-9, 3/2009. e-Pub 2/2009. PMID: 19223493.
51. Truong CD, Feng W, Li W, Khoury T, Li Q, Alrawi S, Yu Y, Xie K, Yao J, Tan D. Characteristics of Epstein-Barr virus-associated gastric cancer: a study of 235 cases at a comprehensive cancer center in U.S.A. J Exp Clin Cancer Res 28:14, 2009. PMCID: PMC2642773.
52. Fan J, Peng Z, Zhou C, Qiu G, Tang H, Sun Y, Wang X, Li Q, Le X, Xie K. Gene-Expression Profiling in Chinese Patients with Colon Cancer by Coupling Experimental and Bioinformatic Genome-Wide Gene-Expression Analysis: Indentification and Validation of IFITM3 as Biomarkers of Early Colon Carcinogenesis. Cancer 113(2):266-75, 7/15/2008. PMID: 18470904.
53. Wang L, Guan X, Zhang J, Jia Z, Wei D, Li Q, Yao J, Xie K. Targeted Inhibition of Sp1-mediated Transcription for Antiangiogenic Therapy of Metastatic Human Gastric Cancer in Orthotopic Nude Mouse Models. Int J Oncol 33(1):161-7, 7/2008. PMID: 18575762.
54. Wei D, Kanai M, Jia Z, Le X, Xie K. Kruppel-like Factor 4 Induces p27Kip1 Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells. Cancer Res 68(12):4631-9, 6/15/2008. PMCID: PMC2481517.
55. Truong CD, Li W, Feng W, Cagle P, Khoury T, Alrawi S, Xie K, Yao J, Tan D. Alpha-Methylacyl-CoA Racemase Expression is Upregulated in Gastric Adenocarcinoma: A Study of 249 Cases. Int J Clin Exp Pathol 1(6):518-23, 2008. PMCID: PMC2480587.
56. Zhang Y, Zhang N, Dai B, Liu M, Sawaya R, Xie K, Huang S. FoxM1B Transcriptionally Regulates Vascular Endothelial Growth Factor Expression and Promotes the Angiogenesis and Growth of Glioma Cells. Cancer Res 68(2):8733-42, 2008. PMID: 18974115.
57. Peng Z, Tang H, Wang X, Zhou C, Fan J, Wang L, Jia Z, Li Q, Le X, Wei D, Xie K. Inhibition of the Growth and Metastasis of Human Colon Cancer by Restoration of RUNX3 Expression in Cancer Cells. Int J Oncol 33(5):979-84, 2008. PMID: 18949360.
58. Huang F-J, Steeg PS, Price JE, Chou P-C, Xie K, Sawaya R, Huang S. Molecular Basis for the Critical Role of Suppressor of Cytokine Signaling-1 in Melanoma Brain Metastasis. Cancer Res 68(23):9634-42, 2008. PMID: 19047140.
59. Yu G, Wang J, Chen Y, Wang X, Pan J, Li Q, Xie K. Tissue Microarray Analysis Reveals Strong Clinical Evidence for a Close Association Between Loss of Annexin A1 Expression and Nodal Metastasis in Gastric Cancer. Clin Exp Metastasis 25(7):695-702, 2008. e-Pub 6/2008. PMID: 18535914.

Grant & Contract Support

Title: Molecular Mediators of Pancreatic Cancer Invasion and Progression
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 4/1/2013 - 3/31/2018
Title: KLF-Pathway-Based Targeted Therapy for Pancreatic Cancer
Funding Source: Khalifa Bin Zayed Al Nahyan Foundation
Role: Principal Investigator-MDACC
Duration: 10/1/2010 - 9/30/2011
Title: Genetic Approaches to Pancreatic Cancer Progression
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 8/1/2010 - 7/31/2015
Title: KLF4 Genetic and Epigenetic Changes in Human Pancreatic Cancer
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 8/1/2010 - 7/31/2014
Title: Functional Validation of Pancreatic Cancer Progression Biomarker
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/1/2010 - 6/30/2015
Title: Transcription factor Sp1 and human pancreatic cancer angiogenesis and metastasis
Funding Source: NIH/NCI
Role: Project Leader
Duration: 9/1/2003 - 8/31/2010
Title: Sp1 in Human Gastric Cancer Angiogenesis and Metastasis|/b
Funding Source: American Cancer Society (ACS)
Role: Principal Investigator

Last updated: 7/18/2016