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Keping Xie, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Professor (Tenured), Department of Gastroenterology, Hepat,& Nutr, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Chief, Section of Gastroenterology Research Director, Laboratory for Gastrointestinal Cancer Research, Department of Gastroenterology, Hepat,& Nutr, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1998 UT M.D. Anderson Cancer Center, Houston, TX, Research Associate, Cancer Metastasis
1982 Zhenjiang Medical College, Zhenjiang, China, MD, Medicine

Selected Publications

Peer-Reviewed Original Research Articles

1. Li Q, Gao Y, Jia Z, Mishra L, Guo K, Li Z, Le X, Wei D, Huang S, Xie K. Dysregulated KLF4 and Vitamin D Receptor Signaling Promotes Hepatocellular Carcinoma Progression. Gastroenterology 143(3):799-810.e1-2, 9/2012. e-Pub 6/2012. PMCID: PMC3653768.
2. Li Q, Jia Z, Wang L, Kong X, Li Q, Guo K, Tan D, Le X, Wei D, Huang S, Mishra L, Xie K. Disruption of klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice. Gastroenterology 142(3):531-42, 3/2012. e-Pub 12/2011. PMID: 22155367.
3. Huang C, Qiu Z, Wang L, Peng Z, Jia Z, Logsdon CD, Le X, Wei D, Huang S, Xie K. A Novel FoxM1-Caveolin Signaling Pathway Promotes Pancreatic Cancer Invasion and Metastasis. Cancer Res 72(3):655-65, 2/2012. e-Pub 12/2011. PMCID: PMC3271134.
4. Huang C, Xie K. Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis. Cytokine Growth Factor Rev 23(1-2):25-35, 2/2012. e-Pub 2/16/2012. PMCID: PMC3307878.
5. Li W, Ma Q, Liu J, Han L, Ma G, Liu H, Shan T, Xie K, Wu E. Hyperglycemia as a mechanism of pancreatic cancer metastasis. Front Biosci 17:1761-74, 2012. e-Pub 1/1/2012. PMID: 22201834.
6. Cui J, Jiang W, Wang S, Wang L, Xie K. Role of Wnt/β-catenin signaling in drug resistance of pancreatic cancer. Curr Pharm Des 18(17):2464-71, 2012. PMID: 22372504.
7. Zhang N, Wei P, Gong A, Chiu WT, Lee HT, Colman H, Huang H, Xue J, Liu M, Wang Y, Sawaya R, Xie K, Yung WK, Medema RH, He X, Huang S. FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell 20(4):427-42, 10/2011. PMCID: PMC3199318.
8. Gao Y, Jia Z, Kong X, Li Q, Chang DZ, Wei D, Le X, Suyun H, Huang S, Wang L, Xie K. Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis. Cancer Res 71(15):5182-93, 8/2011. e-Pub 6/2011. PMCID: PMC3245664.
9. Chiu WT, Lee HT, Huang FJ, Aldape KD, Yao J, Steeg PS, Chou CY, Lu Z, Xie K, Huang S. Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition. Cancer Res 71(14):4932-43, 7/15/2011. e-Pub 5/27/2011. PMID: 21622714.
10. Li D, Peng Z, Tang H, Wei P, Kong X, Yan D, Huang F, Li Q, Le X, Li Q, Xie K. KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis. Clin Cancer Res 17(11):3558-68, 6/1/2011. e-Pub 4/29/2011. PMCID: PMC3107880.
11. Wei D, Wang L, Kanai M, Jia Z, Le X, Li Q, Wang H, Xie K. KLF4a Up-regulation Promotes Cell Cycle Progression and Reduces Survival Time of Patients With Pancreatic Cancer. Gastroenterology 139(6):2135-45, 12/2010. e-Pub 8/2010. PMID: 20727893.
12. Dai B, Pieper RO, Li D, Wei P, Liu M, Woo SY, Aldape KD, Sawaya R, Xie K, Huang S. FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes. Cancer Res 70(7):2951-61, 4/1/2010. e-Pub 3/23/2010. PMCID: PMC2848915.
13. Jia Z, Gao Y, Wang L, Li Q, Zhang J, Le X, Wei D, Yao JC, Chang DZ, Huang S, Xie K. Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity. Cancer Res 70(3):1111-9, 2/2010. e-Pub 1/2010. PMCID: PMC2840649.
14. Hu HT, Ma QY, Zhang D, Shen SG, Han L, Ma YD, Li RF, Xie KP. HIF-1alpha links beta-adrenoceptor agonists and pancreatic cancer cells under normoxic condition. Acta Pharmacol Sin 31(1):102-10, 1/2010. e-Pub 12/28/2009. PMID: 20037603.
15. Li Q, Wei D, Wang L, Wang L, Jia Z, Le X, Gao Y, Huang S, Xie K. Modeling liver metastasis using a tumor cell line derived from an enhanced green fluorescent protein transgenic mouse. Clin Exp Metastasis 27(1):11-8, 2010. e-Pub 10/31/2009. PMID: 19882218.
16. Wang L, Xie K. Nitric oxide and pancreatic cancer pathogenesis, prevention, and treatment. Curr Pharm Des 16(4):421-7, 2010. PMID: 20236070.
17. Hu W, Hofstetter WL, Li H, Zhou Y, He Y, Pataer A, Wang L, Xie K, Swisher SG, Fang B. Putative tumor-suppressive function of kruppel-like factor 4 in primary lung carcinoma. Clin Cancer Res 15(18):5688-95, 9/15/2009. e-Pub 9/8/2009. PMCID: PMC2745510.
18. Zheng Y, Xia Y, Hawke D, Halle M, Tremblay ML, Gao X, Zhou XZ, Aldape K, Cobb MH, Xie K, He J, Lu Z. FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell 35(1):11-25, 7/2009. PMCID: PMC2715139.
19. Li Q, Zhang N, Jia Z, Le X, Dai B, Wei D, Huang S, Tan D, Xie K. Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression. Cancer Res 69(8):3501-9, 4/2009. e-Pub 4/2009. PMID: 19351851.
20. Yu G, Wang J, Chen Y, Wang X, Pan J, Li G, Jia Z, Li Q, Yao JC, Xie K. Overexpression of Phosphorylated Mammalian Target of Rapamycin Predicts Lymph Node Metastasis and Prognosis of Chinese Patients with Gastric Cancer. Clin Cancer Res 15(5):1821-9, 3/2009. e-Pub 2/2009. PMID: 19223493.
21. Truong CD, Feng W, Li W, Khoury T, Li Q, Alrawi S, Yu Y, Xie K, Yao J, Tan D. Characteristics of Epstein-Barr virus-associated gastric cancer: a study of 235 cases at a comprehensive cancer center in U.S.A. J Exp Clin Cancer Res 28:14, 2009. PMCID: PMC2642773.
22. Fan J, Peng Z, Zhou C, Qiu G, Tang H, Sun Y, Wang X, Li Q, Le X, Xie K. Gene-Expression Profiling in Chinese Patients with Colon Cancer by Coupling Experimental and Bioinformatic Genome-Wide Gene-Expression Analysis: Indentification and Validation of IFITM3 as Biomarkers of Early Colon Carcinogenesis. Cancer 113(2):266-75, 7/15/2008. PMID: 18470904.
23. Wang L, Guan X, Zhang J, Jia Z, Wei D, Li Q, Yao J, Xie K. Targeted Inhibition of Sp1-mediated Transcription for Antiangiogenic Therapy of Metastatic Human Gastric Cancer in Orthotopic Nude Mouse Models. Int J Oncol 33(1):161-7, 7/2008. PMID: 18575762.
24. Wei D, Kanai M, Jia Z, Le X, Xie K. Kruppel-like Factor 4 Induces p27Kip1 Expression in and Suppresses the Growth and Metastasis of Human Pancreatic Cancer Cells. Cancer Res 68(12):4631-9, 6/15/2008. PMCID: PMC2481517.
25. Truong CD, Li W, Feng W, Cagle P, Khoury T, Alrawi S, Xie K, Yao J, Tan D. Alpha-Methylacyl-CoA Racemase Expression is Upregulated in Gastric Adenocarcinoma: A Study of 249 Cases. Int J Clin Exp Pathol 1(6):518-23, 2008. PMCID: PMC2480587.
26. Zhang Y, Zhang N, Dai B, Liu M, Sawaya R, Xie K, Huang S. FoxM1B Transcriptionally Regulates Vascular Endothelial Growth Factor Expression and Promotes the Angiogenesis and Growth of Glioma Cells. Cancer Res 68(2):8733-42, 2008. PMID: 18974115.
27. Peng Z, Tang H, Wang X, Zhou C, Fan J, Wang L, Jia Z, Li Q, Le X, Wei D, Xie K. Inhibition of the Growth and Metastasis of Human Colon Cancer by Restoration of RUNX3 Expression in Cancer Cells. Int J Oncol 33(5):979-84, 2008. PMID: 18949360.
28. Huang F-J, Steeg PS, Price JE, Chou P-C, Xie K, Sawaya R, Huang S. Molecular Basis for the Critical Role of Suppressor of Cytokine Signaling-1 in Melanoma Brain Metastasis. Cancer Res 68(23):9634-42, 2008. PMID: 19047140.
29. Yu G, Wang J, Chen Y, Wang X, Pan J, Li Q, Xie K. Tissue Microarray Analysis Reveals Strong Clinical Evidence for a Close Association Between Loss of Annexin A1 Expression and Nodal Metastasis in Gastric Cancer. Clin Exp Metastasis 25(7):695-702, 2008. e-Pub 6/2008. PMID: 18535914.

Grant & Contract Support

Title: Genetic Approaches to Pancreatic Cancer Progression
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 8/1/2010 - 7/31/2015
Title: KLF4 Genetic and Epigenetic Changes in Human Pancreatic Cancer
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 8/1/2010 - 7/31/2014
Title: Functional Validation of Pancreatic Cancer Progression Biomarker
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/1/2010 - 6/30/2015
Title: Transcription factor Sp1 and human pancreatic cancer angiogenesis and metastasis
Funding Source: NIH/NCI
Role: Project Leader
Duration: 9/1/2003 - 8/31/2010

Last updated: 3/11/2015