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Krishna M Sinha, Ph.D

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

Molecular study of osteoblast differentiation and bone formation

Education & Training

Degree-Granting Education

1996 Indian Agricultural Research Institute, New Delhi, India, PHD, Biochemistry
1991 Indian Agricultural Research Institute, New Delhi, India, MS, Biochemistry

Experience/Service

Academic Appointments

Instructor, Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, 8/2002-8/2012
Post-doctoral Associate, Department of Pediatrics - Research, Division of Basic Science Research, Baylor College of Medicine, Houston, TX, 10/2000-7/2002
Post-doctoral Associate, Pharmacology, Division of Basic Science Research, Baylor College of Medicine, Houston, TX, 5/1996-9/2000

Honors and Awards

2008 Best Research Poster Award, Bone Disease Program of Texas
2007 Best Scientific Poster, Gordon Research Conference on Bone and Teeth
2006 The Rolanette and Berdon Lawrence Research Award, The Bone disease Program of Texas
1991-1995 Senior Research Fellowship, Indian Agricultural Research Institute
1989-1991 Junior Research Fellowship, Indian Agricultural Research Institute

Professional Memberships

American Society for Bone and Mineral Research
Annual Member, 1/2009-12/2009
Bone Disease Program of Texas, Houston, TX
served as Judge pannel for Poster presentation award, 2009-2010
Bone Disease Program of Texas, Houston, TX
Member, 1/2006-present
Society for Plant Biochemistry and Biotechnology, New Delhi, India
Life member, 1/1994-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Gerard L. Brien, Guillermo Gambero et al. The Polycomb PHF19 binds H3K36me3 and recruits PRC2 and the NO66. Nature Structural and Molecular Biology. In Press.
2. Zhou X, Zhang Z, Feng JQ, Dusevich VM, Sinha K, Zhang H, Darnay BG, and de Crombrugghe B. Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice. Proc Natl Acad Sci U S A. 107(29):12919-24, Jul 20 2010, 7/2010. e-Pub 7/2010.
3. Sinha KM, Yasuda H,Coombes MM, Dent SR and de Crombrugghe B. Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. EMBO J, 2009.
4. Zhang C, Cho K, Huang Y, Lyons JP, Zhou X, Sinha K, McCrea PD, de Crombrugghe B. Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. PNAS 105:6936-41, 5/2008.
5. Bhattacharya R, Perumal K, Sinha K, Maraia R, Reddy R. Methylphosphate cap structure in small RNAs reduces the affinity of RNAs to La protein. Gene Expr 10(5-6):243-53, 2002. PMID: 12450216.
6. Perumal K, Sinha K, Henning D, Reddy R. Purification, characterization, and cloning of the cDNA of human signal recognition particle RNA 3'-adenylating enzyme. J Biol Chem 276(24):21791-6, 6/2001. PMID: 11287430.
7. Chen Y, Sinha K, Perumal K, Reddy R. Effect of 3' terminal adenylic acid residue on the uridylation of human small RNAs in vitro and in frog oocytes. Rna 6(9):1277-88, 9/2000. PMID: 10999605.
8. Sinha K, Reddy R. Identification of a approximately 30S size non-ribosomal Saccharomyces cerevisiae RNA that is rapidly labeled on its 3' end by ATP or UTP. Mol Biol Rep 27(3):149-56, 9/2000. PMID: 11254104.
9. Sinha K, Perumal K, Chen Y, Reddy R. Post-transcriptional adenylation of signal recognition particle RNA is carried out by an enzyme different from mRNA Poly(A) polymerase. J Biol Chem 274(43):30826-31, 10/22/1999. PMID: 10521474.

Invited Articles

1. Krishna Sinha and Xin Zhou. Genetic and molecular control of Osterix in skeletal formation. Journal of Cellular Biochemistry. In Press.

Abstracts

1. Chen Y, Perumal K, Sinha K, Reddy R. Effect of terminal adenylic acids residue on the 3 end of small RNAs on the 3 uridylation in vitro and in frog oocytes. fifth annual meeting of RNA Society held in Madison, WI, 5/2000.
2. Chen Y, Perumal K, Sinha K, Reddy R. Accurate post-transcriptional 3 end processing and adenylation of the Human Signal Recognition Particle RNA. 4th annual meeting of RNA Society held in Edinburgh, Scotland, 6/1999.
3. Chen Y, Sinha K, Perumal K, Reddy R. Studies on Post-transcriptional Adenylation in small RNAs. 3rd annual meeting of RNA Society in Madison, Wisconsin, 5/1998.
4. Sinha K, Gu J, Chen Y, Reddy R. Adenylation of Human 7SL RNA of Signal Recognition Particles in vivo and in vitro. the mRNA processing meeting held in Cold Spring Harbor Laboratory, 8/1997.
5. Sinha K, Sachdev A, Johari R, Mehta S. Stress-induced polypeptides in Lathyrus sativus. International Conference on Biotechnology and Forestry in New Delhi, India, 11/1996.
6. Sinha K, Madaan T. Regulation of Monophenolase by Kinetin and cAMP in Chickpea. International Conference on Biotechnology and Forestry in New Delhi, India, 2/1993.
7. Sinha K, Madaan T. Regulation of Monophenolase by Kinetin and cAMP in Chickpea. National Symposium on Role of Plant Biochemistry and Biotechnology in Improving Crop Productivity held in New Delhi, India, 11/1991.

Grant & Contract Support

Title: Epigenetic Insights in Calcitonin-Induced Prostate Cancer Bone Metastasis
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 6/1/2013 - 5/31/2014
 
Title: Epigenetic control of osteoblast differentiation and bone formation
Funding Source: NIH/NIAMS
Role: Principal Investigator
Duration: 7/15/2011 - 6/14/2014

Last updated: 5/7/2013