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Kun-Sang Chang, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Translational Molecular Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Faculty Member, Graduate School of Biomedical Sciences, The University of Texas Health Science Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Boulevard
Unit Number: 951
Houston, TX 77030
Room Number: 2SCR4.2014
Phone: (713) 834-6055
Fax: (713) 834-6084
Email: kchang@mdanderson.org

Education & Training

Degree-Granting Education

1982 Otago University, Dunedin, New Zealand, PHD, Biochemistry
1976 Otago University, Dunedin, New Zealand, Postgraduate Diploma of Science, Biochemistry
1974 National Taiwan University, Taipei, Taiwan, China, BS, Agricultural Chemistry

Experience/Service

Academic Appointments

Associate Professor, Hematopathology Program, Division of Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1992-2000
Assistant Professor, Division of Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1985-1992
Research Associate, Department of Cell Biology, Baylor College of Medicine, Houston, TX, 1982-1985

Selected Publications

Peer-Reviewed Original Research Articles
1. Chang CC, Naik MT, Huang YS, Jeng JC, Liao PH, Kuo HY, Ho CC, Hsieh YL, Lin CH, Huang NJ, Naik NM, Kung CC, Lin SY, Chen RH, Chang KS, Huang TH, Shih HM. Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation. Mol Cell 42(1):62-74, 4/2011. PMID: 21474068.
2. Dimov ND, Medeiros LJ, Kantarjian HM, Cortes JE, Chang KS, Bueso-Ramaos CE, Ravandi F. Rapid and reliable confirmation of acute promyelocytic leukemia by immunofluorescence staining with anti-PML antibody - MD Anderson Cancer Center experience of 349 patients with non-lymphoblastic leukemia. Cancer 116:369-376, 2010.
3. Gao C, Cheng X, Lam M, Liu Y, Liu Q, Chang KS, Kao HY. Signal-dependent regulation of transcription by histone deacetylase 7 involves recruitment to promyelocytic leukemia protein nuclear bodies. Mol Biol Cell 19:3020-3027, 7/2008.
4. Reineke EL, Lam M, Liu Q, Liu Y, Stanya KJ, Chang KS, Means AR, Kao HY. Degradation of the tumor suppressor PML by Pin 1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells. Mol Cell Biol 28:997-1006, 2/2008.
5. Lin D.Y., Chang, C.C., Huang, Y.S., Chen, Y.C., Lin, T.P., Kuo, H.Y., Fang H.I., Hung C.C., Hwang, M.J., Chang, K.S., Maul, G.G., Shih, H.M. The role of SUMO-interaction motif in mediating Daxx sumoylation, subnuclear localization and transrepression of sumoylated transcription factors. Mol. Cell. 24:341-354, 2006.
6. Xu ZX, Zou WX, Lin P, Chang KS. A role for PML3 in centrosome duplication and genome stability. Mol Cell 17(5):721-32, 3/2005. PMID: 15749021.
7. Xu ZX, Zhao RX, Ding T, Tran TT, Zhang W, Pandolfi PP, Chang KS. Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression. J Biol Chem 279(3):1838-44, 1/2004. PMID: 14597622.
8. Xu ZX, Timanova-Atanasova A, Zhao RX, Chang KS. PML colocalizes with and stabilizes the DNA damage response protein TopBP1. Mol Cell Biol 23(12):4247-56, 6/2003. PMID: 12773567.
9. Wu, WS, Xu, ZX, Hittelman, WN, Solomoni, P, Pandolfi, PP, Chang, KS. PML sensitizes TNFa-induced apoptosis by inhibiting the NF-kappa B survival pathway. J. Biol. Chem. 278:12294-12304, 2003.

Last updated: 1/29/2013