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Larry W. Kwak, M.D., Ph. D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX
Chairman, Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX
Justin Distinguished Endowed Chair in Leukemia Research, Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1984 Northwestern University Graduate School, Evanston, IL, PHD, Tumor Cell Biology
1982 Northwestern University Medical School, Chicago, IL, MD, 6 year B.S.-M.D. Honors Program
1979 Northwestern University, Evanston, IL, BS, Medical Science

Postgraduate Training

7/1987-6/1991 Fellowship (Clinical and Research), Medical Oncology, Stanford University School of Medicine, Stanford, CA
7/1985-6/1987 Clinical Residency, Internal Medicine, Stanford University Medical Center, Stanford, CA
6/1984-6/1985 Clinical Internship, Internal Medicine, Stanford University Medical Center, Stanford, CA

Board Certifications

1/1989 American Board of Internal Medicine, Subspecialty Medical Oncology
1/1987 American Board of Internal Medicine

Experience/Service

Administrative Appointments/Responsibilities

Associate Director, Center for Cancer Immunology Research, University of Texas, M.D. Anderson Cancer Center, Houston, TX, 3/2004-present

Honors and Awards

2003 American Society for Clinical Investigation (ASCI)
2003 NCI Technology Transfer Award, Center for Cancer Research
2002 European Academy of Sciences
2000 Asian and Pacific Islander-American Organization Outstanding Scientific Achievement Award, NIH
1989 Young Investigator Award, American Society of Clinical Oncology

Professional Memberships

American Association of Immunology, Bethesda, MD
Member, 1993-present
American Society for Clinical Investigation, Ann Arbor, MI
Member, 2003-present
American Society of Clinical Oncology, Alexandria, VA
Member, 1993-present
American Society of Hematology, Washington, DC
Member, 1993-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Lee ST, Liu S, Radvanyi L, Sukhumalchandra P, Molldrem JJ, Wieder ED, Hwu P, Liu YJ, Kwak LW, Lizée G, Neelapu SS. A novel strategy for rapid and efficient isolation of human tumor-specific CD4(+) and CD8(+) T-cell clones. J Immunol Methods 331(1-2):13-26, 2/2008. e-Pub 10/2007. PMCID: PMC2265521.
2. Popescu MC, Robb RJ, Batenjany MM, Boni LT, Neville ME, Pennington RW, Neelapu SS, Kwak LW. A Novel Proteoliposomal Vaccine Elicits Potent Anti-Tumor Immunity in Mice. Blood 15;109 (12):5407-10, 1/2007.
3. Yang J, Qian J, Wezeman M, Wang S, Lin P, Wang M, Yaccoby S, Kwak LW, Barlogie B, Yi Q. Targeting beta2-microglobulin for induction of tumor apoptosis in human hematological malignancies. Cancer Cell 10:295-307, 10/2006. PMID: 17045207.
4. Cha SC, Kwak LW, Ruffini PA, Qin H, Neelapu S, Biragyn A. Cloning of B cell lymphoma-associated antigens using modified phage-displayed expression cDNA library and immunized patient sera. J Immunol Methods 312(1-2):79-93, 5/2006. PMID: 16631194.
5. Neelapu SS, Kwak LW, Kobrin CB, Reynolds CW, Janik JE, Dunleavy K, White T, Harvey L, Pennington R, Stetler-Stevenson M, Jaffe ES, Steinberg SM, Gress R, Hakim F, Wilson WH. Vaccine-induced tumor-specific immunity despite severe B-cell depletion in mantle cell lymphoma. Nat Med 11(9):986-91, 9/2005. PMID: 16116429.
6. Neelapu SS, Munshi NC, Jagannath S, Watson TM, Pennington R, Reynolds C, Barlogie B, Kwak LW. Tumor antigen immunization of sibling stem cell transplant donors in multiple myeloma. Bone Marrow Transplant 36(4):315-23, 8/2005. PMID: 15968284.
7. Baskar S, Kobrin CB, Kwak LW. Autologous lymphoma vaccines induce human T cell responses against multiple, unique epitopes. J Clin Invest 113(10):1498-510, 5/2004. PMID: 15146248.
8. Biragyn A, Ruffini PA, Leifer CA, Klyushnenkova E, Shakhov A, Chertov O, Shirakawa AK, Farber JM, Segal DM, Oppenheim JJ, Kwak LW. Toll like receptor 4 activation of dendritic cells mediated by the endogenous antimicrobial peptide B-defensin-2. Science 298:1025-9, 11/2002. PMID: 12411706.
9. Biragyn A, Belyakov IM, Chow YH, Dimitrov DS, Berzofsky JA, Kwak LW. DNA vaccines encoding human immunodeficiency virus-1 glycoprotein 120 fusions with proinflammatory chemoattractants induce systemic and mucosal immune responses. Blood 100(4):1153-9, 8/2002. PMID: 12149191.
10. Simon RM, Steinberg SM, Hamilton M, Hildesheim A, Khleif S, Kwak LW, Mackall CL, Schlom J, Topalian SL, Berzofsky JA. Clinical trial designs for the early clinical development of therapeutic cancer vaccines. J Clin Oncol 19(6):1848-54, 3/2001. PMID: 11251017.
11. Li Y, Bendandi M, Deng Y, Dunbar C, Munshi N, Jagannath S, Kwak LW, Lyerly HK. Tumor-specific recognition of human myeloma cells by idiotype-induced CD8(+) T cells. Blood 96(8):2828-33, 10/2000. PMID: 11023518.
12. Bendandi M, Gocke CD, Kobrin CB, Benko FA, Sternas LA, Pennington R, Watson TM, Reynolds CW, Gause BL, Duffey PL, Jaffe ES, Creekmore SP, Longo DL, Kwak LW. Complete molecular remissions induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma. Nat Med 5(10):1171-7, 10/1999. PMID: 10502821.
13. Biragyn A, Tani K, Grimm MC, Weeks S, Kwak LW. Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity. Nat Biotechnol 17(3):253-8, 3/1999. PMID: 10096292.
14. Kwak LW, Pennington R, Boni L, Ochoa AC, Robb RJ, Popescu MC. Liposomal formulation of a self lymphoma antigen induces potent protective antitumor immunity. J Immunol 160(8):3637-41, 4/1998. PMID: 9558062.
15. Kwak LW, Young HA, Pennington RW, Weeks SD. Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response. Proc Natl Acad Sci U S A 93(20):10972-7, 10/1996. PMID: 8855293.
16. Levitsky HI, Montgomery J, Ahmadzadeh M, Staveley-O'Carroll K, Guarnieri F, Longo DL, Kwak LW. Immunization with granulocyte-macrophage colony-stimulating factor-transduced, but not B7-1-transduced, lymphoma cells primes idiotype-specific T cells and generates potent systemic antitumor immunity. J Immunol 156(10):3858-65, 5/1996. PMID: 8621924.
17. Kwak LW, Pennington R, Longo DL. Active immunization of murine allogeneic bone marrow transplant donors with B-cell tumor-derived idiotype: a strategy for enhancing the specific antitumor effect of marrow grafts. Blood 87(7):3053-60, 4/1996. PMID: 8639929.
18. Hornung RL, Longo DL, Bowersox OC, Kwak LW. Tumor antigen-specific immunization of bone marrow transplantation donors as adoptive therapy against established tumor. J Natl Cancer Inst 87(17):1289-96, 9/1995. PMID: 7544833.
19. Kwak LW, Taub DD, Duffey PL, Bensinger WI, Bryant EM, Reynolds CW, Longo DL. Transfer of myeloma idiotype-specific immunity from an actively immunized marrow donor. Lancet 345:1016-20, 4/1995. PMID: 7723498.
20. Kwak LW, Campbell MJ, Czerwinski DK, Hart S, Miller RA, Levy R. Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their tumors. N Engl J Med 327(17):1209-15, 10/1992. PMID: 1406793.

Grant & Contract Support

Title: Regulatory T cells in human cancer
Funding Source: Keck Foundation
Role: Project Leader
Principal Investigator: Yong-Jun Liu
Duration: 1/1/2008 - 1/1/2011
 
Title: Specialized Center of Research (SCOR) Translational development of novel vaccine therapies
Funding Source: Leukemia and Lymphoma Society
Role: Principal Investigator
Duration: 10/1/2007 - 9/30/2012
 
Title: Immunization of stem cell transplant donors to enhance graft-vs.-tumor effects
Funding Source: NCI Quick trials for novel cancer therapies
Role: Principal Investigator
Duration: 9/1/2007 - 8/31/2010
 
Title: Antigen discovery and development of tumor-specific lymphoma immunotherapy
Funding Source: NCI
Role: Mentor
Principal Investigator: Sattva Neelapu, MD
Duration: 5/1/2007 - 4/30/2011
 
Title: Peer Reviewed Medical Research program Second-Generation Therapeutic DNA Lymphoma Vaccines
Funding Source: Department of Defense (DOD)
Role: Principal Investigator
Duration: 4/15/2007 - 5/15/2011
 
Title: Adoptive immunotherapy with donor tumor idiotype-specific T cells
Funding Source: Gateway Cancer Research Foundation
Role: Principal Investigator
Duration: 2/1/2007 - 12/31/2009
 
Title: T-cell vaccine therapy for lymphoid malignancies
Funding Source: CCSG Multidisciplinary Research Program
Role: Sub-PI
Principal Investigator: John Mendelsohn, MD
Duration: 10/1/2006 - 6/30/2010
 
Title: Translational Research Grant Genetic Vaccines Eliciting Lymphoma-specific T-cell Immunity
Funding Source: Leukemia and Lymphoma Society
Role: Principal Investigator
Duration: 10/1/2006 - 9/30/2009
 
Title: Foundation Early Career Translational Research Award Synthetic Delivery Systems for Cancer Immunotherapy
Funding Source: Wallace Coulter Foundation
Role: Sub-Contract PI
Principal Investigator: Krishnendu Roy, PhD
Duration: 8/1/2006 - 7/31/2008
 
Title: Career Development Award
Funding Source: ASCO
Role: Mentor
Principal Investigator: Sattva Neelapu, MD
Duration: 7/1/2006 - 7/1/2009

Last updated: 8/17/2009