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Laurence D. Rhines, M.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Neurosurgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Adjunct Professor, Department of Neurosurgery, Baylor College of Medicine, Houston, TX

Education & Training

Degree-Granting Education

1993 Harvard Medical School, Boston, MA, MD, Medicine
1989 Princeton University, Princeton, NJ, AB, Biology, summa cum laude

Postgraduate Training

7/1997-7/1999 Hunterian Neuro-Oncology Fellow, Hunterian Brain Tumor Laboratory, Johns Hopkins School of Medicine, Baltimore, MD
1/1997-7/1997 Chief Resident, Neurosurgery, Johns Hopkins Bayview Medical Center, Baltimore, MD
7/1996-12/1996 Chief Resident, Pediatric Neurosurgical Service, Johns Hopkins Hospital, Baltimore, MD
7/1994-6/1999 Assistant Resident, Neurological Surgery, Johns Hopkins Hospital, Baltimore, MD
7/1993-7/1994 Intern, General Surgery, Johns Hopkins Hospital, Baltimore, MD

Board Certifications

11/2005 American Board of Neurological Surgery
1/1994 Diplomat, National Board of Medical Examiners

Experience/Service

Academic Appointments

Associate Professor, Department of Neurosurgery, Division of Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, 9/2006-8/2010

Honors and Awards

2012 Texas Super Doctor's, Texas Monthly
2011-2012 Best Doctors in America
2009-2010 Best Doctors in America
2009 Regional Castle Connolly Top Doctor
2007-2008 Best Doctors in America
2006 American Radium Society Essay Award, American Radium Society
2006 AOSpine North America Young Faculty Award
2005-2006 Best Doctors in America
1999 Harvey Cushing Hunterian Research Award
1998-1999 NIH National Research Service Award CA-09574-12
1997-1998 NIH National Research Service Award CA-09574-11
1989 Phi Beta Kappa
1989 Princeton University Department of Biology Book Award
1989 Sigma Xi Scientific Research Society
1985-1989 Garden State Distinguished Scholar

Professional Memberships

American Radium Society, Los Angeles, CA
Member, 1/2009-present
AOSpine
Faculty Member, 1999-present
Congress of Neurological Surgeons (CNS)
Member, 1996-present
Harris County Medical Society
Member, 2/2007-present
Texas Association of Neurological Surgeons
Member, 2004-present
The American Association of Neurological Surgeons (AANS)
Member, 1996-present
The American Association of Neurological Surgeons/Congress of Neurological Surgeons Joint Section on Disorders of the Spine and Peripheral Nerves
Member, 1999-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Tatsui CE, Suki D, Rao G, Kim SS, Salaskar A, Hatiboglu MA, Gokaslan ZL, McCutcheon IE, Rhines LD. Factors affecting survival in 267 consecutive patients undergoing surgery for spinal metastasis from renal cell carcinoma. J Neurosurg Spine 20(1):108-16, 1/2014. e-Pub 11/2013. PMID: 24206037.
2. McKnight AJ, Lewis VO, Rhines LD, Hanasono MM. Femur-fibula-fillet of leg chimeric free flap for sacral-pelvic reconstruction. J Plast Reconstr Aesthet Surg 66(12):1784-7, 12/2013. e-Pub 6/2013. PMID: 23735291.
3. Wang X, Yang JN, Li X, Tailor R, Vassilliev O, Brown P, Rhines L, Chang E. Effect of spine hardware on small spinal stereotactic radiosurgery dosimetry. Phys Med Biol 58(19):6733-47, 10/2013. e-Pub 9/2013. PMID: 24018829.
4. Sahgal A, Atenafu EG, Chao S, Al-Omair A, Boehling N, Balagamwala EH, Cunha M, Thibault I, Angelov L, Brown P, Suh J, Rhines LD, Fehlings MG, Chang E. Vertebral Compression Fracture After Spine Stereotactic Body Radiotherapy: A Multi-Institutional Analysis With a Focus on Radiation Dose and the Spinal Instability Neoplastic Score. J Clin Oncol 31(27):3426-31, 9/20/2013. e-Pub 8/19/2013. PMID: 23960179.
5. Garvey PB, Clemens MW, Rhines LD, Sacks JM. Vertical rectus abdominis musculocutaneous flow-through flap to a free fibula flap for total sacrectomy reconstruction. Microsurgery 33(1):32-8, 1/2013. e-Pub 3/31/2012. PMID: 22473534.
6. Weksberg DC, Palmer MB, Vu KN, Rebueno NC, Sharp HJ, Luo D, Yang JN, Shiu AS, Rhines LD, McAleer MF, Brown PD, Chang EL. Generalizable Class Solutions for Treatment Planning of Spinal Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys 84(3):847-53, 11/1/2012. e-Pub 3/22/2012. PMID: 22445000.
7. Garg AK, Shiu AS, Yang J, Wang XS, Allen P, Brown BW, Grossman P, Frija EK, McAleer MF, Azeem S, Brown PD, Rhines LD, Chang EL. Phase 1/2 trial of single-session stereotactic body radiotherapy for previously unirradiated spinal metastases. Cancer 118(20):5069-77, 10/15/2012. e-Pub 4/17/2012. PMCID: PMC3635840.
8. Feiz-Erfan I, Fox BD, Nader R, Suki D, Chakrabarti I, Mendel E, Gokaslan ZL, Rao G, Rhines LD. Surgical treatment of sacral metastases: indications and results. J Neurosurg Spine 17(4):285-91, 10/2012. e-Pub 8/17/2012. PMID: 22900506.
9. Wang XS, Rhines LD, Shiu AS, Yang JN, Selek U, Gning I, Liu P, Allen PK, Azeem SS, Brown PD, Sharp HJ, Weksberg DC, Cleeland CS, Chang EL. Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1-2 trial. Lancet Oncol 13(4):395-402, 4/2012. e-Pub 1/27/2012. PMCID: PMC3605896.
10. Boehling NS, Grosshans DR, Allen PK, McAleer MF, Burton AW, Azeem S, Rhines LD, Chang EL. Vertebral compression fracture risk after stereotactic body radiotherapy for spinal metastases. J Neurosurg Spine 16(4):379-86, 4/2012. e-Pub 1/6/2012. PMID: 22225488.
11. Viswanathan A, Abd-El-Barr MM, Doppenberg E, Suki D, Gokaslan Z, Mendel E, Rao G, Rhines LD. Initial experience with the use of an expandable titanium cage as a vertebral body replacement in patients with tumors of the spinal column: a report of 95 patients. Eur Spine J 21(1):84-92, 1/2012. e-Pub 6/18/2011. PMCID: PMC3252457.
12. Aizenberg MR, Fox BD, Suki D, McCutcheon IE, Rao G, Rhines LD. Surgical management of unknown primary tumors metastatic to the spine. J Neurosurg Spine 16(1):86-92, 1/2012. e-Pub 10/7/2011. PMID: 21981272.
13. Klish DS, Grossman P, Allen PK, Rhines LD, Chang EL. Irradiation of Spinal Metastases: Should We Continue to Include One Uninvolved Vertebral Body Above and Below in the Radiation Field? Int J Radiat Oncol Biol Phys 81(5):1495-9, 12/1/2011. e-Pub 11/11/2010. PMID: 21074335.
14. Hsieh PC, Gallia GL, Sciubba DM, Bydon A, Marco RA, Rhines L, Wolinsky JP, Gokaslan ZL. En Bloc Excisions of Chordomas in the Cervical Spine: Review of Five Consecutive Cases With More Than 4-Year Follow-up. Spine (Phila Pa 1976) 36(24):E1581-7, 11/2011. PMID: 22048652.
15. Fahim DK, Sun K, Tawackoli W, Mendel E, Rhines LD, Burton AW, Kim DH, Ehni BL, Liebschner MA. Premature Adjacent Vertebral Fracture after Vertebroplasty: A Biomechanical Study. Neurosurgery 69(3):733-44, 9/2011. e-Pub 4/2011. PMID: 21499145.
16. Garg AK, Wang XS, Shiu AS, Allen P, Yang J, McAleer MF, Azeem S, Rhines LD, Chang EL. Prospective evaluation of spinal reirradiation by using stereotactic body radiation therapy: The University of Texas MD Anderson Cancer Center Experience. Cancer 117(15):3509-16, 8/2011. e-Pub 2/2011. PMID: 21319143.
17. Fourney DR, Frangou EM, Ryken TC, Dipaola CP, Shaffrey CI, Berven SH, Bilsky MH, Harrop JS, Fehlings MG, Boriani S, Chou D, Schmidt MH, Polly DW, Biagini R, Burch S, Dekutoski MB, Ganju A, Gerszten PC, Gokaslan ZL, Groff MW, Liebsch NJ, Mendel E, Okuno SH, Patel S, Rhines LD, Rose PS, Sciubba DM, Sundaresan N, Tomita K, Varga PP, Vialle LR, Vrionis FD, Yamada Y, Fisher CG. Spinal Instability Neoplastic Score: An Analysis of Reliability and Validity From the Spine Oncology Study Group. J Clin Oncol 29(22):3072-7, 8/2011. e-Pub 6/2011. PMID: 21709187.
18. Sahgal A, Bilsky M, Chang EL, Ma L, Yamada Y, Rhines LD, Létourneau D, Foote M, Yu E, Larson DA, Fehlings MG. Stereotactic body radiotherapy for spinal metastases: current status, with a focus on its application in the postoperative patient. J Neurosurg Spine 14(2):151-66, 2/2011. e-Pub 12/2010. PMID: 21184635.
19. Garvey PB, Rhines LD, Feng L, Gu X, Butler CE. Reconstructive Strategies for Partial Sacrectomy Defects Based on Surgical Outcomes. Plast Reconstr Surg 127(1):190-9, 1/2011. e-Pub 9/2010. PMID: 20871487.
20. Fisher CG, DiPaola CP, Ryken TC, Bilsky MH, Shaffrey CI, Berven SH, Harrop JS, Fehlings MG, Boriani S, Chou D, Schmidt MH, Polly DW, Biagini R, Burch S, Dekutoski MB, Ganju A, Gerszten PC, Gokaslan ZL, Groff MW, Liebsch NJ, Mendel E, Okuno SH, Patel S, Rhines LD, Rose PS, Sciubba DM, Sundaresan N, Tomita K, Varga PP, Vialle LR, Vrionis FD, Yamada Y, Fourney DR. A Novel Classification System for Spinal Instability in Neoplastic Disease: An Evidence-Based Approach and Expert Consensus from the Spine Oncology Study Group. Spine (Phila Pa 1976) 35(22):E1221-9, 10/2010. e-Pub 6/2010. PMID: 20562730.
21. Sciubba DM, Petteys RJ, Dekutoski MB, Fisher CG, Fehlings MG, Ondra SL, Rhines LD, Gokaslan ZL. Diagnosis and management of metastatic spine disease. J Neurosurg Spine 13(1):94-108, 7/2010. PMID: 20594024.
22. Smitherman SM, Tatsui CE, Rao G, Walsh G, Rhines LD. Image-guided multilevel vertebral osteotomies for en bloc resection of giant cell tumor of the thoracic spine: case report and description of operative technique. Eur Spine J 19(6):1021-8, 6/2010. e-Pub 1/2010. PMID: 20069317.
23. Garvey PB, Rhines LD, Dong W, Chang DW. Immediate soft-tissue reconstruction for complex defects of the spine following surgery for spinal neoplasms. Plast Reconstr Surg 125(5):1460-6, 5/2010. PMID: 20134362.
24. Armstrong TS, Gning I, Mendoza TR, Vera-Bolanos E, Gilbert MR, Rhines LD, Weinberg JS, Sanchez-Williams G, Levin V, Burton AW, Cleeland C. Reliability and validity of the M. D. Anderson Symptom Inventory-Spine Tumor Module. J Neurosurg Spine 12(4):421-30, 4/2010. PMID: 20367379.
25. Nguyen QN, Shiu AS, Rhines LD, Wang H, Allen PK, Wang XS, Chang EL. Management of Spinal Metastases from Renal Cell Carcinoma Using Stereotactic Body Radiotherapy. Int J Radiat Oncol Biol Phys 76(4):1185-92, 3/2010. e-Pub 7/2009. PMID: 19632064.
26. Rao G, Chang GJ, Suk I, Gokaslan Z, Rhines LD. Mid-sacral amputation for en bloc resection of chordoma. Neurosurgery 66(3 Suppl Operative):41-4, 3/2010. PMID: 20124926.
27. Yamazaki T, McLoughlin GS, Patel S, Rhines LD, Fourney DR. Feasibility and safety of en bloc resection for primary spine tumors: a systematic review by the Spine Oncology Study Group. Spine 34(22 Suppl):S31-8, 10/2009. PMID: 19829275.
28. Tatsui CE, Lang FF, Gumin J, Suki D, Rhines LD. An orthotopic murine model of human spinal metastasis: histological and functional correlations. J Neurosurg Spine 10(6):501-12, 6/2009. PMID: 19558282.
29. Bolton WD, Rice DC, Goodyear A, Correa AM, Erasmus J, Hofstetter W, Komaki R, Mehran R, Pisters K, Roth JA, Swisher SG, Vaporciyan AA, Walsh GL, Weaver J, Rhines LD. Superior sulcus tumors with vertebral body involvement: a multimodality approach. J Thorac Cardiovasc Surg 137(6):1379-87, 6/2009. PMID: 19464452.
30. Williams BJ, Fox BD, Sciubba DM, Suki D, Tu SM, Kuban D, Gokaslan ZL, Rhines LD, Rao G. Surgical management of prostate cancer metastatic to the spine. J Neurosurg Spine 10(5):414-22, 5/2009. PMID: 19442002.
31. Chan P, Boriani S, Fourney DR, Biagini R, Dekutoski MB, Fehlings MG, Ryken TC, Gokaslan ZL, Vrionis FD, Harrop JS, Schmidt MH, Vialle LR, Gerszten PC, Rhines LD, Ondra SL, Pratt SR, Fisher CG.. An assessment of the reliability of the Enneking and Weinstein-Boriani-Biagini classifications for staging of primary spinal tumors by the spine oncology study group. Spine 15 (35)(4):384-91, 2/2009. PMID: 19214098.
32. Rao G, Suki D, Chakrabarti I, Feiz-Erfan I, Mody MG, McCutcheon IE, Gokaslan ZL, Patel S, Rhines LD. Surgical management of primary and metastatic sarcoma of the mobile spine. J Neurosurg Spine 9(2):120-8, 8/2008. PMID: 18764743.
33. Sciubba DM, Gokaslan ZL, Suk I, Suki D, Maldaun MV, McCutcheon IE, Theriault R, Rhines LD, Shehadi JA. Positive and negative prognostic variables for patients undergoing spine surgery for metastatic breast disease. Eur Spine J 16(10):1659-67, 10/2007.
34. Chang EL, Shiu AS, Mendel E, Mathews LA, Mahajan A, Allen PK, Woo SY, Cleeland C, Maor MH, Rhines LD. Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its patterns of failure. J Neurosurg Spine 7(2):151-60, 8/2007.
35. Shehadi JA, Sciubba DM, Suk I, Suki D, Maldaun MV, McCutcheon IE, Nader R, Theriault R, Rhines LD, Gokaslan ZL. Surgical treatment stratagies and outcome in patients with breast cancer metastatic to the spine: a review of 87 patients. Eur Spine J 16(8):1179-92, 8/2007. PMCID: PMC2200772.
36. Tatsui CE, Rao G, Rhines LD. Radiotherapy for a destructive cervicothoracic lesion from multiple myeloma. J Neurosurg Spine 6(5):493, 5/2007.
37. Rao G, Bohinski R, Feiz-Erfan I, Rhines LD. Dynamic retraction of the psoas muscle to expose the lumbar spine using the retroperitoneal approach. Technical note. J Neurosurg Spine 5:468-70, 11/2006. PMID: 17120900.
38. Sampath P, Rhines LD, DiMeco F, Tyler BM, Park MC, Brem H. Interstitial Docetaxel (Taxotere), Carmustine and Combined Interstitial Therapy: a Novel Treatment for Experimental Malignant Glioma. J Neurooncol 80(1):9-17, 10/2006. e-Pub 4/25/2006. PMCID: PMC1780249.
39. Rao G, Ha CS, Chakrabarti I, Feiz-Erfan I, Mendel E, Rhines LD. Multiple myeloma of the cervical spine: treatment strategies for pain and spinal instability. J Neurosurg Spine 5:140-5, 8/2006. PMID: 16925080.
40. Chakrabarti I, Burton AW, Rao G, Feiz-Erfan I, Hlatky R, Rhines LD, Mendel E. Percutaneous vertebroplasty of a myelomatous compression fracture in the presence of previous posterior instrumentation. Report of two cases. J Neurosurg Spine 5:168-71, 8/2006. PMID: 16925086.
41. Tannir N, Jonasch E, Pagliaro LC, Mathew P, Siefker-Radtke A, Rhines L, Lin P, Tibbs R, Do KA, Lin SH, Tu SM. Pilot trial of bone-targeted therapy with zoledronate, thalidomide, and interferon-gamma for metastatic renal cell carcinoma. Cancer 107:497-505, 8/2006. PMID: 16795067.
42. McPherson CM, Suki D, McCutcheon IE, Gokaslan ZL, Rhines LD, Mendel E. Metastatic disease from spinal chordoma: a 10-year experience. J Neurosurg Spine 5(4):277-80, 2006.
43. Fourney DR, Rhines LD, Hentschel SJ, Skibber JM, Wolinsky JP, Weber KL, Suki D, Gallia GL, Garonzik I, Gokaslan ZL. En bloc resection of primary sacral tumors: classification of surgical approaches and outcome. J Neurosurg Spine 3(2):111-22, 8/2005. PMID: 16370300.
44. Bohinski RJ, Mendel E, Rhines LD. Novel use of a threadwire saw for high sacral amputation. Technical note and description of operative technique. J Neurosurg Spine 3:71-8, (cover article), 7/2005. PMID: 16122028.
45. Holman PJ, Suki D, McCutcheon I, Wolinsky JP, Rhines LD, Gokaslan ZL. Surgical management of metastatic disease of the lumbar spine: experience with 139 patients. J Neurosurg Spine 2(5):550-63, (cover article), 5/2005. PMID: 15945429.
46. Marco RA, Gentry JB, Rhines LD, Lewis VO, Wolinski JP, Jaffe N, Gokaslan ZL. Ewing's sarcoma of the mobile spine. Spine 30(7):769-73, 4/2005. PMID: 15803079.
47. Samartzis D, Marco RA, Benjamin R, Vaporciyan A, Rhines LD. Multilevel en bloc spondylectomy and chest wall excision via a simultaneous anterior and posterior approach for Ewing sarcoma. Spine 30:831-7, 4/2005. PMID: 15803089.
48. Hentschel SJ, Burton AW, Fourney DR, Rhines LD, Mendel E. Percutaneous vertebroplasty and kyphoplasty performed at a cancer center: refuting proposed contraindications. J Neurosurg Spine 2(4):436-40, 4/2005. PMID: 15871483.
49. Burton AW, Rhines LD, Mendel E. Vertebroplasty and kyphoplasty: a comprehensive review. Neurosurg Focus 18(3):e1: 1-9, 3/2005. PMID: 15771389.
50. Rhines LD, Fourney DR, Siadati A, Suk I, Gokaslan ZL. En bloc resection of multilevel cervical chordoma with C-2 involvement. Case report and description of operative technique. J Neurosurg Spine 2:199-205, (cover article), 2/2005. PMID: 15739534.
51. Cohen ZR, Fourney DR, Gokaslan ZL, Walsh GL, Rhines LD. Anterior stabilization of the upper thoracic spine via an "interaortocaval subinnominate window": case report and description of operative technique. J Spinal Disord Tech 17:543-8, 12/2004. PMID: 15570130.
52. Hentschel SJ, Rhines LD, Shah HN, Burton AW, Mendel E. Percutaneous vertebroplasty in vertebra plana secondary to metastasis. J Spinal Disord Tech 17(6):554-7, 12/2004. PMID: 15570132.
53. Chang EL, Shiu AS, Lii MF, Rhines LD, Mendel E, Mahajan A, Weinberg JS, Mathews LA, Brown BW, Maor MH, Cox JD. Phase I clinical evaluation of near-simultaneous computed tomographic image-guided stereotactic body radiotherapy for spinal metastases. Int J Radiat Oncol Biol Phys 59(5):1288-94, 8/2004. PMID: 15275711.
54. Bohinski RJ, Mendel E, Aldape KD, Rhines LD. Intramedullary and extramedullary solitary fibrous tumor of the cervical spine. Case report and review of the literature. J Neurosurg 100(4 Suppl Spine):358-63, 4/2004. PMID: 15070144.
55. Hentschel SJ, Mendel E, Singh S, Rhines LD. Metastatic prostate carcinoma to the intradural extramedullary spinal compartment. Case report. J Neurosurg 100(4 Suppl Spine):375-7, 4/2004. PMID: 15070148.
56. Hentschel SJ, Rhines LD, Wong FC, Gokaslan ZL, McCutcheon IE. Subarachnoid-pleural fistula after resection of thoracic tumors. J Neurosurg 100(4 Suppl Spine):332-6, 4/2004. PMID: 15070140.
57. Fourney DR, Siadati A, Bruner JM, Gokaslan ZL, Rhines LD. Giant cell ependymoma of the spinal cord. Case report and review of the literature. J Neurosurg 100(1 Suppl Spine):75-9, 1/2004. PMID: 14748579.
58. Samdani AF, Kuchner EB, Rhines LD, Adamson DC, Lawson C, Tyler B, Brem H, Dawson VL, Dawson TM. Astroglia induce cytotoxic effects on brain tumors via a nitric oxide-dependent pathway both in vitro and in vivo. Neurosurg 54(5):1231-1238, 2004.
59. Shiu AS, Chang EL, Ye JS, Lii M, Rhines LD, Mendel E, Weinberg J, Singh S, Maor MH, Mohan R, Cox JD. Near simultaneous computed tomography image-guided stereotactic spinal radiotherapy: an emerging paradigm for achieving true stereotaxy. Int J Radiat Oncol Biol Phys 57(3):605-13, 11/2003. PMID: 14529763.
60. Bohinski RJ Rhines LD. Principles and techniques of en bloc vertebrectomy for bone tumors of the thoracolumbar spine: an overview. Neurosurg Focus 15(5):E7, 1-6, 11/2003. PMID: 15323464.
61. Rhines LD, Sampath P, DiMeco F, Lawson HC, Tyler BM, Hanes J, Olivi A, Brem H. Local immunotherapy with interleukin-2 delivered from biodegradable polymer microspheres combined with interstitial chemotherapy: a novel treatment for experimental malignant glioma. Neurosurgery 52:872-9; discussion 879-80, 4/2003. PMID: 12657184.
62. Fourney DR, York JE, Cohen ZR, Suki D, Rhines LD, Gokaslan ZL. Management of atlantoaxial metastases with posterior occipitocervical stabilization. J Neurosurg 98(2 Suppl Spine):165-70, 3/2003. PMID: 12650401.
63. Fourney DR, Prabhu SS, Cohen ZR, Rhines LD, Gokaslan ZL. Thoracolumbopelvic stabilization for the treatment of instability caused by recurrent myxopapillary ependymoma. J Spinal Disord Tech 16(1):108-11, 2/2003. PMID: 12571494.
64. Fourney DR, Schomer DF, Nader R, Chlan-Fourney J, Suki D, Ahrar K, Rhines LD, Gokaslan ZL. Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients. J Neurosurg 98(1 Suppl Spine):21-30, 1/2003. PMID: 12546384.
65. Weinberg JS, Rhines LD, Cohen ZR, Langford L, Levin VA. Posterior fossa decompression for life-threatening tonsillar herniation in patients with gliomatosis cerebri: report of three cases. Neurosurgery 52(1):216-23; discussion 223, 1/2003. PMID: 12493121.
66. Fourney DR, Prabhu SS, Cohen ZR, Gokaslan ZL, Rhines LD. Early sacral stress fracture after reduction of spondylolisthesis and lumbosacral fixation: case report. Neurosurgery 51(6):1507-10; discussion 1510-1, 12/2002. PMID: 12445359.
67. Hanbali F, Fourney DR, Marmor E, Suki D, Rhines LD, Weinberg JS, McCutcheon IE, Suk I, Gokaslan ZL. Spinal cord ependymoma: radical surgical resection and outcome. Neurosurgery 51(5):1162-72; discussion 1172-4, (cover article), 11/2002. PMID: 12383361.
68. Cohen ZR, Fourney DR, Marco RA, Rhines LD, Gokaslan ZL. Total cervical spondylectomy for primary osteogenic sarcoma. Case report and description of operative technique. J Neurosurg 97(3 Suppl Spine):386-92, (cover article), 10/2002. PMID: 12408399.
69. Marmor E, Fourney DR, Rhines LD, Skibber JM, Fuller GN, Gokaslan ZL. Sacrococcygeal ganglioneuroma: case report. J Spinal Disord Tech 15(3):265-8, 6/2002. PMID: 12131432.
70. Wu Q, Tyler B, Sukay L, Rhines LD, DiMeco F, Clatterbuck RE, Guarnieri M, Carson BS, Sr. Animal Models: Experimental rodent models of brainstem tumors. Vet Pathol 39:293-299, 2002.
71. Tierney TS, Clatterbuck RE, Lawson C, Thai QA, Rhines LD, Tamargo RJ. Prevention and reversal of experimental posthemorrhagic vasospasm by the periadventitial administration of nitric oxide from a controlled-release polymer. Neurosurgery 49(4):945-51; discussion 951-3, 10/2001. PMID: 11564257.
72. Marmor E, Rhines LD, Weinberg JS, Gokaslan ZL. Total en bloc lumbar spondylectomy. Case report. J Neurosurg 95(2 Suppl Spine):264-9, (cover article), 10/2001. PMID: 11599851.
73. Fourney DR, Abi-Said D, Rhines LD, Walsh GL, Lang FF, McCutcheon IE, Gokaslan ZL. Simultaneous anterior-posterior approach to the thoracic and lumbar spine for the radical resection of tumors followed by reconstruction and stabilization. J Neurosurg 94(2 Suppl Spine):232-44, (cover article), 4/2001. PMID: 11302626.
74. Rhines LD, Sampath P, Dolan ME, Tyler BM, Brem H, Weingart J. 06-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma. Cancer Res 60:6307-10, 11/2000. PMID: 11103789.
75. DiMeco F, Rhines LD, Hanes J, Tyler BM, Brat D, Torchiana E, Guarnieri M, Colombo MP, Pardoll DM, Finocchiaro G, Brem H, Olivi A. Paracrine delivery of IL-12 against intracranial 9L gliosarcoma in rats. J Neurosurg 92(3):419-27, 3/2000. PMID: 10701528.
76. Sampath P, Rhines LD, Holliday MJ, Brem H, Long DM. Late onset facial nerve palsy after vestibular schwannoma surgery: incidence, putative mechanisms, and prevention. Neurosurgical Focus 5(3):6, 1998.
77. Gelperin A, Rhines LD, Flores J, Tank DW. Coherent network oscillations by olfactory interneurons: modulation by endogenous amines. J Neurophysiol 69(6):1930-9, 6/1993. PMID: 8102394.
78. Rhines LD, Sokolove PG, Flores J, Tank DW, Gelperin A. Cultured olfactory interneurons from Limax maximus: optical and electrophysiological studies of transmitter-evoked responses. J Neurophysiol 69(6):1940-7, 6/1993. PMID: 8102395.
79. Debnam JM, Rhines LD, Ketonen L, Edeiken BS, Hunter GJ, Hamberg LM. Multidetector CT with volume rendered series in the evaluation of primary bone tumors of the spine. Amer J of Neurorad. Submitted.

Invited Articles

1. Feiz-Erfan I, Rhines LD, Weinberg, JS. The role of surgery in the management of metastatic spinal tumors. Semin Oncol 35(2):108-112, 4/2008. PMID: 18396196.
2. Sciubba DM, Chi JH, Rhines LD, Gokaslan ZL. Chordoma of the spinal column. Neurosurg Clin N Am 19(1):5-15, 1/2008. PMID: 18156043.
3. Chi JH, Sciubba DM, Rhines LD, Gokaslan ZL. Surgery for primary vertebral tumors: en bloc versus intralesional resection. Neurosurg Clin N Am 19(1):111-7, 1/2008. PMID: 18156053.
4. Mody MG, Rao G, Rhines LD. Surgical management of spinal mesenchymal tumors. Curr Oncol Rep 8:297-304, 7/2006. PMID: 17254530.
5. Raiszadeh R Rhines LD. Management of thoracic spine infections. Operative Tech in Neurosurg(7):199-205, 2005.

Abstracts

1. Reynolds J, Fisher C, Boriani S, Varga PP, Fehlings MG, Bilsky MH, Dekutoski MB, Rhines L, Bettegowda C, Gokaslan Z. A novel scientific model for rare and often neglected neoplastic conditions. EuroSpine 2013, Liverpool, UK, 10/2013.
2. Fisher C, Boriani S, Varga PP, Fehlings MG, Bilsky MH, Dekutoski MB, Williams RP, Berven SH, Chou D, Reynolds JJ, Quraishi NA, Rhines LD, Bettegowda C, Gokaslan ZL. A novel scientific model for rare and often neglected neoplastic conditions: AOSpine International Knowledge Forum Tumor database for primary tumors of the spine. North American Spine Society (NASS) 28th Annual Meeting, New Orleans, LA, 10/2013.
3. Reynolds J, Fisher C, Boriani S, Varga PP, Rhines L, Kawahara N, Fourney D, Fehlings M, Schouten R, Gokaslan Z. Spinal Instability Neoplastic Score: an analysis of reliability and validity in radiologists. EuroSpine 2013, Liverpool, UK, 10/2013.
4. Mendoza TR, Wang XS, Rhines LD, Selek U, Cleeland CS, Chang EL. The relationships of reduction in pain with other symptoms for cancer patients treated with stereotactic body radiation therapy. ISOQOL 20th Annual Conference, Miami, FL, 10/2013.
5. Fehlings MG, Kopjar B, Fisher CG, Vaccaro AR, Arnold P, Rhines LD, Schuster J, Finkelstein J, Dekutoski MB, Gokaslan ZL, France JC. The Effect of Surgery on Health Related Quality of Life and Functional Outcome in Patients with Metastatic Epidural Spinal Cord Compression -- the AOSpine North America Prospective Multicenter Study. Scoliosis Research Society 48th Annual Meeting & Course, Lyon, France, 9/2013.
6. Fisher C, Fehlings M, Bilsky M, Dekutoski M, Luzzati A, Williams R, Berven S, Quraishi N, Rhines L, Bettegowda C, Gokaslan Z. A novel scientific model for rare and often neglected neoplastic conditions: AOSpine knowledge forum tumor international dataset for primary tumors of the spine. 20th International Meeting on Advanced Spine Techniques, Vancouver, BC, Canada, 7/2013.
7. Fisher C, Rhines L, Kawahara N, Fourney D, Reynolds J, Fehlings M, Schouten R, Gokaslan Z. Spinal Instability Neoplastic Score: an analysis of reliability and validity in radiation oncologists: an AOSpine knowledge forum tumor project. 20th International Meeting on Advanced Spine Techniques, Vancouver, BC, Canada, 7/2013.
8. Fisher C, Boriani S, Varga PP, Fehlings M, Bilsky M, Dekutoski M, Luzzati A, Williams R, Berven S, Chou D, Reynolds J, Quraishi N, Rhines L, Bettegowda C, Gokaslan Z. A novel evidence based model for rare and often neglected neoplastic conditions. Third Charité Spine Tumor Days, Berlin Germany, 6/2013.
9. Fisher C, Boriani S, Varga PP, Rhines L, Kawahara N, Fourney D, Reynolds J, Fehlings M, Schouten R, Gokaslan Z. Assessing the reliability of Spinal Instability Neoplastic Score (SINS) among radiation oncologists and radiologists. Third Charité Spine Tumor Days, Berlin Germany, 5/2013.
10. Fisher C, Boriani S, Varga PP, Rhines LD, Bilsky MH, Dekutoski MB, Fehlings MG, Reynolds JJ, Williams RP, Chou D, Berven S, Quraishi NA, Bettegowda C, Gokaslan ZL. A novel model for rare and often neglected neoplastic conditions. Global Spine Congress 2013, Hong Kong, 4/2013.
11. Fisher C, Boriani S, Varga PP, Rhines LD, Kawahara N, Fourney D, Reynolds JJ, Fehlings MG, Schouten R, Gokaslan ZL. Spinal instability neoplastic score (SINS): reliability and validity among radiation oncologists. Global Spine Congress 2013, Hong Kong, 4/2013.
12. Fisher C, Goldschlager T, Boriani S, Varga P, Fehlings MG, Bilsky M, Dekutoski M, Luzzati A, Williams R, Berven S, Chou D, Quraishi N, Rhines L, Bettegowda C, Gokaslan Z. A novel scientific model for rare and often neglected neoplastic conditions. 11th Annual AOSpine North America Fellows Forum, Banff, AB, Canada, 3/2013.
13. Fisher C, Nadeau M, Varga PP, Boriani S, Rhines L, Kawahara N, Fourney D, Reynolds J, Fehlings M, Schouten R, Gokaslan Z. Spinal instability neoplastic score: an analysis of reliability and validity in radiologists: An AOSpine Knowledge Forum Tumor project. 13th Annual Scientific Conference of the Canadian Spine Society, Monte-Tremblant, QC, Canada, 3/2013.
14. Fehlings MG, Kopjar B, Fisher C, Vaccaro AR, Arnold PM, Rhines LD, Schuster JM, Finkelstein J, Dekutoski MB, Gokaslan ZL, France J. The Effect of Surgery on Health Related Quality of Life and Functional Outcome in Patients with Metastatic Epidural Spinal Cord Compression -- the AOSpine North America Prospective Multicenter Study. American Association of Neurological Surgeons/Congress of Neurological Surgeons Section on Disorders of the Spine and Peripheral Nerves 2013 Annual Meeting, Phoenix, AZ, 3/2013.
15. Fisher C, Boriani S, Varga PP, Rhines LD, Bilsky MH, Dekutoski MB, Fehlings MG, Reynolds JJ, Williams RP, Chou D, Berven S, Quraishi NA, Bettegowda C, Gokaslan ZL. A novel model for rare and often neglected neoplastic conditions. Association for Collaborative Spine Research Meeting, San Diego, CA, 2/2013.
16. Fisher C, Boriani S, Varga P, Fehlings M, Bilsky M, Dekutoski M, Luzzati A, Williams R, Berven S, Chou D, Quraishi N, Rhines L, Bettegowda C, Gokaslan Z. A novel scientific model for rare and often neglected neoplastic conditions. 13th Annual Scientific Conference of the Canadian Spine Society, Monte-Tremblant, QC, Canada, 2/2013.
17. Fisher C, Boriani S, Varga PP, Rhines LD, Kawahara N, Fourney D, Reynolds JJ, Fehlings MG, Schouten R, Gokaslan ZL. Spinal Instability Neoplastic Score (SINS): reliability and validity in radiation oncologists. Association for Collaborative Spine Research Meeting, San Diego, CA, 2/2013.
18. Fehlings MG, Kopjar B, Fisher C, Vaccaro AR, Arnold PM, Schuster JM, Finkelstein J, Rhines LD, Dekutoski MB, Gokaslan ZL, France J. The Effect of Surgery on Health Related Quality of Life and Functional Outcome in Patients with Metastatic Epidural Spinal Cord Compression -- the AOSpine North America Prospective Multicenter Study. Congress of Neurological Surgeons Annual Meeting, Chicago, IL, 10/2012.
19. Fehlings M, Kopjar B, Fisher C, Vaccaro A, Arnold P, Schuster J, Finkelstein J, Rhines L, Dekutoski M, Gokaslan Z, France J. The Effect of Surgery on Health Related Quality of Life and Functional Outcome in Patients with Metastatic Epidural Spinal Cord Compression – the AOSpine North America Prospective Multicenter Study. North American Spine Society Conference, Dallas, TX, 10/2012.
20. Fehlings M, Kopjar B, Fisher C, Vaccaro A, Arnold P, Schuster J, Finkelstein J, Rhines L, Dekutoski M, Gokaslan Z, France J. The Effect of Surgery on Health Related Quality of Life and Functional Outcome in Patients with Metastatic Epidural Spinal Cord Compression – the AOSpine North America Prospective Multicenter Study. Scoliosis Research Society 47th Annual Meeting & Combined Course, Chicago, IL, 9/2012.
21. Fehlings MG, Kopjar B, Fisher C, Rhines LD, Arnold PM, Schuster JM, Vaccaro AR, Gokaslan ZL, Finkelstein J, France J, Dekutoski MB. The Short-Term Effect of Surgery on Health Related Quality of Life and Functional Outcome in Patients with Metastatic Epidural Spinal Cord Compression (MESCC): Results of the Ongoing AOSpine North America Prospective Multicenter Study. American Association of Neurological Surgeons, Maimi, FL, 4/2012.
22. Fehlings MG, Kopjar B, Fisher C, Rhines LD, Arnold PM, Schuster JM, Vaccaro AR, Gokaslan ZL, Finkelstein J, France J, Dekutoski MB. The Short-Term Effect of Surgery on Health Related Quality of Life and Functional Outcome in Patients with Metastatic Epidural Spinal Cord Compression (MESCC): Results of the Ongoing AOSpine North America Prospective Multicenter Study. American Association of Neurological Surgeons/Congress of Neurological Surgeons Section on Disorders of the Spine and Peripheral Nerves 2012 Annual Meeting, Orlando, FL, 3/2012.
23. Fehlings MG, Kopjar B, Vaccaro A, Arnold P, Fisher C, Gokaslan Z, Schuster J, Dekutoski M, Finkelstein J, Rhines, LD. The Effect of Surgery on Neurological Outcomes in Patients with Metastatic Epidural Spinal Cord Compression-the AOSpine NOrth America Prospective Multicenter Study. Cervical Spine Research Society 39th Annual Meeting, Scottsdale, AZ, 12/2011.
24. Fahim DK, Mayer R, Tatsui C, Suki D, McCutcheon IE, Gokaslan ZL, Rhines LD. Longterm Durability of 634 Polymethylmethacrylate Vertebral Body Reconstructions after Vertebrectomy in 581 Consecutive Cancer Patients. European Association of Neurosurgical Societies 2011 Annual Meeting, Florence, Italy, 10/2011.
25. Fehlings MG, Kopjar B, Vaccaro AR, Arnold PM, Fisher C, Gokaslan ZL, Schuster JM, Dekutoski MG, Finkelstein J, Rhines LD. The Short-Term Effect of Surgery on Health Related Quality of Life and Functional Outcome in Patients with Metastatic Epidural Spinal Cord Compression (MESCC): Results of the Ongoing AOSpine North America Prospective Multicenter Study. Congress of Neurological Surgeons 2011 Annual Meeting, Washington, D, 10/2011.
26. Chan P, Boriani S, Fourney DR, Gehlings MG, Biagini R, Dekutoski MB, Ryken TC, Vrionis FD, Harrop JS, Schmidt MH, Vialle LR, Gerszten PC, Rhines LD, Ondra SL, Gokaslan ZL, Pratt SR, Fisher CG. An assessment of the reliability of the Enneking and Weinstein-Boriani-Biagini (WBB) classifications for staging of primary spinal tumors. Canadian Spine Society Annual Meeting, Sun Peaks Resort, British Columbia, Canada, 3/2008. PMID: 19214098.
27. Bolton W, Rice D, Goodyear A, Correa A, Erasmus J, Gokaslan ZL, Hofstetter W, Komaki R, Mehran R, Pisters K, Roth J, Swisher S, Vaporciyan A, Walsh GL, Weaver JA, Rhines LD. Long-term survival with surgical management of superior sulcus tumors with vertebral involvement. American Association of Neurological Surgeons/Congress of Neurological Surgeons Joint Section on Disorders of the Spine and Peripheral Nerves, Orlando, FL, 3/2008.
28. Viswanathan A, Abd-El-Barr M, Mendel E, Doppenberg EMR, Rao G, Rhines LD. Initial experience with the use of an expandable titanium cage as a vertebral body replacement in patients with tumors of the spinal column: a report of 67 patients. Congress of Neurological Surgeons Annual Meeting, San Diego, CA, 9/2007.
29. Benveniste RJ, Rhines LD. Instrumentation across the cervicothoracic junction followin gresection of metastatic tumors. Congress of Neurological Surgeons Annual Meeting, San Diego, CA, 9/2007.
30. Aizenberg MR, Suki D, Rao G, Rhines LD. Metastatic spine disease from unknown primary cancers. Congress of Neurological Surgeons Annual Meeting, San Diego, CA, 9/2007.
31. Gokaslan ZL, Arnold PM, Rhines LD, Knapp K. Vertebral body reconstruction using expandable cage implants following single-level thoracolumbar tumor resections: interim evaluation of a prospective, multi-center study. Congress of Neurological Surgeons Annual Meeting, San Diego, CA, 9/2007.
32. Debnam JM, Rhines LD, Ketonen L, Edeiken BS, Hunter GJ, Hamburg LM. Multidetector CT with volume rendered series in the evaluation of primary bone tumors of the spine. American Society of Neuroradiology, Chicago, IL, 6/2007.
33. Chang E, Shiu A, Mendel E, Mathews L, Mahajan A, Allen P, Weinberg J, Brown B, Wang XS, Woo S, Rhines LD. Phase I/II study of stereotactic spine radiation therapy for spinal metastasis and its pattern of failure. 8th International Stereotactic Radiosurgery Society Congress, San Francisco, CA, 6/2007.
34. Prabhu SS, Kim SS, McCutcheon IE, Sawaya R, Weinberg JS, Lang FF, Heimberger AB, DeMonte F, Hassenbusch SJ, Rhines LD, Ferson DZ, Wefel J, Suki D. Awake craniotomy for brain tumors near eloquent cortex: correlation of intraoperative cortical mapping with neurological outcome in 300 consecutive patients. American Association of Neurological Surgeons Annual Meeting, Washington, DC, 4/2007.
35. Feiz-Erfan I, Suki D, Shi W, Heimberger A, Cohen Zr, Weinberg JS, DeMonte F, McCutcheon IE, Rhines LD, Fuller GN, Hassenbusch S. Extent of resection does increase survival in a select group of patients with newly diagnosed untreated anaplastic astrocytomas. Congress of Neurological Surgeons Annual Meeting, Chicago, IL, 10/2006.
36. Feiz-Erfan I, Rao G, Chakrabarti I, Suki D, Mody MG, McCutcheon IE, Rhines LD. Local recurrence after en bloc resection of previously untreated sacral chordomas. Congress of Neurological Surgeons Annual Meeting, Chicago, IL, 10/2006.
37. Feiz-Erfan I, Nader R, Chakrabarti I, Rao G, Suki D, Mendel E, Gokaslan ZL, Rhines LD. Outcome of surger for metastatic renal cell carcinoma (RCCA) to the sacrum. Congress of Neurological Surgeons Annual Meeting, Chicago, IL, 10/2006.
38. Rao G, Feiz-Erfan I, Chakrabarti I, Suki D, Mody MG, McCutcheon IE, Rhines LD. Surgical management of primary and metastatic sarcoma of the mobile spine. Congress of Neurological Surgeons Annual Meeting (oral presentation), 10/2006.
39. Feiz-Erfan I, Walsh GL, Skibber JM, Gokaslan ZL, Rhines LD. Total sacrectomy for primar bony tumors of the sacrum: a critical analysis of 5 cases. Congress of Neurological Surgeons Annual Meeting, Chicago, IL, 10/2006.
40. Thomas SK, Wang ML, Yao K, Villareal H, Rhines LD. Percutaneous vertebroplasty and/ or kyphoplasty is an effective and safe treatment for painful vertebral compression fractures in multiple myeloma. American Society of Clinical Onology Annual Meeting, Atlanta, GA, 6/2006.
41. Liebschner M, Tawackoli W, Burton AW, Rhines LD, Mendel E. Acoustic vibration as a new diagnostic to detect the onset of vertebal compression. Bone Innovation Summit, Cleveland, OH, 5/2006.
42. Liebschner M, Sun K, Tawackoli W, Burton AW, Fukshansky M, Rhines LD, Mendel E. Aggressive vertebroplasty reduces adjacent bone strength and may lead to premature vertebral bone failure. Bone Innovation Summit, Cleveland, OH, 5/2006.
43. Rao G, Ha CS, Chakrabarti I, Feiz-Erfan I, Mendel E, Rhines LD. Multiple myeloma of the cervical spine: treatment options in the setting of instability. American Radium Society 88th Annual Meeting, Wailea, Maui (oral presentation and the 2006 Young Oncologist Travel Award), 5/2006.
44. Chang EL, Shiu AS, Mendel E, Mathews L, Wang S, Woo S, Mahajan A, Weinberg J, Rhines LD. Interim results of a Phase I/II evaluation of stereotactic radiation for spinal metastases. American Association of Neurlogical Surgeons Annual Meeting, San Fancisco, CA (oral presentation), 4/2006.
45. Debnam JM, Rhines LD, Ketonen L, Hamberg LM, Hunter GJ. MDCT with volume rendered translucent display is a valuable tool in assessing spinal hardware failure in patients with cancer. American Society of Spine Radiology Annual Symposium, Las Vegas, NV, 2/2006.
46. Chang EL, Shiu A, Mendel E, Mathews L, Wang S, Woo S, Gning I, Mahajan A, Weinberg J, Rhines LD. Interim results of Phase I/II evaluation of stereotactic body radiotherapy for spinal metastases. American Society for Therapeutic Radiology and Oncology 47th Annual Meeting, Denver, CO (oral presentation), 10/2005.
47. Raiszadeh R, Mendel E, Rhines LD. Sagittal split osteotomy for en-bloc resection of a multilevel cervical sarcoma: case report and description of operative techniques. Congress of Neurological Surgeons Annual Meeting, Boston, MA, 10/2005.
48. Dagnew E, Rhines LD, Mendel E, Lang F, Gokaslan Z, McCutcheon I. Single-stage transpedicular vertebrectomy (TPV) with circumferential decompression and fixation for the management of spinal metastasis: a 10-year experience. Congress of Neurological Surgeons Annual Meeting, Boston, MA, 10/2005.
49. Raiszadeh R, Doppenberg E, Mendel E, Rhines LD. Trans-sacral approach for resection of giant pre-sacral schwannoma: case report and description of operative techniques. Congress of Neurological Surgeons Annual Meeting, Boston, MA, 10/2005.
50. Fourney DR, Rhines LD, Gokaslan ZL. En bloc resection of primary sacral tumors: classification of surgical approaches and outcome. American Association of Neurological Surgeons Annual Meeting, New Orleans, LA, (oral presentation), 4/2005.
51. Sampath P, Rhines L, Tyler B, Brem H. Combination local delivery of docetaxel (Taxotere) and carmustine by biodegradable polymers for the treatment of 9L gliosarcoma. Congress of Neurological Surgeons Annual Meeting, Seattle, WA, 10/1998.

Book Chapters

1. Lewis VO, Guadagnolo A, Rhines LD, Patel S. Rare Tumors. In: Bone Sarcomas. Ed(s) Lin P, Patel S. Springer: New York, NY. In Press.
2. Klimo Jr P., Rao G, Rhines LD. Evaluation and Management of Spinal Axis Tumors: Metastatic. In: Youmans Neurological Surgery. 3, 6th. Ed(s) Winn HR. Elsevier Saunders: Philadelphia, PA, 3154-3165, 2011. ISBN: 978-1-4160-5316-3.
3. Rhines LD, Groves MD. Tumors of the spinal cord and intradural space. In: Tumors of the Brain and Spine. Ed(s) DeMonte F, Gilbert MR, Mahajan A, McCutcheon IE. Springer: New York, 295-328, 2007.
4. York JE, Gokaslan ZL, Rhines LD. Combined vertebrectomy and chest wall resection for pancoast tumors. In: Spinal Cord and Spinal Column Tumors: Principles and Practice. Ed(s) Dickman C, Fehlings M, Gokaslan Z. Thieme Publishers: New York, NY, 468-76, 2005.
5. Mendel E, Guiot B, Rhines LD, Fessler RG. Management of thoracic disc herniation and the transpedicular decompression. In: Atlas of Neurosurgical Techniques. Ed(s) Fessler RG, Sekhar LH. Thieme Publishers: New York, NY, 469-77, 2005.
6. Bohinski RJ, Rhines LD, Gokaslan Z. Perioperative care for neurosurgical neoplasms-2: spinal surgery. In: Acute Care in Cancer Medicine. Ed(s) Shaw A, Riedel B, Burton A, Fields A, Feeley T. Marcel Dekker: New York, NY, 299-308, 2005.

Last updated: 2/17/2014