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Lee M. Ellis

Present Title & Affiliation

Primary Appointment

Professor of Surgery, Department of Surgical Oncology, Division of Surgery, U.T. M. D. Anderson Cancer Center, Houston, TX
Chair, Ad Interim, Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor of Cancer Biology, Department of Cancer Biology, U.T. M. D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1983 University of Virginia, Charlottesville, VA, MD, Medicine

Postgraduate Training

1990-1992 Surgical Oncology Fellow, Surgical Oncology, U.T. M. D. Anderson Cancer Center, Houston, TX
1986-1988 Post-Doctoral Fellow, Shand's Hospital, University of Florida, Gainesville, FL

Board Certifications

1991 American Board of Surgery

Selected Publications

Peer-Reviewed Original Research Articles
1. Dallas NA, Xia L, Fan F, Gray MJ, Gaur P, van Buren G, Samuel S, Kim MP, Lim SJ, Ellis LM. Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition. Cancer Res 69(5):1951-7, 2009. PMID: 19244128.
2. Gray MJ, Van Buren G, Dallas NA, Xia L, Wang X, Yang AD, Somcio RJ, Lin YG, Lim S, Fan F, Mangala LS, Arumugam T, Logsdon CD, Lopez-Berestein G, Sood AK, Ellis LM. Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver. J Natl Cancer Inst 100(2):109-20, 1/2008. PMID: 18182619.
3. Van Buren G, Yang AD, Dallas NA, Gray MJ, Lim SJ, Xia L, Fan F, Somcio R, Wu Y, Hicklin DJ, Ellis LM. Effect of molecular therapeutics on liver regeneration in a murine model. J Clin Oncol 26(11):1836-1842, 2008. PMID: 18398149.
4. Dallas NA, Xia L, Fan F, Gray MJ, Gaur P, Van Buren II G, Samuel S, Kim MP, Lim SJ, Ellis LM. Neuropilin-2-Mediated tumor growth and angiogenesis in pancreatic adenocarcinoma. Clin Cancer Res 14(24):8052-60, 2008. PMID: 19088020.
5. McCarty MF, Somcio RJ, Stoeltzing O, Wey J, Fan F, Liu W, Bucana C, Ellis LM. Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content. J Clin Invest 117(8):2114-22, 8/2007. PMID: 17641778.
6. Camp ER, Yang A, Gray MJ, Fan F, Hamilton SR, Evans DB, Hooper AT, Pereira DS, Hicklin DJ, Ellis LM. Tyrosine kinase receptor RON in human pancreatic cancer: expression, function, and validation as a target. Cancer 109(6):1030-9, 3/2007. PMID: 17311308.
7. Bauer TW, Fan F, Liu W, Camp ER, Yang A, Somcio RJ, Bucana CD, Singh R, Ellis LM. Targeting of insulin-like growth factor-I receptor with a monoclonal antibody inhibits growth of hepatic metastases from human colon carcinoma in mice. Ann Surg Oncol 14(10):2838-46, 2007. PMID: 17653802.
8. Van Buren G, Rashid A, Yang AD, Abdalla EK, Gray MJ, Liu W, Somcio R, Fan F, Camp ER, Yao JC, Ellis LM. The Development and Characterization of a Human Midgut Carcinoid Cell Line. Clin Cancer Res 13(16):47074-4712, 2007. PMID: 17699847.
9. Yang AD, Fan F, Camp ER, van Buren G, Liu W, Somcio R, Gray MJ, Cheng H, Hoff PM, Ellis LM. Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines. Clin Cancer Res 12:4147-53, 2006. PMID: 16857785.
10. Bauer TW, Somcio RJ, Fan F, Liu W, Johnson M, Lesslie DP, Evans DB, Gallick GE, Ellis LM. Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells. Mol Cancer Ther 5:1676-82, 2006. PMID: 16891453.
11. Camp ER, Yang A, Liu W, Fan F, Somcio R, Hicklin DJ, Ellis LM. Roles of nitric oxide synthase inhibition and vascular endothelial growth factor receptor-2 inhibition on vascular morphology and function in an in vivo model of pancreatic cancer. Clin Cancer Res 12:2628-33, 2006. PMID: 16638876.
12. Ellis LM. The role of neuropilins in cancer. Mol Cancer Ther 5:1099-107, 2006. PMID: 16731741.
13. Yang AD, Camp ER, Fan F, Shen L, Gray MJ, Liu W, Somcio R, Bauer TW, Wu Y, Hicklin DJ, Ellis LM. Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Cancer Res 66:46-51, 2006. PMID: 16397214.
14. Fan F, Wey JS, McCarty MF, Belcheva A, Liu W, Bauer TW, Somcio RJ, Wu Y, Hooper A, Hicklin DJ, Ellis LM. Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene 24:2647-53, 2005. PMID: 15735759.

Invited Articles
1. Ellis LM, Reardon DA. The nuances of therapy. Nature 458:290-292, 2009.
2. Ellis LM, Hicklin DJ. Pathways mediating resistance to VEGF-targeted therapy. Clin Cancer Res 14(20):6371-5, Oct 15, 2008.
3. Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 8:579-591, 2008. PMID: 18596824.

Last updated: 9/22/2009