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Leena M Ketonen, MD, PhD

Present Title & Affiliation

Primary Appointment

Professor, Department of Diagnostic Radiology, Division of Diagnostic Imaging, University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

Dr. Ketonen joined MD Anderson in 2004 as Professor in the Division of Diagnostic Imaging, Department of Diagnostic Radiology, and Section of Neuroradiology. She is currently on the Neuroradiology Executive Committee. Dr. Ketonen is a journal reviewer of many neuroradiology and neurology journals. She has published 140+ articles, 14 book chapters and 3 books that have been translated to several languages. She is also an active participant in 10+ pediatric research protocols.

Research Interests

 MRI Neuroimaging, use of MRI for pediatric neuroimaging, MRI and anatomy correlation

Clinical Interests

 MRI Neuroimaging, use of MRI for pediatric neuroimaging, MRI and anatomy correlation

Education & Training

Degree-Granting Education

1977 Helsinki University, Helsinki, Finland, PHD, Medicine
1969 Helsinki University, Helsinki, Finland, MD, Medicine

Board Certifications

1/1979 Subspecialty in Neuroradiology, Finnish Board of Radiology
11/1974 Finnish Board of Radiology

Experience/Service

Academic Appointments

Professor, Department of Diagnostic Radiology, Division of Diagnostic Imaging, University of Rochester Medical Center, Rochester, NY, 12/2002-8/2004
Associate Professor, Department of Neuroradiology, Division of Diagnostic Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 11/2000-12/2002
Professor, Department of Diagnostic Radiology, Division of Diagnostic Imaging, University of Texas System, Memorial Hermann Hospital, Houston, TX, 1/1999-9/2000
Professor, Department of Diagnostic Radiology, Division of Diagnostic Imaging, University of Texas Medical Branch, Galveston, TX, 1/1995-9/2000

Administrative Appointments/Responsibilities

Neuroradiology Fellowship Program Director, Department of Diagnostic Radiology, Division of Diagnostic Imaging, University of Texas Medical Branch, Galveston, TX, 1/1995-9/2000
Director of Neuroradiology, Department of Diagnostic Radiology, Division of Diagnostic Imaging, University of Texas Medical Branch, Galveston, TX, 1/1995-9/1999

Selected Publications

Peer-Reviewed Original Research Articles

1. Hamilton JD, Lin J, Ison C, Leeds NE, Jackson EF, Fuller GN, Ketonen L, Kumar AJ. Dynamic Contrast-Enhanced Perfusion Processing for Neuroradiologists: Model-Dependent Analysis May Not Be Necessary for Determining Recurrent High-Grade Glioma versus Treatment Effect. AJNR Am J Neuroradiol. e-Pub 12/2014. PMID: 25500312.
2. Khatua S, Hou P, Bodiwala R, Wolff J, Hamilton J, Patil S, Zaky W, Mahajan A, Ketonen L. Preliminary experience with diffusion tensor imaging before and after re-irradiation treatments in children with progressive diffuse pontine glioma. Childs Nerv Syst 30(5):925-30, 5/2014. e-Pub 1/2014. PMID: 24395582.
3. Raslan O, Debnam JM, Ketonen L, Kumar AJ, Schellingerhout D, Wang J. Stereoscopic visualization of diffusion tensor imaging data: a comparative survey of visualization techniques. Radiol Res Pract 2013:780916, 2013. e-Pub 10/2013. PMCID: PMC3819952.
4. Subbiah V, Wolff J, Ketonen L, Ellezam B, Rytting ME. Advanced atypical teratoid/rhabdoid tumor (ATRT) treated with intensive multimodal approach shows continued response to sarcoma type salvage therapy. Pediatr Blood Cancer 58(5):823-4, 5/2012. e-Pub 9/2011. PMID: 21922648.
5. Fontanilla HP, Pinnix CC, Ketonen LM, Woo SY, Vats TS, Rytting ME, Wolff JE, Mahajan A. Palliative reirradiation for progressive diffuse intrinsic pontine glioma. Am J Clin Oncol 35(1):51-7, 2/2012. e-Pub 2/2011. PMID: 21297433.
6. Subbiah V, Slopis J, Hong DS, Ketonen LM, Hamilton J, McCutcheon IE, Kurzrock R. Treatment of patients with advanced neurofibromatosis Type 2 With novel molecularly targeted therapies: from bench to bedside. J Clin Oncol 30(5):e64-e68, 2/2012. e-Pub 12/2011. PMCID: PMC3295556.
7. Wolff JE, Rytting ME, Vats TS, Zage PE, Ater JL, Woo S, Kuttesch J, Ketonen L, Mahajan A. Treatment of recurrent diffuse intrinsic pontine glioma: the MD Anderson Cancer Center experience. J Neurooncol 106(2):391-7, 1/2012. e-Pub 8/2011. PMID: 21858608.
8. Debnam JM, Ketonen L, Guha-Thakurta N. Three-dimensional volume-rendered seriescomplements 2D orthogonal multidetector computed tomography in the evaluation of abnormal spinal curvature in patients at a major cancer center: a retrospective review. ISRN Orthop 2012:639189, 2012. e-Pub 10/2012. PMCID: PMC4063197.
9. Sedrak P, Ketonen L, Hou P, Guha-Thakurta N, Williams MD, Kurzrock R, Debnam JM. Erdheim-chester disease of the central nervous system: new manifestations of a rare disease. AJNR Am J Neuroradiol 32(11):2126-31, 12/2011. e-Pub 9/2011. PMID: 21960492.
10. Wolff JE, Rytting M, Vats T, Ater J, Mahajan A, Woo S, Ketonen L, Kuttesch J, Liu D, Thall P, Chang EL. Induction Treatment for Diffuse Intrinsic Pontine Glioma, Experience of M.D. Anderson Cancer Center. Anticancer Res 31(6):2265-2269, 6/2011. PMID: 21737651.
11. Raslan OA, Schellingerhout D, Fuller GN, Ketonen LM. Rosai-Dorfman disease in neuroradiology: imaging findings in a series of 10 patients. AJR Am J Roentgenol 196(2):W187-W193, 2/2011. PMID: 21257861.
12. Debnam JM, Chi TL, Ketonen L, Mahfouz YM, Guha-Thakurta N. Co-registration of sequential multidetector computed tomography studies for the evaluation of surgical instrumentation following resection of spinal tumors. Case Rep Radiol 2011:676410, 2011. e-Pub 7/2011. PMCID: PMC3350213.
13. Subbiah V, Ketonen L, Bruner JM, Nunez R, Weinberg J, Wolff JE. 99mTc-sestamibi scan differentiates tumor from other contrast enhancing tissue in choroid plexus tumors. J Pediatr Hematol Oncol 32(2):160-2, 3/2010. PMID: 20168252.
14. Muzzafar S, Ketonen L, Weinberg JS, Schellingerhout D. Imaging and clinical features of an intra-axial brain stem schwannoma. AJNR Am J Neuroradiol 31(3):567-9, 3/2010. e-Pub 10/2009. PMID: 19833800.
15. Subbiah V, Huff V, Wolff JE, Ketonen L, Lang FF, Stewart J, Langford L, Herzog CE. Bilateral gonadoblastoma with dysgerminoma and pilocytic astrocytoma with WT1 GT-IVS 9 mutation: a 46 XY phenotypic female with Frasier syndrome. Pediatr Blood Cancer 53(7):1349-51, 12/2009. PMID: 19653292.
16. Debnam JM, Schellingerhout D, Kumar AJ, Ketonen L, Shah K, Hamberg LM, Hunter GJ. Multidetector CT-guided lumbar puncture in patients with cancer. Interv Neuroradiol 15(1):61-66, 3/2009. e-Pub 4/2009. PMCID: PMC3306150.
17. Amini E, Roffidal T, Lee A, Fuller GN, Mahajan A, Ketonen L, Kobrinsky N, Cairo MS, Wells RJ, Wolff JE. Central neurocytoma responsive to topotecan, ifosfamide, carboplatin. Pediatr Blood Cancer 51(1):137-140, 7/2008. PMID: 18338396.
18. Raslan O, Ketonen LM, Fuller GN, Schellingerhout D. Intracranial Rosai-Dorfman disease with relapsing spinal lesions. J Clin Oncol 26(18):3087-3089, 6/2008. PMID: 18565897.
19. Masoudi A, Amini E, Wolff JE, Fuller GN, Ketonen L, Mahajan A. Shrinkage of germinoma by dexamethasone only. Pediatr Blood Cancer 50(5):1079, 5/2008. PMID: 18000859.
20. Zhang M, Segerer F,Ketonen L, Mahajan A, Wolff J. Prediction of tumour regrowth of pontine glioma using a two-term model. Anticancer Res 28(2A):741-749, Mar-Apr, 3/2008. PMID: 18507015.
21. Raslan O, Schellingerhout D, Ketonen L, Debnam M, Kumar A, Wang J. Stereoscopic visualization of diffusion tensor imaging data: a comparative survey of several DTI visualization techniques. Medical Physics 35(6):2641, 2008. PMCID: PMCPMC3819952.
22. Debnam JM, Ketonen L, Hamberg LM, Hunter GJ. Current techniques used for the radiologic assessment of intracranial neoplasms. Arch Pathol Lab Med 131(2):252-260, 2/2007. PMID: 17284110.
23. Lee PL, Yiannoutsos CT, Ernst T, Chang L, Marra CM, Jarvik JG, Richards TL, Kwok EW, Kolson DL, Simpson D, Tang CY, Schifitto G, Ketonen L, Meyerhoff DJ, Lenkinski RE, Gonzalez RG, Navia BA, HIV MRS Consortium. A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis. J Magn Reson Imaging 17(6):625-633, 6/2003. PMID: 12766890.
24. Ingram F, Ketonen L, Paar D, Avery E. Memory implications of a "fornix white line" in HIV infection. J NeuroAIDS 2(3):83-90, 2002. PMID: 16873201.
25. Muffoletto AJ, Ketonen L, Mader JT, Crow WN, Hadjipavlou AG. Hematogenous pyogenic facet joint infection. Spine 26(14):1570-1576, 2001. PMID: 11462088.
26. Hillman GR, Chang CW, Ying H, Yen J, Ketonen L, Kent TA. A fuzzy logic approach to identifying brain structures in MRI using expert anatomic knowledge. Comput Biomed Res 32(6):503-516, 1999. PMID: 10587468.
27. De La Peña RC, Ketonen L, Villanueva-Meyer J. Imaging of brain tumors in AIDS patients by means of dual-isotope thallium-201 and technetium-99m sestamibi single-photon emission tomography. Eur J Nucl Med 25(10):1404-1411, 1998. PMID: 9818280.
28. Ketonen L. Neuroimaging of the aging brain. Neurol Clin 16(3):581-598, 1998. PMID: 9666038.
29. Valanne L, Ketonen L, Majander A, Suomalainen A, Pihko H. Neuroradiologic findings in children with mitochondrial disorders. AJNR Am J Neuroradiol 19(2):369-377, 1998. PMID: 9504497.
30. Ketonen L, Kieburtz KD, Tuite MJ, Eskin T, Simon J. CNS lymphoma in an AIDS patient involving the posterior fornix case report. J NeuroAIDS 1(3):43-49, 1997. PMID: 16873170.
31. Kieburtz K, Ketonen L, Cox C, Grossman H, Holloway R, Booth H, Hickey C, Feigin A, Caine ED. Cognitive performance and regional brain volume in human immunodeficiency virus type 1 infection. Arch Neurol 53(2):155-158, 1996. PMID: 8639065.
32. Valanne L, Paetau A, Suomalainen A, Ketonen L, Pihko H. Laminar cortical necrosis in MELAS syndrome: MR and neuropathological observations. Neuropediatrics 27(3):154-160, 1996. PMID: 8837076.
33. Ketonen L, De la Peña RC, Villanueva-Meyer J. MR and TL-201 spect imaging with pathologic correlation for the assessment of CNS lymphoma vs. toxoplasmosis in AIDS patients. J NeuroAIDS 2(1):21-42, 1996. PMID: 16873183.
34. Sheth RD, Riggs JE, Bodenstenier JB, Gutierrez AR, Ketonen L, Ortiz OA. Parietal occipital edema in hypertensive encephalopathy: a pathogenic mechanism. Eur Neurol 36(1):25-28, 1996. PMID: 8719646.
35. Valanne LK, Ketonen L, Berg MJ. Pseudoprogression of cerebral cavernous angiomas: the importance of proper magnetic resonance imaging technique. J Neuroimaging 6(3):195-196, 1996. PMID: 8704299.
36. Ketonen L, Kieburtz K, Kazee AM, Tuite M. Putaminal iron deposition in HIV infection. J NeuroAIDS 1(2):33-40, 1996. PMID: 16873163.
37. Riggs JE, Ketonen L, Wang DD, Valanne LK. Cerebral infarction in a child with sickle cell trait. J Child Neurol 10(3):253-254, 1995. PMID: 7642903.
38. Chess MA, Barsotti JB, Chang JK, Ketonen L, Westesson PL. Duplication of the extracranial internal carotid artery. AJNR Am J Neuroradiol 16(7):1545-1547, 1995. PMID: 7484653.
39. Ketonen L, Schwid S, Valanne LK, Peterson P, Okawara S. Herpes simplex myelitis simulating neoplasm on magnetic resonance imaging. J Neuroimaging 5(3):190-191, 1995. PMID: 7626828.
40. Koskinen T, Valanne L, Ketonen L, Pihko H. Infantile-onset spinocerebellar ataxia: MR and CT findings. AJNR Am J Neuroradiol 16(7):1427-1433, 1995. PMID: 7484627.
41. Berg MJ, Erba G, Burchfiel JL, Oestreich L, Langfitt J, Behman H, McBride M, Ketonen L. New onset intractable bitemporal epilepsy, amnesia, and hippocampal/amygdalar atrophy beginning with status epilepticus in adulthood. Epilepsia 36(Suppl. 4):112, 1995.
42. Valanne L, Ketonen L, Barsotti J, Peterson P, Pilcher W. Posttraumatic nonfunctioning arm. J Child Neurol 10(1):30-31, 1995. PMID: 7769174.
43. Ashton EA, Berg MJ, Parker KJ, Weisberg J, Chen CW, Ketonen L. Segmentation and feature extraction techniques, with applications to MRI head studies. Magn Reson Med 33(5):670-677, 1995. PMID: 7596271.
44. Riggs JE, Ketonen L, Wymer JP, Barbano RL, Valanne LK, Bodensteiner JB. Acute and delayed cerebral infarction after wasp sting anaphylaxis. Clin Neuropharmacol 17(4):384-388, 1994. PMID: 9316687.
45. Bland LI, Lapham LW, Ketonen L, Okawara SH. Acute cerebellar hemorrhage secondary to capillary telangiectasia in an infant: a case report. Arch Neurol 51(11):1151-1154, 1994. PMID: 7980112.
46. Ketonen L, Roddy S, Lannan M. Band heterotopia. J Child Neurol 9(4):384-385, 1994. PMID: 7822729.
47. Ashton A, Berg M, Parker K, Weisberg J, Chang WC, Ketonen L. Segmentation and feature extraction techniques with application to biomedical images. IEEE:726-730, 1994.
48. Kinnunen E, Järvinen P, Ketonen L, Sepponen R. Co-twin control study on cerebral manifestations of systemic lupus erythematosus. Acta Neurol Scand 88(6):422-6, 12/1993. PMID: 8116344.
49. Kinnunen E, Müller K, Keto P, Ketonen L, Helve T, Sepponen R. Cerebrospinal fluid and MRI findings in three patients with multiple sclerosis and systemic lupus erythematosus. Acta Neurol Scand 87(5):356-360, 1993. PMID: 8333238.
50. Kinnunen E, Timonen T, Pirttilä T, Kalliomäki P, Ketonen L, Matikainen E, Sepponen R, Juntunen J. Effects of recombinant alpha-2b-interferon therapy in patients with progressive MS. Acta Neurol Scand 87(6):457-460, 1993. PMID: 8356874.
51. Tuite M, Ketonen L, Kieburtz K, Handy B. Efficacy of gadolinium in MR brain imaging of HIV-infected patients. AJNR Am J Neuroradiol 14(1):257-263, Jan-Feb, 1993. PMID: 8427101.
52. Jennings MT, Slatkin N, D'Angelo M, Ketonen L, Johnson MD, Rosenblum M, Creasy J, Tulipan N, Walker R. Neoplastic meningitis as the presentation of occult primitive neuroectodermal tumors. J Child Neurol 8(4):306-312, 1993. PMID: 8228025.
53. Kieburtz KD, Eskin TA, Ketonen L, Tuite MJ. Opportunistic cerebral vasculopathy and stroke in patients with the acquired immunodeficiency syndrome. Arch Neurol 50(4):430-432, 1993. PMID: 8460966.
54. Schiffer RB, Giang DW, Mushlin A, Ketonen L, Joy S, Kido D, Goodman AD, Mattson DH, Mooney C. Perils and pitfalls of magnetic resonance imaging in the diagnosis of multiple sclerosis. The Rochester-Toronto MRI Study Group. J Neuroimaging 3(2):81-88, 1993. PMID: 10148526.
55. Riggs JE, Ketonen L, Bodensteiner JB, Benesch CG. Wasp sting-associated cerebral infarction: a role for cerebrovascular sympathetic innervation. Clin Neuropharmacol 16(4):362-365, 1993. PMID: 8374916.
56. Ketonen L, Tuite MJ. Brain imaging in human immunodeficiency virus infection. Semin Neurol 12(1):57-69, 1992. PMID: 1615241.
57. Giang DW, Poduri KR, Eskin TA, Ketonen L, Friedman PA, Wang DD, Herndon RM. Multiple sclerosis masquerading as a mass lesion. Neuroradiology 34(2):150-154, 1992. PMID: 1603315.
58. Farley TJ, Ketonen L Bodensteiner JB, Wang DD. Serial MRI and CT findings in infantile Krabbe disease. Pediatr Neurol 8(6):455-458, Nov-Dec, 1992. PMID: 1476576.
59. Riggs JE, Ketonen L. The initial impact of computed tomography on mortality attributed to brain tumor. J Neuroimaging 2(3):136-138, 1992. PMID: 10147938.
60. Pacini R, Simon J, Ketonen L, Kido D, Kieburtz K. Chemical-shift imaging of a spontaneous internal carotid artery dissection: case report. AJNR Am J Neuroradiol 12(2):360-362, Mar-Apr, 1991. PMID: 1902044.
61. Kido DK, Panzer RJ, Szumowski J, Hollander J, Ketonen L, Monajati A, Ouriel K, Manzione JV, Dumoulin CL, Souza SP. Clinical evaluation of stenosis of the carotid bifurcation with magnetic resonance angiographic techniques. Arch Neurol 48(5):484-489, 1991. PMID: 2021361.
62. Kieburtz K, Zettelmaier AE, Ketonen L, Tuite M, Caine ED. Manic syndrome in AIDS. Am J Psychiatry 148(8):1068-1070, 1991. PMID: 1853958.
63. Westesson PL, Dahlberg G, Hansson LG, Eriksson L, Ketonen L. Osseous and muscular changes after vertical ramus osteotomy. A magnetic resonance imaging study. Oral Surg Oral Med Oral Pathol 72(2):139-145, 1991. PMID: 1923390.
64. Ketonen L, Totterman S, Simon JH, Foster TH, Kido DK, Szumowski J, Joy SE. A comparison of default and reduced bandwidth MR imaging of the spine at 1.5 T. AJNR Am J Neuroradiol 11(1):9-15, Jan-Feb, 1990. PMID: 2105622.
65. Kinnunen E, Kauppi M, Ketonen L, Sepponen R, Tanttu J, Konttinen YT, Isomäki H. Low-field MRI in the evaluation of rheumatoid cervical spine. Comparison with neurological findings and routine plain radiography. Clin Exp Rheumatol 8(4):365-369, Jul-Aug, 1990. PMID: 2397626.
66. Kieburtz KD, Ketonen L, Zettelmaier AE, Kido D, Caine ED, Simon JH. Magnetic resonance imaging findings in HIV cognitive impairment. Arch Neurol 47(6):643-645, 1990. PMID: 2346391.
67. Kinnunen E, Juntunen J, Konttinen Y, Kemppinen P, Ketonen L, Kleemola M, Valle M, Koskimies S, Koskenvuo M. MS and SLE in twins of successive generations. Acta Neurol Scand 81(3):246-249, 1990. PMID: 2353574.
68. Santavuori P, Pihko H, Sainio K, Lappi M, Somer H, Haltia M, Raitta C, Ketonen L, Leisti J. Muscle-eye-brain disease and Walker-Warburg syndrome. Am J Med Genet 36(3):371-374, 1990. PMID: 2363444.
69. Santavuori P, Somer H, Sainio K, Rapola J, Kruus S, Nikitin T, Ketonen L, Leisti J. Muscle-eye-brain disease (MEB). Brain Dev 11(3):147-153, 1989. PMID: 2751061.
70. Simon JH, Foster TH, Ketonen L, Totterman S, Szumowski J, Kido DK, Manzione JV, Joy SE. Reduced-bandwidth MR imaging of the head at 1.5 T1. Radiology 172(3):771-775, 1989. PMID: 2772187.
71. Erkinjuntti T, Sulkava R, Palo J, Ketonen L. White matter low attenuation on CT in Alzheimer's disease. Arch Gerontol Geriatr 8(1):95-104, 1989. PMID: 2653256.
72. Erkinjuntti T, Larsen T, Sulkava R, Ketonen L, Laaksonen R, Palo J. EEG in the differential diagnosis between Alzheimer's disease and vascular dementia. Acta Neurol Scand 77(1):36-43, 1988. PMID: 3354310.
73. Roine RO, Hillbom M, Valle M, Haltia M, Ketonen L, Neuvonen E, Lumio J, Lähdevirta J. Fatal encephalitis caused by a bat-borne rabies-related virus. Clinical findings. Brain 111 (Pt 6):1505-1516, 1988. PMID: 3208067.
74. Kinnunen E, Juntunen J, Ketonen L, Koskimies S, Konttinen YT, Salmi T, Koskenvuo M, Kaprio J. Genetic susceptibility to multiple sclerosis. A co-twin study of a nationwide series. Arch Neurol 45(10):1108-1111, 1988. PMID: 3263109.
75. Riikonen R, Ketonen L, Sipponen J. Magnetic resonance imaging, evoked responses and cerebrospinal fluid findings in a follow-up study of children with optic neuritis. Acta Neurol Scand 77(1):44-49, 1988. PMID: 3128051.
76. Ojala M, Ketonen L, Palo J. The value of CT and very low field MRI in the etiological diagnosis of dizziness. Acta Neurol Scand 78(1):26-29, 1988. PMID: 3176878.
77. Erkinjuntti T, Ketonen L, Sulkava R, Vuorialho M, Palo J. CT in the differential diagnosis between Alzheimer's disease and vascular dementia. Acta Neurol Scand 75(4):262-270, 1987. PMID: 3591276.
78. Launes J, Ketonen L. Dense middle cerebral artery sign: an indicator of poor outcome in middle cerebral artery area infarction. J Neurol Neurosurg Psychiatry 50(11):1550-1552, 1987. PMID: 3694213.
79. Erkinjuntti T, Ketonen L, Sulkava R, Sipponen J, Vuorialho M, Iivanainen M. Do white matter changes on MRI and CT differentiate vascular dementia from Alzheimer's disease. J Neurol Neurosurg Psychiatry 50(1):37-42, 1987. PMID: 3819754.
80. Kinnunen E, Larsen A, Ketonen L, Koskimies S, Sandström A. Evaluation of central nervous system involvement in uncomplicated optic neuritis after prolonged follow-up. Acta Neurol Scand 76(2):147-151, 1987. PMID: 3499741.
81. Ketonen L, Oksanen V, Kuuliala I. Preliminary experience of magnetic resonance imaging in neurosarcoidosis. Neuroradiology 29(2):127-129, 1987. PMID: 3587585.
82. Lumio J, Hillbom M, Roine R, Ketonen L, Haltia M, Valle M, Neuvonen E, Lähdevirta J. Human rabies of bat origin in Europe. Lancet 1(8477):378, 1986. PMID: 2868310.
83. Ketonen L, Oksanen V, Kuuliala I, Somer H. Hypodense white matter lesions in computed tomography of neurosarcoidosis. J Comput Assist Tomogr 10(2):181-183, Mar-Apr, 1986. PMID: 3950142.
84. Ketonen L, Gyldensted C. Lumbar disc disease evaluated by myelography and postmyelography spinal computed tomography. Neuroradiology 28(2):144-149, 1986. PMID: 3703237.
85. Ketonen L Suoranta H. Magnetic resonance imaging of the central nervous system. Duodecim 102(20):1416-1426, 1986. PMID: 3769830.

Invited Articles

1. Ketonen L, Valanne V. Neuroimaging of pediatric disease. Semin Neurol 28:558-569, 2008.
2. Ketonen L. Magnetic resonance in epilepsy. J Epilepsy 53:12-13, 1996.
3. Ketonen L, Valanne L, Berman E. Current status of MRI imaging. Ophthal Clinic 12:1-12, 1994.
Other Articles
1. Ketonen L. Giant Virhow-Robin spaces case report. Department of Radiology, University of Rochester Medical Center, 2007. e-Pub 2007.
2. Sidhu R, Ketonen L Westesson P-L. Acute basilar artery thrombosis. Neuroradiology case of the week #76. Department of Radiology, University of Rochester Medical Center, Rochester, NY, 2000. e-Pub 2000.
3. Sidhu R, Almast J, Ketonen L, Westesson P-L. Acute spinal cord ischemia syndrome Neuroradiology case of the week #56. Department of Radiology, University of Rochester Medical Center, Rochester, NY, 2000. e-Pub 2000.
4. Chun T, Ketonen L, Westesson P-L. Arnold-Chiari II malformation. Neuroradiology case of the week #87. Department of Radiology, University of Rochester Medical Center, Rochester, NY, 2000. e-Pub 2000.
5. Sidhu R, Ketonen L, Westesson P-L. Caudal regression syndrome. Neuroradiology case of the week #82. Department of Radiology, University of Rochester Medical Center, Rochester, NY, 2000. e-Pub 2000.
6. Sidhu R, Ketonen L, Berg MJ, Westesson P-L. Cerebellar degeneration associated with CoQ 10 deficiency. Neuroradiology case of the week #55. Department of Radiology, University of Rochester Medical Center, Rochester, NY, 2000. e-Pub 2000.
7. Sidhu R, Ketonen L, Westesson P-L. Leptomeningeal melanosis. Neuroradiology case of the week #106. Department of Radiology, University of Rochester Medical Center, Rochester, NY, 2000. e-Pub 2000.
8. Ketonen L. Magnetic resonance imaging of the brain and spine. Arch Neurol, 2000.
9. Popuri D, Ketonen L, Westesson P-L. Mesial temporal sclerosis (MTS). Neuroradiology case of the week #105. Department of Radiology, University of Rochester Medical Center, Rochester, NY, 2000. e-Pub 2000.
10. Sidhu R, Almast J, Ketonen L, Westesson P-L. Metastatic malignant melanoma. Neuroradiology case of the week #72. Department of Radiology, University of Rochester Medical Center, Rochester, NY, 2000. e-Pub 2000.
11. Popuri D, Ketonen L, Westesson P-L. Multiple sclerosis of cord. Neuroradiology case of the week #108. Department of Radiology, University of Rochester Medical Center, Rochester, NY, 2000. e-Pub 2000.
12. Sidhu R, Ketonen L, Wang H, Westesson P-L. Non-accidental head injury (child abuse). Neuroradiology case of the week #88. Department of Radiology, University of Rochester Medical Center, Rochester, NY, 2000. e-Pub 2000.
13. Sidhu R, de Guzman R, Ketonen L, Westesson P-L. Ossification of posterior longitudinal ligament Neuroradiology Case of the Week #54. e-Publication: Department of Radiology, University of Rochester Medical Center, 2000.
14. Sidhu R, Almast J, Ketonen L, Westesson P-L. Plasmablastic lymphoma. Neuroradiology case of the week #78. Department of Radiology, University of Rochester Medical Center, Rochester, NY, 2000. e-Pub 2000.
15. Ketonen R, Ketonen L, Sidhu R, Kathuria, R. Sanfilippo syndrome. Neuroradiology case of the week #107. Department of Radiology, University of Rochester Medical Center, Rochester, NY, 2000. e-Pub 2000.
16. Sidhu R, Almast J, Ketonen L, Westesson P-L. Secondary hemochromatosis due to iron overload by repeated blood transfusions. Neuroradiology case of the week #60. Department of Radiology, University of Rochester Medical Center, Rochester, NY, 2000. e-Pub 2000.
17. Sidhu R, Ketonen L Westesson P-L. Spinal epidural hematoma. Neuroradiology Case of the Week #70. Department of Radiology, University of Rochester Medical Center, Rochester, NY, 2000. e-Pub 2000.
18. Popuri D, Ketonen R, Ketonen L, Chengazi V, Harrow A, Westesson P-L. Toxoplasmosis. Neuroradiology case of the week #74. Department of Radiology, University of Rochester Medical Center, Rochester, NY, 2000. e-Pub 2000.
19. Ketonen L. Magnetic resonance in epilepsy. Arch Neurol 53:12-13, 1996.
20. Ketonen L. Fundamentals of neuroimaging. Arch Neurol 52:747, 1/1995.
21. Ketonen L. Magnetic resonance imaging in epilepsy. Arch Neurol 52:555, 1/1995.
22. Ketonen L, Berg M. Functional neuroimaging: technical foundations. Arch Neurol 52:746, 1995.
23. Barsotti JB, Westesson PL, Ketonen L. Diagnostic and interventional angiographic procedures in the maxillofacial region. Oral and Maxillofacial Surgery Clinics of North America 4(1):35-49, 1/1992.
24. Palo J, Ketonen L, Wikström J. A follow-up study of very low field MRI findings and clinical course in multiple sclerosis. J Neurol Sci 84(2-3):177-87, 1988. PMID: 3379445.

Abstracts

1. Wang B, Ketonen L. Chordoid glioma involving posterior body of corpus callosum. The American Society of Neuroradiology 51st Annual Meeting Proceedings Book, 5/2013.
2. Wang B, Fuller G, Ketonen L. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. The American Society of Neuroradiology 51st Annual Meeting Proceedings Book, 5/2013.
3. Ison CB, Kumar AJ, Ketonen L, Schellingehout D, Jackson EF, Hou P, Hamilton JD. Physiologic mr imaging for assessment of nonenhancing T2 signal abnormalities before or after treatment of brain tumors: myoinositol and apparent diffusion coefficient values may be more helpful than choline ratios and perfusion imaging. The American Society of Neuroradiology 51st Annual Meeting Proceedings Book, 5/2013.
4. Hamilton JD, Jackson EF, Leeds NE, Ketonen L, Schellingerhout D, Jones J, Tatum LS, Hou P, Evans DT, Underwood ML, Jones JR, Reed BJ, Hash S, Steele J, Albright HW, Kumar AJ. Predicting recurrent glioma versus treatment-related necrosis using multiparameter advanced mr imaging: accurate and cost-effective clinical decision-making. The American Society of Neuroradiology 51st Annual Meeting Proceedings Book, 5/2013.
5. Santosh S, Sedrak P, Guha-Thakurta N, Ketonen L, Williams MD, Debnam JM. CNS and head/neck histiocytoses: spectrum of imaging findings in 26 patients. Proceedings Book of the 50th Annual Meeting of the American Society of Neuroradiology, 4/2012.
6. Wang B, Ketonen, LM. Isolated intraprencymal cerebellar Rosai-Dorfman disease in a child, 2012.
7. Sawale KB, Wolff J, Vats T, Ketonen L. Redefining diagnostic MRI parameters for diffuse intrinsic pontine glioma measurement. 15th Society for Neuro-Oncology Annual Scientific Meeting, 2012.
8. Wolff J, Patel H, Ketonen L, Mahajan A. Reirradiation for progressive diffuse intrinsic pontine glioma and subsequent radiographic changes. 42nd Congress of the International Society of Pediatric Oncology, 2012.
9. Wolff J, Rytting M, Vats T, Zage P, Ater J, Woo S, Kuttesch JF, Ketonen L, Slopis J, Mahajan A. Treatment of recurrent diffuse intrinsic pontine glioma: how should they be analysed?. 43rd Congress of the International Society for Paediatric Oncology (#731), 2012.
10. Bodiwala R, Ketonen L, Hou P, Wolff J, Mahajan A. Diffusion tensor imaging date confim efficacy of reradiation treatment in pediatric patients with diffuse intrinsic pontine glioma. Proceedings Book of the 49th Annual Meeting of the American Society of Neuroradiology, 5/2011.
11. Subbiah V, Sawale K, Vats T, Rytting M, Mahajan A, Ketonen L, Wolff J. Combination radiotherapy plus chemotherapy vs radiotherapy alone in pediatric diffuse intrinsic pontine glioma: a single-institution experience. Pediatr Blood Cancer 55(5):924, 11/2010.
12. Dhamne C, Subbiah V, Ketonen L, Wolff J, Vats T, Adesina A, Rytting M. MR spectroscopic findings in bithalamic astrocytoma: case report and review of literature. 14th International Symposium on Pediatric Neuro-Oncology, 6/2010.
13. Patel HJ, Pinnix CC, Wolff J, Ketonen L, Mahajan A. Reirradiation for progressive diffuse intrinsic pontine glioma. 14th International Symposium on Pediatric Neuro-Oncology, 6/2010.
14. Wolf JE, Brown R, Rytting M, Vats T, Bingham R, Epps R, Fletcher S, Pfister S, Ketonen L, Slopis J, Thall P. Targeted personalized therapy for pediatric patients with refractory brain tumors. 14th International Symposium on Pediatric Neuro-Oncology, 6/2010.
15. Debnam JM, Mahfouz YMM, Chi L, Ketonen L, Guha-Thakurta N. Coregistration of sequential MDCT studies for the evaluation of surgical instrumentation following resection of spinal tumors. 48th American Society of Neuroradiology Annual Meeting, 5/2010.
16. Debnam JM, Raslan O, Schellingerhout D, Ketonen L, Kumar AJ, Wang J. Comparison of conventional and stereoscopic diffusion tensor imaging visualization techniques. 47th American Society of Neuroradiology Annual Meeting, 2009.
17. Li L, Nagel P, Ketonen L, Mahajan A, Wolff J. Improved response of pontine glioma with concurrent radiochemotherapy: results of a retrospective image analysis. 3rd World Federation of Neuro-Oncology, 2009.
18. Subbiah V, Huff V, Wolff J, Ketonen L , Frederick L Jr, Stewart J, Langford L, Herzog C. Bilateral gonadoblastoma with dysgerminoma and pilocytic astrocytoma with WT1 GT-IVS 9 mutation- a 46 XY phenotypic female with Frasier syndrome and review of literature. 23rd American Society of Pediatric Hematology/Oncology Annual Meeting, 2008.
19. Amini E, Roffidal T, Fuller G, Wells R, Ketonen L, Mahajan A, Petropoulos D, Kobrinsky N, Wolff J. Central neurocytoma: responsiveness to topotecan, ifosfamide, carboplatin chemotherapy. 13th Society of Neuro-Oncology Annual Scientific Meeting, 2008.
20. Lee JC, Ketonen L., Westesson PL. Chronological imaging atlas of normal myelination. 94th Radiological Society of North America Annual Meeting, 2008.
21. Amini E, Masoudi A, Fuller G, Ketonen L, Lang F, Wolff J. Shrinkage of germinoma by dexamethasone only, case report. 13th Society of Neuro-Oncology Annual Scientific Meeting, 2008.
22. Wolff J, Segerer F, Ketonen L, Nagel M, Gothe M, Zhang M, Gopalakrishnan V, Jahajan V, Ater J. Predicting tumor growth in pontine glioma. 39th Congress of the International Society of Pediatric Oncology (#351), 2007.
23. Segerer F, Ketonen L, Zhang M, Nagel P, Wolff J. Prognostic factors in pontine glioma. 12th Society of Neuro-Oncology Annual Scientific Meeting, 2007.
24. Maragh M, Ketonen L. Advances of magnetic resonance gadolinium enhanced T1 fluid attenuated inversion recovery (FLAIR) imaging over gadolinium T1 weighted spin echo imaging in evaluation various brain lesions. 90th Radiological Society of North America Annual Meeting, 2004.
25. Garcia-Morales F, Moritani T, Hiwatashi A, Ekholm S, Ketonen L, Westesson P. Utility of diffusion-weighted imaging over conventional magnetic resonance imaging in complicated course of bacterial meningitis. 42nd American Society of Neuroradiology Annual Meeting, 2004.
26. Garcia-Morales F, Moritani T, Hiwatashi A, Ketonen L, Ekholm S, Westesson P. Complications of bacterial meningitis: the utility of diffusion weighetd imaging. 89th Radiological Society of North America Annual Meeting, 2003.
27. Moritani TT, Hiwatashi A, Wang H,Ketonen L, Ekholm S, Westesson P. Diffusion tensor imaging of the acoustic radiation. 89th Radiological Society of North America Annual Meeting, 2003.
28. Moritani T, Hiwatashi A, Wang H, Ketonen L, Ekholm S, Westesson P. Diffusion-weighted imaging of intraventricular hemorrhage: comparison with conventional and gradient echo imaging. 89th Radiological Society of North America Annual Meeting, 2003.
29. Moritani T , Hiwatashi A , Wang H, Ketonen L, Ekholm S, Westesson P. Hemispheric involvement of postictal encephalopathy: value of diffusion-weighted imaging. 89th Radiological Society of North America Annual Meeting, 2003.
30. Crow W, Muffoletto AJ, Hadjipavlou AG, Ketonen L, Grisson A, Patterson D Borowski A, Sitton C. Pyogenic facet infection and its management. 38th American Society of Neuroradiology Annual Meeting, 2000.
31. Guinto F, Pincus T, Ketonen L. Surgically relevant anatomic variants in the paranasal sinuses. 38th American Society of Neuroradiology Annual Meeting, 2000.
32. Ketonen L, Hendrick E, Huynh K, Guinto FC, Swischuk L. Effect of anesthesia on vascular enhancement and CSF signal on fast fluid attenuated inversion recovery brain images. 37th American Society of Neuroradiology Annual Meeting, 1999.
33. Muffoletto AJ, Hadjipavlou AG, Ketonen L, Crow WN. Management of pyogenic facet infection of the spine. 14th North American Spine Society Annual Meeting, 1999.
34. Muffoletto AJ, Hadjipavlou AG, Ketonen L, Crow WN. Management of pyogenic facet injection of the spine. 12th International Intradiscal Therapy Society and International Society of Minimal Intervention in Spinal Surgery Annual Meeting, 1999.
35. Borowski A, Crow W, Sitton C, Hedgecock J, Chaljub G, Guinto F, Ketonen L. Imaging of spondylodiscitis. 36th American Society of Neuroradiology Annual Meeting, 1998.
36. Ketonen L, Swischuk L, John S, Sitton C, Chaljub G, Guinto FC. Initial clinical experience with MR imaging of the pediatric brain with fluid-attenuated-inversion-recovery (FLAIR) pulse sequence. 84th Radiological Society of North America Annual Meeting, 1998.

Book Chapters

1. Raslan O, Ketonen LM, Fuller GN, Schellingerhout D. Central nervous system Rosai-Dorfman disease. In: Methods of Cancer Diagnosis, Therapy and Prognosis. Springer: Hayat, 2011.
2. Ketonen LM, Valanne L. Neuroimaging of pediatric diseases. In: Semin Neurol. 28, 4. Oxford Press: Oxford, 558-569, e-Book 2008. ISBN: 18843582.
3. Ketonen L, Bakshi R. Imaging of the central nervous system complications of HIV and AIDS related illnesses. In: Neuro-Aids. Nova Science, Inc. Hauppauge, 2006.
4. Debnam M, Ketonen L, Hamberg L, Hunter G. Radiology of brain tumors: structure and physiology. In: Intracranial and Spinal Tumors, Volume 6 MD Anderson Cancer Care Series. Ed(s) MF DeMonte, MR Gilbert, A Ahajan, IE McCuthceon. Springer Science + Business, LLC: New York, NY, 37-52, 2005.
5. Bakshi R, Ketonen L. MRI of the brain in clinical neurology. In: Clinical Neurology. Ed(s) R Griggs and R Joynt. Lippincott-Raven: Philadelphia, 2004.
6. Ketonen L, Guinto F. Spine MRI. In: Clinical Neurology. Ed(s) R Griggs, R Joynt. Lippincott-Raven: Philadelphia, 2003.
7. Ketonen L. CT angiography, CT venography and CT perfusion in neuroradiology. In: Clinical Neurology. Ed(s) R Griggs, R Joynt. Lippincott-Raven: Philadelphia, 2002.
8. Ketonen L, Guinto F. Spine MRI. In: Clinical Neurology. Ed(s) R Griggs, R Joynt. Lippincott-Raven: Philadelphia, 1570-76, 2001.
9. Bakshi R, Ketonen L. Advanced MR imaging of the brain in clinical neurology. In: Clinical Neurology. Ed(s) R Griggs, R Joynt. Lippincott-Raven: Philadelphia, 1999.
10. Ketonen L. Clinical magnetic resonance angiography. In: Clinical Neurology. Ed(s) R Griggs and R Joynt. Lippincott-Raven: Philadelphia, 1999.
11. Ketonen L. Computerized tomography in clinical neurology. In: Clinical Neurology. Ed(s) R Griggs and R Joynt. Lippincott-Raven: Philadelphia, 1997.
12. Suramo I, Ketonen L Korhola O. MRI imaging with a low field imaging. In: The Topics in Radiology. Ultima Thule Co. Oulu, Finland, 50-55, 1986.

Books (edited and written)

1. Fischer HW, Ketonen L. Radiographic neuroanatomy: a working atlas. McGraw Hill: Ohio, 1990.
2. Fischer HW, Ketonen L. Radiographic neuroanatomy: a working atlas, Greek Edition. McGraw Hill: Ohio, 1990.
3. Ketonen L, Berg M. 100 maxims in neuroradiology. Edward Arnold LTD: London, 1997.
4. Ketonen L, Berg M. 100 maxims in neuroradiology, Japanese Edition. Edward Arnold LTD: London, 1997.
5. Ketonen L, Hiwatashi A, Sidhu R, Westesson PL. Pediatric brain and spine: an atlas of MRI and spectroscopy. Springer: New York, NY, 2004.

Letters to the Editor

1. Wolff J, Rytting ME, Ketonen L. Advanced atypical teratoid/rhaboid tumor (ATRT) treated with intensive multimodal approach shows continued response to sarcoma type salvage therapy. Pediatric Blood and Cancer, 8/2011.
2. Ketonen L, Tuite M, Kieburtz K. Routine use of contrast-enhanced MR scans in AIDS. AJNR Am J Neuroradiol 14:1324-1325, 1993.

Manuals, Teaching Aids, Other Teaching Publications

1. Benesch C, Jozefowicz R, Ketonen L. Neurology/Neuroradiology Syllabus & Teaching File. University of Rochester Medical Center, 1992.

Last updated: 7/28/2015