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Lezlee G. Coghlan, DVM, MS

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX

Dual/Joint/Adjunct Appointment

Associate Professor, Department of Pathobiology, College of Veterinary Science, Texas A&M University, College Station, TX

Research Interests

Animal cancer models, epithelial cancers, optical imaging, facility management, rodent diseases, parasitology

Investigators in the Department of Molecular Carcinogenesis make extensive use of animal models to study the development and prevention of the carcinogenic process.  Animal models are used to examine host and environmental risk factors and to identify biomarkers for diagnosis, prognosis and assessment of therapeutic responses.  Models in use or in development include those for cancers of the prostate, mammary gland, uterus, kidney, urinary bladder, esophagus, gall bladder, pancreas, head and neck, skin and lymphoid system. Well over 350 genetically unique rodent lines are bred and used in our facilities and shared with colleagues around the world.  As campus Animal Resource Director, I oversee the operation of 30,000 sq. ft. of specialized animal research facilities.  The resource receives partial operational support from M.D. Anderson's Cancer Center Support Grant (CCSG).  The CCSG Research Animal Support Facility-Smithville (RASF-S) provides animal husbandry, veterinary care, health and genetic quality assurance, consultation and an assortment oftechnical services to support the department's and institution's research. Animal Genetic Services (GS), such as speed congenics and Mutant Mouse Pathology Services (MMPS), are also available as part of the RASF-S.   For more details, please refer to our website.

My current collaborative research efforts are focused on developing new animal models of epithelial cancers, in support of optical imaging diagnostic technology in a multi-institutional consortium. Bioengineers in this project are developing novel imaging technologies for early diagnosis of epithelial cancers, and have several ongoing clinical trials.  Currently we are using or developing animal models of oral, esophageal, urinary bladder, melanoma and lung cancers in both rodents and genetically engineered mini-swine. 



Education & Training

Degree-Granting Education

1984 Texas A&M University, College Station, TX, DVM, Veterinary Medicine
1984 Texas A&M University, College Station, TX, MS, Laboratory Animal Medicine
1982 Texas A&M University, College Station, TX, BS, Veterinary Science
1978 Texas A&M University, College Station, TX, BS, Biomedical Science

Postgraduate Training

9/1980-12/1984 Dual DVM/MS Program and Postdoctoral Fellowship, Laboratory Animal Medicine, Texas A&M University, College Station, TX, Dr. Gary Joiner, School of Veterinary Medicine, Dept Vet-Public Health and Dr. David N. McMurray, School of Medicine, Dept of Medical Microbiology & Immunology, Advisors

Experience/Service

Administrative Appointments/Responsibilities

Director of Animal Resources, Department of Molecular Carcinogenesis, Science Park, The University of Texas MD Anderson Cancer Center, Smithville, TX, 3/2001-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Boulware SB, Christensen LA, Thames H, Coghlan L, Vasquez KM, Finch RA. Triplex-forming oligonucleotides targeting c-MYC potentiate the anti-tumor activity of gemcitabine in a mouse model of human cancer. Mol Carcinog. e-Pub 5/2013. PMCID: PMC4004705.
2. Regunathan R, Woo J, Pierce MC, Polydorides AD, Raoufi M, Roayaie S, Schwartz M, Labow D, Shin D, Suzuki R, Bhutani MS, Coghlan LG, Richards-Kortum R, Anandasabapathy S, Kim MK. Feasibility and preliminary accuracy of high-resolution imaging of the liver and pancreas using FNA compatible microendoscopy (with video). Gastrointest Endosc 76(2):293-300, 2012.
3. Carlson AL, Coghlan LG, Gillenwater AM, Richards-Kortum RR. Dual-mode reflectance and fluorescence near-video-rate confocal microscope for architectural, morphological and molecular imaging of tissue. J Microsc 228(Pt 1):11-24, 10/2007. PMID: 17910693.
4. Aaron J, Nitin N, Travis K, Kumar S, Collier T, Park SY, Jose-Yacaman M, Coghlan L, Follen M, Richards-Kortium R, Sokolov K. Plasmon resonance coupling of metal nanoparticles for molecular imaging of carcinogenesis in vivo. J Biomed Opt 12(3):034007, 6/2007. PMID: 17614715.
5. Lomada D, Liu B, Coghlan L, Hu Y, Richie ER. Thymus medulla formation and central tolerance are restored in IKKalpha-/- mice that express an IKKalpha transgene in keratin 5+ thymic epithelial cells. J Immunol 178(2):829-37, 1/2007. PMID: 17202344.
6. Patrawala L, Calhoun T, Schneider-Broussard R, Li H, Bhatia B, Tang S, Reilly JG, Chandra D, Zhou J, Claypool K, Coghlan L, Tang DG. Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene 25(12):1696-708, 3/2006. PMID: 16449977.
7. Park SY, Aaron J, Markey MK, Richards-Kortum R, Sokolov K, Mackinnon N, MacAulay C, Coghlan L, Milbourne A, Follen M. Multispectral digital microscopy for in vivo monitoring of oral neoplasia in the hamster cheek pouch model of carcinogenesis. Opt Express 13(3):749-62, 2/2005.

Book Chapters

1. Coghlan LG. Animal Models of Human Cancer. In: Handbook of Laboratory Animal Science. 3, Third Edition. Ed(s) J Hau, SJ Schapiro. CRC Press: United States, 219-300, 2013.

Last updated: 6/2/2014