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Likun Li, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Genitourinary Medical Oncology - Research, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1989 Xiamen University, Fujian Province, China, PhD, Cell Biology
1985 Xiamen University, Fujian Province, China, MS, Cell Biology
1982 Xiamen University, Fujian Province, China, BS, Biology

Postgraduate Training

1993-1997 Research Fellowship, Department of Biochemistry and Cell Biology, Rice University, Houston, TX
1989-1992 Research Fellowship, Department of Botany, The University of Texas at Austin, Austin, TX

Honors and Awards

2005 3rd Annual Cancer Center Symposium--1st Place, Baylor College of Medicine
1991 Distinguished Presentation, Cellulose 91
1989 Award of Excellent Paper for Young Scientists, Chinese Association of Cell Biology
1987 Research Award for Graduation Student -1st Place, Xiamen University

Selected Publications

Peer-Reviewed Original Research Articles

1. Ok CY, Li L, Young KH. EBV-driven B-cell lymphoproliferative disorders: from biology, classification and differential diagnosis to clinical management. Exp Mol Med 47:e132, 2015. e-Pub 1/23/2015. PMCID: PMC4314582.
2. Karanika S, Karantanos T, Kurosaka S, Wang J, Hirayama T, Yang G, Park S, Golstov AA, Tanimoto R, Li L, Thompson TC. GLIPR1-?TM synergizes with docetaxel in cell death and suppresses resistance to docetaxel in prostate cancer cells. Mol Cancer 14:122, 2015. e-Pub 6/19/2015. PMCID: PMC4484888.
3. Thompson TC, Li L. New targets for resistant prostate cancer. Oncotarget 5(19):8816-7, 10/15/2014. PMCID: PMC4253400.
4. Karanika S, Karantanos T, Li L, Corn PG, Thompson TC. DNA damage response and prostate cancer: defects, regulation and therapeutic implications. Oncogene 0. e-Pub 8/18/2014. PMID: 25132269.
5. Li L, Chang W, Yang G, Ren C, Park S, Karantanos T, Karanika S, Wang J, Yin J, Shah PK, Takahiro H, Dobashi M, Zhang W, Efstathiou E, Maity SN, Aparicio AM, Li Ning Tapia EM, Troncoso P, Broom B, Xiao L, Lee HS, Lee JS, Corn PG, Navone N, Thompson TC. Targeting Poly(ADP-Ribose) Polymerase and the c-Myb-Regulated DNA Damage Response Pathway in Castration-Resistant Prostate Cancer. Sci Signal 7(326):ra47, 5/20/2014. e-Pub 5/20/2014. PMCID: PMC4135429.
6. Li L, Yang G, Ren C, Tanimoto R, Hirayama T, Wang J, Hawke D, Kim SM, Lee JS, Goltsov AA, Park S, Ittmann MM, Troncoso P, Thompson TC. Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2. Mol Oncol 7(3):484-96, 6/2013. e-Pub 12/31/2012. PMCID: PMC3907183.
7. Li L, Ren C, Yang G, Fattah EA, Goltsov AA, Kim SM, Lee JS, Park S, Demayo FJ, Ittmann MM, Troncoso P, Thompson TC. GLIPR1 suppresses prostate cancer through targeted oncoprotein destruction. Cancer Res 71(24):7694-704, 12/15/2011. e-Pub 10/24/2011. PMCID: PMC3813470.
8. Thompson TC, Tahir SA, Li L, Watanabe M, Naruishi K, Yang G, Kadmon D, Logothetis CJ, Troncoso P, Ren C, Goltsov A, Park S. The role of caveolin-1 in prostate cancer: clinical implications. Prostate Cancer Prostatic Dis 13(1):6-11, 3/2010. e-Pub 7/2009. PMCID: PMC2887695.
9. Li L, Ren C, Yang G, Goltsov AA, Tabata K, Thompson TC. Caveolin-1 promotes autoregulatory, Akt-mediated induction of cancer-promoting growth factors in prostate cancer cells. Mol Cancer Res 7(11):1781-91, 11/2009. PMID: 19903767.
10. Li L, Abdel Fattah E, Cao G, Ren C, Yang G, Goltsov AA, Chinault AC, Cai WW, Timme TL, Thompson TC. Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species-c-Jun-NH2 kinase signaling. Cancer Res 68(2):434-43, 1/2008. PMID: 18199537.
11. Ren C, Ren CH, Li L, Goltsov AA, Thompson TC. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. Genomics 88(2):163-72, 8/2006. PMID: 16714093.
12. Li L, Ittmann MM, Ayala G, Tsai MJ, Amato RJ, Wheeler TM, Miles BJ, Kadmon D, Thompson TC. The emerging role of the PI3-K-Akt pathway in prostate cancer progression. Prostate Cancer Prostatic Dis 8(2):108-18, 3/2005. PMID: 15724144.
13. Bondos SE, Catanese DJ, Tan XX, Bicknell A, Li L, Matthews KS. Hox transcription factor ultrabithorax Ib physically and genetically interacts with disconnected interacting protein 1, a double-stranded RNA-binding protein. J Biol Chem 279(25):26433-44, 6/2004. PMID: 15039447.
14. Ren C, Li L, Yang G, Timme TL, Goltsov A, Ren C, Ji X, Addai J, Luo H, Ittmann MM, Thompson TC. RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer. Cancer Res 64(3):969-76, 2/2004. PMID: 14871827.
15. Li L, Ren CH, Tahir SA, Ren C, Thompson TC. Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A. Mol Cell Biol 23(24):9389-404, 12/2003. PMID: 14645548.
16. Mouraviev V, Li L, Tahir SA, Yang G, Timme TM, Goltsov A, Ren C, Satoh T, Wheeler TM, Ittmann MM, Miles BJ, Amato RJ, Kadmon D, Thompson TC. The role of caveolin-1 in androgen insensitive prostate cancer. J Urol 168(4 Pt 1):1589-96, 10/2002. PMID: 12352463.
17. Ren C, Li L, Goltsov AA, Timme TL, Tahir SA, Wang J, Garza L, Chinault AC, Thompson TC. mRTVP-1, a novel p53 target gene with proapoptotic activities. Mol Cell Biol 22(10):3345-57, 5/2002. PMID: 11971968.
18. Tan XX, Bondos S, Li L, Matthews KS. Transcription activation by ultrabithorax Ib protein requires a predicted alpha-helical region. Biochemistry 41(8):2774-85, 2/26/2002. PMID: 11851425.
19. Li L, Yang G, Ebara S, Satoh T, Nasu Y, Timme TL, Ren C, Wang J, Tahir SA, Thompson TC. Caveolin-1 mediates testosterone-stimulated survival/clonal growth and promotes metastatic activities in prostate cancer cells. Cancer Res 61(11):4386-92, 6/2001. PMID: 11389065.
20. Tahir SA, Yang G, Ebara S, Timme TL, Satoh T, Li L, Goltsov A, Ittmann M, Morrisett JD, Thompson TC. Secreted caveolin-1 stimulates cell survival/clonal growth and contributes to metastasis in androgen-insensitive prostate cancer. Cancer Res 61(10):3882-5, 5/2001. PMID: 11358800.
21. Timme TL, Goltsov A, Tahir S, Li L, Wang J, Ren C, Johnston RN, Thompson TC. Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis. Oncogene 19(29):3256-65, 7/2000. PMID: 10918582.
22. Thompson TC, Timme TL, Li L, Goltsov A. Caveolin-1, a metastasis-related gene that promotes cell survival in prostate cancer. Apoptosis 4(4):233-7, 8/1999. PMID: 14634273.
23. Thompson TC, Timme TL, Li L, Goltsov A, Yang G. Caveolin-1: a complex and provocative therapeutic target in prostate cancer and potentially other malignancies. Emerging Therapeutic Target 3:337, 6/1999.
24. Nasu Y, Timme TL, Yang G, Bangma CH, Li L, Ren C, Park SH, DeLeon M, Wang J, Thompson TC. Suppression of caveolin expression induces androgen sensitivity in metastatic androgen-insensitive mouse prostate cancer cells. Nat Med 4(9):1062-4, 9/1998. PMID: 9734401.
25. Li L, Matthews KS. Differences in water release with DNA binding by ultrabithorax and deformed homeodomains. Biochemistry 36(23):7003-11, 6/10/1997. PMID: 9188697.
26. Li L, von Kessler D, Beachy PA, Matthews KS. pH-dependent enhancement of DNA binding by the ultrabithorax homeodomain. Biochemistry 35(30):9832-9, 7/30/1996. PMID: 8703957.
27. Li L, Matthews KS. Characterization of mutants affecting the KRK sequence in the carboxyl-terminal domain of lac repressor. J Biol Chem 270(18):10640-9, 5/5/1995. PMID: 7738001.
28. Kudlicka K, Brown RM, Li L, Lee JH, Shin H, Kuga S. [beta]-Glucan synthesis in the cotton fiber (IV. In Vitro Assembly of the Cellulose I Allomorph). Plant Physiol 107(1):111-123, 1/1995. PMID: 12228346.
29. Brown RM, Li L, Okuda K, Kuga S, Kudlicka K, Drake R, Santos R, Clement S. In Vitro Cellulose Synthesis in Plants. Plant Physiol 105(1):1-2, 5/1994. PMID: 12232180.
30. Okuda K, Li L, Kudlicka K, Kuga S, Brown RM. [beta]-Glucan synthesis in the cotton fiber (I. Identification of [beta]-1,4- and [beta]-1,3-Glucans synthesized in vitro). Plant Physiol 101(4):1131-1142, 4/1993. PMID: 12231764.
31. Li L, Brown RM. [beta]-Glucan synthesis in the cotton fiber (II. Regulation and Kinetic Properties of [beta]-Glucan Synthases. Plant Physiol 101(4):1143-1148, 4/1993. PMID: 12231765.
32. Li L, Drake RR, Clement S, Brown RM. [beta]-Glucan Synthesis in the cotton fiber (III. Identification of UDP-Glucose-Binding Subunits of [beta]-Glucan Synthases by Photoaffinity Labeling with [[beta]-32P]5[prime]-N3-UDP-Glucose. Plant Physiol 101(4):1149-1156, 4/1993. PMID: 12231766.
33. Li L, Ying Y, Wang D. Cytochemical localization by EM on fructose 1,6-diphosphatase in the mesophyll cells of plants and the alkaline property of the enzyme. Chinese Bulletin of Botany 5:122-124, 1988.
34. Li L, Wang D. Cytochemical study of electron microscopy on fructose 1, 6-diphosphatase and uridine diphospho-glucose pyrophsophorylase in the mesophyll cells of Stevia rebaudiana Bertoni. Scientia Sinica (series B) 31:171-178, 1988.
35. Hong W, Chen M, Li L, Liu D. Study on structure of different-staged leaf cells of Stevia rebaudiana Bertoni and distribution of stevioside content. J Wuhan Bot Res 5:211-218, 1987.
36. Li L, Chang W, Yang G, Ren C, Park S, Takahiro H, Troncoso P, Brrom B, Lee HS, Lee JS, Thompson TC. Activation of c-Myb and a c-Myb-regulated DNA damage response gene program contributes to drug resistance in prostate cancer. Cancer Discovery. Submitted.
37. Thompson TC, Karanika S, Karantanos T, Yin J, Li L. Novel Anti-androgen Receptor Signaling Agents: Understanding the Mechanisms of Resistance. Asian Journal. Submitted.

Abstracts

1. Thompson TC, Li L, Ren C, Yang G, Goltsov A, Abdel-Fattah E. Glioma pathogenesis-related protein 1, a tumor suppressor that stimulates oncoprotein destruction. 7th Annual National Symposium on Prostate Cancer, 5/2011.
2. Thompson TC, Li L, Ren C, Yang G, Goltsov A, Abdel-Fattah E. Thompson TC, Li L, Ren C, Yang G, Goltsov A, Abdel-Fattah E. The 5th severence-MD Anderson Cancer Center joint symposium - "Personalized Cancer Therapy and Prevention", 5/2011.
3. Thompson TC, Li L, Ren C, Yang G, Goltsov A, Abdel-Fattah E. Glioma pathogenesis-related protein 1, a tumor suppressor that stimulates oncoprotein destruction. United States Department of Defense-Innovative Minds in Prostate Cancer Today (DOD-IMPACT) Conference, 3/2011.
4. Li L, Ren C, Yang G, Abdel Fattah E, Timme TL, Goltsov AA, Park SH, Thompson TC. GLIPR1 tumor suppressor activities involve suppression of specificity protein1 and its target genes c-myc, 4/2009.
5. Goltsov AA, Ren CZ, Yang G, Wang J, Li L, Timme TL and Thompson TC. Expression and functional analysis of PERP in mouse and human prostate cancer, 11/2006.
6. Goltsov A, Ren CZ, Yang G, Wang J, Li L, Timme TL, and Thompson TC. Expression and functional analysis of PERP in mouse and human prostate cancer, 4/2006.
7. Thompson TC, Li L, Ren C, Ren CZ, Abdelfattah E-M, Goltsov A, Yang G, Wang J, Troung LD, Ittmann M, Wheeler TM, Ayala G, Kadmon D. Identification, characterization and functional analysis of RTVP-1/GLIPR-like genes – a novel p53 target gene cluster with tumor suppressor functions, 2/2006.
8. Thompson TC, Kadmon D, Li L, Ren CZ, Ren CH, Tahir S, Ayala G, Wheeler TM, Mims MP, Hayes T and Lynch GR. Development of RTVP-1 protein therapy for prostate cancer, 11/2005.
9. Kadmon D, Tahir S, Li L, Ayala G, Wheeler TM, Frolov A, Thompson TC. The role of secreted caveolin-1 in prostate cancer progression, 10/2005.
10. Thompson TC, Kadmon D, Li L, Ren CZ, Ren C, Tahir S, Ayala G, Wheeler TM, Mims MP, Hayes T, Lynch GR. Development of RTVP-1 protein therapy for prostate cancer, 7/2005.
11. Kadmon D, Tahir S, Li L, Ayala G, Wheeler TM, Frolov A, Thompson TC. The role of secreted caveolin-1 in prostate cancer progression, 7/2005.
12. Li L, Ren C, Tahir SA, Thompson TC. Caveolin-1 stimulates expression and secretion of antiogenic growth factors/cytokines in human prostate cancer cells, 4/2005.
13. Kadmon D, Tahir SA, Li L, Ayala G, Wheeler TM, Frolov A, Thompson TC. The role of secreted caveolin-1 in prostate cancer progression, 2/2005.
14. Kadmon D, Tahir SA, Timme TL, Li L, Abd-El-Fattah E-M, Frolov A, Ayala G, Wheeler TM and Thompson TC. Serum caveolin-1 as a biomarker for prostate cancer, 1/2004.
15. Li L, Ren C-H, Tahir SA, Ren C and Thompson TC. Caveolin-1 maintains activated akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A, 11/2003.
16. Ren C, Goltsov A, Yang G, Timme TL, Li L, Tahir SA, Wang J, Ebara S, Satoh T, Saika T, Chinault AC and Thompson TC. mRTVP-1 is up-regulated by p53; has pro-apoptotic, anti-angiogenic, and immunostimulatory activities; and suppresses prostate cancer growth and metastasis, 7/2002.
17. Thompson TC, Tahir S, Gdor Y, Ren C, Mouraviev V, Frolov A, Li L, Timme TL, and Morrisett. Serum caveolin-1 as a novel biomarker for prostate cancer, 7/2002.
18. Ren C, Li L, Goltsov A, Timme TL, Tahir SA, Wang J, Garza L, Chinault CA and Thompson TC. mRTVP-1, a novel p53 target gene with pro-apoptotic activities, 4/2002.
19. Goltsov AA, Ren C, Wang J, Tahir S, Li L, Timme TL, and Thompson TC. Overexpression of PERP is associated with increased motility of prostate cancer cells, 4/2002.
20. Tahir SA, Gdor Y, Mouraviev V, Frolov A, Ren C, Li L, Timme TL, Morrisett JD and Thompson TC. Serum caveolin-1 as a novel biomarker for prostate cancer, 4/2002.

Book Chapters

1. Thompson TC, Tahir S, Li L, Watanabe M, Naruishi K, Yang G, Tabata K, Kurosaka S, Edamura K, Tanimoto R, Corn P, Kadmon D, Logothetis CJ, Troncoso P, Ren C, Goltsov A, Park S. Local and distant effects of caveolin-1 on prostate cancer progression. In: Caveolins in Cancer Pathogenesis. Springer: United Kingdom, 1-15, 2012.
2. Thompson TC, Timme T, Li L, Ren C, Goltsov A, Tahir S, Yang G. Molecular pathways underlying prostate cancer progression: The role of caveolin-1. In: Prostate Cancer: Biology, Genetics, and the New Therapeutics. Ed(s) Chung LWK, Isaacs WB and Siomon JW. Humana Press, Inc: Totowa, New Jeresy, 267-27, 2001.

Last updated: 5/4/2016