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Lisa S. Chen, Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1901 East Road
Unit Number: 1950
Houston, TX 77054
Room Number: 4SCR3.1041
Phone: (713) 563-6962
Fax: (713) 794-4316
Email: lschen@mdanderson.org

Education & Training

Degree-Granting Education

2004 Northwestern University, Evanston, IL, PHD, Chemistry
2002 Northwestern University, Evanston, IL, MS, Chemistry
1999 Tufts University, Medford, MA, BS, Quantitative Economics and Chemistry

Postgraduate Training

2004-2008 Postdoctoral Fellow, The University of Texas MD Anderson Cancer Center, Houston, TX, Varsha Gandhi

Experience/Service

Academic Appointments

Instructor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2008-2010

Selected Publications

Peer-Reviewed Original Research Articles
1. Pillai RN, Chen LS, Ayres ML, Nowak BJ, Thomas MW, Shpall EJ, Keating MJ, Gandhi V. Multifaceted actions of 8-amino-adenosine kill BCR-ABL positive cells. Leuk Lymphoma 53(10):2024-32, 10/2012. e-Pub 4/2012. PMID: 22448923.
2. Yang Q, Chen LS, Neelapu SS, Miranda RN, Medeiros LJ, Gandhi V. Transcription and Translation are Primary Targets of Pim Kinase Inhibitor, SGI-1776, in Mantle Cell Lymphoma. Blood 120(17):3491-500, 10/2012. e-Pub 9/2012. PMCID: PMC3482859.
3. Chen LS, Redkar S, Taverna P, Cortes JE, Gandhi V. Mechanisms of cytotoxicity to pim kinase inhibitor, SGI-1776, in acute myeloid leukemia. Blood 118(3):693-702, 7/2011. e-Pub 5/2011. PMCID: PMC3142906.
4. Chen LS, Du-Cuny L, Vethantham V, Hawke DH, Manley JL, Zhang S, Gandhi V. Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues. Biochem Pharmacol 79(5):669-77, 3/2010. e-Pub 10/2009. PMCID: PMC2812641.
5. Chen LS, Redkar S, Bearss D, Wierda WG, Gandhi V. Pim kinase inhibitor, SGI-1776, induces apoptosis in CLL lymphocytes. Blood 114(19):4150-7, 11/2009. e-Pub 9/2009. PMCID: PMC2774551.
6. Chen LS, Nowak BJ, Ayres ML, Krett NL, Rosen ST, Zhang S, Gandhi V. Inhibition of ATP synthase by chlorinated adenosine analogue. Biochem Pharmacol 78(6):583-91, 9/2009. e-Pub 5/2009. PMID: 19477165.
7. Chen LS, Plunkett W, Gandhi V. Polyadenylation inhibition by the triphosphates of deoxyadenosine analogues. Leuk Res 32(10):1573-81, 10/2008. e-Pub 4/2008. PMID: 18433867.
8. Chen LS, Stellrecht CM, Gandhi V. RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells. Br J Haematol 140(6):682-391, 3/2008. e-Pub 1/2008. PMID: 18205859.
9. Chen LS, Sheppard TL. Chain termination and inhibition of Saccharomyces cerevisiae poly(A) polymerase by C-8-modified ATP analogs. J Biol Chem 279(39):40405-11, 9/2004. e-Pub 7/2004. PMID: 15265873.
10. Chen LS, Bahr MH, Sheppard TL. Effects of 8-Chlorodeoxyadenosine on DNA synthesis by Klenow fragment of DNA polymerase l. Bioorg Med Chem Lett 13(9):1509-12, 5/2003. PMID: 12699743.
11. Chen LS, Sheppard TL. Synthesis and hybridization properties of RNA containing 8-chloroadenosine. Nucleosides Nucleotides Nucleic Acids 21(8-9):599-617, 2002. PMID: 12484453.
12. Rybak-Akimova EV, Nazarenko AY, Chen L, Krieger PW, Herrera AM, Tarasov VV, robinson PD. Synthesis, Characterization, redox properties, and representative X-ray structures of four-and five-coordinate copper(II) complexes with polydentate aminopyridine ligands. Inorg. Chim. Acta(324):1-15, 2001.

Invited Articles
1. Chen LS, Balakrishnan K, Gandhi V. Inflammation and Survival Pathways: Chronic Lymphocytic Leukemia as a Model System. Biochem Pharmacol 80(12):1936-45, 12/2010. e-Pub 8/2010. PMID: 20696142.

Editorials
1. Gandhi V, Balakrishnan K, Chen LS. Mcl-1: the 1 in CLL. Blood 112(9):3538-40, 11/2008. PMID: 18948586.

Last updated: 3/2/2013