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Lopa Mishra, M.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Gastroenterology, Hepat,& Nutr, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Department Chair, Department of Gastroenterology, Hepat,& Nutr, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1400 Pressler Street, FCT13.6038
Unit Number: 1466
Houston, TX 77030
Phone: 713-794-3221
Fax: 713-745-1886
Email: lmishra@mdanderson.org

Education & Training

Degree-Granting Education

1982 University of London School of Medicine, London, England, United Kingdom, MD, Medicine

Postgraduate Training

7/1987-9/1990 Clinical Fellowship, Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, MD
7/1984-6/1987 Clinical Residency, Internal Medicine, Mt. Sinai Medical Center, New York, NY
7/1983-6/1984 Clinical Residency, Medicine, Royal Northern/Whittington Hospital, London, England, United Kingdom, Prof. Dame Sheila Sherlock
7/1982-6/1983 Clinical Internship, Medicine and Surgery, Royal Free Hospital & Whittington Hospital, London, England, United Kingdom, Prof. Dame Sheila Sherlock

Board Certifications

1989 American Board of Gastroenterology
1987 American Board of Internal Medicine

Experience/Service

Academic Appointments

Professor, Surgical Sciences, Georgetown University Medical Center, Washington, DC, 2003-2009

Administrative Appointments/Responsibilities

Vice Chair, Department of Surgery, Georgetown Universtiy Medical Center, Washington, DC, 2005-2009
Director, Cancer Genetics, Georgetown University Medical Center, Washington, DC, 2003-2009
Director, Digestive Diseases, Department of Veterans Affairs Medical Center, Washington, DC, 1999-2009

Other Appointments/Responsibilities

Chair, Department of Surgery Research Committee, Georgetown University Medical Center, Washington, DC, 2005-2009

Honors and Awards

2003-2005 Funderburg Scholar in Gastric Cancer
1998 Betty and Harry Myerberg Award for Excellence in Research in Liver Development
1996 Elisabeth and John Cox Award for Innovative Clinical Therapy of Esophageal Cancer
1995 USV Industry New Investigator Award
1981 Stuart Mill Prize in Tropical Medicine

Professional Memberships

American Association for Cancer Research, Philadelphia, PA
Member, 2005
American Association for the Study of Liver Diseases, Alexandria, VA
Member, 1992-present
American Gastroenterological Association, Bethesda, MD
Member, 1992
American Society for Cell Biology, Bethesda, MD
Member, 2006
American Society for Clinical Investigation, Ann Arbor, MI
Member, 2003-present
Society of Developmental Biology, Bethesda, MD
Member, 1996

Selected Publications

Peer-Reviewed Original Research Articles
1. Yao Z, Mishra L. Cancer stem cells and hepatocellular carcinoma. Cancer Biol Ther 8(18):1691-8, 9/2009. PMID: 19901516.
2. Lin L, Amin R, Gallicano GI, Glasgow E, Jogunoori W, Jessup JM, Zasloff M, Marshall JL, Shetty K, Johnson L, Mishra L, He AR. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 28(7):961-72, 2/2009. e-Pub 1/2009. PMCID: PMC2703464.
3. Mishra L, Banker T, Murray J, Byers S, Thenappan A, He AR, Shetty K, Johnson L, Reddy EP. Liver stem cells and hepatocellular carcinoma. Hepatology 49(1):318-29, 1/2009. PMCID: PMC2726720.
4. Mishra L. The 21st century hepatologist and a systems biology based approach to liver diseases. Hepatology 48(6):1731-3, 12/2008. PMCID: PMC2712824.
5. Baek HJ, Lim SC, Kitisin K, Jogunoori W, Tang Y, Marshall MB, Mishra B, Kim TH, Cho KH, Kim SS, Mishra L. Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis. Hepatology 48(4):1128-37, 10/2008. PMCID: PMC2747753.
6. Fishbein T, Novitskiy G, Mishra L, Matsumoto C, Kaufman S, Goyal S, Shetty K, Johnson L, Lu A, Wang A, Hu F, Kallakury B, Lough D, Zasloff M. NOD2-expressing bone marrow-derived cells appear to regulate epithelial innate immunity of the transplanted human small intestine. Gut 57(3):323-30, 3/2008. e-Pub 10/2007. PMID: 17965060.
7. Glasgow E, Mishra L. Transforming growth factor-beta signaling and ubiquitinators in cancer. Endocr Relat Cancer 15(1):59-72, 3/2008. PMID: 18310276.
8. Laguinge LM, Samara RN, Wang W, El-Deiry WS, Corner G, Augenlicht L, Mishra L, Jessup JM. DR5 receptor mediates anoikis in human colorectal carcinoma cell lines. Cancer Res 68(3):909-17, 2/2008. PMID: 18245494.
9. Tang Y, Kitisin K, Jogunoori W, Li C, Deng CX, Mueller SC, Ressom HW, Rashid A, He AR, Mendelson JS, Jessup JM, Shetty K, Zasloff M, Mishra B, Reddy EP, Johnson L, Mishra L. Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. Proc Natl Acad Sci U S A 105(7):2445-50, 2/2008. e-Pub 2/2008. PMCID: PMC2268156.
10. He AR, Mendelson J, Blake T, Mishra L, Marshall JL. Stem cells in gastrointestinal cancers. Dis Markers 24(4-5):217-22, 2008. PMCID: PMC2703461.
11. Yun C, Mendelson J, Blake T, Mishra L, Mishra B. TGF-beta signaling in neuronal stem cells. Dis Markers 24(4-5):251-5, 2008. PMID: 18525119.
12. Kitisin K, Ganesan N, Tang Y, Jogunoori W, Volpe EA, Kim SS, Katuri V, Kallakury B, Pishvaian M, Albanese C, Mendelson J, Zasloff M, Rashid A, Fishbein T, Evans SR, Sidawy A, Reddy EP, Mishra B, Johnson LB, Shetty K, Mishra L. Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation. Oncogene 26(50):7103-10, 11/2007. e-Pub 6/2007. PMID: 17546056.
13. Kitisin K, Saha T, Blake T, Golestaneh N, Deng M, Kim C, Tang Y, Shetty K, Mishra B, Mishra L. Tgf-Beta signaling in development. Sci STKE 2007(399):cm1, 8/2007. PMID: 17699101.
14. Kitisin K, Shetty K, Mishra L, Johnson LB. Hepatocellular stem cells. Cancer Biomark 3(4-5):251-62, 2007. PMID: 17917154.
15. Kitisin K, Pishvaian MJ, Johnson LB, Mishra L. Liver stem cells and molecular signaling pathways in hepatocellular carcinoma. Gastrointest Cancer Res 1(4 Suppl 2):S13-21, 2007. PMCID: PMC2666844.
16. Kitisin K, Mishra L. Molecular biology of colorectal cancer: new targets. Semin Oncol 33(6 Suppl 11):S14-23, 12/2006. PMID: 17178280.
17. Golestaneh N, Tang Y, Katuri V, Jogunoori W, Mishra L, Mishra B. Cell cycle deregulation and loss of stem cell phenotype in the subventricular zone of TGF-beta adaptor elf-/- mouse brain. Brain Res 1108(1):45-53, 9/2006. e-Pub 8/2006. PMID: 16884701.
18. Baek HJ, Kim SS, da Silva FM, Volpe EA, Evans S, Mishra B, Mishra L, Marshall MB. Inactivation of TGF-beta signaling in lung cancer results in increased CDK4 activity that can be rescued by ELF. Biochem Biophys Res Commun 346(4):1150-7, 8/2006. e-Pub 6/2006. PMID: 16782056.
19. Kim SS, Shetty K, Katuri V, Kitisin K, Baek HJ, Tang Y, Marshall B, Johnson L, Mishra B, Mishra L. TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF. Biochem Biophys Res Commun 344(4):1216-23, 6/2006. e-Pub 4/2006. PMID: 16650383.
20. Katuri V, Tang Y, Li C, Jogunoori W, Deng CX, Rashid A, Sidawy AN, Evans S, Reddy EP, Mishra B, Mishra L. Critical interactions between TGF-beta signaling/ELF, and E-cadherin/beta-catenin mediated tumor suppression. Oncogene 25(13):1871-86, 3/2006. PMID: 16288220.
21. Faler BJ, Macsata RA, Plummer D, Mishra L, Sidawy AN. Transforming growth factor-beta and wound healing. Perspect Vasc Surg Endovasc Ther 18(1):55-62, 3/2006. PMID: 16628336.
22. Mishra L, Marshall B. Adaptor proteins and ubiquinators in TGF-beta signaling. Cytokine Growth Factor Rev 17(1-2):75-87, Feb-Apr, 2/2006. e-Pub 12/2005. PMID: 16359909.
23. Saha T, Vardhini D, Tang Y, Katuri V, Jogunoori W, Volpe EA, Haines D, Sidawy A, Zhou X, Gallicano I, Schlegel R, Mishra B, Mishra L. RING finger-dependent ubiquitination by PRAJA is dependent on TGF-beta and potentially defines the functional status of the tumor suppressor ELF. Oncogene 25(5):693-705, 2/2006. PMID: 16247473.
24. Wang RH, Li C, Xu X, Zheng Y, Xiao C, Zerfas P, Cooperman S, Eckhaus M, Rouault T, Mishra L, Deng CX. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2(6):399-409, 12/2005. PMID: 16330325.
25. Katuri V, Tang Y, Marshall B, Rashid A, Jogunoori W, Volpe EA, Sidawy AN, Evans S, Blay J, Gallicano GI, Premkumar Reddy E, Mishra L, Mishra B. Inactivation of ELF/TGF-beta signaling in human gastrointestinal cancer. Oncogene 24(54):8012-24, 12/2005. PMID: 16158060.
26. Mishra L, Derynck R, Mishra B. Transforming growth factor-beta signaling in stem cells and cancer. Science 310(5745):68-71, 10/2005. PMID: 16210527.
27. Mishra L, Katuri V, Evans S. The role of PRAJA and ELF in TGF-beta signaling and gastric cancer. Cancer Biol Ther 4(7):694-9, 7/2005. e-Pub 7/2005. PMID: 16096365.
28. Tang Y, Katuri V, Srinivasan R, Fogt F, Redman R, Anand G, Said A, Fishbein T, Zasloff M, Reddy EP, Mishra B, Mishra L. Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis. Cancer Res 65(10):4228-37, 5/2005. PMID: 15899814.
29. Redman RS, Katuri V, Tang Y, Dillner A, Mishra B, Mishra L. Orofacial and gastrointestinal hyperplasia and neoplasia in smad4+/- and elf+/-/smad4+/- mutant mice. J Oral Pathol Med 34(1):23-9, 1/2005. PMID: 15610403.
Other Articles
1. Thenappan A, Li Y, Shetty K, Johnson L, Reddy EP, Mishra L. New therapeutics targeting colon cancer stem cells. Curr Colorectal Cancer Rep 5(4):209-216, 2009.
2. Mishra L. Stem cell and cancer. Cancer Biomark 3(5):109-274, 2007.
3. Mishra L and Roberts A. Role of TGF-ß in stem cells and cancer. Oncogene Rev 24:5667, 2005.
4. Mishra L, Shetty K, Tang Y, Stuart A, Byers S. The role of TGF-ß and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene Rev 24:5775-5789, 2005.

Last updated: 11/29/2010