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Louise C. Strong, M.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, The University of Texas Graduate School of Biomedical Sciences, Houston, TX

Dual/Joint/Adjunct Appointment

Professor of Cancer Genetics, Department of Breast Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

  • Human cancer genetics
  • Genetic epidemiology

The program involves the study of genetic etiology of human cancer using genetic epidemiologic approach to identify the most likely etiologic model(s) to account for the distribution of tumors in kindreds, and to test for genetic/etiologic heterogeneity. We then identify families in which a genetic etiology seems likely for collaborative study using cytogenetic, biochemical and molecular markers to localize the gene. We are further investigating the role of radiation, chemotherapy and host predisposing factors in the risk of subsequent tumors in childhood cancer survivors and in the reproductive outcomes in childhood cancer survivors.

A tutorial in this laboratory would include introduction to field work of data collection by interview, analytic techniques of genetic epidemiology and interpretation of laboratory findings from the collaborative laboratory studies.

View a complete list of Dr. Strong's publications.

Office Address

The University of Texas MD Anderson Cancer Center
Department of Genetics Unit 209
1515 Holcombe Blvd.
Houston, TX 77030
Room Number: B6.4806
Phone: (713) 792-2589

Education & Training

Degree-Granting Education

1970 University of Texas Medical Branch, Galveston, TX, MD, Medicine
1966 University of Texas, Austin, TX, BA, Mathematics

Postgraduate Training

9/1970-8/1972 Postdoctoral Fellowship, Texas Research Institute of Mental Sciences and The University of Texas Graduate School of Biomedical Sciences, Houston, TX, Alfred G. Knudson Jr., M.D., Ph.D.

Experience/Service

Consultantships

Member, Scientific Advisory Board, St. Jude Children's Research Hospital, Memphis, TN, 3/2008

Honors and Awards

2013-present Fellow of the AACR Academy, American Association of Cancer Research

Selected Publications

Peer-Reviewed Original Research Articles

1. Fang S, Krahe R, Bachinski LL, Zhang B, Amos CI, Strong LC.. Sex-specific effect of TP53 PIN3 polymorphism on cancer risk in a cohort study of TP53 germline mutation carriers. Hum Genet 130(6):789-94, 12/2011. PMID: 21688173.
2. Wu, CC, Krahe R, Lozano G, Zhang B, Wilson CD, Jo EJ, Shete S, Amos CI, Strong LC. Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome. Hum Genet 129(6):663-73, 6/2011. PMID: 21305319.
3. Fang, S, Krahe R, Lozano G, Han Y, Chen W, Post SM, Zhang B, Wilson C, Bachinski LL, Strong LC, Amos CI. Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in carriers of TP53 germline mutations. PLoS ONE 5(5):e10813, 5/2010. PMCID: PMCPMC2877078.
4. Wu CC, Strong LC, Shete S.. Effects of measured susceptibility genes on cancer risk in family studies. Hum Genet 127(3):349-357, 3/2010. PMCID: PMCPMC2918266.
5. Peterson SK, Pentz RD, Blanco AM, Ward PA, Marani SK, LaRue D, Vogel K, Solomon T, Strong LC. Psychological functioning in persons considering genetic counseling and testing for Li-Fraumeni syndrome. Psycho-Oncology 17(8):783-789, 8/2008. PMID: 18688785.
6. Peterson SK, Pentz RD, Blanco AM, Ward PA, Watts BG, Marani SK, James LC, Strong LC. Evaluation of a decision aid for families considering p53 genetic counseling and testing. Genet Med 8(4):226-33, 4/2006. PMID: 16617243.
7. Li FP, Garber JE, Friend SH, Strong LC, Patenaude AF, Juengst ET, Reilly PR, Correa P, Fraumeni JF, Jr. Recommendations on predictive testing for germ line p53 mutations among cancer-prone individuals. J Natl Cancer Inst 84(15):1156-60, 8/1992. PMID: 1635084.
8. Lustbader ED, Williams WR, Bondy ML, Strom S, Strong LC. Segregation analysis of cancer in families of childhood soft-tissue-sarcoma patients. Am J Hum Genet 51(2):344-56, 8/1992. PMID: 1642235.
9. Malkin D, Li FP, Strong LC, Fraumeni JF, Jr, Nelson CE, Kim DH, Kassel J, Gryka MA, Bischoff FZ, Tainsky MA, Friend SH. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250(4985):1233-8, 11/1990. PMID: 1978757.
10. Strong LC, Stine M, Norsted TL. Cancer in survivors of childhood soft tissue sarcoma and their relatives. J Natl Cancer Inst 79(6):1213-20, 12/1987. PMID: 3480372.

Last updated: 11/12/2013