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Mala Pande, PhD, MPH, MBBS

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Gastroenterology - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Assistant Professor, The University of Texas School of Public Health, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number: 1466
Houston, TX 77030
Room Number: FCT13.6043
Phone: 713-745-5625
Email: mpande@mdanderson.org

Education & Training

Degree-Granting Education

2007 The University of Texas School of Public Health, Houston, TX, PHD, Epidemiology
2003 The University of Texas School of Public Health, Houston, TX, MPH, Disease Control
1979 Armed Forces Medical College, Pune, Maharashtra, India, MBBS, Medicine

Postgraduate Training

1/2008-12/2009 Research Fellowship, Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, Christopher I. Amos

Experience/Service

Academic Appointments

Instructor, Department of Epidemiology, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 1/2010-10/2013

Institutional Committee Activities

Senator, Faculty Senate, 9/2011-8/2014
Member, Psychosocial, Behavioral, and Health Services Research Committee (PBHSRC), 8/2010-8/2013

Honors and Awards

2011 Cancer Post-GWAS U19 exchange program travel award, NCI
2009 Bayer HealthCare Pharmaceuticals Poster finalist award for Population/Patient-Oriented Research, Bayer HealthCare Pharmaceuticals
2009 Postdoctoral Outstanding Trainee in Cancer Prevention: Honorable mention, Cancer Prevention Research training Program, MD Anderson Cancer Center
2009 Trainee Excellence Award, MD Anderson Trainee and Alumni Association
2008-2009 Postdoctoral Fellowship in Cancer Prevention Research, NIH / MD Ansderson Cancer Center
2008 Fred Annegers Scholarship in Epidemiology, The University of Texas School of Public Health at Houston
2005-2007 Predoctoral Fellowship in Cancer Prevention Research, NIH / MD Anderson Cancer Center

Selected Publications

Peer-Reviewed Original Research Articles

1. Ross W, Thirumurthi S, Lynch PM, Rashid A, Pande M, Shafi MA, Lee JH, Raju GS. Detection rates of premalignant polyps during screening colonoscopy: Time to revise quality standards? Gastrointestinal Endoscopy. In Press.
2. Pande M, Bondy ML, Do KA, Sahin AA, Ying J, Mills GB, Thompson PA, Brewster AM. Association between germline single nucleotide polymorphisms in the PI3K-AKT-mTOR pathway, obesity, and breast cancer disease-free survival. Breast Cancer Res Treat. e-Pub 8/2014. PMID: 25108739.
3. Park SL, Fesinmeyer MD, Timofeeva M, Caberto CP, Kocarnik JM, Han Y, Love SA, Young A, Dumitrescu L, Lin Y, Goodloe R, Wilkens LR, Hindorff L, Fowke JH, Carty C, Buyske S, Schumacher FR, Butler A, Dilks H, Deelman E, Cote ML, Chen W, Pande M, Christiani DC, Field JK, Bickebller H, Risch A, Heinrich J, Brennan P, Wang Y, Eisen T, Houlston RS, Thun M, Albanes D, Caporaso N, Peters U, North KE, Heiss G, Crawford DC, Bush WS, Haiman CA, Landi MT, Hung RJ, Kooperberg C, Amos CI, Le Marchand L, Cheng I. Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: The PAGE and TRICL consortia. J Natl Cancer Inst 106(4):dju061, 4/2014. e-Pub 3/2014. PMCID: PMC3982896.
4. Wang H, Burnett T, Kono S, Haiman CA, Iwasaki M, Wilkens LR, Loo LW, Van Den Berg D, Kolonel LN, Henderson BE, Keku TO, Sandler RS, Signorello LB, Blot WJ, Newcomb PA, Pande M, Amos CI, West DW, Bézieau S, Berndt SI, Zanke BW, Hsu L, GECCO consortium members:, Lindor NM, Haile RW, Hopper JL, Jenkins MA, Gallinger S, Casey G, CCFR consortium members:, Stenzel SL, Schumacher FR, Peters U, Gruber SB, CORECT consortium members:, Tsugane S, Stram DO, Le Marchand L, GECCO consortium members, CCFR consortium members, CORECT consortium members. Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. Nat Commun 5:4613, 2014. e-Pub 8/2014. PMID: 25105248.
5. Wei C*, Chen J*, Pande M, Lynch PM, Frazier ML. A pilot study comparing protein expression in different segments of the normal colon and rectum and in normal colon versus adenoma in patients with Lynch syndrome. J Cancer Res Clin Oncol 139(7):1241-50, 7/2013. e-Pub 4/2013. PMCID: PMC3708474.
6. Wang H, Haiman CA, Burnett T, Fortini BK, Kolonel LN, Henderson BE, Signorello LB, Blot WJ, Keku TO, Berndt SI, Newcomb PA, Pande M, Amos CI, West DW, Casey G, Sandler RS, Haile R, Stram DO, Le Marchand L. Fine-mapping of Genome-wide Association Study-identified Risk Loci for Colorectal Cancer in African Americans. Hum Mol Genet. e-Pub 7/2013. PMCID: PMC3836473.
7. Murray JL, Thompson P, Yoo SY, Do KA, Pande M, Zhou R, Liu Y, Sahin AA, Bondy ML, Brewster AM. Prognostic Value of Single Nucleotide Polymorphisms of Candidate Genes Associated with Inflammation in Early Stage Breast Cancer. Breast Cancer Res Treat 138(3):917-24, 4/2013. e-Pub 3/2013. PMCID: PMC3746974.
8. Pande M, Thompson PA, Do KA, Sahin AA, Amos CI, Frazier ML, Bondy ML, Brewster AM. Genetic Variants in the Vitamin D Pathway and Breast Cancer Disease Free Survival. Carcinogenesis 34(3):587-94, 3/2013. e-Pub 11/2012. PMCID: PMC3581599.
9. Chen J* and Pande M*, Huang YJ, Wei C, Amos CI, Talseth-Palmer BA, Meldrum CJ, Chen WV, Gorlov IP, Lynch PM, Scott RJ, Frazier ML. Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients. Carcinogenesis 34(2):299-306, 2/2013. e-Pub 11/2012. PMCID: PMC3564440.
10. Timofeeva MN, Hung RJ, Rafnar T, Christiani DC, Field JK, Bickeböller H, Risch A, McKay JD, Wang Y, Dai J, Gaborieau V, McLaughlin J, Brenner D, Narod SA, Caporaso NE, Albanes D, Thun M, Eisen T, Wichmann HE, Rosenberger A, Han Y, Chen W, Zhu D, Spitz M, Wu X, Pande M, Zhao Y, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Krokan HE, Gabrielsen ME, Skorpen F, Vatten L, Njølstad I, Chen C, Goodman G, Lathrop M, Benhamou S, Vooder T, Välk K, Nelis M, Metspalu A, Raji O, Chen Y, Gosney J, Liloglou T, Muley T, Dienemann H, Thorleifsson G, Shen H, Stefansson K, Brennan P, Amos CI, Houlston R, Landi MT, Transdisciplinary Research in Cancer of the Lung (TRICL) Research Team. Influence of Common Genetic Variation on Lung Cancer Risk: Meta-Analysis of 14,900 Cases and 29,485 Controls. Hum Mol Genet 21(22):4980-95, 11/2012. e-Pub 8/2012. PMCID: PMC3607485.
11. Pande M, Wei C, Chen J, Amos CI, Lynch PM, Lu KH, Lucio LA, Boyd-Rogers SG, Bannon SA, Mork ME, Frazier ML. Cancer spectrum in DNA mismatch repair gene mutation carriers: results from a hospital based Lynch syndrome registry. Fam Cancer 11(3):441-7, 9/2012. e-Pub 6/2012. PMCID: PMC3475767.
12. Pande M, Spitz MR, Wu X, Gorlov IP, Chen WV, Amos CI. Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk. Carcinogenesis 32(10):1493-9, 10/2011. e-Pub 7/2011. PMCID: PMC3179422.
13. Chen J, Wu X, Pande M, Amos CI, Killary AM, Sen S, Frazier ML. Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer. Pancreas 40(6):872-5, 8/2011. e-Pub 6/2011. PMCID: PMC3138891.
14. Pande M, Amos CI, Eng C, Frazier ML. Interactions between cigarette smoking and selected polymorphisms in xenobiotic metabolizing enzymes in risk for colorectal cancer: A case-only analysis. Mol Carcinog 49(11):974-80, 11/2010. PMCID: PMC3034292.
15. Pande M, Lynch PM, Hopper JL, Jenkins MA, Gallinger S, Haile RW, LeMarchand L, Lindor NM, Campbell PT, Newcomb PA, Potter JD, Baron JA, Frazier ML, Amos CI. Smoking and colorectal cancer in Lynch syndrome: results from the Colon Cancer Family Registry and the University of Texas M.D. Anderson Cancer Center. Clin Cancer Res 16(4):1331-9, 2/2010. e-Pub 2/2010. PMCID: PMC2822883.
16. Pande M, Amos CI, Osterwisch DR, Chen J, Lynch PM, Broaddus R, Frazier ML. Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome. Cancer Epidemiol Biomarkers Prev 17(9):2393-401, 9/2008. PMCID: PMC3028532.
17. Pande M, Chen J, Amos CI, Lynch PM, Broaddus R, Frazier ML. Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associated risk for colorectal cancer in a caucasian lynch syndrome population. Cancer Epidemiol Biomarkers Prev 16(9):1753-9, 9/2007. PMID: 17855693.
18. Jones JS, Amos CI, Pande M, Gu X, Chen J, Campos IM, Wei Q, Rodriguez-Bigas M, Lynch PM, Frazier ML. DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset. Cancer Epidemiol Biomarkers Prev 15(5):886-91, 5/2006. PMID: 16702365.

Invited Articles

1. Chen J, Zhu J, Pande M, Amos J, Frazier ML, Wei C. Modifiers of Expression in Mutations of Mismatch Repair Gene Carriers in Hereditary Nonpolyposis Colorectal Cancer. Current Colorectal Cancer Reports 2:179-184, 2006.

Abstracts

1. Thirumurthi S, Ross WA, Lum P, Miller ED, Weston BR, Pande M, Lynch PM, Shafi MA, Bhutani MS, Dekovich AA, Blechacz B, Lee JH, Davila MA< Bresalier RS, Guha S, Asif R, Routbort MJ, Slack RS, Shuttlesworth G, Mishra L, Strohlein JR, Raju GS. Adenoma & Sessile Serrated Adenoma Detection Rate Trends With Increasing Age: A Study Using A Natural Language Processing Computer Program. Digestive Disease Week 2014 (#Sa1412), 5/2014.
2. Weston BR, Ross WA, Lum P, Thirumurthi S, Miller ED, Bhutani MS, Blechacz B, Bresalier RS, Davila ML, Dekovich AA, Guha S, Lee JH, Lyynch PM, Pande M, Asif R, Shafi MA, Shuttlesworth G, Slack RS, Mishra L, Stroehlein JR, Gottumukkala GS. Adenoma Detection Rates (ADR) and Serrated Adenoma Detection Rates (SDR) During Screening Colonoscopy with and without a Personal Cancer History (PCH) in a Tertiary Referral Cancer Center. Digestive Diseases Week 2014 (#Sa1411), 5/2014.
3. Thirumurthi S, Raju GS, Pande M, Ruiz JR, Carlson RF, Lee JH, Ross WA. Does Sedation Method Affect Adenoma Detection Rates During Screening Colonoscopy?. Digestive Disease Week 2014 (#Tu1464), 5/2014.
4. Phillip L, Ross WA, Pande M, Lynch PM, Miller ED, Bhutani MS, Weston BR, Thirumurthi S, Dekovich AA, Guha S, Shafi MA, Davila ML, Bresalier RS, Lee JH, Blechacz B, Shuttlesworth G, Mishra L, Raju GS. Measures to Improve Colonoscopy Quality Metrics. Digestive Disease Week 2014 (#Sa1409), 5/2014.
5. Miller ED, Ross WA, Phillip L, Selvi T, Weston BR, Pande M, Bhutani MS, Blechacz B, Bresalier RS, Davila ML, Dekovich AA, Guha S, Lee JH, Lynch PM, Shafi MA, Shuttlesworth G, Slack RS, Mishra L, Stroehlein JR, Raju GS. Screening Colonoscopy Quality Metrics for Males and Females Across Ethnic Groups Using a Natural Language Processing Algorithm. Digestive Disease Week 2014 (#Sa1408), 5/2014.
6. Pande M, Bondy M, Sahin A, Ying J, Mills G, Thompson P, Brewster AM. The association between germline genetic variants in the PI3K-AKT-mTOR pathway and breast cancer disease free survival. AACR Annual Meeting 2014 (#3271). e-Pub 4/2014.
7. Wang H, Burnett T, Kono S, Haiman CA, Iwasaki M, Wilkens LR, Loo LWM, Ven Den Berg D, Mirel D, Kolonel LN, Henderson BE, Keku TO, Sandler RS, Signorello LB, Blot WJ, Newcomb PA, Pande M, Amos CI, West DW, Bézieau S, Berndt SI, Zanke B, Hsu L, and the GECCO consortium, Lindor NM, Haile RW, Hopper JL, Jenkins MA, Gallinger S, Casey G, and the CFR consortium, Stenzel SL, Schumacher FR, Peters U, Gruber SB, and the CORECT consortium, Tsugane S, Stram DO, LeMarchand L. Transethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. American Association of Cancer Research Proceedings (#LB-282 (8884)), 4/2014. e-Pub 4/2014.
8. Wang H, Haiman CA, Burnett T, Fortini BK, Kolonel LN, Henderson BE, Signorello LB, Blot WJ, Keku TO, Berndt SI, Newcomb PA, Pande M, Amos CI, West DW, Casey G, Sandler RS, Haile R, Stram DO, Le Marchand L. Fine-mapping of Genome-wide Association Study-identified Risk Loci for Colorectal Cancer in African Americans. American Society of Human Genetics ASHG 2013 (#3292T), 10/2013.
9. Dhar S, Gor B, Pande M, Krishnan S, Jones L. Differences in health perspectives may impact cancer and health disparities among Asian Indians. Global Academic Programs Annual Meeting 2013, 4/2013.
10. Pande M*, Chen J*, Huang YJ, Wei C, Amos CI, Talseth-Palmer B, Meldrum CJ, Chen WV, Gorlov IP, Lynch PM, Scott R, Frazier ML. Cell cycle–related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients. AACR Frontiers in Cancer Prevention Research Conference (#A108), 10/2012.
11. Wei C, Huang Y, Chen J, Pande M, Amos CI, Frazier ML. Genetic variants in 15q25.1 and age of onset of pancreatic cancer. AACR Frontiers in Cancer Prevention Research Conference (#A25), 10/2012.
12. Dhar S, Gor BJ, Pande M, Krishnan SK, Dorai VK, Jones L. Health Perceptions of Asian Indians May Differ by Age, Gender and Nativity. 2012 Biennial Symposium on Minorities, the Medically Underserved & Health Equity: Empowering Communities in the Era of Health Reform, 6/2012.
13. Pande M, Thompson PA, You SY, Do KA, Sahin AA, Amos CI, Bondy ML, Brewster A. Genetic Variants in the Vitamin D Pathway and Breast Cancer Disease Free Survival. Cancer Research, Supplement 1 72(8) (#2607), 4/2012.
14. Pande M, Spitz MR, Chen W, Wu X, Amos CI. Novel genetic variants in the chromosome 5p15 region associate with lung cancer risk. Inaugural CPRIT conference, 11/2010.
15. Pande M, Lynch PM, Lucio LM, Frazier ML. Cancers in DNA mismatch repair mutation carriers: results from a hospital based Lynch syndrome registry. 14th Annual meeting of the Collaborative Group of the Americas on Inherited Colorectal Cancer, 10/2010.
16. Pande M, Frazier ML, Lynch PM, Broaddus R, Amos CI. Genome wide association identified colorectal cancer susceptibility loci and colorectal cancer risk in Lynch syndrome. Hereditary Cancer in Clinical Practice 8(Suppl 1):P16, 5/2010. PMCID: PMC2876288.
17. Pande M, Frazier ML, Lynch PM, Broaddus R, Reuther J, Jiang W, Amos CI. Genome-wide association identified susceptibility loci as modifiers of colorectal cancer risk in Lynch syndrome. Cancer Prev Res 3(1 Suppl) (#A124), 1/2010.
18. Pande M, Amos CI, Osterwisch DR, Frazier ML. Interactions between cigarette smoking and selected candidate gene polymorphisms in risk for colorectal cancer: a case-only analysis. 59th Annual Meeting of The American Society of Human Genetics, 2009.
19. Pande M, Osterwisch DR, Amos CI, Frazier ML. Making sense of Missense Variants in DNA mismatch repair genes. Annual Meeting of the American Association of Cancer Research (AACR), 2009.
20. Pande M, Amos CI, Lynch PM, Campbell PT, Jenkins MA, Hopper JL, Lindor N, Le Marchand L, Gallinger S, Haile RW, Newcomb PA, Potter JD, Frazier ML. Association between smoking and colorectal cancer in individuals with Lynch Syndrome. 12th Annual Meeting of the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGAICC), 2008.
21. Pande M, Amos CI, Viscofsky N, Lynch PM, Frazier ML. Probands and non-probands differ by age of onset to colorectal cancer in Lynch syndrome. Hereditary Cancer in Clinical Practice 5(1):46-47, 2007.
22. Pande M, Chen J, Viscofsky N, Amos CI, Lynch PM, Frazier ML. MTHFR Polymorphism C677T is associated with an earlier age of onset of Colorectal Cancer in Lynch Syndrome. AACR International Conference on Frontiers in Cancer Prevention Research, 2006.
23. Pande M, Amos CI, Lynch PM, Frazier ML. EPHX1 Polymorphisms and age of onset of Hereditary Nonpolyposis Colorectal Cancer. Annual Meeting of the American Society of Preventive Oncology, 2005.
24. Pande M Sablotne E, Jones JS, Viscofsky N, Frazier ML. SULT1A1 Polymorphisms and age of onset of Hereditary Nonpolyposis Colorectal Cancer. Annual Meeting of the American Association for Cancer Research (AACR), 2004.

Book Chapters

1. Pande M, and Frazier ML. Epidemiology. In: Colorectal Cancer: Diagnosis and Clinical Management. Ed(s) Schloefield J, and Eng C. Wiley-Blackwell: Oxford, UK, 2014. ISBN: 978-0-470-67480-2.
2. Pande M, Chen J, Wei C, Huang Y, Frazier ML. Mutations in non-MMR genes modifying or mimicking Lynch syndrome phenotype. In: DNA alterations in Lynch syndrome: advances in molecular diagnosis and genetic counselling. Ed(s) Matjaz Vogelsang. Springer: Cape Town, South Africa, 135-170, 2013. ISBN: 978-94-007-6596-2.

Grant & Contract Support

Title: Susceptibility markers for a breast-colon cancer phenotype
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 9/5/2012 - 9/5/2017

Last updated: 4/11/2014