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Marsha L. Frazier, PhD

Present Title & Affiliation

Primary Appointment

Professor, Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Adjunct Professor, The University of Texas Health Science Center, Graduate School of Biomedical Sciences, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1155 Pressler Blvd
Unit Number: 1365
Houston, TX 77030
Room Number: CPB 7.3536
Fax: (713) 792-563-0999
Email: mlfrazier@mdanderson.org

Education & Training

Degree-Granting Education

1978 Pennsylvania State University, University Park, PA, PHD, Microbiology, Minor Biochemistry
1976 Miami University, Oxford, OH, MS, Microbiology
1972 Michigan State University, East Lansing, MI, BS, Biology

Postgraduate Training

1981-1982 Project Investigator, Department of Biochemistry, The University of Texas MD Anderson Cancer Center, Houston, TX
1979-1981 NIH National Research Service Award, Department of Biochemistry, The University of Texas MD Anderson Cancer Center, Houston, TX
1978-1979 Project Investigator, Department of Biochemistry, The University of Texas System Cancer Center MD Anderson Hospital and Tumor Institute, Houston, TX
1977-1978 Postdoctoral Fellow, Department of Pathology, The University of Texas Health Science Center, Houston, TX

Experience/Service

Academic Appointments

Adjunct Associate Professor, The University of Texas Health Science, Graduate School of Biomedical Sciences, Houston, TX, 1992-2005
Adjunct Assistant Professor, The University of Texas Health Science Center, Graduate School of Biomedical Sciences, Houston, TX, 1987-1992
Assistant Professor of Biochemistry & Assistant Biochemist, Section of Gastrointestinal Oncology & Digestive Diseases, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1985-1992
Research Assistant Professor, Department of Medicine, Baylor College of Medicine, Houston, TX, 1982-1985

Administrative Appointments/Responsibilities

Advisory Committee for the Molecular Diagnostics Laboratory, The University of Texas MD Anderson Cancer Center, Houston, TX, 1997-present
Human Clinical Cancer Genetics Implementation Committee, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 1997-2000
Faculty Selection Committee for the 1996 and 1997 BPW Past State President Award, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 1996-1997
Faculty Senator (elected), The University of Texas M.D. Anderson Cancer Center, Houston, TX, 1995-1997
DNA Analysis Facility Oversight Committee, The University of Texas MD Anderson Cancer Center, Houston, TX, 1994-present

Institutional Committee Activities

Chair, Epidemiology Faculty Mentoring Committee, 3/2013-present
Member, Epidemiology Exemplary Award Review Committee, 3/2013-present
Member, GSBS Admissions Committee, 1/2013-present
Co-Chair, Personalized Risk Prediction Program, 2010-present
Member, Faculty Achievement Awards Committee, 2008-2010
Member, Lockton Distinguished Chair Search Committee, 2003
Member, Institutional Grants Committee, 2002
Member, Institutional Safety Committee, 1999-2001
Member, Study Section Review Committee for Basic Research Projects, 1999-2000
Member, Institutional Research Support Committee, 1997-1999
Member, Program Review Ad Hoc Committee for Faculty Senate, 1/1994-1996
Member, Biosafety Committee, 1992-1995
Member, Institutional Research Grant Committee, 1991-1994
Co-Chairman, Recombinant DNA Subcommittee, 1989-1995
Member, Animal Care and Use Committee, 1988-1990
Member, Recombinant DNA Subcommittee, 1987-1989

Honors and Awards

1988 Past Presidents' Award, The Texas Federation of Business and Professional Women

Selected Publications

Peer-Reviewed Original Research Articles

1. Chen N, Balasenthil S, Reuther J, Frayna A, Chandler D, Abruzzo L, Rashid A, Wang Y, Guillermina L, Cao Y, Chen J, Frazier ML Sen S, Lott S, Killary AM. DEAR1 is a Chromosome 1p35 Tumor Suppressor and Master Regulator of TGFB-Driven Epithelial-Mesenchymal Transition. Cancer Discovery. In Press.
2. Liu Q, Chen J,Wang J, Amos CA, Killary AM, Sen S, Wei C,Frazier ML. Putative Tumor suppressor gene SEL1L was downregulated by aberrantly upregulated hsa-mir-155 in human pancreatic ductal adenocarcinoma. Molecular Carcinogenesis, 5/2013.
3. Wei C, Chen J, Pande M, Lynch PM, Frazier ML. A pilot study comparing protein expression in different segments of the normal colon and rectum and in normal colon versus adenoma in patients wth Lynch Syndrome. Journal of Cancer Research and Clinical Oncology. e-Pub 4/2013. PMID: 23604467.
4. Yang C, Lu W, Lin T, You P, Ye M, Huang Y, Jiang X, Wang C, Wang F, Lee MH, Yeung SC, Johnson RL, Wei C, Tsai RY, Frazier ML, McKeehan WL, Luo Y. Activation of liver FGF21 in hepatocarcinogenesis and during hepatic stress. BMC Gastroenterol, 4/2013. PMCID: PMC3637159.
5. Burton-Chase, AM, Hovick, SR, Peterson, SK, Marani, SK, Vernon, SW, Amos, CI, Frazier,ML, Lynch, PM, Gritz, ER. Changes in screening behaviors and attitudes toward screening from pre-test genetic counseling to post-disclosure in Lynch syndrome families. Clinical Genetics. e-Pub 3/2013. PMID: 23414081.
6. Pande M, Thompson PA, Do K, Sahin AA, Amos CI,Frazier ML, Bondy ML, Brewster AM. Genetic variants in the vitamin D pathway and breast cancer disease-free survival. Carcinogenesis. e-Pub 3/2013. PMCID: PMC3581599.
7. Chen J,Pande M, Huang YJ,Wei C, Amos CI, Talseth-Palmer BA, Meldrum CJ,Chen WV,Gorlov IP., Lynch PM, Scott RJ,FrazierML. Cell cycle–related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients. Carcinogenesis. e-Pub 2/2013. PMCID: PMC3564440.
8. Walsh K, Gorlov IP, Hansen HM, Wu X, Spitz MR, Zhang H, Lu E, Wenzlaff AS, Sison JD, Wei C, Lloyd SM, Chen W, Frazier ML, Seldin MF, Bierut LJ, Bracci PM, Wrencsch MR, Schwartz AG, Wiencke JK, Amos CI. Fine-mapping of the 5p15.33, 6p22.1-p21.31 and 15q25.1 regions identifies functional an histotogy-specific lung cancer susceptibility loci in African-Americans. Cancer Epidemiology, Biomarkers & Prevention. e-Pub 12/2012.
9. Walsh KM, Amos CI, Wenzlaff AS, Gorlov IP, Sison JD, Wu X, Spitz MR, Hansen HM, Lu EY, Wei C, Zhang H, Chen W, Lloyd SM, Frazier ML, Bracci PM, Seldin MF, Wrensch MR, Schwartz AG, Wiencke JK. Association study of nicotinic acetylcholine receptor genes identifies a novel luntg cancer susceptibility locus near CHRNA1 in African-Americans. Oncotarget, 11/2012. PMID: 23232035.
10. Pande, M, Wei C, Chen J, Amos CI, Lynch PM, Lu KH, Lucio La, Boyd-Roger SG, Bannon Sa, Mork ME,Frazier ML. Cancer spectrum in DNA mismatch repair gene mutation carriers; results from a hospital based Lynch syndrome registry. Fam Cancer, 6/2012. PMID: 22714864.
11. Liu Q, Chen J, Mai B, Amos C, Killary AM, Sen S, Wei C, Frazier ML. A Single Nucleotide Polymorphism in Tumor Suppressor gene SEL1L as a Predictive and Prognostic Marker for Pancreatic Ductal Adenocarcinoma in Caucasians. Mol Carcinog 51(5):433-8, 5/2012. e-Pub 6/2011. PMID: 21656579.
12. Wei C, Han Y, Spitz MR, Wu X, Chancoco H, Akiva P, Rechavi G, Brand H, Wun I, Frazier ML, Amos CI.. A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk. Cancer Epidemiol Biomarkers Prev 20(12):2603-9, 12/2011. e-Pub 10/2011. PMID: 22028403.
13. Chen LL, Chen X, Choi H, Sang H, Chen LC, Zhang H, Gouw L, Andtbacka RH, Chan BK, Rodesch CK, Jimenez A, Cano P, Jones KA, Oyedeji CO, Martins T, Hill HR, Schumacher J, Willmore C, Scaife CL, Ward JH, Morton K, Lor Randall R, Lazar AJ, Patel S, Trent JC, Frazier ML, Lin P, Jensen P, Benjamin RS. Exploiting Antitumor Immunity to Overcome Relapse and Improve Remission Duration. Cancer Immunol Immunother. e-Pub 12/2011. PMID: 22198309.
14. Bellows CF, Zhang Y, Chen J, Frazier ML, Kolonin MG. Circulation of Progenitor Cells in Obese and Lean Colorectal Cancer Patients. Cancer Epidemiol Biomarkers Prev 20(11):2461-8, 11/2011. e-Pub 9/2011. PMID: 21930958.
15. Chen J, Wu X, Pande M, Amos CI, Killary AM, Sen S, Frazier ML. Susceptibility Locus for Lung Cancer at 15q25.1 is not Associated with Risk of Pancreatic Cancer. Pancreas 40(6):872-5, 8/2011. PMCID: PMC3138891.
16. Balasenthil S, Chen N, Lott ST, Chen J, Carter J, Grizzle WE, Frazier ML, Sen S, Killary AM. A Migration Signature and Plasma Biomarker Panel for Pancreatic Adenocarcinoma. Cancer Prev Res (Phila) 4(1):137-49, 1/2011. e-Pub 11/2010. PMID: 21071578.
17. Hu P, Lee CW, Xu JP, Simien C, Fan CL, Tam M, Ramagli L, Brown BW, Lynch P, Frazier ML, Siciliano MJ, Coolbaugh-Murphy M. Microsatellite Instability in Saliva from Patients with Hereditary Non-polyposis Colon Cancer and Siblings Carrying Germline Mismatch Repair Gene Mutations. Ann Clin Lab Sci 41(4):321-30, 2011. PMID: 22166501.
18. Hansen HN, Wu X, Spitz MR, Zang H, Lu EY, Wenzlaff AS, Sison JD, Wei C, Lloyd SM, Chen W, Frazier ML, Seldin MF, Bierut LJ, Bracci PM, Wrensch MR, Schwartz AG, Wiencke JK, Amos CI. Fine-mapping of the 5p15.33.6p22.1-p21.31 and 15q25.10 regions identifies functional and histology-spe3cific lung cancer susceptibility loci in African-Amercans. Cancer Epidemiol Biomarkers Prevention. e-Pub 12/2010. PMID: 23221128.
19. Pande M, Amos CI, Eng C, Frazier ML. Interactions between cigarette smoking and selected polymorphisms in xenobiotic metabolizing enzymes in risk for colorectal cancer: a case-only analysis. Mol Carcinog 49(11):974-80, 11/2010. PMID: 20886582.
20. Burton AM, Peterson SK, Marani SK, Vernon SW, Amos CI, Frazier ML, Lynch PM, Gritz ER. Health and lifestyle behaviors among persons at risk of Lynch syndrome. Cancer Causes Control 21(4):513-21, 4/2010. e-Pub 12/2009. PMID: 20012181.
21. Coolbaugh-Murphy MI, Xu JP, Ramagli LS, Ramagli BC, Brown BW, Lynch PM, Hamilton SR, Frazier ML, Siciliano MJ. Microsatellite instability in the peripheral blood leukocytes of HNPCC Patients. Hum Mutat 31(3):317-24, 3/2010. e-Pub 1/2010. PMID: 20052760.
22. Pande M, Lynch PM, Hopper JL, Jenkins MA, Gallinger S, Haile RW, LeMarchand L, Lindor NM, Campbell PT, Newcomb PA, Potter JD, Baron JA, *Frazier ML, *Amos CI. *These Investigators Contributed Equally.. Smoking and colorectal cancer in Lynch syndrome: results from the Colon Cancer Family Registry and the University of Texas M.D. Anderson Cancer Center. Clin Cancer Res 16(4):1331-9, 2/2010. e-Pub 2/2010. PMCID: PMC2822883.
23. Zhu J, Sen S, Wei C, Frazier ML. Cyclin D1b represses breast cancer cell growth by antagonizing the action of cyclin D1a on estrogen receptor alpha-mediated transcription. Int J Oncol 36(1):39-48, 1/2010. PMID: 19956831.
24. Chen J, Amos CI, Merriman KW, Wei Q, Sen S, Killary AM, Frazier ML. Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic whites: a case-control study. Pancreas 39:1-4, 1/2010. PMCID: PMC2796289.
25. Chen J, Etzel CJ, Amos CI, Zhang Q, Viscofsky N, Lindor NM, Lynch PM, Frazier ML. Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome. Cancer Causes Control 20(9):1769-77, 11/2009. e-Pub 8/2009. PMID: 19690970.
26. Wang J, Chen J, Chang P, LeBlanc A, Li D, Abbruzzesse JL, Frazier ML, Killary AM, Sen S. MicroRNAs in Plasma of Pancreatic Ductal Adenocarcinoma Patients as Novel Blood Based Biomarkers of Disease. Cancer Prev Res (Phila Pa) 2(2(9)):807-13, 9/2009. e-Pub 9/2009. PMID: 19723895.
27. Reyes-Gibby CC, Shete S, Yennurajalingam S, Frazier M, Bruera E, Kurzrock R, Crane CH, Abbruzzese J, Evans D, Spitz MR. Genetic and nongenetic covariates of pain severity in patients with adenocarcinoma of the pancreas: assessing the influence of cytokine genes. J Pain Symptom Manage 38(6). e-Pub 8/2009. PMCID: PMC2795073.
28. Wei C, Amos CI, Zhang N, Zhu J, Wang X, Frazier ML. Chemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model. Cancer Lett 277(2):149-54, 5/2009. e-Pub 1/2009. PMID: 19147279.
29. Lott ST, Chen N, Chandler DS, Yang Q, Wang L, Rodriguez M, Xie H, Balasenthil S, Buchholz TA, Sahin AA, Chaung K, Zhang B, Olufemi SE, Chen J, Adams H, Band V, El-Naggar AK, Frazier ML, Keyomarsi K, Hunt KK, Sen S, Haffty B, Hewitt SM, Krahe R, Killary AM. DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer. PLoS Med 6(5):e1000068, 5/2009. e-Pub 5/2009. PMCID: PMC2673042.
30. Chen J, Li D, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation. Ann Surg Oncol 16(2):431-9, 2/2009. e-Pub 11/2008. PMID: 19020940.
31. Chen J, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer. Cancer Lett 272(1):32-9, 12/2008. e-Pub 8/2008. PMID: 18694622.
32. Ye Y, Lippman SM, Lee JJ, Chen M, Frazier ML, Spitz MR, Wu X. Genetic variations in cell-cycle pathway and the risk of oral premalignant lesions. Cancer 113(9):2488-95, 11/2008. PMCID: PMC2577230.
33. Kim KB, Eton O, Davis DW, Frazier ML, McConkey DJ, Diwan AH, Papadopoulos NE, Bedikian AY, Camacho LH, Ross MI, Cormier JN, Gershenwald JE, Lee JE, Mansfield PF, Billings LA, Ng CS, Charnsangavej C, Bar-Eli M, Johnson MM, Murgo AJ, Prieto VG. Phase II trial of imatinib mesylate in patients with metastatic melanoma. British Journal of Cancer 99(5):734-40, 9/2008. PMID: 18728994.
34. Chen LL, Holden JA, Choi H, Zhu J, Wu EF, Jones KA, Ward JH, Andtbacka RH, Randall RL, Scaife CL, Hunt KK, Prieto VG, Raymond AK, Zhang W, Trent JC, Benjamin RS, Frazier ML. Evolution from heterozygous to homozygous KIT mutation in gastrointestinal stromal tumor correlates with the mechanism of mitotic nondisjunction and significant tumor progression. Mod Pathol 21(7):826-36, 7/2008. PMID: 18488000.
35. Wei C, Amos CI, Zhang N, Wang X, Rashid A, Walker CL, Behringer RR, Frazier ML. Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling. Clin Cancer Res 14(4):1167-71, 2/2008. PMID: 18281551.
36. Chen J, Li D, Wei C, Sen S, Killary AM, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Aurora-A and p16 Polymorphisms Contribute to an Earlier Age at Diagnosis of Pancreatic Cancer in Caucasians. Clin Cancer Res 13(10):3100-4, 5/2007. PMID: 17505013.
37. Li D, Frazier M, Evans DB, Hess KR, Crane CH, Jiao L, Abbruzzese JL. Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. J Clin Oncol 24(11):1720-8, 4/2006. e-Pub 3/2006. PMCID: PMC1435378.
38. Zecevic M, Amos CI, Gu X, Campos IM, Jones JS, Lynch PM, Rodriguez-Bigas MA, Frazier ML. IGF1 gene polymorphism and risk for hereditary nonpolyposis colorectal cancer. J Natl Cancer Inst 98(2):139-43, 1/2006. PMID: 16418517.
39. Gu J, Berman D, Lu C, Wistuba II, Roth JA, Frazier M, Spitz MR, Wu X. Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer. Clin Cancer Res 12:7329-38, 2006. PMID: 17189404.
40. Wei C, Amos CI, Stephens LC, Campos I, Deng JM, Behringer RR, Rashid A, Frazier ML. Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. Cancer Res 65(24):11297-303, 12/2005. PMID: 16357136.
41. Jones JS, Gu X, Lynch PM, Rodriguez-Bigas M, Amos CI, Frazier ML. ATM polymorphism and hereditary nonpolyposis colorectal cancer (HNPCC) age of onset (United States). Cancer Causes Control 16(6):749-53, 8/2005. PMID: 16049814.
42. Chen LL, Sabripour M, Wu EF, Prieto VG, Fuller GN, Frazier ML. A mutation-created novel intra-exonic pre-mRNA splice site causes constitutive activation of KIT in human gastrointestinal stromal tumors. Oncogene 24(26):4271-80, 6/2005. PMID: 15824741.
43. Gritz ER, Peterson SK, Vernon SW, Marani SK, Baile WF, Watts BG, Amos CI, Frazier ML, Lynch PM. Psychological impact of genetic testing for hereditary nonpolyposis colorectal cancer. J Clin Oncol 23(9):1902-10, 3/2005. PMID: 15774782.
44. Gorlov IP, Gorlova OY, Frazier ML, Amos CI. Missense mutations in cancer suppressor gene TP53 are colocalized with exonic splicing enhancers (ESEs). Mutat Res 554(1-2):175-83, 10/2004. PMID: 15450416.
45. Chen LL, Trent JC, Wu EF, Fuller GN, Ramdas L, Zhang W, Raymond AK, Prieto VG, Oyedeji CO, Hunt KK, Pollock RE, Feig BW, Hayes KJ, Choi H, Macapinlac HA, Hittelman W, Velasco MA, Patel S, Burgess MA, Benjamin RS, Frazier ML. A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res 64(17):5913-9, 9/2004. PMID: 15342366.
46. Jones JS, Chi X, Gu X, Lynch PM, Amos CI, Frazier ML. p53 polymorphism and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population. Clin Cancer Res 10(17):5845-9, 9/2004. PMID: 15355915.
47. Coolbaugh-Murphy M, Maleki A, Ramagli L, Frazier M, Lichtiger B, Monckton DG, Siciliano MJ, Brown BW. Estimating mutant microsatellite allele frequencies in somatic cells by small-pool PCR. Genomics 84(2):419-30, 8/2004. PMID: 15234004.
48. Amos CI, Keitheri-Cheteri MB, Sabripour M, Wei C, McGarrity TJ, Seldin MF, Nations L, Lynch PM, Fidder HH, Friedman E, Frazier ML. Genotype-phenotype correlations in Peutz-Jeghers syndrome. J Med Genet 41(5):327-33, 5/2004. PMCID: PMC1735760.
49. Zhu Y, Spitz MR, Zhang H, Grossman HB, Frazier ML, Wu X. Methyl-CpG-binding domain 2: a protective role in bladder carcinoma. Cancer 100(9):1853-8, 5/2004. PMID: 15112265.
50. Jones JS, Gu X, Campos IM, Lynch PM, Amos CI, Frazier ML. GSTM1 polymorphism does not affect hereditary nonpolyposis colorectal cancer age of onset. Cancer Epidemiol Biomarkers Prev 13(4):676-8, 4/2004. PMID: 15066938.
51. Wei C, Amos CI, Rashid A, Sabripour M, Nations L, McGarrity TJ, Frazier ML. Correlation of staining for LKB1 and COX-2 in hamartomatous polyps and carcinomas from patients with Peutz-Jeghers syndrome. J Histochem Cytochem 51(12):1665-72, 12/2003. PMID: 14623934.
52. Gorlov IP, Gorlova OY, Frazier ML, Amos CI. Missense mutations in hMLH1 and hMSH2 are associated with exonic splicing enhancers. Am J Hum Genet 73(5):1157-61, 11/2003. e-Pub 10/2003. PMCID: PMC1180494.
53. Frazier ML, Xi L, Zong J, Viscofsky N, Rashid A, Wu EF, Lynch PM, Amos CI, Issa JP. Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer. Cancer Res 63(16):4805-8, 8/2003. PMID: 12941799.
54. McGarrity TJ, Peiffer LP, Amos CI, Frazier ML, Ward MG, Howett MK. Overexpression of cyclooxygenase 2 in hamartomatous polyps of Peutz-Jeghers syndrome. Am J Gastroenterol 98(3):671-8, 3/2003. PMID: 12650805.
55. Lott ST, Chandler DS, Curley SA, Foster CJ, El-Naggar A, Frazier M, Strong LC, Lovell M, Killary AM. High frequency loss of heterozygosity in von Hippel-Lindau (VHL)-associated and sporadic pancreatic islet cell tumors: evidence for a stepwise mechanism for malignant conversion in VHL tumorigenesis. Cancer Res 62(7):1952-5, 4/2002. PMID: 11929809.
56. Zheng Y, Shen H, Sturgis EM, Wang LE, Eicher SA, Strom SS, Frazier ML, Spitz MR, Wei Q. Cyclin D1 polymorphism and risk for squamous cell carcinoma of the head and neck: a case-control study. Carcinogenesis 22(8):1195-9, 8/2001. PMID: 11470749.
57. Kong S, Wei Q, Amos CI, Lynch PM, Levin B, Zong J, Frazier ML. Cyclin D1 polymorphism and increased risk of colorectal cancer at young age. J Natl Cancer 93(14):1106-08, 7/2001. PMID: 11459873.
58. Frazier ML, O'Donnell FT, Kong S, Gu X, Campos I, Luthra R, Lynch PM, Amos CI. Age-associated risk of cancer among individuals with N-acetyltransferase 2 (NAT2) mutations and mutations in DNA mismatch repair genes. Cancer Res 61(4):1269-71, 2/2001. PMID: 11245417.
59. Peracaula R, Cleary KR, Lorenzo J, de Llorens R, Frazier ML. Human pancreatic ribonuclease 1: expression and distribution in pancreatic adenocarcinoma. Cancer 89(6):1252-8, 9/2000. PMID: 11002220.
60. Peng H, Xu F, Pershad R, Hunt KK, Frazier ML, Berchuck A, Gray JW, Hogg D, Bast RC, Jr, Yu Y. ARHI is the center of allelic deletion on chromosome 1p31 in ovarian and breast cancers. Int J Cancer 86(5):690-4, 6/2000. PMID: 10797292.
61. Amos CI, Frazier ML, Wang W. DNA pooling in mutation detection with reference to sequence analysis. Am J Hum Genet 66(5):1689-92, 5/2000. PMID: 10733464.
62. Fernandez-Salas E, Peracaula R, Frazier ML, de Llorens R. Ribonucleases expressed by human pancreatic adenocarcinoma cell lines. Eur J Biochem 267(5):1484-94, 3/2000. PMID: 10691987.
63. Kong S, Amos CI, Luthra R, Lynch PM, Levin B, Frazier ML. Effects of cyclin D1 polymorphism on age of onset of hereditary nonpolyposis colorectal cancer. Cancer Res 60(2):249-52, 1/2000. PMID: 10667569.
64. Molina MA, Sitja-Arnau M, Lemoine MG, Frazier ML, Sinicrope FA. Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. Cancer Res 59(17):4356-62, 9/1999. PMID: 10485483.
65. Sinicrope FA, Lemoine M, Xi L, Lynch PM, Cleary KR, Shen Y, Frazier ML. Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers. Gastroenterology 117(2):350-8, 8/1999. PMID: 10419916.
66. Frazier ML, Sinicrope FA, Amos CI, Cleary KR, Lynch PM, Levin B, Luthra R. Loci for efficient detection of microsatellite instability in hereditary non-polyposis colorectal cancer. Oncol Rep 6(3):497-505, 5/1999. PMID: 10203581.
67. Lin X, Choi JH, Lynch P, Xi L, Wu E, Frazier ML. Reduction in hMSH2 mRNA levels by premature translation termination: implications for mutation screening in hereditary nonpolyposis colorectal cancer. Dig Dis Sci 44(3):553-9, 3/1999. PMID: 10080150.
68. Frazier ML, Inamdar N, Alvula S, Wu E, Kim YH. Few point mutations in elongation factor-1gamma gene in gastrointestinal carcinoma. Mol Carcinog 22(1):9-15, 5/1998. PMID: 9609096.
69. Sinicrope FA, Roddey G, Lemoine M, Ruan S, Stephens LC, Frazier ML, Shen Y, Zhang W. Loss of p21WAF1/Cip1 protein expression accompanies progression of sporadic colorectal neoplasms but not hereditary nonpolyposis colorectal cancers. Clin Cancer Res 4(5):1251-61, 5/1998. PMID: 9607584.
70. Blanco-Aparicio C, Molina MA, Fernandez-Salas E, Frazier ML, Mas JM, Querol E, Aviles FX, de Llorens R. Potato carboxypeptidase inhibitor, a T-knot protein, is an epidermal growth factor antagonist that inhibits tumor cell growth. J Biol Chem 273(20):12370-7, 5/1998. PMID: 9575190.
71. Mathur S, Cleary KR, Inamdar N, Kim YH, Steck P, Frazier ML. Overexpression of elongation factor-1gamma protein in colorectal carcinoma. Cancer 82(5):816-21, 3/1998. PMID: 9486568.
72. Curley SA, Lott ST, Luca JW, Frazier ML, Killary AM. Surgical decision-making affected by clinical and genetic screening of a novel kindred with von Hippel-Lindau disease and pancreatic islet cell tumors. Ann Surg 227(2):229-35, 2/1998. PMID: 9488521.
73. Teng DH, Hu R, Lin H, Davis T, Iliev D, Frye C, Swedlund B, Hansen KL, Vinson VL, Gumpper KL, Ellis L, El-Naggar A, Frazier M, Jasser S, Langford LA, Lee J, Mills GB, Pershouse MA, Pollack RE, Tornos C, Troncoso P, Yung WK, Fujii G, Berson A, Steck PA, et al. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res 57(23):5221-5, 12/1997. PMID: 9393738.
74. Amos CI, Bali D, Thiel TJ, Anderson JP, Gourley I, Frazier ML, Lynch PM, Luchtefeld MA, Young A, McGarrity TJ, Seldin MF. Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p. Cancer Res 57(17):3653-6, 9/1997. PMID: 9288765.
75. Jones DV, Wu E, Manire M, Frazier ML. Cis-acting elements required for expression of the nonspecific cross-reacting antigen gene in colorectal carcinoma. Gastroenterology 112:776-82, 3/1997. PMID: 9041239.
76. Abbruzzese JL, Evans DB, Raijman I, Larry L, King T, Leach SD, Frazier ML. Detection of mutated c-Ki-ras in the bile of patients with pancreatic cancer. Anticancer Res 17(2A):795-801, 3/1997. PMID: 9137410.
77. Souza RF, Appel R, Yin J, Wang S, Smolinski KN, Abraham JM, Zou TT, Shi YQ, Lei J, Cottrell J, Cymes K, Biden K, Simms L, Leggett B, Lynch PM, Frazier M, Powell SM, Harpaz N, Sugimura H, Young J, Meltzer SJ. Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours. Nat Genet 14(3):255-7, 11/1996. PMID: 8896552.
78. Ghusn H, Arem R, Frazier M, Chamakhi S, Ezzaouia G, Chan L. Restriction fragment length polymorphism of the human apo B and apo AII gene regions among type II diabetics. Res Commun Mol Pathol Pharmacol 93(1):25-32, 7/1996. PMID: 8865367.
79. Stern MP, Mitchell BD, Blangero J, Reinhart L, Krammerer CM, Harrison CR, Shipman PA, O'Connell P, Frazier ML, MacCluer JW. Evidence for a major gene for type II diabetes and linkage analyses with selected candidate genes in Mexican-Americans. Diabetes 45(5):563-8, 5/1996. PMID: 8621004.
80. Evans DB, Frazier ML, Charnsangavej C, Katz RL, Larry L, Abbruzzese JL. Molecular diagnosis of exocrine pancreatic cancer using a percutaneous technique. Ann Surg Oncol 3(3):241-6, 5/1996. PMID: 8726178.
81. Frazier ML, Fernandez E, de Llorens R, Brown NM, Pathak S, Cleary KR, Abbruzzese JL, Berry K, Olive M, Le Maistre A, Evans DB. Pancreatic adenocarcinoma cell line, MDAPanc-28, with features of both acinar and ductal cells. Int J Pancreatol 19(1):31-8, 2/1996. PMID: 8656025.
82. Jeon HM, Lynch PM, Howard L, Ajani J, Levin B, Frazier ML. Mutation of the hMSH2 gene in two families with hereditary nonpolyposis colorectal cancer. Hum Mutat 7(4):327-33, 1996. PMID: 8723682.
83. Mitchell BD, Kammerer CM, O'Connell P, Harrison CR, Manire M, Shipman P, Moyer MP, Stern MP, Frazier ML. Evidence for linkage of postchallenge insulin levels with intestinal fatty acid-binding protein (FABP2) in Mexican-Americans. Diabetes 44(9):1046-53, 9/1995. PMID: 7657027.
84. Githens S, Schexnayder JA, Moses RL, Denning GM, Smith JJ, Frazier ML. Mouse pancreatic acinar/ductular tissue gives rise to epithelial cultures that are morphologically, biochemically, and functionally indistinguishable from interlobular duct cell cultures. In Vitro Cell Dev Biol Anim 30A(9):622-35, 9/1994. PMID: 7529626.
85. Fernandez E, Fallon MJ, Frazier ML, de Llorens R, Cuchillo CM. Expression of acinar and ductal products in Capan-1 cells growing in synthetic serum and serum-free media. Cancer 73(9):2285-95, 5/1994. PMID: 7513248.
86. Dohi DF, Sutton RC, Frazier ML, Nakamori S, McIsaac AM, Irimura T. Regulation of sialomucin production in colon carcinoma cells. J Biol Chem 268(14):10133-8, 5/1993. PMID: 8098036.
87. Ioannides CG, Fisk B, Pollack MS, Frazier ML, Taylor Wharton J, Freedman RS. Cytotoxic T-cell clones isolated from ovarian tumour infiltrating lymphocytes recognize common determinants on non-ovarian tumour clones. Scand J Immunol 37(4):413-24, 4/1993. PMID: 8469924.
88. Ender B, Lynch P, Kim YH, Inamdar NV, Cleary KR, Frazier ML. Overexpression of an elongation factor-1 gamma-hybridizing RNA in colorectal adenomas. Mol Carcinog 7(1):18-20, 1993. PMID: 8382068.
89. Chi K, Jones DV, Frazier ML. Expression of an elongation factor 1 gamma-related sequence in adenocarcinomas of the colon. Gastroenterology 103(1):98-102, 7/1992. PMID: 1612363.
90. Frazier ML, Brown N, Pathak S, Mackay B, Cleary K, Olive M, Byrd DR, Evans DB, Levin B. Human cell line from an adenocarcinoma of the ampulla of Vater. In Vitro Cell Dev Biol 28A(3 Pt 1):149-53, 3/1992. PMID: 1582987.
91. Githens S, Schexnayder JA, Frazier ML. Carbonic anhydrase II gene expression in mouse pancreatic duct cells. Pancreas 7(5):556-61, 1992. PMID: 1381098.
92. Lew Y, Jones DV, Mars WM, Evans D, Byrd D, Frazier ML. Expression of elongation factor-1 gamma-related sequence in human pancreatic cancer. Pancreas 7(2):144-52, 1992. PMID: 1372736.
93. Chi KF, Jessup JM, Frazier ML. Predominant expression of mRNA coding for nonspecific cross-reacting antigen in colorectal carcinomas. Tumour Biol 12(5):298-308, 1991. PMID: 1962152.
94. Frazier ML, Lilly BJ, Wu EF, Ota T, Hewett-Emmett D. Carbonic anhydrase II gene expression in cell lines from human pancreatic adenocarcinoma. Pancreas 5(5):507-14, 9/1990. PMID: 1700414.
95. Frazier ML, Pathak S, Wang ZW, Cleary K, Singletary SE, Olive M, Mackay B, Steck PA, Levin B. Establishment of a new human pancreatic adenocarcinoma cell line, MDAPanc-3. Pancreas 5(1):8-16, 1990. PMID: 1688394.
96. Raboudi SH, Frazier ML. Restriction fragment length polymorphism of the human insulin receptor gene among Mexican Americans. Res Commun Chem Pathol Pharmacol 65(3):319-35, 9/1989. PMID: 2573118.
97. Raboudi SH, Mitchell BD, Stern MP, Eifler CW, Haffner SM, Hazuda HP, Frazier ML. Type II diabetes mellitus and polymorphism of insulin-receptor gene in Mexican Americans. Diabetes 38(8):975-80, 8/1989. PMID: 2568958.
98. Stallings RL, Siciliano MJ, Frazier ML, al-Ubaidi MR, Kellems RE. Hypomethylation and ADA gene expression in mouse CAK cells. Somat Cell Mol Genet 15(1):1-11, 1989. PMID: 2464855.
99. Su CJ, White JW, Li WH, Luo CC, Frazier ML, Saunders GF, Chan L. Structure and evolution of somatostatin genes. Mol Endocrinol 2(3):209-16, 3/1988. PMID: 2899837.
100. D'Agostino J, Younes MA, White JW, Besch PK, Field JB, Frazier ML. Cloning and nucleotide sequence analysis of complementary deoxyribonucleic acid for bovine preproinsulin. Mol Endocrinol 1(4):327-31, 4/1987. PMID: 2456452.
101. Mars WM, Stellrecht CM, Stass S, Frazier ML, Saunders GF. Localization of an abundant myeloid mRNA to individual leukocytes in mixed cell populations. Leukemia 1(3):167-72, 3/1987. PMID: 3478537.
102. Frazier ML, Ferrell RE, Arem R, Chamakhi S, Field JB. Restriction fragment length polymorphism of the human insulin gene region among type II diabetic Mexican-Americans and Tunisians. Res Commun Chem Pathol Pharmacol 52(3):371-86, 6/1986. PMID: 3016846.
103. Nicolson GL, LaBiche RA, Frazier ML, Blick M, Tressler RJ, Reading CL, Irimura T, Rotter V. Differential expression of metastasis-associated cell surface glycoproteins and mRNA in a murine large cell lymphoma. J Cell Biochem 31(4):305-12, 1986. PMID: 3760037.
104. D'Agostino J, Field JB, Frazier ML. Ontogeny of immunoreactive insulin in the fetal bovine pancreas. Endocrinology 116(3):1108-16, 3/1985. PMID: 3882396.
105. Majumdar AP, Frazier ML. Cell-free synthesis of rat epidermal growth factor-like polypeptide. Res Commun Chem Pathol Pharmacol 46(1):103-11, 10/1984. PMID: 6334338.
106. Lopez LC, Li WH, Frazier ML, Luo CC, Saunders GF. Evolution of glucagon genes. Mol Biol Evol 1(4):335-44, 7/1984. PMID: 6599970.
107. Lopez LC, Frazier ML, Su CJ, Kumar A, Saunders GF. Mammalian pancreatic preproglucagon contains three glucagon-related peptides. Proc Natl Acad Sci U S A 80(18):5485-9, 9/1983. PMID: 6577439.
108. Frazier ML, Mars W, Florine DL, Montagna RA, Saunders GF. Efficient extraction of RNA from mammalian tissue. Mol Cell Biochem 56(2):113-22, 1983. PMID: 6196612.
109. Hall SW, Strong JE, Broughton A, Frazier ML, Benjamin RS. Bleomycin clinical pharmacology by radioimmunoassay. Cancer Chemother Pharmacol 9(1):22-5, 1982. PMID: 6183016.
110. Frazier ML, Montagna RA, Saunders GF. Insulin gene expression during development of the fetal bovine pancreas. Biochemistry 20(2):367-71, 1/1981. PMID: 6162484.
111. Frazier ML, Zimmerman LN. Plasmid-borne resistance to ultraviolet light and phage in Streptococcus faecalis ssp. zymogens. Can J. Microbioliol 26(10):1253-5, 10/1980. PMID: 6780172.
112. Frazier ML, Zimmerman LN. Genetic loci of hemolysinm in production Streptococcus faecalis subsp. zymogenes. J Bacteriol 130(3):1064-71, 6/1977.
113. Liu Q, Killary AM, Sen S, Amos C, Wei C, Frazier ML. Aberrant RNA splicing and loss of heterozygosity of the tumors-suppressor gene SEL1L in human pancreatic ductal adenocarcinoma. Journal of Nucleic Acids. Submitted.

Invited Articles

1. Irimura T, Matsushita Y, Hoff SD, Yamori T, Nakamori S, Frazier ML, Giacco GG, Cleary KR, Ota DM. Ectopic expression of mucins in colorectal cancer metastasis. Semin Cancer Biol 2:129-39, 4/1991. PMID: 1680492.
2. Frazier ML, Fernandez E, de Llorens R. Cell lines and transgenic animals as models for studies on gene expression in pancreatic adenocarcinoma. International Journal of Pancreatology 16:289-290, 1994.
3. Bell, JrRH, Frazier ML. Cellular and animal models having high-priority applications in pancreatic cancer. International Journal of Pancreatology 16:305, 1994.
4. Frazier ML, Fernández E. Gene expression in the developing pancreas and pancreatic adenocarinoma. Cancer Bulletin 46:485-491, 1994.
5. Frazier ML. Gene expression in pancreatic adenocarcinoma. Ann N Y Acad Sci 880:1-4, 6/1999. PMID: 10415845.
6. Gritz, ER, Vernon SW, Peterson SK, Baile WB, Marani SK, Amos CI, Frazier ML, Lynch PM. Distress in the cancer patient and its association with genetic testing and counseling for hereditary non-polyposis colon cancer. Cancer Research, Therapy and Control 18:35-50, 1999.
7. Frazier ML, Su LK, Amos CI, Lynch PM. Current applications of genetic technology in predisposition testing and microsatellite instability assays. J Clin Oncol 18:70S-4S, 11/2000. PMID: 11060331.
8. Amos, CI, Frazier ML, McGarrity TJ. Peutz-Jeghers Syndrome. Clinical Genetics: Clinical Genetic Information Resource, 2001.
9. Chen LL, Sabripour M, Andtbacka RH, Patel SR, Feig BW, Macapinlac HA, Choi H, Wu EF, Frazier ML, Benjamin RS. Imatinib resistance in gastrointestinal stromal tumors. Curr Oncol Rep 7(4):293-9, 7/2005. PMID: 15946589.
10. Chen J, Jhu J, Pande M, Amos J, Frazier ML Wei C. Modifiers of expression in mutation of mismatch repair gene carriers in hereditary nonpolyposis colorectal cancer. Current Colorectal Cancer Reports 12:7329-38, 2006.
11. Wei C, Frazier ML. LKB1: A critical mediator in suppression initiation, differentiation and metastasis in lung cancer. Cell Science Reviews(4(2)):40-47, 2007.
12. Gorlov IP, Gorlova OY, Frazier ML, Spitz MR, Amos CI. Evolutionary evidence of the effect of rare variants on disease etiology. Clin Genet 79(3):199-206, 3/2011. e-Pub 9/2010. PMID: 20831747.

Editorials

1. Wei, Q, Frazier ML, Levin B. DNA Repair: a Double-Edged Sword. Journal of the National Cancer Institute 92:440-441, 2000.
Other Articles
1. Amos CI, Frazier ML, Wei C, McGarrity TJ. Peutz-Jeghers Syndrome. GeneReviews, 2/2011. PMID: 20301443.

Abstracts

1. Chen J, Wang J, Balasenthil S, Liu Q, Chen N, Killary AM, Sen S, Frazier ML. A Genomic Pathway Approach to Biomarker Discovery for the Early Detection and Risk Assessment of Pancreatic Cancer. EDRN Pancreas Working Group. In Press.
2. Chen J, Pande M, Huang YJ, Wei C, Amos CI, Talseth-Palmer BA, Meldrum C, Chen W, Gorlov IP, Lynch PM, Scott RJ, and Frazier ML. Cell cycle–related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic White patients. 11th Annual AACR International Conference on Frontiers in Cancer Prevention Research, California, USA. e-Pub 10/2012.
3. Pande M, Thompson PA, Liu Y, You SY, Do KA, Sahin AA, Amos CI, Frazier ML, Bondy ML, Brewster A. Genetic Variants in the Vitamin D Pathway and Breast Cancer Disease Free Survival. Annual Meeting of the AACR 2012 (#2607). e-Pub 4/2012.
4. Armstrong L, Huang Y, Rother JD, Frazier ML. A single nucleotide polymorphism of the CCKBR receptor and age of onset for pancreatic cancer. College Student Trainee Poster Presentation. e-Pub 2012.
5. Wei C, Huang YJ, Chen J, Pande M, Amos CI, Frazier ML. Genetic Variants in 15q25.1 and age onset of Pancreatic Cancer. Frontiers in Cancer Prevention Research. e-Pub 2012.
6. Thamaravelil G, Rother JD, Chen J,Chancoco HD, Hu PC, Frazier ML,. IGF2/H19 DMR Mutations and Risk for Development of Colorectal Cancer. Molecular Genetic Technology, School of Health Profession. e-Pub 2012.
7. Wei C, Han Y, Spitz M, Wu X, Chancoco H, Frazier ML, Amos C. A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk. Innovations in Cancer Prevention and Research Conference, 2011.
8. Liu Q, Chen J, Mai B, Amos C, Killary AM, Sen S, Abbruzzese J, Frazier ML. A Single Nucleotide Polymorphism in Tumor Suppressor Gene SEL1L as Predictive and Prognostic Marker for Pancreatic Ductal Adenocarcinoma in Caucasians. Pancreas Journal, American Pancreatic Association Meeting 39(8):1330, 11/2010.
9. Pande M, Lynch PM, Lucio LM, Frazier ML. Cancers in DNA Mismatch repair mutation carriers: results from a hospital based Lynch syndrome registry. 14th Annual Meeting of the Collaborative Group of the Americas on Inherited Colorectal Cancer, 10/2010.
10. Pande M, Frazier ML, Lynch PM, Broaddus R, Amos CI. Genome-wide association identified colorectal cancer susceptibility loci and colorectal cancer risk in Lynch syndrome. Hereditary Cancer in Clinical Practice 8 (Suppl 1):P16, 5/2010. PMCID: PMC2876288.
11. Liu Q, Chen J, Amos C, Killary AM, Sen S, Frazier ML. MicroRNAs and SEL1 gene regulation in human pancreatic ductal adenocarcinoma. The University of Texas M.D. Anderson Cancer Center (Finalist for Poster Competition of Trainee Research Day), Houston, TX, 5/2010.
12. Pande M, Frazier ML, Lynch PM, Broaddus R, Reuther J, Jiang W, Amos CI. Genome--wide association identified susceptibility loci as modifiers of colorectal cancer risk in Lynch syndrome. Cancer Prev Res 3 (1 Suppl) (#A124), 1/2010.
13. Wei C, Zhang N, Liu Q, Amos C, Frazier M. Dysregulation of tumor suppress gene LKB1 in Pancreatic Cancer. e-Pub 2010.
14. Liu Q, Chen J, Amos C, Killary AM, Sen S, Frazier ML. MicroRNAs and SEL1L gene regulation in human pancreatic ductal adenocarcinoma. Eight Annual AACR International Conference on Frontiers in Cancer Prevention Research, Houston, TX, 12/2009.
15. Mai B, Chen J, Liu Q, Frazier ML. Role of SEL1L SNP in determining prognosis of pancreatic cancer patients after treatment. Texas Association for Clinical Laboratory Science (TACLS) Convention, Galveston, TX, 3/2009.
16. Killary AM, Frazier ML, Lott S, Carter J, Stivers D, Chen J, Wang R, Abbruzzese J, Sen S,. A Functional Gemomic Approach to Biomarker Discovery in Pancreatic Cancer. EDRN Pancreas Working Group Meeting, 2009.
17. Wei C, Amos CI, Frazier ML. Downregulation of LKB1 in Pancreatic Cancer. 2009 APA Annual Meeting, 2009.
18. Pande M, Frazier ML, Osterwisch DR, Amos CI,. Geonome wide Association Identified Colorectal Cancer Susceptibility Loci and Colorectal Cancer risk in Lynch Syndrome. 13th Annual CGA-ICC Meeting, 2009.
19. Pande M, Amos CI, Osterwisch DR, Frazier ML. Ieractions between cigarette smoking and selected candidate gene polymorphisms in risk for colorectal cancer: a case-only analysis (abstract/program 1127/W). 59th Annual Meeting of The American Society of Human Genetics, 2009.
20. Pande M, Osterwisch DR, Amos CI, Frazier ML. Making sense of Missense Variants in DNA mismatch repair genes. Annual Meeting of the American Association of Cancer Research (AACR),, 2009.
21. Chen J, Wu X, Amos CI, Killary AM, Frazier ML. Susceptibility locus for lung cancer at 15q25.1 associated with protective effect in pancreatic cancer. American Pancreatic Association Meeting, 2009.
22. Amos Ci, Wei C, Spitz MR, Wun I, Frazier ML. The Nicotinic Acetylcholine Receptor region on chronomosome 15q25 assoicates with adencoarcinoma of the lung in African-Americans. ASHG Annual Meeting, 2009.
23. Pande M, Amos CI, Lynch PM, Campbell PT, Jenkins MA, Hopper JL, Lindor N, Le Marchand L, Gallinger S, Haile RW, Newcomb PA, Potter JD, Frazier ML. Association between smoking and colorectal cancer in individuals with Lynch Syndrome. 12th Annual Meeting of the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGAICC), 2008.
24. Chen J, Killary AM, Sen S, Amos CI, Evans DB, Frazier ML. IGF1 CA Repeat Polymorphisms Contribute to an Earlier Age at Diagnosis of Pancreatic Cancer. American Pancreatic Association Meeting, 2008.
25. Chen J, Killary AM, Sen S, Amos CI, Evans DB, Frazier ML. P21 and P27 Polymorphisms Coorperatively Contribute to an Earlier Age at Diagnosis of Pancreatic Cancer. American Society of Preventive Oncology 31st Annual Meeting, 2007.
26. Wei C, Zhang N, Amos CI, Wang X, Walker. Rapamycin trial on a mouse model for Peutz-Jeghers Syndrome. 60th Annual Symposium on Cancer Research, 2007.
27. Wei C, Amos CI, Zhang N, Frazier ML,. Targeting mTOR signaling in a mouse model for Peutz-Jeghers Syn drome. Colorectal Cancer: Celebrating a Career in Cancer Prevention, 2007.
28. Chen J,Etzel CJ, Amos CI, Zhang Q, Viscofsky N, Lynch PM, Frazier ML. Using tree-model to identify genetic detrminant of early onset of Hereditary Nonpolyposis Colorectal Cancr. American Society of Prevetive Oncology 31st Annual Meeting, 2007.
29. Killary AM, Frazier ML, Lott S, Carter J, Stivers D, Chen J, Hwang R, Abbruzzese J, Sen S. A Functional Genomic Approach to Biomarker Discovery in Pancreatic Cancer. 4th Early Detection Reseach Network (EDRN) Scientific Workshop, 2006.
30. Pande M, Chen J, Viscofsky N, Amos CI, Lynch PM, Frazier ML. MTHFR Polymorphism C677T is associated with an earlier age of onset of Colorectal Cancer in Lynch Syndrome. Annual AACR International conference on Frontiers in Cancer Prevention Research, 2006.
31. Pande M, Amos CI, Viscofsky N, Lynch PM, Frazier ML. Probands and non-probands differ by age of onset to colorectal cancer in Lynch syndrome. 10th Annual Meeting of CGAICC, 2006.
32. Wei C, Longnecker D, Rashid a, Zhu J, Amos C, Gannon M, Frazier ML. The role of LKB1 gene in the pancreatic tumorigenesis. Day of Prevention Science, 2006.
33. Chen j, Frazier ML. Association Between Aurora-A Polymorphism and Onset Age of Hereditary Nonpolyposis Colorectal Cancer. 2nd NCI Epidemiology Leadership Workshop, 2005.
34. Wei C, Amos C, Stephens C, Behringer RI, Frazier ML. Cooperative tumorigenic effects of germline mutations in the LKB1 and p53. 2nd Annual cell signaling symposium, 2005.
35. Pande M, Amos CI, Lynch PM, Frazier ML. EPHX1 Polymorphisms and age of onset of Hereditary Nonpolyposis Colorectal Cancer. American Society of Preventive Oncology, 2005.
36. Li D, Liu H, Evans DB, Abbruzzese JL, Frazier ML. Genetic Polymorphisms as Significant Prognosis Factors for Patients with Pancreatic Adenocarcinoma. 13th Spore Investigator Workshop, 2005.
37. Frazier ML, Chen J, Jones JS, Lynch PM, Lindor N, Amos CI. Influence of SNPs in Cell Cycle Control Genes on Age Associated Risk for Hereditary Nonpolyposis Colorectal Cancer, Breast & Colon Cancer. Family Registry (BC-CFR) Biannual Meeting, 2005.
38. Wei C, Rashid A, Amos C, Gannon M, Frazier ML. LKB1 Gene Tissue Specific Knockout Mouse Model for Pancreatic Cancer. 36th annual Meeting of American Pancrease Association, 2005.
39. Pande M, Amos CI, Lynch PM, Frazier ML. SULT1A1 Polymorphisms and age of onset of Hereditary Nonpolyposis Colorectal Cancer. American Society of Preventive Oncology, 2005.
40. Zecevic M, Jones SJ, Campos IM, Amos CI, Lynch PM, Frazier ML. Insulin-like growth factor-1 (IGF-1) gene polymorphism and colon cancer risk in hereditary non-polyposis colorectal cancer (HNPCC). Third Annual American Association for Cancer Research International Conference: Frontiers in Cancer Prevention (AACR), Seattle, Washington, 10/2004.
41. Eaton O, Billings L, Kim K, Prieto V, Davis D, Frazier ML, Diwan AH, McGary E, Papadopoulos N, and Bedikian AY. Phase II trial of imatinib mesylate (STI-571) in metastatic melanoma (MM). American Society of Clinical Oncology, New Orleans, Louisiana, 6/2004.
42. Amos CI, Broaddus R, Jones S, Zong J, Pande M, Frazier ML. Risk assessment for HNPCC. Cancer Risk Prediction Meeting, Bethesda, Maryland, 5/2004.
43. Jones JS, Gu X, Lynch PM, Amos CI, Frazier ML. ATM Polymorphism and Age of Onset in Hereditary Nonpolyposis Colorectal Cancer. American Association for Cancer Research Annual Meeting, Orlando, Florida, 3/2004.
44. Wei C, Behringer R, Amos C, Frazier ML. Mutatin in the LKB1 and p53 genes cooperate in tumorigensis. Day of Preventin Science, 2004.
45. Chen J, Frazier ML. Polymorphisms in the DNA repair Gene XRCC1 and Hereditary Nonpolyposis Colorectal Cancer. Day of Pion Science, 2004.
46. Coolbaugh-Murphy MI, Frazier ML, Brown BW, Strong LC, Monckton DG, and Siciliano MJ. Microsatellite instability low (MSI-L) hereditary non-polyposis colon cancer (HNPCC) demonstrates MSI at multiple loci in tumor and constitutive DNA by small pool PCR. American Association for Cancer Research, San Francisco, California, 4/2002.
47. Molina M, Blanco C, Wu E, Sitja M, de Llorens R, and Frazier ML. Potato carboxypeptidase inhibitor, an EGF TGF antagonist, inhibits pancreatic tumor cell growth in vitro and in nude mice. American Pancreatic Association, Chicago Illinois, 11/1998.

Book Chapters

1. Pande M, Chen J, Wei C, Huang Y, Frazier ML. Mutations in Non-MMR Genes Modifying or Mimicking Lynch Syndrome Phenotype. In: DNA Alterations in Lynch Syndrome. Ed(s) Matjaz Vogelsang. Springer: Cape Town, South Africa, 136-170, 2013. ISBN: 978-94-007-6596-2.

Grant & Contract Support

Title: Genetic Predisposition to Early Onset of Colorectal Cancer
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Principal Investigator
Duration: 12/1/2011 - 11/30/2014
 
Title: Chemoprevention of Peutz-Jeghers Polyposis in a Mouse Model by Niclosamide
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Chongjuan Wei
Duration: 8/15/2011 - 7/31/2013
 
Title: Genetic Analysis of Anticipation in Lynch Syndrome
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Principal Investigator
Duration: 12/1/2010 - 11/30/2013
 
Title: Effects From Nicotinic Receptor Variations on Lung Cancer Risk and Smoking
Funding Source: CPRIT
Role: Co-Investigator
Principal Investigator: Christopher Amos
Duration: 5/1/2010 - 4/30/2013
 
Title: Mouse Model of Pancreatic Tumorigenesis with Dysregulation of mTOR
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Chongjuan Wei
Duration: 6/6/2008 - 5/31/2010
 
Title: The Microsatellite Instability Phenotype
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Michael Siciliano
Duration: 12/1/2005 - 11/30/2008
 
Title: Biomarkers for the Early Detection of Pancreatic Cancer
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Principal Investigator: Marsha Frazier, Ann Killary, Subrata Sen
Duration: 9/28/2004 - 6/30/2015
 
Title: Molecular Based Therapy for Oral Cancer Prevention, Project 4: Molecular Epidemiology and Pharmacogenetics in Oral Carcinogenesis
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Scott Lippman, Project 4 PI: Xifeng Wu
Duration: 8/1/2004 - 7/31/2010
 
Title: Cancer Center Support Grant - Biospecimen Extraction Resource
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Ronald A. DePinho
Duration: 9/4/1998 - 6/30/2013
 
Title: Molecular Genetics of Hereditary Nonpolyposis Colorectal Cancer
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 6/1/1997 - 6/30/2013

Last updated: 8/14/2013