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Marsha L. Frazier, PhD

Present Title & Affiliation

Primary Appointment

Adjunct Professor, The University of Texas Health Science Center, Graduate School of Biomedical Sciences, Houston, TX

Dual/Joint/Adjunct Appointment

Adjunct Professor, The University of Texas Health Science Center, Graduate School of Biomedical Sciences, Houston, TX

Office Address

The University of Texas M. D. Anderson Cancer Center
1155 Pressler Blvd
Unit Number: 1365
Houston, TX 77030
Room Number: CPB 7.3536
Fax: (713) 792-563-0999
Email: mlfrazier@mdanderson.org

Education & Training

Degree-Granting Education

1978 Pennsylvania State University, University Park, PA, PHD, Microbiology, Minor Biochemistry
1976 Miami University, Oxford, OH, MS, Microbiology
1972 Michigan State University, East Lansing, MI, BS, Biology

Experience/Service

Academic Appointments

Professor, Division of OVP, Cancer Prevention and Population Sciences, Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 2005-present
Adjunct Professor, The Universtiy of Texas Health Science, Graduate School of Biomedical Sciences, Houston, TX, 1992-2005
Assistant Professor of Biochemistry & Assistant Biochemist, Section of Gastrointestinal Oncology & Digestive Diseases, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1985-1992
Research Assistant Professor, Department of Medicine, Baylor College of Medicine, Houston, TX, 1982-1985

Administrative Appointments/Responsibilities

Advisory Committee for the Molecular Diagnostics Laboratory, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 1997-present
Human Clinical Cancer Genetics Implementation Committee, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 1997-2000
Faculty Selection Committee for the 1996 and 1997 BPW Past State President Award, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 1996-1997
Faculty Senator (elected), The University of Texas M.D. Anderson Cancer Center, Houston, TX, 1995-1997
DNA Analysis Facility Oversight Committee, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 1994-present

Institutional Committee Activities

Member, Lockton Distinguished Chair Search Committee, 2003
Member, Institutional Grants Committee, 2002
Member, Institutional Safety Committee, 1999-2001
Member, Study Section Review Committee for Basic Research Projects, 1999-2000
Member, Institutional Research Support Committee, 1997-1999
Member, Program Review Ad Hoc Committee for Faculty Senate, 1/1994-1996
Member, Biosafety Committee, 1992-1995
Member, Institutional Research Grant Committee, 1991-1994
Co-Chairman, Recombinant DNA Subcommitte, 1989-1995
Member, Animal Care and Use Committee, 1988-1990
Member, Recombinant DNA Subcommittee, 1987-1989

Honors and Awards

2009 Faculty Acheivement Awards Committee 2009, University of Texas M.D. Anderson Cancer Center
1988 Past Presidents' Award, The Texas Federation of Business and Professional Women

Selected Publications

Peer-Reviewed Original Research Articles
1. Reyes-Gibby CC, Shete S, Yennurajalingam S, Frazier ML, Bruera E, Kurzrock R, Crane CH, Abbruzzese J, Evans D, Spitz MR. Genetic and non-genetic covariates of pain severity in patients with adenocarcinoma of the pancreas: Assessing the influence of cytokine genes Journal of Pain and Symptom Management. In Press.
2. Chen J, Amos CI, Merriman KW, Wei Q, Sen S, Killary AM, Frazier ML. Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic whites: a case-control study. Pancreas. In Press.
3. Sen S, Wang J, Chen J, Chang P, Leblanc AB, Li D, Abbruzzese JL, Frazier ML, Killary AM. MicroRNAs in Plasma of Pancreatic Ductal Adenocarcinoma Patients as Novel Blood Based Biomarkers of Disease. Cancer Prevention Research. In Press.
4. Chen J, Li D, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Polymorphisms of p16, p27, p73 and MDM2 modulate response and survival of the pancreatic cancer patients treated with preoperative chemoradiation. Annals of Surgical Oncology. In Press.
5. Lott ST, Chen N, Chandler DS, Yang Q, Wang L, Rodriguez M, Xie H, Balasenthil S, Buchholz TA, Sahin AA, Chaung K, Zhang B, Olufemi SE, Chen J, Adams H, Band V, El-Naggar AK, Frazier ML, Keyomarsi K, Hunt KK, Sen S, Haffty B, Hewitt SM, Krahe R, Killary AM. DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer. PLoS Med 6(5). e-Pub 5/2009. PMCID: PMC2673042.
6. Wei C, Amos CI, Zhang N, Zhu J, Wang X, Frazier ML. Chemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model. Cancer Lett 277(2). e-Pub 1/2009. PMID: 19147279.
7. Ye Y, Lippman SM, Lee JJ, Chen M, Frazier ML, Spitz MR, Wu X. Genetic variations in cell-cycle pathway and the risk of oral premalignant lesions. Cancer 113(9):2488-95, 11/2008. PMCID: PMC2577230.
8. Pande M, Amos CI, Osterwisch DR, Chen J, Lynch PM, Broaddus R, Frazier ML. Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome. Cancer Epidemiol Biomarkers Prev 17(9):2393-401, 9/2008. PMID: 18768509.
9. Kim KB, Eton O, Davis DW, Frazier ML, McConkey DJ, Diwan AH, Papadopoulos NE, Bedikian AY, Camacho LH, Ross MI, Cormier JN, Gershenwald JE, Lee JE, Mansfield PF, Billings LA, Ng CS, Charnsangavej C, Bar-Eli M, Johnson MM, Murgo AJ, Prieto VG. Phase II trial of imatinib mesylate in patients with metastatic melanoma. British Journal of Cancer 99(5):734-40, 9/2008. PMID: 18728994.
10. Chen J, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer. Cancer Lett.272(1):32-9, 8/2008. e-Pub 8/2008. PMID: 18694622.
11. Chen LL, Holden JA, Choi H, Zhu J, Wu EF, Jones KA, Ward JH, Andtbacka RH, Randall RL, Scaife CL, Hunt KK, Prieto VG, Raymond AK, Zhang W, Trent JC, Benjamin RS, Frazier ML. Evolution from heterozygous to homozygous KIT mutation in gastrointestinal stromal tumor correlates with the mechanism of mitotic nondisjunction and significant tumor progression. Mod Pathol 21(7):826-36, 7/2008. PMID: 18488000.
12. Wei C, Amos CI, Zhang N, Wang X, Rashid A, Walker CL, Behringer RR, Frazier ML. Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling. Clin Cancer Res 14(4):1167-71, 2/2008. PMID: 18281551.
13. Pande M, Chen J, Amos CI, Lynch PM, Broaddus R, Frazier ML. Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associated risk for colorectal cancer in a caucasian lynch syndrome population. Cancer Epidemiol Biomarkers Prev 16(9):1753-9, 9/2007. PMID: 17855693.
14. Chen J, Li D, Wei C, Sen S, Killary AM, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Aurora-A and p16 Polymorphisms Contribute to an Earlier Age at Diagnosis of Pancreatic Cancer in Caucasians. Clin Cancer Res 13(10):3100-4, 5/2007. PMID: 17505013.
15. Chen J, Sen S, Amos CI, Wei C, Jones JS, Lynch P, Frazier ML. Association between Aurora-A kinase polymorphisms and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population. Mol Carcinog 46(4):249-256, 1/2007. PMID: 17219423.
16. Jones JS, Amos CI, Pande M, Gu X, Chen J, Campos IM, Wei Q, Rodriguez-Bigas M, Lynch PM, Frazier ML. DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset. Cancer Epidemiol Biomarkers Prev 15(5):886-91, 5/2006. PMID: 16702365.
17. Zecevic M, Amos CI, Gu X, Campos IM, Jones JS, Lynch PM, Rodriguez-Bigas MA, Frazier ML. IGF1 gene polymorphism and risk for hereditary nonpolyposis colorectal cancer. J Natl Cancer Inst 98(2):139-43, 1/2006. PMID: 16418517.
18. Gu J, Berman D, Lu C, Wistuba II, Roth JA, Frazier M, Spitz MR, Wu X. Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer. Clin Cancer Res 12:7329-38, 2006.
19. Li D, Frazier ML, Evans DB, Hess KR, Crane CH, Jiao L, Abbruzzese JL. Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. J Clin Oncol 24:1720-8, 2006.
20. Wei C, Amos CI, Stephens LC, Campos I, Deng JM Behringer RR Rashid A, Frazier ML. Mutation of LBK1 and p53 genes exert a cooperative effect on tumorigenesis. Cancer Research 65(24):11297-303, 12/2005.
21. Wei C, Amos CI, Stephens LC, Campos I, Deng JM, Behringer RR, Rashid A, Frazier ML. Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. Cancer Res 65(24):11297-303, 12/2005. PMID: 16357136.
22. Jones JS, Gu X, Lynch PM, Rodriguez-Bigas M, Amos CI, Frazier ML. ATM polymorphism and hereditary nonpolyposis colorectal cancer (HNPCC) age of onset (United States). Cancer Causes Control 16(6):749-53, 8/2005. PMID: 16049814.
23. Chen LL, Sabripour M, Wu EF, Prieto VG, Fuller GN, Frazier ML. A mutation-created novel intra-exonic pre-mRNA splice site causes constitutive activation of KIT in human gastrointestinal stromal tumors. Oncogene 24(26):4271-80, 6/2005. PMID: 15824741.
24. Gritz ER, Peterson SK, Vernon SW, Marani SK, Baile WF, Watts BG, Amos CI, Frazier ML, Lynch PM. Psychological impact of genetic testing for hereditary nonpolyposis colorectal cancer. J Clin Oncol 23(9):1902-10, 3/2005. PMID: 15774782.
25. Gorlov IP, Gorlova OY, Frazier ML, Amos CI. Missense mutations in cancer suppressor gene TP53 are colocalized with exonic splicing enhancers (ESEs). Mutat Res 554(1-2):175-83, 10/2004. PMID: 15450416.
26. Chen LL, Trent JC, Wu EF, Fuller GN, Ramdas L, Zhang W, Raymond AK, Prieto VG, Oyedeji CO, Hunt KK, Pollock RE, Feig BW, Hayes KJ, Choi H, Macapinlac HA, Hittelman W, Velasco MA, Patel S, Burgess MA, Benjamin RS, Frazier ML. A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res 64(17):5913-9, 9/2004. PMID: 15342366.
27. Jones JS, Chi X, Gu X, Lynch PM, Amos CI, Frazier ML. p53 polymorphism and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population. Clin Cancer Res 10(17):5845-9, 9/2004. PMID: 15355915.
28. Coolbaugh-Murphy M, Maleki A, Ramagli L, Frazier M, Lichtiger B, Monckton DG, Siciliano MJ, Brown BW. Estimating mutant microsatellite allele frequencies in somatic cells by small-pool PCR. Genomics 84(2):419-30, 8/2004. PMID: 15234004.
29. Amos CI, Keitheri-Cheteri MB, Sabripour M, Wei C, McGarrity TJ, Seldin MF, Nations L, Lynch PM, Fidder HH, Friedman E, Frazier ML. Genotype-phenotype correlations in Peutz-Jeghers syndrome. J Med Genet 41(5):327-33, 5/2004. PMCID: PMC1735760.
30. Zhu Y, Spitz MR, Zhang H, Grossman HB, Frazier ML, Wu X. Methyl-CpG-binding domain 2: a protective role in bladder carcinoma. Cancer 100(9):1853-8, 5/2004. PMID: 15112265.
31. Jones JS, Gu X, Campos IM, Lynch PM, Amos CI, Frazier ML. GSTM1 polymorphism does not affect hereditary nonpolyposis colorectal cancer age of onset. Cancer Epidemiol Biomarkers Prev 13(4):676-8, 4/2004. PMID: 15066938.
32. Wei C, Amos CI, Rashid A, Sabripour M, Nations L, McGarrity TJ, Frazier ML. Correlation of staining for LKB1 and COX-2 in hamartomatous polyps and carcinomas from patients with Peutz-Jeghers syndrome. J Histochem Cytochem 51(12):1665-72, 12/2003. PMID: 14623934.
33. Gorlov IP, Gorlova OY, Frazier ML, Amos CI. Missense mutations in hMLH1 and hMSH2 are associated with exonic splicing enhancers. Am J Hum Genet 73(5):1157-61, 11/2003. e-Pub 10/2003. PMCID: PMC1180494.
34. Frazier ML, Xi L, Zong J, Viscofsky N, Rashid A, Wu EF, Lynch PM, Amos CI, Issa JP. Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer. Cancer Res 63(16):4805-8, 8/2003. PMID: 12941799.
35. McGarrity TJ, Peiffer LP, Amos CI, Frazier ML, Ward MG, Howett MK. Overexpression of cyclooxygenase 2 in hamartomatous polyps of Peutz-Jeghers syndrome. Am J Gastroenterol 98(3):671-8, 3/2003. PMID: 12650805.
36. Lott ST, Chandler DS, Curley SA, Foster CJ, El-Naggar A, Frazier M, Strong LC, Lovell M, Killary AM. High frequency loss of heterozygosity in von Hippel-Lindau (VHL)-associated and sporadic pancreatic islet cell tumors: evidence for a stepwise mechanism for malignant conversion in VHL tumorigenesis. Cancer Res 62(7):1952-5, 4/2002. PMID: 11929809.
37. Zheng Y, Shen H, Sturgis EM, Wang LE, Eicher SA, Strom SS, Frazier ML, Spitz MR, Wei Q. Cyclin D1 polymorphism and risk for squamous cell carcinoma of the head and neck: a case-control study. Carcinogenesis 22(8):1195-9, 8/2001. PMID: 11470749.
38. Kong S, Wei Q, Amos CI, Lynch Wei C, Frazier MLM, Levin B, Zong j. Frazier ML,. Cyclin D1 polymorphis and increased risk of colorectal cancer at young age. J Natl Cancer 93(14):1106-08, 7/2001.
39. Frazier ML, O'Donnell FT, Kong S, Gu X, Campos I, Luthra R, Lynch PM, Amos CI. Age-associated risk of cancer among individuals with N-acetyltransferase 2 (NAT2) mutations and mutations in DNA mismatch repair genes. Cancer Res 61(4):1269-71, 2/2001. PMID: 11245417.
40. Peracaula R, Cleary KR, Lorenzo J, de Llorens R, Frazier ML. Human pancreatic ribonuclease 1: expression and distribution in pancreatic adenocarcinoma. Cancer 89(6):1252-8, 9/2000. PMID: 11002220.
41. Peng H, Xu F, Pershad R, Hunt KK, Frazier ML, Berchuck A, Gray JW, Hogg D, Bast RC, Jr, Yu Y. ARHI is the center of allelic deletion on chromosome 1p31 in ovarian and breast cancers. Int J Cancer 86(5):690-4, 6/2000. PMID: 10797292.
42. Amos CI, Frazier ML, Wang W. DNA pooling in mutation detection with reference to sequence analysis. Am J Hum Genet 66(5):1689-92, 5/2000. PMID: 10733464.
43. Fernandez-Salas E, Peracaula R, Frazier ML, de Llorens R. Ribonucleases expressed by human pancreatic adenocarcinoma cell lines. Eur J Biochem 267(5):1484-94, 3/2000. PMID: 10691987.
44. Kong S, Amos CI, Luthra R, Lynch PM, Levin B, Frazier ML. Effects of cyclin D1 polymorphism on age of onset of hereditary nonpolyposis colorectal cancer. Cancer Res 60(2):249-52, 1/2000. PMID: 10667569.
45. Molina MA, Sitja-Arnau M, Lemoine MG, Frazier ML, Sinicrope FA. Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. Cancer Res 59(17):4356-62, 9/1999. PMID: 10485483.
46. Sinicrope FA, Lemoine M, Xi L, Lynch PM, Cleary KR, Shen Y, Frazier ML. Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers. Gastroenterology 117(2):350-8, 8/1999. PMID: 10419916.
47. Frazier ML, Sinicrope FA, Amos CI, Cleary KR, Lynch PM, Levin B, Luthra R. Loci for efficient detection of microsatellite instability in hereditary non-polyposis colorectal cancer. Oncol Rep 6(3):497-505, 5/1999. PMID: 10203581.
48. Lin X, Choi JH, Lynch P, Xi L, Wu E, Frazier ML. Reduction in hMSH2 mRNA levels by premature translation termination: implications for mutation screening in hereditary nonpolyposis colorectal cancer. Dig Dis Sci 44(3):553-9, 3/1999. PMID: 10080150.
49. Frazier ML, Inamdar N, Alvula S, Wu E, Kim YH. Few point mutations in elongation factor-1gamma gene in gastrointestinal carcinoma. Mol Carcinog 22(1):9-15, 5/1998. PMID: 9609096.
50. Sinicrope FA, Roddey G, Lemoine M, Ruan S, Stephens LC, Frazier ML, Shen Y, Zhang W. Loss of p21WAF1/Cip1 protein expression accompanies progression of sporadic colorectal neoplasms but not hereditary nonpolyposis colorectal cancers. Clin Cancer Res 4(5):1251-61, 5/1998. PMID: 9607584.
51. Blanco-Aparicio C, Molina MA, Fernandez-Salas E, Frazier ML, Mas JM, Querol E, Aviles FX, de Llorens R. Potato carboxypeptidase inhibitor, a T-knot protein, is an epidermal growth factor antagonist that inhibits tumor cell growth. J Biol Chem 273(20):12370-7, 5/1998. PMID: 9575190.
52. Mathur S, Cleary KR, Inamdar N, Kim YH, Steck P, Frazier ML. Overexpression of elongation factor-1gamma protein in colorectal carcinoma. Cancer 82(5):816-21, 3/1998. PMID: 9486568.
53. Curley SA, Lott ST, Luca JW, Frazier ML, Killary AM. Surgical decision-making affected by clinical and genetic screening of a novel kindred with von Hippel-Lindau disease and pancreatic islet cell tumors. Ann Surg 227(2):229-35, 2/1998. PMID: 9488521.
54. Teng DH, Hu R, Lin H, Davis T, Iliev D, Frye C, Swedlund B, Hansen KL, Vinson VL, Gumpper KL, Ellis L, El-Naggar A, Frazier M, Jasser S, Langford LA, Lee J, Mills GB, Pershouse MA, Pollack RE, Tornos C, Troncoso P, Yung WK, Fujii G, Berson A, Steck PA, et al. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res 57(23):5221-5, 12/1997. PMID: 9393738.
55. Amos CI, Bali D, Thiel TJ, Anderson JP, Gourley I, Frazier ML, Lynch PM, Luchtefeld MA, Young A, McGarrity TJ, Seldin MF. Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p. Cancer Res 57(17):3653-6, 9/1997. PMID: 9288765.
56. Jones DV, Wu E, Manire M, Frazier ML. Cis-acting elements required for expression of the nonspecific cross-reacting antigen gene in colorectal carcinoma. Gastroenterology 112:776-82, 3/1997. PMID: 9041239.
57. Abbruzzese JL, Evans DB, Raijman I, Larry L, King T, Leach SD, Frazier ML. Detection of mutated c-Ki-ras in the bile of patients with pancreatic cancer. Anticancer Res 17(2A):795-801, 3/1997. PMID: 9137410.
58. Souza RF, Appel R, Yin J, Wang S, Smolinski KN, Abraham JM, Zou TT, Shi YQ, Lei J, Cottrell J, Cymes K, Biden K, Simms L, Leggett B, Lynch PM, Frazier M, Powell SM, Harpaz N, Sugimura H, Young J, Meltzer SJ. Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours. Nat Genet 14(3):255-7, 11/1996. PMID: 8896552.
59. Ghusn H, Arem R, Frazier M, Chamakhi S, Ezzaouia G, Chan L. Restriction fragment length polymorphism of the human apo B and apo AII gene regions among type II diabetics. Res Commun Mol Pathol Pharmacol 93(1):25-32, 7/1996. PMID: 8865367.
60. Stern MP, Mitchell BD, Blangero J, Reinhart L, Krammerer CM, Harrison CR, Shipman PA, O'Connell P, Frazier ML, MacCluer JW. Evidence for a major gene for type II diabetes and linkage analyses with selected candidate genes in Mexican-Americans. Diabetes 45(5):563-8, 5/1996. PMID: 8621004.
61. Evans DB, Frazier ML, Charnsangavej C, Katz RL, Larry L, Abbruzzese JL. Molecular diagnosis of exocrine pancreatic cancer using a percutaneous technique. Ann Surg Oncol 3(3):241-6, 5/1996. PMID: 8726178.
62. Frazier ML, Fernandez E, de Llorens R, Brown NM, Pathak S, Cleary KR, Abbruzzese JL, Berry K, Olive M, Le Maistre A, Evans DB. Pancreatic adenocarcinoma cell line, MDAPanc-28, with features of both acinar and ductal cells. Int J Pancreatol 19(1):31-8, 2/1996. PMID: 8656025.
63. Jeon HM, Lynch PM, Howard L, Ajani J, Levin B, Frazier ML. Mutation of the hMSH2 gene in two families with hereditary nonpolyposis colorectal cancer. Hum Mutat 7(4):327-33, 1996. PMID: 8723682.
64. Mitchell BD, Kammerer CM, O'Connell P, Harrison CR, Manire M, Shipman P, Moyer MP, Stern MP, Frazier ML. Evidence for linkage of postchallenge insulin levels with intestinal fatty acid-binding protein (FABP2) in Mexican-Americans. Diabetes 44(9):1046-53, 9/1995. PMID: 7657027.
65. Githens S, Schexnayder JA, Moses RL, Denning GM, Smith JJ, Frazier ML. Mouse pancreatic acinar/ductular tissue gives rise to epithelial cultures that are morphologically, biochemically, and functionally indistinguishable from interlobular duct cell cultures. In Vitro Cell Dev Biol Anim 30A(9):622-35, 9/1994. PMID: 7529626.
66. Fernandez E, Fallon MJ, Frazier ML, de Llorens R, Cuchillo CM. Expression of acinar and ductal products in Capan-1 cells growing in synthetic serum and serum-free media. Cancer 73(9):2285-95, 5/1994. PMID: 7513248.
67. Dohi DF, Sutton RC, Frazier ML, Nakamori S, McIsaac AM, Irimura T. Regulation of sialomucin production in colon carcinoma cells. J Biol Chem 268(14):10133-8, 5/1993. PMID: 8098036.
68. Ioannides CG, Fisk B, Pollack MS, Frazier ML, Taylor Wharton J, Freedman RS. Cytotoxic T-cell clones isolated from ovarian tumour infiltrating lymphocytes recognize common determinants on non-ovarian tumour clones. Scand J Immunol 37(4):413-24, 4/1993. PMID: 8469924.
69. Ender B, Lynch P, Kim YH, Inamdar NV, Cleary KR, Frazier ML. Overexpression of an elongation factor-1 gamma-hybridizing RNA in colorectal adenomas. Mol Carcinog 7(1):18-20, 1993. PMID: 8382068.
70. Chi K, Jones DV, Frazier ML. Expression of an elongation factor 1 gamma-related sequence in adenocarcinomas of the colon. Gastroenterology 103(1):98-102, 7/1992. PMID: 1612363.
71. Frazier ML, Brown N, Pathak S, Mackay B, Cleary K, Olive M, Byrd DR, Evans DB, Levin B. Human cell line from an adenocarcinoma of the ampulla of Vater. In Vitro Cell Dev Biol 28A(3 Pt 1):149-53, 3/1992. PMID: 1582987.
72. Githens S, Schexnayder JA, Frazier ML. Carbonic anhydrase II gene expression in mouse pancreatic duct cells. Pancreas 7(5):556-61, 1992. PMID: 1381098.
73. Lew Y, Jones DV, Mars WM, Evans D, Byrd D, Frazier ML. Expression of elongation factor-1 gamma-related sequence in human pancreatic cancer. Pancreas 7(2):144-52, 1992. PMID: 1372736.
74. Chi KF, Jessup JM, Frazier ML. Predominant expression of mRNA coding for nonspecific cross-reacting antigen in colorectal carcinomas. Tumour Biol 12(5):298-308, 1991. PMID: 1962152.
75. Frazier ML, Lilly BJ, Wu EF, Ota T, Hewett-Emmett D. Carbonic anhydrase II gene expression in cell lines from human pancreatic adenocarcinoma. Pancreas 5(5):507-14, 9/1990. PMID: 1700414.
76. Frazier ML, Pathak S, Wang ZW, Cleary K, Singletary SE, Olive M, Mackay B, Steck PA, Levin B. Establishment of a new human pancreatic adenocarcinoma cell line, MDAPanc-3. Pancreas 5(1):8-16, 1990. PMID: 1688394.
77. Raboudi SH, Frazier ML. Restriction fragment length polymorphism of the human insulin receptor gene among Mexican Americans. Res Commun Chem Pathol Pharmacol 65(3):319-35, 9/1989. PMID: 2573118.
78. Raboudi SH, Mitchell BD, Stern MP, Eifler CW, Haffner SM, Hazuda HP, Frazier ML. Type II diabetes mellitus and polymorphism of insulin-receptor gene in Mexican Americans. Diabetes 38(8):975-80, 8/1989. PMID: 2568958.
79. Stallings RL, Siciliano MJ, Frazier ML, al-Ubaidi MR, Kellems RE. Hypomethylation and ADA gene expression in mouse CAK cells. Somat Cell Mol Genet 15(1):1-11, 1989. PMID: 2464855.
80. Su CJ, White JW, Li WH, Luo CC, Frazier ML, Saunders GF, Chan L. Structure and evolution of somatostatin genes. Mol Endocrinol 2(3):209-16, 3/1988. PMID: 2899837.
81. D'Agostino J, Younes MA, White JW, Besch PK, Field JB, Frazier ML. Cloning and nucleotide sequence analysis of complementary deoxyribonucleic acid for bovine preproinsulin. Mol Endocrinol 1(4):327-31, 4/1987. PMID: 2456452.
82. Mars WM, Stellrecht CM, Stass S, Frazier ML, Saunders GF. Localization of an abundant myeloid mRNA to individual leukocytes in mixed cell populations. Leukemia 1(3):167-72, 3/1987. PMID: 3478537.
83. Frazier ML, Ferrell RE, Arem R, Chamakhi S, Field JB. Restriction fragment length polymorphism of the human insulin gene region among type II diabetic Mexican-Americans and Tunisians. Res Commun Chem Pathol Pharmacol 52(3):371-86, 6/1986. PMID: 3016846.
84. Nicolson GL, LaBiche RA, Frazier ML, Blick M, Tressler RJ, Reading CL, Irimura T, Rotter V. Differential expression of metastasis-associated cell surface glycoproteins and mRNA in a murine large cell lymphoma. J Cell Biochem 31(4):305-12, 1986. PMID: 3760037.
85. D'Agostino J, Field JB, Frazier ML. Ontogeny of immunoreactive insulin in the fetal bovine pancreas. Endocrinology 116(3):1108-16, 3/1985. PMID: 3882396.
86. Majumdar AP, Frazier ML. Cell-free synthesis of rat epidermal growth factor-like polypeptide. Res Commun Chem Pathol Pharmacol 46(1):103-11, 10/1984. PMID: 6334338.
87. Lopez LC, Li WH, Frazier ML, Luo CC, Saunders GF. Evolution of glucagon genes. Mol Biol Evol 1(4):335-44, 7/1984. PMID: 6599970.
88. Lopez LC, Frazier ML, Su CJ, Kumar A, Saunders GF. Mammalian pancreatic preproglucagon contains three glucagon-related peptides. Proc Natl Acad Sci U S A 80(18):5485-9, 9/1983. PMID: 6577439.
89. Frazier ML, Mars W, Florine DL, Montagna RA, Saunders GF. Efficient extraction of RNA from mammalian tissue. Mol Cell Biochem 56(2):113-22, 1983. PMID: 6196612.
90. Hall SW, Strong JE, Broughton A, Frazier ML, Benjamin RS. Bleomycin clinical pharmacology by radioimmunoassay. Cancer Chemother Pharmacol 9(1):22-5, 1982. PMID: 6183016.
91. Frazier ML, Montagna RA, Saunders GF. Insulin gene expression during development of the fetal bovine pancreas. Biochemistry 20(2):367-71, 1/1981. PMID: 6162484.
92. Frazier ML, Zimmerman LN. Plasmid-borne resistance to ultraviolet light and phage in Streptococcus faecalis ssp. zymogens. Can J. Microbioliol 26(10):1253-5, 10/1980. PMID: 6780172.

Invited Articles
1. Chen LL, Sabripour M, Andtbacka RH, Patel SR, Feig BW, Macapinlac HA, Choi H, Wu EF, Frazier ML, Benjamin RS. Imatinib resistance in gastrointestinal stromal tumors. Curr Oncol Rep 7(4):293-9, 7/2005. PMID: 15946589.

Abstracts
1. Wei C, Amos CI, Frazier ML. Downregulation of LKB1 in Pancreatic Cancer. 2009 APA Annual Meeting, 2009.
2. Pande M, Frazier ML, Osterwisch DR, Amos CI,. Geonome wide Association Identified Colorectal Cancer Susceptibility Loci and Colorectal Cancer risk in Lynch Syndrome. 13th Annual CGA-ICC Meeting, 2009.
3. Pande M, Amos CI, Osterwisch DR, Frazier ML. Ieractions between cigarette smoking and selected candidate gene polymorphisms in risk for colorectal cancer: a case-only analysis (abstract/program 1127/W). 59th Annual Meeting of The American Society of Human Genetics, 2009.
4. Pande M, Osterwisch DR, Amos CI, Frazier ML. Making sense of Missense Variants in DNA mismatch repair genes. Annual Meeting of the American Association of Cancer Research (AACR),, 2009.
5. Amos Ci, Wei C, Spitz MR, Wun I, Frazier ML. The Nicotinic Acetylcholine Receptor region on chronomosome 15q25 assoicates with adencoarcinoma of the lung in African-Americans. ASHG Annual Meeting, 2009.
6. Pande M, Amos CI, Lynch PM, Campbell PT, Jenkins MA, Hopper JL, Lindor N, Le Marchand L, Gallinger S, Haile RW, Newcomb PA, Potter JD, Frazier ML. Association between smoking and colorectal cancer in individuals with Lynch Syndrome. 12th Annual Meeting of the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGAICC), 2008.
7. Wei C, Zhang N, Amos CI, Wang X, Walker. Rapamycin trial on a mouse model for Peutz-Jeghers Syndrome. 60th Annual Symposium on Cancer Research, 2007.
8. Wei C, Amos CI, Zhang N, Frazier ML,. Targeting mTOR signaling in a mouse model for Peutz-Jeghers Syn drome. Colorectal Cancer: Celebrating a Career in Cancer Prevention, 2007.
9. Chen J,Etzel CJ, Amos CI, Zhang Q, Viscofsky N, Lyynch PM, Frazier ML. Using tree-model to identify genetic detrminant of early onset of Hereditary Nonpolyposis Colorectal Cancr. American Society of Prevetive Oncology 31st Annual Meeting, 2007.
10. Killary AM, Frazier ML, Lott S, Carter J, Stivers D, Chen J, Hwang R, Abbruzzese J, Sen S. A Functional Genomic Approach to Biomarker Discovery in Pancreatic Cancer. 4th Early Detection Reseach Network (EDRN) Scientific Workshop, 2006.
11. Pande M, Chen J, Viscofsky N, Amos CI, Lynch PM, Frazier ML. MTHFR Polymorphism C677T is associated with an earlier age of onset of Colorectal Cancer in Lynch Syndrome. Annual AACR International conference on Frontiers in Cancer Prevention Research, 2006.
12. Pande M, Amos CI, Viscofsky N, Lynch PM, Frazier ML. Probands and non-probands differ by age of onset to colorectal cancer in Lynch syndrome. 10th Annual Meeting of CGAICC, 2006.
13. Wei C, Longnecker D, Rashid a, Zhu J, Amos C, Gannon M, Frazier ML. The role of LKB1 gene in the pancreatic tumorigenesis. Day of Prevention Science, 2006.
14. Chen j, Frazier ML. Association Between Aurora-A Polymorphism and Onset Age of Hereditary Nonpolyposis Colorectal Cancer. 2nd NCI Epidemiology Leadership Workshop, 2005.
15. Wei C, Amos C, Stephens C, Behringer RI, Frazier ML. Cooperative tumorigenic effects of germline mutations in the LKB1 and p53. 2nd Annual cell signaling symposium, 2005.
16. Pande M, Amos CI, Lynch PM, Frazier ML. EPHX1 Polymorphisms and age of onset of Hereditary Nonpolyposis Colorectal Cancer. American Society of Preventive Oncology, 2005.
17. Li D, Liu H, Evans DB, Abbruzzese JL, Frazier ML. Genetic Polymorphisms as Significant Prognosis Factors for Patients with Pancreatic Adenocarcinoma. 13th Spore Investigator Workshop, 2005.
18. Frazier ML, Chen J, Jones JS, Lynch PM, Lindor N, Amos CI. Influence of SNPs in Cell Cycle Control Genes on Age Associated Risk for Hereditary Nonpolyposis Colorectal Cancer, Breast & Colon Cancer. Family Registry (BC-CFR) Biannual Meeting, 2005.
19. Wei C, Rashid A, Amos C, Gannon M, Frazier ML. LKB1 Gene Tissue Specific Knockout Mouse Model for Pancreatic Cancer. 36th annual Meeting of American Pancrease Association, 2005.
20. Pande M, Amos CI, Lynch PM, Frazier ML. SULT1A1 Polymorphisms and age of onset of Hereditary Nonpolyposis Colorectal Cancer. American Society of Preventive Oncology, 2005.
21. Zecevic M, Jones SJ, Campos IM, Amos CI, Lynch PM, and Frazier ML. Insulin-like growth factor-1 (IGF-1) gene polymorphism and colon cancer risk in hereditary non-polyposis colorectal cancer (HNPCC). Third Annual American Association for Cancer Research International Conference: Frontiers in Cancer Prevention (AACR), Seattle, Washington, 10/2004.
22. Eaton O, Billings L, Kim K, Prieto V, Davis D, Frazier ML, Diwan AH, McGary E, Papadopoulos N, and Bedikian AY. Phase II trial of imatinib mesylate (STI-571) in metastatic melanoma (MM). American Society of Clinical Oncology, New Orleans, Louisiana, 6/2004.
23. Amos CI, Broaddus R, Jones S, Zong J, Pande M, and Frazier ML. Risk assessment for HNPCC. Cancer Risk Prediction Meeting, Bethesda, Maryland, 5/2004.
24. Jones JS, Gu X, Lynch PM, Amos CI, and Frazier ML. ATM Polymorphism and Age of Onset in Hereditary Nonpolyposis Colorectal Cancer. American Association for Cancer Research Annual Meeting, Orlando, Florida, 3/2004.
25. Wei C, Behringer R, Amos C, Frazier ML. Mutatin in the LKB1 and p53 genes cooperate in tumorigensis. Day of Preventin Science, 2004.
26. Chen J, Frazier ML. Polymorphisms in the DNA repair Gene XRCC1 and Hereditary Nonpolyposis Colorectal Cancer. Day of Pion Science, 2004.

Grant & Contract Support

Title: Mouse Model of Pancreatic Tumorigenesis with Dysregulation of mTOR
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 6/1/2008 - 5/31/2010
 
Title: Biomarkers for the Early Detection of Pancreatic Cancer
Funding Source: NIH/NCI
Role: PI on Project 3
Principal Investigator: Ann M Killary
Duration: 12/1/2004 - 11/30/2007
 
Title: Molecular Based Therapy for Oral Cancer Prevention, Project 4: Molecular Epidemiology and Pharmacogenetics in Oral Carcinogenesis
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Scott Lippman, Project 4 PI: Xifeng Wu
Duration: 8/1/2004 - 7/31/2010

Last updated: 8/18/2009