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Marta Penas-Prado, M.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Neuro-Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

I received my medical degree from the Universidad de Santiago de Compostela, Spain in 1998. My Postgraduate training is as follows: residency training in Neurology at the Hospital Universitario Doce de Octubre in Madrid, Spain (1999-2003). Fellowship in Neuro-Oncology at M. D. Anderson Cancer Center in Houston, Texas (2005-2007). Master’s degree in Molecular Oncology from the Centro Nacional de Investigaciones Oncologicas (CNIO) (Spanish National Cancer Research Center) in Madrid, Spain (2008-2010). My research during my Neuro-oncology fellowship focused on the analysis of treatment modalities and outcome of adult patients with medulloblastoma. My research project for the master’s degree evaluated the prognostic value of Wnt/beta-catenin pathway in adult PNETs and medulloblastomas. After my fellowship, I worked as a neurologist/neuro-oncologist in Hospital Universitario Doce de Octubre and Hospital Ruber Internacional (2008-2011) in Madrid, Spain. I joined the Department of Neuro-Oncology at MD Anderson Cancer Center as Assistant Professor in November 2011.

 My main research interests are the development of clinical trials with targeted agents for malignant gliomas and adult medulloblastoma. My research overview is as follows: active enrollment of patients in clinical trials for newly diagnosed and recurrent malignant gliomas and implementation of a clinical research program in adult medulloblastomas. I am principal investigator of the following active clinical trials (selected): Protocol 2011-0374. A Phase I lead-in to a 2x2x2 Factorial Trial of Dose Dense Temozolomide, Memantine, Mefloquine, and Metformin As Post-Radiation Adjuvant Therapy of Glioblastoma Multiforme. Protocol BTTC09-01. Phase I-II Everolimus and Sorafenib in Recurrent High-Grade Gliomas. Protocol 2012-0392. A Phase Ib, Multi-Center, Open Label, Dose Escalation Study of Oral LDE225 in Combination with BKM120 in Patients with Advanced Solid Tumors. Protocol CLDE225C2301. A Phase III, multi-center, open-label, randomized, controlled study of the efficacy and safety of oral LDE225 versus temozolomide in patients with Hh-pathway activated relapsed medulloblastoma.

 

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number: 431
Houston, TX 77030

Education & Training

Degree-Granting Education

1998 Facultad de Medicina y Odontología. Universidad de Santiago de Compostela, Madrid, Spain, MD, Medicine

Postgraduate Training

6/2009 Clinical Observer, Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
1/2005-12/2007 Fellow, Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
3/2003-4/2003 Clinical Observer, Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
7/1999-6/2003 Resident, Neurology, Hospital Universitario Doce de Octubre., Madrid, Spain

Experience/Service

Institutional Committee Activities

Member, Clinical Research Committee (CRC3), 9/2013-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Ghia AJ, Chang EL, Allen PK, Mahajan A, Penas-Prado M, McCutcheon IE, Brown PD. Intracranial hemangiopericytoma: patterns of failure and the role of radiation therapy. Neurosurgery 73(4):624-30; discussion 630-1, 10/2013. PMID: 23839520.
2. Yust-Katz S, Garciarena P, Liu D, Yuan Y, Ibrahim N, Yerushalmi R, Penas-Prado M, Groves MD. Breast cancer and leptomeningeal disease (LMD): hormone receptor status influences time to development of LMD and survival from LMD diagnosis. J Neurooncol 114(2):229-35, 9/2013. e-Pub 6/12/2013. PMID: 23756727.
3. Fakhreddine MH, Mahajan A, Penas-Prado M, Weinberg J, McCutcheon IE, Puduvalli V, Brown PD. Treatment, prognostic factors, and outcomes in spinal cord astrocytomas. Neuro Oncol 15(4):406-12, 4/2013. e-Pub 1/14/2013. PMCID: PMC3607259.
4. Ghia AJ, Allen PK, Mahajan A, Penas-Prado M, McCutcheon IE, Brown PD. Intracranial Hemangiopericytoma and the Role of Radiation Therapy: A Population Based Analysis. Neurosurgery 72(2):203-9, 2/2013. e-Pub 11/2012. PMID: 23149953.
5. Penas-Prado M, Armstrong TS, Gilbert MR. Glioblastoma. Handb Clin Neurol 105:485-506, 2012. PMID: 22230514.
6. Sierra-Hidalgo F, Penas-Prado M, Martín-Gil L, Herreros-Rodríguez J, Hilario-Barrio A, Ruiz-Morales J. Cerebral infarctions and leptomeningeal carcinomatosis. Rev Neurol 49(3):156, Aug 1-15, 8/2009. PMID: 19621311.
7. Penas-Prado M, Loghin ME. Spinal cord compression in cancer patients: review of diagnosis and treatment. Curr Oncol Rep 10(1):78-85, 1/2008. PMID: 18366964.
8. Penas-Prado M, Gilbert MR. Molecularly targeted therapies for malignant gliomas: advances and challenges. Expert Rev Anticancer Ther 7(5):641-61, 5/2007. PMID: 17492929.
9. Penas-Prado M, Martínez-Salio A, Porta-Etessam J, Villarejo-Galende A, García-Ramos R, Saiz-Díaz RA, Moreno-Ramos T. Post-traumatic supraorbital neuralgia: a benign condition. Rev Neurol 44(2):89-91, Jan 16-31, 1/2007. PMID: 17236147.
10. Fernández-Miranda C, de la Peña P, Penas M, Saiz R, Gómez P, Gómez de la Cámara A. Hyperhomocysteinemia and treatment with antiepileptic drugs. Effects of different doses of folic acid. Med Clin (Barc) 124(14):521-4, 4/2005. PMID: 15847747.
11. Galende AV, Camacho A, Gomez-Escalonilla C, Penas M, Juntas R, Ramos A, Esteban J. Lateral medullary infarction secondary to vertebral artery dissection presenting as a trigeminal autonomic cephalalgia. Headache 44(1):70-4, 1/2004. PMID: 14979886.
12. Villarejo A, Porta-Etessam J, Camacho A, González De La Aleja J, Martínez-Salio A, Penas M. Gabapentin for painful legs and moving toes syndrome. Eur Neurol 51(3):180-1, 2004. e-Pub 4/2004. PMID: 15073446.
13. Villarejo-Galende A, Camacho-Salas A, Penas-Prado M, Juntas-Morales R, Gonzalez-de la Aleja J, Ramos A, Rodríguez-Vallejo A. Spinal epidural abscess in a patient with septicaemia. Rev Neurol 36(12):1152-5, Jun 16-30, 6/2003. PMID: 12833235.
14. González de la Aleja Tejera J, Penas Prado M, González Martínez V, Rodríguez Peña-Marín M. Spontaneous spinal epidural hematoma. Neurologia 18(5):285-6, 6/2003. PMID: 12768518.
15. Villarejo A, Camacho A, García-Ramos R, Moreno T, Penas M, Juntas R, Ruiz J. Cholinergic-dopaminergic imbalance in Pisa syndrome. Clin Neuropharmacol 26(3):119-21, May-Jun, 5/2003. PMID: 12782913.
16. Villarejo-Galende A, Camacho-Salas A, Penas-Prado M, García-Ramos R, Mendoza MC, Simón de las Heras R, Mateos-Beato F. Unilateral isolated paralysis of the soft palate: a case report and a review of the literature. Rev Neurol 36(4):337-9, Feb 15-28, 2/2003. PMID: 12599130.
17. Martínez-Salio A, Penas M, Porta-Etessam J, Lizasoain M. Autoimmune meningitis simulating bacterial meningitis. Enferm Infecc Microbiol Clin 20(10):535-6, 12/2002. PMID: 12433357.
18. Penas M, Blanco A, Villarejo A, Juntas R, Miranda P, Martínez A. Subacute combined degeneration of the spinal cord: MR findings. Neurologia 17(8):447-8, 10/2002. PMID: 12396977.
19. Martínez-Salio A, Penas M, Blanco A, Miranda P, Porta-Etessam J, Posada I. Brachial plexopathy in varicella of the adults. A case report. Rev Neurol 33(6):599-600, Sep 16-30, 9/2001. PMID: 11727250.
20. Penas-Prado M, Díaz-Guzmán J, Jiménez-Huerta I, Juntas-Morales R, Villarejo-Galende A, Díez-Torres I. Gradenigo syndrome as the form of presentation of nasopharyngeal carcinoma. Rev Neurol 32(7):638-40, Apr 1-15, 4/2001. PMID: 11391492.

Abstracts

1. Anderson MD, Theeler BJ, Penas-Prado M, Groves MD, Yung WK. Bevacizumab use in disseminated choroid plexus papilloma. J Neurooncol 114(2):251-3, 9/2013. e-Pub 6/2013. PMID: 23761024.

Last updated: 11/25/2014