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Mary E. Edgerton, M.D., PH.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Adjunct Professor, School of Health Information Sciences, University of Texas Health Science Center at Houston, Houston, TX

Bio Statement

 Mary E. Edgerton was born in Austin, Texas and was raised in the Rio Grande Valley. She received a B.S. in Physics with Highest Honors from the University of Texas at Austin.  Following this, she was a Marshall Scholar to the United Kingdom where she received a Ph.D. in Biophysics from the University of East Anglia. She completed postdoctoral studies at the Unviersity of California at San Francisco and at the State university of New York at Stony Brook, and then worked for nine years for Exxon and then Mobil Oil Company in their research laboratories.  She left the research laboratoires to attend medical school, and obtained her MD. from Medical College of Pennsylvania in Philadelphia. She completed her pathology residency and surgical pathology fellowship at the Hospital of the University of Pennsylvania.  She is board certified in Anatomic and Clinical Pathology and was an Assistant Professor of Pathology at Vanderbilt University and an Associate Professor in the Division of Anatomic Pathology at the Moffitt Cancer Center before coming to MD Anderson, where she is currently an Associate Professor with tenure. 

Research Interests

Dr. Edgerton’s research is focused on discovery of mechanisms in cancer genesis and progression. She has worked on the development of mathematical models for computer simulations of spread of ductal carcinoma in situ, and the role of cell motility in extensive disease. She also researches methods for the analysis of gene expression array data for pathway discovery. She has published on the application of these methods to lung cancer and breast cancer profiles data. In addition to researching mechanisms, Dr. Edgerton has worked on the development of integrated information platforms for tissue acquisition, clinical annotation, and molecular profiling. She has contributed to the development of standards for data sharing and to ontologies to be used for tissue annotation.    

Clinical Interests

Mary E. Edgerton,M.D., Ph.D. is board certified in Anatomic and Clinical Pathology. She completed a fellowship in surgical pathology before she joined David L. Page at Vanderbilt University where she worked for five years in breast and surgical pathology. She has also worked in the area of pathology informatics. Dr. Edgerton works now as a breast pathologist and as a pathology informatician. Her clinical interests are in breast neoplasia and in informatics related to tissue banking.

Education & Training

Degree-Granting Education

1994 Medical College of Pennsylvania, Philadelphia, PA, MD, Medicine
1979 University of East Anglia, Norwich, United Kingdom, PHD, Biophysics
1976 University of Texas, Austin, TX, BS, Physics

Postgraduate Training

7/1999-6/2000 Clinical Fellowship, Surgical Pathology, Hospital of the University of Pennsylvania, Philadelphia, PA, John Tomaszewski, MD
7/1995-6/1999 Clinical Residency, Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, James Wheeler, MD
6/1994-6/1995 Clinical Internship, Medical College of Pennsylvania, Philadelphia, PA, Alan Tunkel, MD, PhD
9/1980-8/1981 Research Fellowship, State University of New York, Stony Brook, NY, Cheng-Wen Wu, MD, PhD
9/1979-8/1980 Research Fellowship, University of California, San Francisco, CA, Walther Stoeckenius, PhD

Board Certifications

10/1999 American Board of Pathology

Experience/Service

Academic Appointments

Associate Professor, Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 7/2005-8/2006
Associate Professor, Department of Interdisciplinary Oncology, School of Medicine, University of South Florida, Tampa, FL, 7/2005-8/2006
Assistant Professor, Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, 7/2000-7/2005
Assistant Professor, Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN, 7/2000-7/2005

Administrative Appointments/Responsibilities

Director of Biorepository Informatics, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011-present
Co-Director, Tissue Shared Resource, H. Lee Moffitt Research Institute, Tampa, FL, 9/2005-8/2006
Member, Scientific Advisory Committee, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 7/2005-8/2006
Member, Scientific Leadership Council, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 7/2005-8/2006
Committee Chair, Bioinformatics Steering Committee, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 7/2005-8/2006
Member, Promotion and Tenure Committee, Department of Interdisciplinary Oncology, University of South Florida, Tampa, FL, 7/2005-8/2006
Committee Co-Chair, Biospecimen Repository Working Group, Total Cancer Care, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 7/2005-8/2006
Committee Chair, Bioinformatics Working Group, Total Cancer Care, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 7/2005-8/2006
Director, Informatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 7/2005-8/2006
Member, Informatics Cluster Advisory Board, Vanderbilt-Ingram Cancer Center, Nashville, TN, 1/2003-5/2006
Committee Chair, Tissue Informatics Core Advisory Board, Vanderbilt-Ingram Cancer Center, Nashville, TN, 10/2002-5/2005
Member, Tissue Core Advisory Board, Vanderbilt-Ingram Cancer Center, Nashville, TN, 10/2002-5/2005
Director, Tissue Informatics Shared Resource, Vanderbilt-Ingram Cancer Center, Nashville, TN, 8/2001-5/2005

Other Appointments/Responsibilities

Senior Research Physicist, Mobil Research & Development Corporation, Princeton, NJ, 10/1985-8/1990
Senior Analyst, Exxon Research & Engineering Company, Annandale, NJ, 7/1985-8/1985
Analyst, Exxon Research & Engineering Company, Annandale, NJ, 9/1980-7/1985

Consultantships

Ad Hoc Consulting, Academic Institutions and Cancer Centers, Academic Institutions both US and non-US, 2006-present
Consultant, Advisory Board, Multiple Myeloma Research Consortium/Multiple Myeloma Research Foundation Scientific Advisory Board, Chicago, IL, 2005
Member, CaBIG Integrative Cancer Research Workspace, National Cancer Institute, Washington, D.C., 2004-2007
Member, National Functional Genomics Consortium Advisory Board, Tampa, FL, 2004-2005
Member, Lung Adenocarcinoma Group, National Cancer Institute, Washington, D.C., 2002-2006
Tissue Informatics Consultant for National Biospecimen Network, National Cancer Institute, Washington, D.C., 2002-2003
Member, Lung Progress Review Board, National Cancer Institute, Washington, D.C., 2001
Consultant, National Institute of Health, Washington, D.C., 1/1999-4/1999

Institutional Committee Activities

Tissue Banking Informatics Consultant, Global Oncology Associates for Pathology, 3/2011-present
Member, eResearch Steering Committee, 1/2011-present
Co-Chair, TissueStation Deployment Steering Committee, 1/2011-present
Member, Structured Pathology Reporting Development Team, 11/2010-present
Member, Research and Education Information Services Steering Team, 10/2010-present
Member, Special Committee to Evaluate caTissue, 2009-2010
Non-Voting Member, Breast Tumor Bank Steering Committee, 5/2008-present
Member, Velos Evaluation Committee, 2008
Member, TissueStation Deployment Steering Committee, 9/2007-12/2010
Member, Clinical and Research Informatics Committee, 9/2006-present

Honors and Awards

1999-2000 Arthur Purdy Stout Fellow, Arthur Purdy Stout Society
1999 Informatics Award (Fall), College of American Pathologists
1999 Informatics Award (Spring), College of American Pathologists
1994-present Member, Alpha Omega Alpha
1994 Janet Glasgow Memorial Citation, American Medical Women's Association
1994 Magna Cum Laude, Medical College of Pennsylvania
1994 Rittenhouse Book Award, Rittenhouse Bookstore
1991-1994 Merit Scholarship, Medical College of Pennsylvania
1991-1992 Career Development Scholarship, American Association of University Women
1988 Innovative Research Award, Mobil Research & Development Corporation
1976-present Member, Phi Beta Kappa
1976-present Member, Phi Kappa Phi
1976-present Member, Mortar Board
1976-1979 Marshall Scholarship to the United Kingdom, Marshall Commission
1976 Summa Cum Laude, University of Texas at Austin
1975-1976 Junior Fellow, University of Texas
1972-1976 Dean's Honor List, University of Texas at Austin

Professional Memberships

American Association for Cancer Research
Member, 2007-present
American Association of Cancer Institutes
Chair, Bioinformatics Subcommittee, 2001
American Association of Clinical Oncologists
Member, 2007-present
Association of Pathology Informatics
Member, 2000-present
Chairman, Research Committee, 2000-2003
Member, Technical Standards Committee, 2000-2003
Member, Executive Planning Committee, 1999-2000
College of American Pathologists
Junior Member, Informatics Committee, 1999-2001
Member, 1995-present
Houston Society of Clinical Pathologists, Houston, TX
Member, 2008-present
National Dialogue on Cancer (now C-Change)
Co-Chair, Tissue Informatics Working Group for National Biospecimen Network, 2002-2003
United States and Canadian Academy of Pathology
Member, 1995-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Macklin P, Edgerton ME, Thompson AM, Cristini V. Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): from microscopic measurements to macroscopic predictions of clinical progression. J Theor Biol 301:122-40, 5/2012. e-Pub 2/2012. PMCID: PMC3322268.
2. Edgerton ME, Byrne GD, Ho WS. Numerical calculation of the simultaneous absorption of two gases with reversible reactions. Computers and Chem Eng 10:551-556, 1986.
3. DeGregoria AJ, Edgerton ME. Thermal modeling of Bridgman solidification using DISPL. Proceedings of the Fifth IMACS International Symposium on Computer Methods for Partial Differential Equations, 6/1984.
4. Edgerton ME, Handler FA, Wu CW. Methods for the analysis of the kinetics of cooperative binding of ligands to a two-site lattice. Biopolymers 22:787-805, 1983.
5. Edgerton ME, Brimblecombe PG. Thermodynamics of halobacterial environments. Can J Mic 27:899-909, 1981.
6. Edgerton ME, Moore TA, Greenwood C. Investigations into the properties of an acid-induced species of purple membrane from Halobacterium halobium. Biochem J 189:413-429, 1980.
7. Edgerton ME, Greenwood C. Evidence for a model of regeneration of a protonated species, bR, from a phototransient, M, in the photochemical cycle of bacteriorhodopsin from Halobacterium halobium. Biochem Soc Trans 7:1075-1077, 1979.
8. Moore TA, Edgerton ME, Parr G, Greenwood C, Perham RN. Studies of an acid-induced species of purple membrane from Halobacterium halobium. Biochem. J 171:469-476, 1978.
Other Articles
1. Borghard WS, Edgerton ME, Tsao YP, Schoennagel HJ. Activity and Diffusivity of Hydrocarbons in ZSM-5-Activity of External Sites for Octadecane Cracking at MLDW Conditions. Technical Report, Central Laboratory, Mobil Research Corporation DAN 87-115, 1987.
2. Edgerton ME. Analysis of Uptake on ZSM-5C Crystals: Inadequacies of Simple Models. Technical Report, Mobil Research Corporation DAN 87-021, 1987.
3. Edgerton ME. An Advanced Technique for the Determination of Diffusion Coefficients. Technical Report, Mobil Research Corporation DAN 86-257, 1986.
4. Edgerton ME. Kinetics of Diffusion Controlled Reactions-1. Sensitivity to Adsorption and Diffusivity. Technical Report, Mobil Research Corporation DAN 6-340, 1986.
5. Edgerton ME. Review of Adsorption Isotherm Models for Application at High Temperatures. Technical Report, Exxon Research and Engineering Company CISD-1-BL-85, 1985.
6. Constantino SJ, Edgerton ME, Tandowski B. CTSD Laboratory Automation Study: A Proposed Strategy and Recommendations. Technical Report, Exxon Research & Engineering Company CTSD.7DH.83, 1983.

Abstracts

1. Kumar A, Chuang YL. Macklin P, Sanga S, Kim J, Tamaiuolo G, Cristini V, Edgerton ME. A model to predict the proliferation index of ductal carcinoma in situ. AACR Meeting Abstracts Online 2009:Abstract # (#2444), 2009.
2. Edgerton ME, Fisher DH, Tang L, Frey LJ, Chen Z. Using rule induction to discover molecular targets in lung cancer microarray data. AACR Meeting Abstracts 2005:383 Abstract #1630, 4/2005.

Book Chapters

1. Macklin P, Sanga S, Kim J, Tomaiuolo G, Edgerton ME, and Cristini V. Chapter 6 Discrete Modeling of Cancer. In: Multiscale Modeling of Cancer: An Integrated Experimental and Mathematical Modeling Approach. Ed(s) V. Cristini and J. S. Lowengrub. Cambridge University Press: New York, 88-22, 2010. ISBN: 9780521884426.

Grant & Contract Support

Title: TissueStation Satellite Bank Migration
Funding Source: MDACC IS Division
Role: Project Sponsor
Principal Investigator: Hamilton, SR
Duration: 9/1/2011 - 8/31/2012
 
Title: TissueStation Satellite Bank Migration
Funding Source: MDACC IS Division
Role: Project Sponsor
Principal Investigator: S Hamilton
Duration: 9/1/2010 - 8/31/2011
 
Title: Integrative Pipeline for Analysis & Translational Application of TCGA Data (GDAC)
Funding Source: NIH/NCI
Role: Collaborator
Principal Investigator: Weinstein, John N.
Duration: 9/1/2009 - 8/31/2014
 
Title: Ductal Carcinoma in silico
Funding Source: NIH/NCI
Role: Principal Investigator-MDACC
Duration: 5/1/2009 - 4/30/2013
 
Title: Virtual Cancer
Funding Source: Cullen Health Trust Fund
Role: Principal Investigator-MDACC
Principal Investigator: V Cristini
Duration: 4/1/2009 - 10/30/2010
 
Title: Epidemiology of Breast Cancer in Hispanic Women
Funding Source: Avon Foundation
Role: Collaborator
Principal Investigator: Bondy
Duration: 1/1/2009 - 12/20/2010
 
Title: TissueStation Expansion
Funding Source: MDACC IS Division
Role: Project Sponsor
Principal Investigator: S Hamilton
Duration: 9/1/2008 - 8/31/2010
 
Title: Mining Transcripts Data for Molecular Targets in Brain Cancer
Funding Source: MDACC CTT
Role: Principal Investigator
Duration: 1/1/2008 - 1/3/2011
 
Title: H. Lee Moffitt Cancer Center and Research Institute Support Grant
Funding Source: NIH/NCI
Role: Director Informatics Core
Duration: 8/1/2005 - 8/31/2006
 
Title: Vanderbilt Ingram Cancer Center Support Grant
Funding Source: NIH/NCI
Role: Director of Tissue Clinical Informatics Core
Duration: 9/1/2004 - 5/31/2005
 
Title: Clinical & Microarray Data Predict Outcomes in Lung Cancer
Funding Source: NIH/NLM
Role: Principal Investigator
Duration: 4/1/2004 - 5/31/2009
 
Title: Tools for Electronic Collaboration
Funding Source: Vanderbilt University Medical Center
Role: Principal Investigator
Duration: 1/1/2004 - 7/31/2005
 
Title: SPORE in Breast Cancer
Funding Source: NIH/NCI
Role: Director of Biomedical Informatics Core
Duration: 8/7/2003 - 5/31/2008
 
Title: SPORE in GI Cancer
Funding Source: NIH/NCI
Role: Director of Biomedical Informatics Core
Duration: 6/1/2002 - 5/31/2007
 
Title: Tissue Microarray Informatics Standards Workshop
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 9/1/2001 - 8/31/2002
 
Title: SPORE in Lung Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 6/28/2001 - 12/31/2006
 
Title: Tennessee Valley Cooperative Human Tissue Network
Funding Source: NIH/NCI
Role: PI of Subcontract
Principal Investigator: M. Kay Washington, M.D., Ph.D.
Duration: 4/1/2001 - 3/31/2008
 
Title: Vanderbilt NIDDK Biotechnology Center
Funding Source: NIH/NIDDK
Role: Co-Director of Bioinformatics Core
Duration: 9/30/2000 - 8/31/2003
 
Title: Pagetoid Spread in Ductal Carcinoma in situ
Funding Source: American Cancer Society (ACS)
Role: Principal Investigator
Duration: 1/1/2000 - 12/31/2001

Last updated: 4/29/2014