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Melinda S. Yates

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1155 Pressler Street
Unit Number: 1362
Houston, TX 77030
Room Number: CPB Duncan Building - CPB6.3413
Fax: 713-792-7586

Education & Training

Degree-Granting Education

2009 Johns Hopkins School of Medicine, Baltimore, MD, PHD, Pharmacology and Molecular Sciences
2001 Purdue University, West Lafayette, IN, BS, Chemistry

Selected Publications

Peer-Reviewed Original Research Articles

1. Zhang Q, Schmandt R, Celestino J, McCampbell A, Yates MS, Urbauer DL, Broaddus RR, Loose DS, Shipley GL, Lu KH. CGRRF1 as a novel biomarker of tissue response to metformin in the context of obesity. Gynecol Oncol 133(1):83-9, 4/2014. PMID: 24680596.
2. Iglesias DA, Yates MS, van der Hoeven D, Rodkey TL, Zhang Q, Co NN, Burzawa J, Chigurupati S, Celestino J, Bowser J, Broaddus R, Hancock JF, Schmandt R, Lu KH. Another surprise from metformin: novel mechanism of action via K-Ras influences endometrial cancer response to therapy. Mol Cancer Ther 12(12):2847-56, 12/2013. e-Pub 9/27/2013. PMCID: PMC3883498.
3. Huang M, Djordjevic B, Yates MS, Urbauer D, Sun C, Burzawa J, Daniels M, Westin SN, Broaddus R, Lu K. Molecular pathogenesis of endometrial cancers in patients with Lynch syndrome. Cancer 119(16):3027-33, 8/15/2013. e-Pub 6/12/2013. PMID: 23760948.
4. Lu KH, Loose DS, Yates MS, Nogueras-Gonzalez GM, Munsell MF, Chen LM, Lynch H, Cornelison T, Boyd-Rogers S, Rubin M, Daniels MS, Conrad P, Milbourne A, Gershenson DM, Broaddus RR. Prospective multicenter randomized intermediate biomarker study of oral contraceptive versus depo-provera for prevention of endometrial cancer in women with Lynch syndrome. Cancer Prev Res (Phila) 6(8):774-81, 8/2013. e-Pub 5/2/2013. PMCID: PMC3737517.
5. Zhang Q, Celestino J, Schmandt R, McCampbell AS, Urbauer DL, Meyer LA, Burzawa JK, Huang M, Yates MS, Iglesias D, Broaddus RR, Lu KH. Chemopreventive effects of metformin on obesity-associated endometrial proliferation. Am J Obstet Gynecol 209(24):e1-e12, 7/2013. e-Pub 3/15/2013. PMCID: PMC3819145.
6. Yates MS, Meyer LA, Deavers MT, Daniels MS, Keeler ER, Mok SC, Gershenson DM, Lu KH. Microscopic and early stage ovarian cancers in BRCA1/2 mutation carriers: building a model for early BRCA-associated tumorigenesis. Cancer Prev Res (Phila) 4(3):463-70, 3/2011. e-Pub 1/28/2011. PMCID: PMC3048908.
7. Reddy NM, Suryanaraya V, Yates MS, Kleeberger SR, Hassoun PM, Yamamoto M, Liby KT, Sporn MB, Kensler TW, Reddy SP. The triterpenoid CDDO-Imidazolide confers potent protection against hyperoxic acute lung injury in mice. Am J Respir Crit Care Med 180(9):867-74, 11/1/2009. e-Pub 8/13/2009. PMCID: PMC2773914.
8. Shin S, Wakabayashi J, Yates MS, Wakabayashi N, Dolan PM, Aja S, Liby KT, Sporn MB, Yamamoto M, Kensler TW. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide. Eur J Pharmacol 620(1-3):138-44, 10/12/2009. e-Pub 8/19/2009. PMCID: PMC2752754.
9. Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, Kensler TW. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid treated mice. Carcinogenesis 30(6):1024-31, 6/2009. e-Pub 4/21/2009. PMCID: PMC2691141.
10. Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, Biswal S. Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc Natl Acad Sci U S A 106(1):250-5, 1/6/2009. e-Pub 12/22/2008. PMCID: PMC2629210.
11. Liby K, Yore MM, Roebuck BD, Baumgartner KJ, Honda T, Sundararajan C, Yoshizawa H, Gribble GW, Williams CR, Risingsong R, Royce DB, Dinkova-Kostova AT, Stephenson KK, Egner PA, Yates MS, Groopman JD, Kensler TW, Sporn MB. A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin. Cancer Res 68(16):6727-33, 8/15/2008. PMCID: PMC3767150.
12. Osburn WO, Yates MS, Dolan PD, Chen S, Liby KT, Sporn MB, Taguchi K, Yamamoto M, Kensler TW. Genetic or pharmacologic amplification of Nrf2 signaling inhibits acute inflammatory liver injury in mice. Toxicol Sci 104(1):218-27, 7/2008. e-Pub 4/15/2008. PMCID: PMC2435415.
13. Aggarwal S, Brennen WN, Kole TP, Schneider E, Topaloglu O, Yates M, Cotter RJ, Denmeade SR. Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites. Biochemistry 47(3):1076-086, 1/22/2008. e-Pub 12/21/2007. PMID: 18095711.
14. Wang GT, Mantei RA, Kawai M, Tedrow JS, Barnes DM, Wang J, Zhang Q, Lou P, Garcia LA, Bouska J, Yates M, Park C, Judge RA, Lesniewski R, Sheppard GS, Bell RL. Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids. Bioorg Med Chem Lett 17(10):2817-22, 5/15/2007. e-Pub 2/25/2007. PMID: 17350258.
15. Heyman HR, Frey RR, Bousquet PF, Cunha GA, Moskey MD, Ahmed AA, Soni NB, Marcotte PA, Pease LJ, Glaser KB, Yates M, Bouska JJ, Albert DH, Black-Schaefer CL, Dandliker PJ, Stewart KD, Rafferty P, Davidsen SK, Michaelides MR, Curtin ML. Thienopyridine urea inhibitors of KDR kinase. Bioorg Med Chem Lett 17(5):1246-9, 3/1/2007. e-Pub 12/9/2006. PMID: 17188869.
16. Yates MS, Tauchi M, Katsuoka F, Flanders KC, Liby KT, Honda T, Gribble GW, Johnson DA, Johnson JA, Burton NC, Guilarte TR, Yamamoto M, Sporn MB, Kensler TW. Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Mol Cancer Ther 6(1):154-62, 1/2007. PMID: 17237276.
17. Thimmulappa RK, Scollick C, Traore K, Yates M, Trush MA, Liby KT, Sporn MB, Yamamoto M, Kensler TW, Biswal S. Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochem Biophys Res Commun 351(4):883-9, 12/29/2006. e-Pub 10/30/2006. PMCID: PMC2293275.
18. Ji Z, Ahmed AA, Albert DH, Bouska JJ, Bousquet PF, Cunha GA, Glaser KB, Guo J, Li J, Marcotte PA, Moskey MD, Pease LJ, Stewart KD, Yates M, Davidsen SK, Michaelides MR. Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases. Bioorg Med Chem Lett 16(16):4326-30, 8/15/2006. e-Pub 6/2/2006. PMID: 16735117.
19. Yates MS, Kwak MK, Egner PA, Groopman JD, Bodreddigari S, Sutter TR, Baumgartner KJ, Roebuck BD, Liby KT, Yore MM, Honda T, Gribble GW, Sporn MB, Kensler TW. Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. Cancer Res 66(4):2488-94, 2/15/2006. PMID: 16489057.
20. Zhang ZY, Shum P, Yates M, Messersmith PB, Thompson DH. Formation of fibrinogen-based hydrogels using phototriggerable diplasmalogen liposomes. Bioconjug Chem 13(3):640-6, May-Jun, 5/2002. PMID: 12009956.

Invited Articles

1. Lu KH, Yates MS, Mok SC. The monkey, the hen and the mouse: models to advance ovarian cancer chemoprevention. Cancer Prev Res (Phila) 2(9):773-5, 9/2009. e-Pub 9/8/2009. PMID: 19737981.
2. Yates MS, Kensler TW. Keap1 eye on the target: chemoprevention of liver cancer. Acta Pharmacol Sin 28(9):1331-1342, 9/2007. PMID: 17723167.
3. Yates MS, Kensler TW. Chemopreventive promise of targeting the Nrf2 pathway. Drug News Perspect 2(2):109-17, 3/2007. PMID: 17440634.

Abstracts

1. Ring KL, Celestino J, Yates MS, Zhang Q, Iglesias DA, Schmandt R, Lu KH. Selective response of endometrial tumors to metformin and RAD001 based on PTEN and KRas status. Poster presentation at the American Society of Clinical Oncology Annual Meeting, Chicago, Illinois,, 2013.
2. Iglesias DA, Burzawa J, Zhang Q, Co NN, Celestino J, Yates MS, Schmandt R, Lu KH. Preclinical in vitro and in vivo evidence to support personalized biologic treatment of endometrial cancer with metformin and PI3K pathway inhibitors. Poster at The Society of Gynecologic Oncology Annual Meeting, Austin, Texas, 2012.
3. Yates MS, Meyer LA, Deavers MT, Daniels MS, Urbauer D, Mok SC, Lu KH. Clinical outcomes in BRCA1 and BRCA2 mutation carriers with early stage ovarian or fallopian tube cancer. Poster presentation at the Biennial Meeting of the International Gynecologic Cancer Society, Prague, Czech Republic, 2010.
4. Yates MS, Meyer LA, Deavers MT, Daniels MS, Keeler ER, Mok SC, Lu KH. Microscopic and early stage ovarian cancers in BRCA1/2 mutation carriers: building a model for early BRCA-associated tumorigenesis. Poster presentation at the Biennial Meeting of the International Gynecologic Cancer Society, Prague, Czech Republic, 2010.
5. Yates MS, Tran QT, Osburn WO, Dolan PM, Liby KT, McCulloch C, Silkworth JB, Taguchi K, Yamamoto M, Sporn MB, Sutter TR, Kensler TW. Genetic and pharmacologic activation of Keap1-Nrf2 signaling modulate overlapping yet distinct gene expression profile. Poster presentation at the Molecular Mechanisms of Environmental Response to Food and Oxygen Conference, Sendai, Japan, 2009.
6. Yates MS, Tran QT, Osburn WO, Dolan PM, Liby KT, McCulloch C, Silkworth JB, Taguchi K, Yamamoto M, Sporn MB, Sutter TR, Kensler TW. Genetic and pharmacologic activation of Keap1-Nrf2 signaling modulate overlapping yet distinct gene expression profiles. Poster presentation AACR Chemical and Biological Aspects of Inflammation and Cancer, Ko Olina, Hawaii, 2008.
7. Yates MS, Tran QT, Osburn WO, Dolan PM, Liby KT, Taguchi K, Yamamoto M, Sporn MB, Sutter TR, Kensler TW. The synthetic triterpenoid CDDO-Im modulates pathways beyond Keap1-Nrf2 signaling at doses relevant to chemoprevention. Poster Resentation at NIH National Graduate Student Research Festival, Bethesda, Maryland, 2008.

Book Chapters

1. Yates MS and Kensler TW. Detoxication of Chemical Carcinogens and Chemoprevention. In: Chemical Carcinogenesis. Ed(s) Penning T. Springer: New York, 2011.

Last updated: 4/3/2014