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Mian M. Alauddin, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

Dr. Alauddin’s research goals are development of radiotracers for molecular imaging and improvement in detection and monitoring therapy outcome of cancer by non-invasive modality, including PET. Dr. Alauddin’s team has developed a variety of PET radiotracers during the past years of basic research, some of which are in the clinical trials. These include 11C-FMAU, 18F-FMAU,  18F-FHBG and 18F-IPQA. To achieve these goals, Dr. Alauddin’s team plans to continue in designing and synthesizing new radiotracers for PET imaging, and investigate their biological activities both in vitro and in vivo to pursue for clinical translation.

Further research interests are to develop novel radiolabeled monclonal antibodies and peptides with radiometals for cancer diagnosis, therapy and treatment-follow up. These include radiolabeled monoclonal antibodies and peptides with Zr-89, Cu-64, In-111, Y-90 etc. for diagnostic and therapeutic applications.

Research Interests

·       Development of PET probes for non-invasive in vivo molecular imaging of early stage cancer and therapy evaluation.

·       Radiolabeling of monoclonal antibodies and peptides for cancer diagnosis and therapy.


Area of specialization include: Synthesis and radiosynthesis of small organic molecules, which are substrates for specific target such as enzymes or receptors over expressing in cancer cells. In addition, biological evaluation of the newly developed PET probes in vitro in cell culture and in vivo in small and large animals for preclinical evaluation are also part of the research interest. Development of radiolabeled monoclonal antibodies and peptides using radiometal for cancer diagnosis and therapy, and monitoring therapy outcome are of special interest.


Education & Training

Degree-Granting Education

1987 The University of Manitoba, Winnipeg, Canada, PHD, Organic Chemistry
1982 Brock University, St. Catherines, Ontario, Canada, MS, Organic Chemistry
1968 Rajshahi University, Rajshahi, Bangladesh, MS, Chemistry
1966 Rajshahi University, Rajshahi, Bangladesh, BS, Chemistry, Physics, Mathematics

Postgraduate Training

4/1987-11/1988 Postdoctoral Fellowship, California Institute of Technology, Pasadena, CA


Academic Appointments

Associate Member, The University of Texas Graduate School of Biomedical Science, Houston, TX, 4/2012-present
Associate Professor, Department of Experimental Diagnostic Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 4/2004-5/2013
Associate Professor, Department of Pathology, University of Southern California, Los Angeles, CA, 9/2001-3/2004
Associate Professor, Department of Radiology, USC School of Medicine, Los Angeles, CA, 7/2000-3/2004
Instructor, Tred Technical College, Department of Chemistry, Los Angeles, CA, 1999-2000
Instructor, Southwest College, Department of Chemistry, Los Angeles, CA, 9/1994-5/1999
Assistant Professor, Department of Radiology, USC School of Medicine, Los Angeles, CA, 7/1994-6/2000
Research Associate, University of Southern California, School of Pharmacy, Los Angeles, CA, 2/1991-7/1992
Postdoctoral Research Fellow, California Institute of Technology, Pasadena, CA, 4/1987-11/1988
Teaching/Research Assistant, Dept of Chemistry, Univ of Manitoba, Winnipeg, Manitoba, Canada, 9/1983-4/1987

Other Appointments/Responsibilities

Resident Faculty Fellow, USC, Los Angeles, CA, 9/1994-3/2004
Visiting Scientist, The Johns Hopkins University, Baltimore, MD, 8/1992-7/1993

Institutional Committee Activities

Member, Radiation Safety Committee, 9/2009-present
Member, Radioactive Drug Research Committee (RDRC), 2007-2010

Honors and Awards

1996 Zumberge Fellow, University of Southern California, Los Angeles, CA
1987-1988 Postdoctoral Fellowship, California Institute of Technology, California
1983-1987 Teaching and Research Assistantship, University of Manitoba, Canada
1980-1982 Teaching and Research Assistantship, Brock University, Ontario, Canada

Professional Memberships

Member, 11/2012-present
American Chemical Society, Washington, DC
Member, 1990-present
American Chemical Society, Houston, TX
Member, 1990-present
Society of Molecular Imaging
Member, 2005-present
Society of Nuclear Medicine
Member, 1992-present
Society of Nuclear Medicine, Houston, TX
Member, 1992-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Varkaris A, Corn PG, Parikh NU, Efstathiou E, Song JH, Lee YC, Aparicio AM, Hoang A, Gaur S, Thorpe L, Maity SN, Bar-Eli M, Czerniak BA, Shao Y, Alauddin M, Lin SH, Logothetis CJ, Gallick GE. Integrating murine and clinical trials with cabozantinib to understand roles of MET and VEGFR-2 as targets for growth inhibition of prostate cancer. Clin Cancer Res. e-Pub 8/2015. PMCID: PMCPMC4703437 [Available on 2017-01-01].
2. Alauddin MM, De Palatis L. Current and Future Trends in Early Detection of Pancreatic Cancer: Molecular Targets and PET Probes. Curr Med Chem 22(29):3370-89, 2015. e-Pub 9/2015. PMID: 26295468.
3. Bhatnagar P, Alauddin M, Bankson JA, Kirui D, Seifi P, Huls H, Lee DA, Babakhani A, Ferrari M, Li KC, Cooper LJ. Tumor Lysing Genetically Engineered T Cells Loaded with Multi-Modal Imaging Agents. Sci Rep 4:4502, 2014. e-Pub 3/2014. PMCID: PMC3968458.
4. Chan PC, Wu CY, Chang WT, Lin CY, Tseng YL, Liu RS, Alauddin MM, Lin WJ, Wang HE.. Monitoring tumor response with [(18)F]FMAU in a sarcoma-bearing mouse model after liposomal vinorelbine treatment. Nucl Med Biol 40(8). e-Pub 8/2013. PMID: 23969084.
5. Turkman N, Gelovani JG, Alauddin MM. An improved synthesis of 1′-[18F]fluoroethyl-β-D-lactose ([18F]-FEL) for PET imaging of pancreatic cancer. J Labelled Comp Radiopharm 56(7):351-355, 6/2013. e-Pub 3/2013. PMCID: PMC4171848.
6. Flores LG, Yeh HH, Soghomonyan S, Young D, Bankson J, Hu Q, Alauddin M, Huff V, Gelovani JG. Monitoring Therapy with MEK Inhibitor U0126 in a Novel Wilms Tumor Model in Wt1 Knockout Igf2 Transgenic Mice Using 18F-FDG PET with Dual-Contrast Enhanced CT and MRI: Early Metabolic Response Without Inhibition of Tumor Growth. Mol Imaging Biol 15(2):175-85, 4/2013. e-Pub 8/2012. PMCID: PMC3591528.
7. Yeh HH, Tian M, Hinz R, Young D, Shavrin A, Mukhapadhyay U, Flores LG, Balatoni J, Soghomonyan S, Jeong HJ, Pal A, Uthamanthil R, Jackson JN, Nishii R, Mizuma H, Onoe H, Kagawa S, Higashi T, Fukumitsu N, Alauddin M, Tong W, Herholz K, Gelovani JG. Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with 18F-FAHA. Neuroimage 1(64):630-9, 1/2013. e-Pub 9/2012. PMCID: PMC3540799.
8. Turkman N, Paolillo V, Gelovani JG, Alauddin MM. An investigation on stereospecific fluorination at the 2′-arabino-position of a pyrimidine nucleoside: radiosynthesis of 2′-deoxy-2′-[18F]fluoro-5-methyl-1-β-D-arabinofuranosyluracil. Tetrahedron 68(50):10326-10332, 12/2012. PMCID: PMC3539786.
9. Turkman N, Shavrin A, Paolillo V, Yeh HH, Flores L, Soghomonian S, Rabinovich B, Volgin A, Gelovani J, Alauddin MM.. Synthesis and preliminary evaluation of [18F]-labeled 2-oxoquinoline derivatives for PET imaging of cannabinoid CB2 receptor. Nucl Med Biol 39(4):593-600, 5/2012. e-Pub 1/2012. PMCID: PMC3324652.
10. Nishii R, Tong W, Wendt R, Soghomonyan S, Mukhopadhyay U, Balatoni J, Mawlawi O, Bidaut L, Tinkey P, Borne A, Alauddin M, Gonzalez-Lepera C, Yang B, Gelovani JG. Pharmacokinetics, Metabolism, Biodistribution, Radiation Dosimetry, and Toxicology of 18F-Fluoroacetate (18F-FACE) in Non-Human Primates. Mol Imaging Biol 14(2):213-24, 4/2012. e-Pub 3/2011. PMCID: PMC3902791.
11. Paolillo V, Yeh HH, Mukhopadhyay U, Gelovani JG, Alauddin MM. Improved detection and measurement of low levels of [18F]fluoride metabolized from [18F]-labeled pyrimidine nucleoside analogues in biological samples. Nucl Med Biol 38(8):1129-1134, 11/2011. e-Pub 7/2011. PMCID: PMC3230730.
12. Chan PC, Wu CY, Chang WY, Chang WT, Alauddin MM, Liu RS, Lin WJ, Chen FD, Chen CL, Wang HE.. Evaluation of F-18-labeled 5-iodocytidine (18F-FIAC) as a new potential positron emission tomography probe for herpes simplex virus type 1 thymidine kinase imaging. Nucl. Med. Biol. 38(7):987-995, 10/2011. PMID: 21982570.
13. Pal A, Balatoni JA, Mukhopadhyay U, Ogawa K, Gonzalez-Lepera C, Shavrin A, Volgin A, Tong W, Alauddin MM, Gelovani JG. Radiosynthesis and Initial In Vitro Evaluation of [(18)F]F-PEG (6)-IPQA-A Novel PET Radiotracer for Imaging EGFR Expression-Activity in Lung Carcinomas. Mol Imaging Biol 13(5):853-861, 10/2011. e-Pub 9/2010. PMID: 20859697.
14. Turkman N, Shavrin A, Ivanov RA, Rabinovich B, Volgin A, Gelovani JG, Alauddin MM. Fluorinated cannabinoid CB2 receptor ligands: synthesis and in vitro binding characteristics of 2-oxoquinoline derivatives. Bioorg Med Chem 19(18):5698-707, 9/2011. e-Pub 8/2011. PMCID: PMC3174488.
15. Perin E, Tian M, Silva G, Marini FC, Zheng Y, Baimbridge F, Quan X, Young D, Paolilo V, Mukhopadhyay U, Gonzales-Lepera C, Borne A, Uthamanthil R, Brammer D, Jackson J, Decker W, Najjar, A, Thomas M, Soghomonyan S, Jeong H, Rois J, Vela D, Steiner D, Robinson S, Mawlawi O, Pan T, Stafford J, Kundra V, Li C, Alauddin MM, Shpall E, Gelovani JG.. Imaging the Long-Term Fate of Mesenchymal Stem Cells after Intramyocardial Transplantation in a Porcine Model of Myocardial Infarction. PLoS ONE 6(9), 9/2011. PMCID: PMC3164664.
16. Turkman N, Pal A, Tong W, Gelovani JG, Alauddin MM. Radiosynthesis of 1′-[18F]fluoroethyl-β-D-lactose ([18F]-FEL) for early detection of pancreatic carcinomas with PET. J. Labelled. Comp. Radiopharm. 54:233-238, 7/2011.
17. Ying Y, Ghosh P, Guo L, Pal A, Mukhapadhyay U, Peng Z, Yeh HH, Bertolini S, Flores LG, Young D, Volgin A, Soghomonyan S, Bornmann W, Logsdon C, Alauddin MM, Gelovani JG. Synthesis and Ex Vivo Autoradiographic Evaluation of Ethyl-beta-D: -galactopyranosyl-(1,4')-2'-deoxy-2'-[(18)F]fluoro-beta-D: -glucopyranoside-A Novel Radioligand for Lactose-Binding Protein: Implications for Early Detection of Pancreatic Carcinomas with PET. Mol Imaging Biol 13(3):546-546, 6/2011. e-Pub 7/2010. PMID: 20593279.
18. Tian M, Ogawa K, Wendt R, Mukhopadhyay U, Balatoni J, Fukumitsu N, Uthamanthil R, Borne A, Brammer D, Jackson J, Mawlawi O, Yang B, Alauddin MM, Gelovani JG. Whole-body biodistribution kinetics, metabolism, and radiation dosimetry estimates of 18F-PEG6-IPQA in nonhuman primates. J Nucl Med 52(6):934-41, 6/2011. e-Pub 5/2011. PMCID: PMC4013275.
19. Schwartz DL, Bankson J, Bidaut L, He Y, Williams R, Lemos R, Thitai AK, Oh J, Volgin A, Soghomonyan S, Yeh HH, Nishii R, Mukhopadhay U, Alauddin MM, Mushkudiani I, Kuno N, Krishnan S, Bornman W, Lai SY, Powis G, Hazle J, Gelovani J. HIF-1 Dependent Stromal Adaptation to Ischemia Mediates In Vivo Tumor Radiation Resistance. Mol Cancer Res 9(3):259-270, 3/2011. e-Pub 3/2011. PMCID: PMC3077053.
20. Yeh HH, Ogawa K, Balatoni J, Mukhapadhyay U, Pal A, Gonzalez-Lepera C, Shavrin A, Soghomonyan S, Flores L, Young D, Volgin AY, Najjar AM, Krasnykh V, Tong W, Alauddin MM, Gelovani JG. Molecular imaging of active mutant L858R EGF receptor (EGFR) kinase-expressing nonsmall cell lung carcinomas using PET/CT. Proc Natl Acad Sci U S A 108(4):1603-8, 1/2011. e-Pub 1/2011. PMCID: PMC3029752.
21. Staquicini FI, Ozawa MG, Moya CA, Driessen WH, Barbu EM, Nishimori H, Soghomonyan S, Flores LG, Liang X, Paolillo V, Alauddin MM, Basilion JP, Furnari FB, Bogler O, Lang FF, Aldape KD, Fuller GN, Höök M, Gelovani JG, Sidman RL, Cavenee WK, Pasqualini R, Arap W. Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma. J Clin Invest 121(1):161-73., 1/2011. e-Pub 12/2010. PMCID: PMC3007161.
22. Alauddin MM, Gelovani JG. Pyrimidine nucleosides in molecular PET imaging of tumor proliferation. Curr Med Chem 17(11):1010-1029, 2010. PMID: 20156163.
23. Turkman N, Gelovani JG, Alauddin MM. Radiosynthesis of N5-[18F]fluoroacetylornithine (N5-[18F]FAO) for PET imaging of ornithine decarboxylase (ODC) in malignant tumors. J. Labelled. Comp. Radiopharm. 53:33-37, 2010.
24. Conti PS, Bading JR, Mouton PP, Links JM, Alauddin MM, Fissekis JD, Ravert HT, Hilton J, Wong DF, Anderson JH. In vivo measurement of cell proliferation in canine brain tumor using C-11 labeled FMAU and PET. Nucl Med Biol 35(1):131-141, 1/2008. e-Pub 11/2007. PMID: 18158952.
25. Conti PS, Hilton J, Wong DF, Alauddin MM, Dannals RF, Ravert HT, Wilson AA, Anderson JH. High performance liquid chromatography of carbon-11 labeled thymidine and its major catabolites for clinical PET studies. Nucl Med Biol 21(8):1045-1051, 11/1994. PMID: 9234362.
26. Najafi A, Alauddin MM, Sosa A, Ma GQ, Chen DC, Epstein AL, Siegel ME. The evaluation of 186Re-labeled antibodies using N2S4 chelate in vitro and in vivo using tumor-bearing nude mice. Int J Rad Appl Instrum B 19(2):205-212, 2/1992. PMID: 1601674.
27. Driessen WHP, Mandelin J. et al. Combinatorial selection of ligand/receptor pairs for a theranostic approach in the management of androgen-independent prostate cancer. Cancer Cell. Submitted.
28. Manuri PR, Najjar AM, Olivares1 S, Flores LG, Mi T, Huls H, Shpall EJ, Champlin RE, Turkman N, Paolillo V, Roszik J, Rabinovich B, Lee1 DA, Alauddin M, Gelovani JG, Cooper LJ. Imaging of Sleeping Beauty-Modified CD19-Specific T Cells Expressing HSV1-Thymidine Kinase by Positron Emission Tomography. The FASEB Journal FASEBJ. Submitted.

Invited Articles

1. Alauddin MM. Nucleoside-based probes for imaging tumor proliferation using positron emission tomography. J Labelled Comp Radiopharm 56(3-4):237-243, Mar-Apr, 3/2013. PMID: 24285330.
2. Hajitou A, Rangel R, Trepel M, Soghomonyan S, Gelovani JG, Alauddin MM, Pasqualini R, Arap W. Design and construction of targeted AAVP vectors for mammalian cell transduction. Nat Protoc 2(3):523-31, 2007. PMID: 17406616.
3. Soghomonyan S, Hajitou A, Rangel R, Trepel M, Pasqualini R, Arap W, Gelovani JG, Alauddin MM. Molecular PET imaging of HSV1-tk reporter gene expression using [18F]FEAU. Nat Protoc 2(2):416-23, 2007. PMID: 17406603.
Other Articles
1. Alauddin MM. Preparation and Reactions of o-quinodimethanes. Ph.D. Thesis, Department of Chemistry, The University of Manitoba, Canada. 1987.

Letters to the Editor

1. Epstein A, Khawli LA, Alauddin MM. Authors reply to letter to the editors by Mather S. J. Nucl. Med. Biol. 20:376, 1993.

Grant & Contract Support

Title: PC150196: PET Imaging of Immune Checkpoint Blockade
Funding Source: Department of Defense (DOD)
Role: Co-Investigator
Principal Investigator: Piwnica-Worms, David
Duration: 10/1/2016 - 9/30/2019
Title: Targeting Cancer-Associated Fibroblasts to Enhance Drug Delivery and Immunotherapy
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Collaborator
Principal Investigator: Li, Chun
Duration: 6/1/2016 - 5/31/2021
Title: Imaging Core of the Pancreatic Moon Shot
Funding Source: MDACC
Role: Co-Investigator
Principal Investigator: David Piwnica-Worms
Duration: 9/1/2014 - 8/31/2016
Title: New generation of radiotracers for PET imaging of molecular signatures of tumors
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Victor Krasnykh
Duration: 8/7/2014 - 7/31/2017
Title: Detection of early stage pancreatic cancer using PET and 18F-FEL.
Funding Source: Institutional (IRG)
Role: Principal Investigator
Duration: 3/1/2014 - 4/30/2016
Title: In situ redirection of T cell specificity and imaging of targeted CAR expression
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Eshhar
Duration: 9/1/2013 - 8/31/2017
Title: Improving cord blood transplantation.
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Elizabeth Shpall
Duration: 9/1/2011 - 8/31/2016

Last updated: 4/28/2016