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Mian M. Alauddin, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1881 East Road
Unit Number: 1907
Houston, TX 77054
Room Number: 3SCR4.3626
Phone: 713-563-4872
Fax: 713-834-6035

Education & Training

Degree-Granting Education

1987 The University of Manitoba, Winnipeg, Canada, PHD, Organic Chemistry
1982 Brock University, St. Catherines, Ontario, Canada, MS, Organic Chemistry
1968 Rajshahi University, Rajshahi, Bangladesh, MS, Chemistry
1966 Rajshahi University, Rajshahi, Bangladesh, BS, Chemistry, Physics, Mathematics

Postgraduate Training

4/2004-5/2004 Continuing Education, University of Texas MD Anderson Cancer Center, Houston
11/1988-1/1989 Continuing Education, University of Southern California, Los Angeles, CA
4/1987-11/1988 Postdoctoral Fellowship, California Institute of Technology, Pasadena, CA

Experience/Service

Academic Appointments

Associate Member, The University of Texas Graduate School of Biomedical Science, Houston, TX, 4/2012-present
Associate Professor, Department of Experimental Diagnostic Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 4/2004-5/2013
Associate Professor, Department of Pathology, University of Southern California, Los Angeles, CA, 9/2001-3/2004
Instructor, Tred Technical College, Department of Chemistry, Los Angeles, CA, 1999-2000
Instructor, Southwest College, Department of Chemistry, Los Angeles, CA, 9/1994-5/1999
Assistant Professor, Department of Radiology, USC School of Medicine, Los Angeles, CA, 7/1994-6/2000
Research Associate, University of Southern California, School of Pharmacy, Los Angeles, CA, 2/1991-7/1992
Postdoctoral Research Fellow, California Institute of Technology, Pasadena, CA, 4/1987-11/1988
Teaching/Research Assistant, Dept of Chemistry, Univ of Manitoba, Winnipeg, Manitoba, Canada, 9/1983-4/1987
Teaching & Research Assistant, Brock University, St. Catherines, Ontario, Canada, 9/1980-7/1982
Lecturer in Chemistry, Government College, Kushtia, Bangladesh, 8/1969-8/1980

Administrative Appointments/Responsibilities

Coordinator, Government College, Sirajgani, Bangladesh, 9/1982-8/1983

Other Appointments/Responsibilities

Member, Tolman Award Committee, Am. Chem. Soc., Southern California Section, Los Angeles, CA, 1/1998
Member, Scientific Council Committee, USC, Dept of Radiology, Los Angeles, CA, 9/1996-3/2004
Judge, Science Fair, State of California, Los Angeles, CA, 1/1996
Judge, Science Fair, Bravo Magnet High School, Los Angeles, CA, 1/1996
Member, Strategic Planning Subcommittee, USC, Dept of Radiology, Los Angeles, CA, 9/1994-3/2004
Resident Faculty Fellow, USC, Los Angeles, CA, 9/1994-3/2004
Visiting Scientist, The Johns Hopkins University, Baltimore, MD, 8/1992-7/1993
Judge, Science Fair, Alhambra High School, Alhambra, CA, 1/1989-12/1991

Consultantships

Cancer Therapeutics, Los Angeles, CA, 1/2000-12/2000
Medex Inc., Wood Dale, IL, 1/1996-12/1996
Rokus & Associates, Valencia, CA, 1/1995-12/1995
CoCensys Inc., Irvine, CA, 1/1991-12/1992

Institutional Committee Activities

Member, Radiation Safety Committee, 9/2009-present
Member, Radioactive Drug Research Committee (RDRC), 2007-present
Interviewer, Medical School Admission, 9/1997-3/2004

Honors and Awards

2007-present Listed in Whos Who of North America, 61st edition, 2007., Whos Who of North America
1996 Zumberge Fellow, University of Southern California, Los Angeles, CA
1987-1988 Postdoctoral Fellowship, California Institute of Technology, California
1983-1987 Teaching and Research Assistantship, University of Manitoba, Canada
1980-1982 Teaching and Research Assistantship, Brock University, Ontario, Canada

Professional Memberships

AACR
Member, 11/2012-present
American Chemical Society, Washington, DC
Member, 1990-present
American Chemical Society, Houston, TX
Member, 1990-present
Society of Molecular Imaging
Member, 2005-present
Society of Nuclear Medicine
Member, 1992-present
Society of Nuclear Medicine, Houston, TX
Member, 1992-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Bhatnagar P, Alauddin M, Bankson JA, Kirui D, Seifi P, Huls H, Lee DA, Babakhani A, Ferrari M, Li KC, Cooper LJ. Tumor Lysing Genetically Engineered T Cells Loaded with Multi-Modal Imaging Agents. Sci Rep 4:4502, 2014. e-Pub 3/2014. PMCID: PMC3968458.
2. Chan PC, Wu CY, Chang WT, Lin CY, Tseng YL, Liu RS, Alauddin MM, Lin WJ, Wang HE.. Monitoring tumor response with [(18)F]FMAU in a sarcoma-bearing mouse model after liposomal vinorelbine treatment. Nucl Med Biol 40(8). e-Pub 8/2013. PMID: 23969084.
3. Flores LG, Yeh HH, Soghomonyan S, Young D, Bankson J, Hu Q, Alauddin MM, Huff V, Gelovani JG.. Monitoring Therapy with MEK Inhibitor U0126 in a Novel Wilms Tumor Model in Wt1 Knockout Igf2 Transgenic Mice Using 18F-FDG PET with Dual-Contrast Enhanced CT and MRI: Early Metabolic Response Without Inhibition of Tumor Growth. Mol Imaging Biol 15(2):175-85, 4/2013. e-Pub 8/2012. PMCID: PMC3591528.
4. Turkman N, Gelovani J, Alauddin MM. An improved synthesis of 1′-[18F]fluoroethyl-β-D-lactose ([18F]-FEL) for PET imaging of pancreatic cancer. J. Labelled Comp Radiopharm. 56(7):351-355, 3/2013. PMID: 24285438.
5. Yeh HH, Tian M, Hinz R, Young D, Shavrin A, Mukhapadhyay U, Flores LG, Balatoni J, Soghomonyan S, Jeong HJ, Pal A, Uthamanthil R, Jackson JN, Nishii R, Mizuma H, Onoe H, Kagawa S, Higashi T, Fukumitsu N, Alauddin M, Tong W, Herholz K, Gelovani JG. Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with 18F-FAHA. Neuroimage 1(64):630-9, 1/2013. e-Pub 9/2012. PMCID: PMC3540799.
6. Turkman N, Paolillo V, Gelovani JG, Alauddin MM.. An investigation on stereospecific fluorination at the 2′-arabino-position of a pyrimidine nucleoside: radiosynthesis of 2′-deoxy-2′-[18F]fluoro-5-methyl-1-β-D-arabinofuranosyluracil. Tetrahedron 68(50):10326-10332, 12/2012. PMCID: PMC3539786.
7. Turkman N, Paolillo V, Gelovani JG, Alauddin MM.. An investigation on stereospecific fluorination at the 2'-arabino-position of a pyrimidine nucleoside: radiosynthesis of 2'-deoxy-2'-[(18)F]fluoro-5-methyl-1-β-D-arabinofuranosyluracil. Tetrahedron 68(50):10326-10332, 12/2012. PMCID: PMC3539786.
8. Turkman N, Shavrin A, Paolillo V, Yeh HH, Flores L, Soghomonian S, Rabinovich B, Volgin A, Gelovani J, Alauddin MM.. Synthesis and preliminary evaluation of [18F]-labeled 2-oxoquinoline derivatives for PET imaging of cannabinoid CB2 receptor. Nucl Med Biol 39(4):593-600, 5/2012. e-Pub 1/2012. PMCID: PMC3324652.
9. Nishii R, Tong W, Wendt R, Soghomonyan S, Mukhopadhyay U, Balatoni J, Mawlawi O, Bidaut L, Tinkey P, Borne A, Alauddin MM, Gonzalez-Lepera C, Yang B, Gelovani JG. Pharmacokinetics, Metabolism, Biodistribution, Radiation Dosimetry, and Toxicology of 18F-Fluoroacetate (18F-FACE) in Non-Human Primates. Mol Imaging Biol 14(2):213-24, 4/2012. e-Pub 3/2011. PMID: 21437735.
10. Paolillo V, Yeh HH, Mukhopadhyay U, Gelovani JG, Alauddin MM.. Improved detection and measurement of low levels of [18F]fluoride metabolized from [18F]-labeled pyrimidine nucleoside analogues in biological samples. Nucl Med Biol 38(8):1129-1134, 11/2011. e-Pub 7/2011. PMCID: PMC3230730.
11. Chan PC, Wu CY, Chang WY, Chang WT, Alauddin MM, Liu RS, Lin WJ, Chen FD, Chen CL, Wang HE.. Evaluation of F-18-labeled 5-iodocytidine (18F-FIAC) as a new potential positron emission tomography probe for herpes simplex virus type 1 thymidine kinase imaging. Nucl. Med. Biol. 38(7):987-995, 10/2011. PMID: 21982570.
12. Pal A, Balatoni JA, Mukhopadhyay U, Ogawa K, Gonzalez-Lepera C, Shavrin A, Volgin A, Tong W, Alauddin MM, Gelovani JG.. Radiosynthesis and Initial In Vitro Evaluation of [(18)F]F-PEG (6)-IPQA-A Novel PET Radiotracer for Imaging EGFR Expression-Activity in Lung Carcinomas. Mol Imaging Biol 13(5):853-861, 10/2011. e-Pub 9/2010. PMID: 20859697.
13. Turkman N, Shavrin A, Ivanov RA, Rabinovich B, Volgin A, Gelovani JG, Alauddin MM.. Fluorinated cannabinoid CB2 receptor ligands: synthesis and in vitro binding characteristics of 2-oxoquinoline derivatives. Bioorg Med Chem 19(18):5698-707, 9/2011. e-Pub 8/2011. PMCID: PMC3174488.
14. Perin E, Tian M, Silva G, Marini FC, Zheng Y, Baimbridge F, Quan X, Young D, Paolilo V, Mukhopadhyay U, Gonzales-Lepera C, Borne A, Uthamanthil R, Brammer D, Jackson J, Decker W, Najjar, A, Thomas M, Soghomonyan S, Jeong H, Rois J, Vela D, Steiner D, Robinson S, Mawlawi O, Pan T, Stafford J, Kundra V, Li C, Alauddin MM, Shpall E, Gelovani JG.. Imaging the Long-Term Fate of Mesenchymal Stem Cells after Intramyocardial Transplantation in a Porcine Model of Myocardial Infarction. PLoS ONE 6(9), 9/2011. PMCID: PMC3164664.
15. Turkman N, Pal A, Tong W, Gelovani JG, Alauddin MM. Radiosynthesis of 1′-[18F]fluoroethyl-β-D-lactose ([18F]-FEL) for early detection of pancreatic carcinomas with PET. J. Labelled. Comp. Radiopharm. 54:233-238, 7/2011.
16. Ying Y, Ghosh P, Guo L, Pal A, Mukhopadhyay U, Peng Z, Yeh HH, Bertolini S, Flores LG, Young D, Volgin A, Soghomonyan S, Bornmann W, Logsdon C, Alauddin MM, Gelovani JG.. Synthesis and Ex Vivo Autoradiographic Evaluation of Ethyl-beta-D: -galactopyranosyl-(1,4')-2'-deoxy-2'-[(18)F]fluoro-beta-D: -glucopyranoside-A Novel Radioligand for Lactose-Binding Protein: Implications for Early Detection of Pancreatic Carcinomas with PET. Mol Imaging Biol 13(3):546-546, 6/2011. e-Pub 7/2010. PMID: 20593279.
17. Tian M, Ogawa K, Wendt R, Mukhopadhyay U, Balatoni J, Fukumitsu N, Uthamanthil R, Borne A, Brammer D, Jackson J, Mawlawi O, Yang B, Alauddin MM, Gelovani JG.. Whole-body biodistribution kinetics, metabolism, and radiation dosimetry estimates of 18F-PEG6-IPQA in nonhuman primates. J Nucl Med 52(6):934-41, 6/2011. e-Pub 5/2011. PMID: 21571803.
18. Schwartz DL, Bankson J, Bidaut L, He Y, Williams R, Lemos R, Thitai AK, Oh J, Volgin A, Soghomonyan S, Yeh HH, Nishii R, Mukhopadhay U, Alauddin MM, Mushkudiani I, Kuno N, Krishnan S, Bornman W, Lai SY, Powis G, Hazle J, Gelovani J. HIF-1 Dependent Stromal Adaptation to Ischemia Mediates In Vivo Tumor Radiation Resistance. Mol Cancer Res 9(3):259-270, 3/2011. e-Pub 3/2011. PMCID: PMC3077053.
19. Yeh HH, Ogawa K, Balatoni J, Mukhopadhyay U, Pal A, Gonzales-Lepera C, Shavrin A, Soghomonyan S, Flores L, Yang D, Volgin A, Najjar A, Krasnykh V, Tong W, Alauddin MM, Gelovani JG. Molecular imaging of active mutant L858R EGF receptor (EGFR) kinase-expressing nonsmall cell lung carcinomas using PET/CT. Proc Natl Acad Sci U S A 108(4):1603-8, 1/2011. e-Pub 1/2011. PMCID: PMC3029752.
20. Staquicini FI, Ozawa MG, Moya CA, Driessen WHP, Nishimori H, Soghomonyan S, Flores LG, Paolillo V, Alauddin MM, Basilion JP, Furnari FB, Bogler O, Lang FF, Aldape KD, Fuller GN, Gelovani JG, Sidman RL, Cavenee WK, Pasqualini R, Arap W. Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma. Journal of Clinical Investigation 121(1):161-73., 2011. PMCID: PMC30007161.
21. Alauddin MM, Gelovani JG. Pyrimidine nucleosides in molecular PET imaging of tumor proliferation. Curr Med Chem 17(11):1010-1029, 2010. PMID: 20156163.
22. Turkman N, Gelovani JG, Alauddin MM. Radiosynthesis of N5-[18F]fluoroacetylornithine (N5-[18F]FAO) for PET imaging of ornithine decarboxylase (ODC) in malignant tumors. J. Labelled. Comp. Radiopharm. 53:33-37, 2010.
23. Conti PS, Bading JR, Mouton PP, Links JM, Alauddin MM, Fissekis JD, Ravert HT, Hilton J, Wong DF, Anderson JH. In vivo measurement of cell proliferation in canine brain tumor using C-11 labeled FMAU and PET. Nucl Med Biol 35(1):131-141, 1/2008. e-Pub 11/2007. PMID: 18158952.
24. Conti PS, Hilton J, Wong DF, Alauddin MM, Dannals RF, Ravert HT, Wilson AA, Anderson JH. High performance liquid chromatography of carbon-11 labeled thymidine and its major catabolites for clinical PET studies. Nucl Med Biol 21(8):1045-1051, 11/1994. PMID: 9234362.
25. Najafi A, Alauddin MM, Sosa A, Ma GQ, Chen DC, Epstein AL, Siegel ME. The evaluation of 186Re-labeled antibodies using N2S4 chelate in vitro and in vivo using tumor-bearing nude mice. Int J Rad Appl Instrum B 19(2):205-212, 2/1992. PMID: 1601674.
26. Driessen WHP, Mandelin J. et al. Combinatorial selection of ligand/receptor pairs for a theranostic approach in the management of androgen-independent prostate cancer. Cancer Cell. Submitted.
27. Manuri PR, Najjar AM, Olivares1 S, Flores LG, Mi T, Huls H, Shpall EJ, Champlin RE, Turkman N, Paolillo V, Roszik J, Rabinovich B, Lee1 DA, Alauddin M, Gelovani JG, Cooper LJ. Imaging of Sleeping Beauty-Modified CD19-Specific T Cells Expressing HSV1-Thymidine Kinase by Positron Emission Tomography. The FASEB Journal FASEBJ. Submitted.

Invited Articles

1. Alauddin MM. Nucleoside-based probes for imaging tumor proliferation using positron emission tomography. J Labelled Comp Radiopharm 56(3-4):237-243, Mar-Apr, 3/2013. PMID: 24285330.
2. Hajitou A, Rangel R, Trepel M, Soghomonyan S, Gelovani JG, Alauddin MM, Pasqualini R, Arap W. Design and construction of targeted AAVP vectors for mammalian cell transduction. Nat Protoc 2(3):523-31, 2007. PMID: 17406616.
3. Soghomonyan S, Hajitou A, Rangel R, Trepel M, Pasqualini R, Arap W, Gelovani JG, Alauddin MM. Molecular PET imaging of HSV1-tk reporter gene expression using [18F]FEAU. Nat Protoc 2(2):416-23, 2007. PMID: 17406603.
Other Articles
1. Alauddin MM. Preparation and Reactions of o-quinodimethanes. Ph.D. Thesis, Department of Chemistry, The University of Manitoba, Canada. 1987.
2. Alauddin MM. The importance of H-bonding in the alkylation of phenols. M. Sc. Thesis, Department of Chemistry, Brock University, Canada. 1982.

Letters to the Editor

1. Epstein A, Khawli LA, Alauddin MM. Authors reply to letter to the editors by Mather S. J. Nucl. Med. Biol. 20:376, 1993.

Grant & Contract Support

Title: Imaging Core of the Pancreatic Moon Shot
Funding Source: MDACC
Role: Co-Investigator
Principal Investigator: David Piwnica-Worms
Duration: 9/1/2014 - 8/31/2015
 
Title: Improving cord blood transplantation.
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Eliabeth Shpall
Duration: 9/1/2011 - 8/31/2016
 
Title: Novel HDAC Class III Specific Radiotracers for PET Imaging
Funding Source: NIH/NIDA
Role: Co-Investigator
Principal Investigator: J. Gelovani
Duration: 10/1/2010 - 9/30/2015
 
Title: PET imaging of ornithine decaroxylase (ODC) in tumors;
Funding Source: Institutional grant
Role: Principal Investigator
Duration: 1/1/2010 - 12/31/2011
 
Title: HDAC Class IIa specific PET radiotracers for PET imaging of CNS.
Funding Source: NIH/NIDA
Role: Co-Investigator
Principal Investigator: Gelovani
Duration: 10/1/2009 - 9/30/2011
 
Title: Assessing Drug Response and Prognosis in Breast Cancer Using AAVP-Based Targeted Molecular-Genetic Imaging
Funding Source: Department of Defense (DOD)
Role: Co-Investigator
Principal Investigator: Pasqualini
Duration: 6/6/2009 - 6/30/2014
 
Title: Molecular imaging of Stem Cell Transplantation in Heart,
Funding Source: NIH/NHLBI
Role: Co-Investigator
Principal Investigator: Yeh & Gelovani
Duration: 8/2008 - 8/2011
 
Title: Integration of vascular genomics and proteomics for diagnosis and therapy of cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Pasqualini
Duration: 7/2008 - 6/2011
 
Title: Experimental Cancer Imaging Research Program (ECIRP)
Funding Source: NIH/NCI
Role: Co-Program Leader
Principal Investigator: John Hazle
Duration: 7/1/2007 - 2/29/2012
 
Title: Expanding the application of tracerlab FX modules for synthesis of [18F]-labeled arabino pyrimidine nucleosides, NaF and fluoroacetate
Funding Source: General Electric
Role: Principal Investigator
Duration: 2007 - present
 
Title: Imaging of Histone Deacetylase (HDAC) inhibition using novel radiotracer technology
Funding Source: Merck
Role: Co-Investigator
Principal Investigator: Gelovani
Duration: 1/2007 - 1/2010
 
Title: PLK-Inhibition Imaging Studies
Funding Source: GlaxoSmithKline
Role: Co-Investigator
Principal Investigator: J. Gelovani, MD, PhD
Duration: 2007 - 2008
 
Title: Creation of novel fluorescent and radiolabeled agents for in vivo molecular imaging of caspase activity
Funding Source: Merck
Role: Co-Investigator
Principal Investigator: J. Gelovani
Duration: 7/2006 - 6/2008
 
Title: PLK-Inhibition Imaging Studies
Funding Source: GlaxoSmithKline (GSK)
Role: Co-Investigator
Principal Investigator: Gelovani
Duration: 7/2006 - 7/2007
 
Title: Preclinical Master agreement
Funding Source: Astrazeneca
Role: Co-Investigator
Principal Investigator: Gelovani
Duration: 7/2005 - 7/2009
 
Title: IMPACT: Imaging and molecular markers for patients with lung cancer: Approaches with Molecular targets
Funding Source: Department of Defense (DOD)
Role: Co-Investigator
Principal Investigator: Hong & Gelovani
Duration: 2005 - 2010
 
Title: In-vivo imaging Cord Blood Progenitors in Lung Injury
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Martin J. Korbling, M.D.
Duration: 1/1/2004 - 1/1/2008
 
Title: Cellular and Molecular Imaging of the CV, Pulmonary, and Hematopoietic System
Funding Source: NHLBI
Role: Co-Investigator
Principal Investigator: Edward Tu-Sing Yeh, M.D.
Duration: 2004 - 2008
 
Title: In vivo cellular Imaging of Cord Blood Transplantation
Funding Source: NIH/NIDCR
Role: Co-Investigator
Principal Investigator: Elizabeth Shpall, M.D.
Duration: 2004 - 2008
 
Title: Non-invasive, cell proliferation-based assessment of treatment response in human malignant glioma with positron emission tomography
Funding Source: Dana foundation
Role: Co-Investigator
Duration: 1/1/2002 - 2004
 
Title: Image guided targeting of gene therapy vectors in colon cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 1/1/2002 - 1/2004
 
Title: An in vivo marker of cell proliferation for PET studies
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 1/1/1997 - 1/1/2000

Last updated: 12/15/2014