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Michael A. Curran, Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX
Member, Graduate Faculty, The University of Texas Graduate School of Biomedical Science, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
7455 Fannin Street
Unit Number: 901
Houston, TX 77054
Room Number: SCR3.2015

Education & Training

Degree-Granting Education

2001 Stanford University, Stanford, CA, PHD, Immunology
1995 University of Virginia, Charlottesville, VA, BA, Foreign Affairs
1995 University of Virginia, Charlottesville, VA, BA, Biology

Postgraduate Training

2004-2012 Postdoctoral Fellow, Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY, Advisor: James P. Allison
2001-2004 Postdoctoral Fellow, Immunology, University of California, Berkeley, CA, James P. Allison

Honors and Awards

2014 ASGCT New Investigator of the Month, American Society of Gene & Cell Therapy
2011 MSKCC Immunology Program Post-doctoral Publication Award, Memorial Sloan-Kettering Cancer Center
2010 iSBTc (SITC) Annual Meeting Presidential Award, Society for Immunotherapy of Cancer
2001-2004 IDEC/Genentech/Ronald Levy Postdoctoral Fellowship Award, American Cancer Society
2001 The Hugh McDevitt Prize, Stanford University
1996-1999 Markey Predoctoral Fellowship, Stanford University
1995 Katz Undergraduate Research Symposium, First Prize, University of Virginia
1995 Phi Beta Kappa, University of Virginia

Professional Memberships

American Association for Cancer Research
Member, 2007-present
American Society of Gene Therapy
Member, 1998-present
American Society of Immunologists
Member, 2011-present
American Society of Immunologists
Member, 2002-2003
American Society of Microbiology
Member, 1996-1998
Society for Immunotherapy of Cancer
Member, 2010-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Mittendorf EA, Philips AV, Meric-Bernstam F, Qiao N, Wu Y, Harrington S, Su X, Wang Y, Gonzalez-Angulo AM, Akcakanat A, Chawla A, Curran M, Hwu P, Sharma P, Litton JK, Molldrem JJ, Alatrash G. PD-L1 Expression in Triple-Negative Breast Cancer. Cancer Immunol Res 2(4):361-70, 2014. PMCID: PMC4000553.
2. Curran MA, Geiger TL, Montalvo W, Kim M, Reiner SL, Al-Shamkhani A, Sun JC, Allison JP. Systemic 4-1BB activation induces a novel T-cell phenotype driven by high expression of Eomesodermin. J Exp Med 210(4):743-55, 2013. PMCID: PMC3620352.
3. Mineharu Y, Muhammad AK, Yagiz K, Candolfi M, Kroeger KM, Xiong W, Puntel M, Liu C, Levy E, Lugo C, Kocharian A, Allison JP, Curran MA, Lowenstein PR, Castro MG. Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model. Neurotherapeutics 9(4):827-43, 2012. PMCID: PMC3480576.
4. Curran MA, Jenq RR, Goldberg GL, Liu C, Allison JP, van den Brink MR. Repertoire enhancement with adoptively transferred female lymphocytes controls the growth of pre-implanted murine prostate cancer. PLoS One 7(4):e35222, 2012. PMCID: PMC3320876.
5. Curran MA, Kim M, Montalvo W, Al-Shamkhani A, Allison JP. Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production. PLoS One 6(4):e19499, 2011. PMCID: PMC3085474.
6. Curran MA, Montalvo W, Yagita H, Allison JP. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci U S A 107(9):4275-80, 2010. PMCID: PMC2840093.
7. Duan F. Lin Y, Liu C, Engelhorn ME, Cohen AD, Curran M, Sakaguchi S, Merghoub T, Terzulli S, Wolchok JK, Houghton AN. Immune rejection of mouse tumors expressing mutated self. Cancer Res 69(8):3545-53, 2009. PMCID: PMC2767208.
8. Curran MA, Allison JP. Tumor vaccines expressing Flt3-ligand synergize with CTLA-4 blockade to reject pre-implanted tumors. Cancer Res 69(19):7747-55, 2009. PMCID: PMC2756314.
9. Fenjves ES, Ochoa MS, Cechin S, Gay-Rabinstein C, Perez-Alvarez I, Ichii H, Mendez A, Ricordi C, Curran MA. Protection of human pancreatic islets using a lentiviral vector expressing two genes: cFLIP and GFP. Cell Transplant 17(7):793-802, 2008. PMID: 19044206.
10. Quezada SA, Peggs KS, Curran MA, Allison JP. CTLA4 blockade and GM-CSF combination immunotherapy alters the intra-tumor balance of effector and regulatory T cells. J Clin Invest 116(7):1935-45, 2006. PMCID: PMC1479425.
11. Shai E, Palmon A, Panet A, Marmary Y, Sherman Y, Curran MA, Condiotti R. Prolonged transgene expression in murine salivary glands following non-primate lentiviral vector transduction. Molecular Therapy 12(1):137-143, 2005. PMID: 15963929.
12. Condiotti R, Curran MA, Nolan GP, Giladi H, Ketzinel-Gilad M, Gross E, Galun E. Prolonged liver-specific transgene expression by a non-primate lentiviral vector. Biochem. Biophys. Res. Commun. 320(3):998-1006, 2004. PMID: 15240147.
13. Fenjves ES, Ochoa MS, Gay-Raginstein C, Ricordi C, Curran MA. Retrovirally transferred genes inhibit apoptosis in an insulin-secreting cell line: implications for islet transplantation. Cell Transplant 13(5):489-96, 2004. PMID: 15565861.
14. Curran MA, Ochoa MS, Inverardi L, Nolan GP, Ricordi C, Fenjves ES. Efficient transduction of pancreatic islets by feline immunodeficiency virus vector. Transplantation 74(3):299-306, 2002. PMID: 12177606.
15. Price MA, Case SS, Carbonaro DA, Yu X-J, Petersen D, Sabo KM, Curran MA, Engel BC, Margarian H, Abkowitz JL, Nolan GP, Kohn DB, Crooks GM. Expression from second-generation feline immunodeficiency virus vectors is impaired in human hematopoietic cells. Molecular Therapy 6(5):645-652, 2002. PMID: 12409263.
16. Curran MA, Kaiser SK, Achacoso P, Nolan GP. Efficient transduction of non-dividing cells by optimized feline immunodeficiency virus vectors. Molecular Therapy 1(1):31-38, 2000.

Invited Articles

1. Curran MA, Callahan MK, Subudhi SK, Allison JP. Response to "Ipilimumab (Yervoy) and the TGN1412 catastrophe.". Immunobiology 217(6):590-2, 2012. PMID: 22459268.

Book Chapters

1. Wolkowicz R, Nolan GP, Curran MA. Gene Delivery Using Lentiviral Vectors. In: Gene Delivery to Mammalian Cells" Methods and Protocols. Ed(s) W. Heiser. Humana Press: Totowa, NJ, 2003.
2. Curran M, Nolan GP. Non-Primate Lentiviral Vectors. In: Lentiviral Vectors. Ed(s) Didier Trono. Preinger-Verlag, 2002.
3. Curran MA, Nolan HP. Recombinant Feline Immunodeficiency Virus Vectors: Preparation and use. In: Gene Therapy Protocols. 69. Ed(s) J. R. Morgan. Humana Press, 335-50, 2002.

Grant & Contract Support

Title: Aptamer targeted immune modulation of glioblastoma
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Co-Principal Investigator
Duration: 6/1/2015 - 5/31/2020
Title: Immunologic rejection of Prostate Cancer without autoimmune side effects
Funding Source: DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role: Principal Investigator
Duration: 6/1/2015 - 5/31/2018
Title: Immunologic rejection of Pancreatic Cancer without autoimmune side effects
Funding Source: DOD/Congressionally Directed Medical Research Programs (DOD/CDMRP)
Role: Principal Investigator
Duration: 6/1/2015 - 5/31/2018
Title: Immunobiology and translational application of the ThEO/TcEO T cell program
Funding Source: UTMDACC Institutional Research Grant
Role: Principal Investigator-MDACC
Duration: 5/1/2015 - 4/30/2015
Title: T cell immune checkpoint combinations for head and neck squamous cell carcinoma
Funding Source: MD Anderson Oropharynx Program, Discover Section
Role: Principal Investigator-MDACC
Duration: 3/1/2015 - 2/28/2016
Title: Identifying mechanisms of acquired resistance to Immunotherapy
Funding Source: UTMDACC Melanoma SPORE Developmental Research Program
Role: Principal Investigator
Duration: 1/1/2015 - 12/31/2016
Title: Opening the central nervous system to immunotherapy by blocking TREK1
Funding Source: Cancer Prevention and Research Institute of Texas (CPRIT) High Impact, High Risk Research Award
Role: Principal Investigator
Duration: 10/1/2014 - 9/30/2016

Last updated: 8/10/2015