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Michael Z. Gilcrease, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1991 Vanderbilt Medical School, Nashville, TN, MD, Medicine
1989 Vanderbilt Graduate School, Nashville, TN, PHD, Pathology
1984 Yale College, New Haven, CT, BA, Religious studies

Postgraduate Training

1994-1995 Clinical Fellowship, Surgical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
1991-1994 Clinical Residency, Anatomic Pathology, Baylor College of Medicine, Houston, TX

Board Certifications

1997 Cytopathology, American Board of Pathologists
1994 Anatomic Pathology, American Board of Pathologists

Selected Publications

Peer-Reviewed Original Research Articles

1. Dave B, Granados-Principal S, Zhu R, Benz S, Rabizadeh S, Soon-Shiong P, Yu KD, Shao Z, Li X, Gilcrease MZ, Lai Z, Chen Y, Huang TH, Shen H, Liu X, Ferrari M, Zhan M, Wong ST, Kumaraswami M, Mittal V, Chen X, Gross SS, Chang JC. Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling. Proc Natl Acad Sci USA 111(24):8838-43, 2014.
2. Krishnamurthy S, Mathews K, McClure S, Murray M, Gilcrease M, Albarracin C, Spinosa J, Chang B, Ho J, Holt J, Cohen A, Giri D, Garg K, Bassett RL, Liang K. Multi-institutional comparison of whole slide digital imaging and optical microscopy for interpretation of hematoxylin-eosin-stained breast tissue sections. Arch Pathol Lab Med 137(12):1733-9, 12/2013. e-Pub 8/2013. PMID: 23947655.
3. Nayak A, Wu Y, Gilcrease MZ. Primary squamous cell carcinoma of the breast: predictors of locoregional recurrence and overall survival. Am J Surg Pathol 37(6):867-73, 6/2013. PMID: 23629447.
4. de la Cruz J, Andre F, Harrell RK, Bassett RL, Arun B, Mathieu MC, Delaloge S, Gilcrease MZ. Tissue-based Predictors of Germline BRCA1 Mutations: Implications for Triaging of Genetic Testing. Hum Pathol 43(11):1932-39, 11/2012. e-Pub 5/2012. PMID: 22591913.
5. Alvarado R, Yi M, Le-Petross H, Gilcrease MZ, Mittendorf EA, Bedrosian I, Hwang RF, Caudle AS, Babiera GV, Akins JS, Kuerer HM, Hunt KK. The role for sentinel lymph node dissection after neoadjuvant chemotherapy in patients who present with node-positive breast cancer. Ann Surg Oncol 19(10):3177-84, 10/2012. e-Pub 7/2012. PMID: 22772869.
6. Lester TR, Hunt KK, Nayeemuddin KM, Bassett RL, Gonzalez-Angulo AM, Feig BW, Huo L, Rourke LL, Davis WG, Valero V, Gilcrease MZ. Metaplastic sarcomatoid carcinoma of the breast appears more aggressive than other triple receptor-negative breast cancers. Breast Cancer Res Treat 131(1):41-8, 1/2012. e-Pub 2/2011. PMCID: PMC3867807.
7. Brown AS, Hunt KK, Shen J, Huo L, Babiera GV, Ross MI, Meric-Bernstam F, Feig BW, Kuerer HM, Boughey JC, Ching CD, Gilcrease MZ. Histologic changes associated with false-negative sentinel lymph nodes after preoperative chemotherapy in patients with confirmed lymph node-positive breast cancer before treatment. Cancer 116(12):2878-83, 6/2010. PMID: 20564394.
8. Nguyen CV, Falcón-Escobedo R, Hunt KK, Nayeemuddin KM, Lester TR, Harrell RK, Bassett RL, Gilcrease MZ. Pleomorphic ductal carcinoma of the breast: predictors of decreased overall survival. Am J Surg Pathol 34(4):486-93, 4/2010. PMID: 20154588.
9. Hennessy BT, Gonzalez-Angulo AM, Stemke-Hale K, Gilcrease MZ, Krishnamurthy S, Lee JS, Fridlyand J, Sahin A, Agarwal R, Joy C, Liu W, Stivers D, Baggerly K, Carey M, Lluch A, Monteagudo C, He X, Weigman V, Fan C, Palazzo J, Hortobagyi GN, Nolden LK, Wang NJ, Valero V, Gray JW, Perou CM, Mills GB. Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Res 69(10). e-Pub 5/2009. PMCID: PMC2737191.
10. Gilcrease MZ, Woodward WA, Nicolas MM, Corley LJ, Fuller GN, Esteva FJ, Tucker SL, Buchholz TA. Even low-level HER2 expression may be associated with worse outcome in node-positive breast cancer. Am J Surg Pathol 33(5):759-67, 5/2009. NIHMSID: NIHMSNIHMS269613.
11. Downs-Kelly E, Nayeemuddin KM, Albarracin C, Wu Y, Hunt KK, Gilcrease MZ. Matrix-producing carcinoma of the breast: an aggressive subtype of metaplastic carcinoma. Am J Surg Pathol 33(4):534-41, 4/2009. PMID: 19047898.
12. Gilcrease MZ, Kilpatrick SK, Woodward WA, Zhou X, Nicolas MM, Corley LJ, Fuller GN, Tucker SL, Diaz LK, Buchholz TA, Frost JA. Coexpression of alpha6beta4 Integrin and Guanine Nucleotide Exchange Factor Net1 Identifies Node-Positive Breast Cancer Patients at High Risk for Distant Metastasis. Cancer Epidemiol Biomarkers Prev 18(1):80-6, 1/2009. PMCID: PMC2669542.
13. Gilcrease MZ, Zhou X, Lu X, Woodward WA, Hall BE, Jorrisey PJ. Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer. J Exp Clin Cancer Res 28:67, 2009. PMCID: PMC2694164.
14. Gilcrease MZ. Integrin signaling in epithelial cells. Cancer Letters 247:1-25, 2007. PMID: 16725254.
15. Diaz LK, Cristofanilli M, Zhou X, Welch KL, Smith TL, Yang Y, Sneige N, Sahin AA, Gilcrease MZ. Beta4 integrin subunit gene expression in node-negative invasive breast carcinoma: correlation with tumor size and nuclear grade. Modern Pathology 18:1165-75, 2005. PMID: 15920552.
16. Diaz LK, Zhou X, Wright ET, Cristofanilli M, Smith T, Yang Y, Sneige N, Sahin A, Gilcrease MZ. CD44 expression is associated with increased survival in node-negative invasive breast carcinoma. Clin Cancer Res 11:3309-14, 2005. PMID: 15867228.
17. Davis WG, Hennessy B, Babiera G, Hunt K, Valero V, Buchholz TA, Sneige N, Gilcrease MZ. Metaplastic sarcomatoid carcinoma of the breast with absent or minimal overt invasive carcinomatous component: a misnomer. American Journal of Surgical Pathology 29:1456-63, 2005. PMID: 16224212.
18. Gilcrease MZ, Zhou X, Welch K. Adhesion-independent alpha6beta4 integrin clustering is mediated by phosphatidylinositol 3-kinase. Cancer Research 64:7395-8, 2004. PMID: 15492261.
19. Diaz LK, Zhou X, Welch K, Sahin A, Gilcrease MZ. Chromogenic in situ hybridization for alpha6beta4 integrin in breast cancer: correlation with protein expression. Journal of Molecular Diagnostics 6:10-5, 2004. PMID: 14736821.
20. Diaz LK, Hunt K, Ames F, Meric F, Kuerer H, Babiera G, Ross M, Singletary E, Middleton LP, Symmans WF, Krishnamurthy S, Sahin A, Sneige N, Gilcrease MZ. Histologic localization of sentinel lymph node metastases in breast cancer. American Journal of Surgical Pathology 27:385-9, 2003. PMID: 12604895.

Last updated: 10/9/2014