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Michael H Kroll, M.D.

Present Title & Affiliation

Primary Appointment

Professor of Medicine and Chief of the Section of Benign Hematology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Baylor College of Medicine, Houston, TX

Education & Training

Degree-Granting Education

1981 Cornell University Medical College, New York, NY, MD, Medicine
1977 Harpur College, State University of New York @ Binghamton, Binghamton, NY, BS, Medicine

Postgraduate Training

7/1986-6/1988 Research/Clinical Fellow, Medicine, Harvard Medical School-Brigham & Women's Hospital, Boston, MA
7/1985-6/1986 Clinical Fellowship, Medicine, Harvard Medical School-Brigham & Women's Hospital, Boston, MA
7/1984-6/1985 Chief Medical Resident, Medicine, Brown University-Roger Williams General Hospital, Providence, RI
7/1982-6/1984 Clinical Residency, Medicine, Brown University-Roger Williams General Hospital, Providence, RI
7/1981-6/1982 Clinical Internship, Medicine, Brown University-Roger Williams General Hospital, Providence, RI

Board Certifications

1989 American Board of Internal Medicine- subspecialty of Medical Oncology
1988 American Board of Internal Medicine
1984 American Board of Internal Medicine

Experience/Service

Institutional Committee Activities

Co-Chair, MD Anderson Cancer Center Thrombosis Work Group, 2008-present
Member, MD Anderson Cancer Center Clinical Effectivness Committee, 2008-present
Member, MD Anderson Cancer Center CRC 2, 2008-2011
Member, Scientific Advisory Committee, Baylor College of Medicine Clinical Research Center, 1991-2007
Member, Medical Residency and Service Evaluation Committee, Baylor College of Medicine, 1990-2008

Honors and Awards

2012-present Clinical Leader of the Year MDACC, Division of Internal Medicine
2011 Keynote Speaker, University of Helsinki, Finland

Selected Publications

Peer-Reviewed Original Research Articles

1. Dong JF, Cruz MA, Sboulffatova K, Martin C, Choi H, Bergeron AL, Martini SR, Kroll MH, Kent TA. Magnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions. Thrombosis and Haemostasis(99):586-593, 2008.
2. Resendiz JC, Kroll MH, Lassila R. Protease activated receptors-induced Akt activation - regulation and possible function. J Thromb Haemost(5):2484-93, 2007.
3. Feng S, Lu X, Resendiz JC, Kroll MH. Pathological shear stress directly regulates platelet aIIbB3 signaling. Am J Physiol Cell Physiol(291):C1346-C1354, 2006.
4. Hassan A, Kroll MH. Acquired platelet disorders. Hematology:403-408, 2005.
5. Feng S, Lu X, Kroll MH. Filamin A binding stabilizes GpIba trafficking and thereby enhances it's surface expression. J Biol Chem(280):6709-6715, 2005.
6. Feng S, Kroll MH. Shear-induced platelet activation:is lesion-specific antithrombotic therapy a realistic clinical goal? Expert Rev Cardiovasc Ther(3):941-952, 2005.
7. Sun L, Feng S, Lu X, Resendiz JC, Durante W, Kroll MH. Role of the Pyk2-MAP kinase-cytosolic PLA2 pathway in shear-induced platelet aggregation. Ann Biomed Eng(32):1193-1201, 2004.
8. Resendiz JC, Feng S, Gi G, Kroll MH. von Willebrand factor binding to platelet glycoprotein IB-IX-V stimulates the assembly of an a-actinin based signaling complex. J Thromb Haemost(2):161-169, 2004.
9. Feng S, Resendiz JC, Lu X, Kroll MH. Filamin A binding to the cytoplasmic tail of glycoprotein IBa regulates von Willebrand factor-induced platelet activation. Blood(102):2122-2129, 2003.
10. Massarweh S, Udden MM, Shahab I, Kroll MH, Sears DA, Lynch GR, Teh BS, Lu HH. HIV-related Hodgkin's disease with central nervous system involvement and association with Epstein-Barr virus. Am J Hematol(72):216-219, 2003.
11. Resendiz JC, Feng S, Ji G, Francis KA, Berndt MC, Kroll MH. Purinergic P2Y receptor blockade inhibits shear-induced platelet phosphatidylinositol 3-kinase activation. Molecular Pharmacology(63):639-645, 2003.
12. Vilchez RA, Kozinetz CA, Jorgensen JL, Kroll MH, Butel JS. AIDS-related systemic non-Hodgkin's lymphoma at a large communicty program. AIDS Research and Human Retroviruses(18):237-242, 2002.
13. Feng S, Resendiz JC, Christodoulides N, Lu X, Arboleda D, Berndt MC, Kroll MH. Pathological shear stress stimulates the tyrosine phosphorylation of a-actinin associated with the GpIb-IX complex. Biochemistry(41):1100-1108, 2002.
14. Anstadt MP, Carwile JM, Guill CK, Conklin LD, Soltero ER, Lucci A, Kroll MH. Relapse of thrombotic thrombocytopenic purpura associated with decreased von Willebrand factor cleaving enzyme activity. Am J Med Sci(323):281-284, 2002.
15. Christodoulides N, Feng S, Resendiz JC, Berndt MC, Kroll MH. Glycoprotein IB/IX/V binding to the membrane skeleton maintains shear-induced platelets aggregation. Thrombosis Research(102):133-142, 2001.
16. Teh BS, Lu H, Lynch GR, Banez E, Kroll MH. AIDS related kaposi's sarcoma involving bone and bone marrow. South Med J(92):60-64, 1999.
17. Feng S, Christodoulides N, Kroll MH. The glycoprotein Ib complex regulates cell proliferation. Blood(93):4256-4263, 1999.
18. Durante W, Kroll MH, Christodoulides N, Peyton KJ, Schafer AI. Nitric oxide induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells. Circ Research(80):557-564, 1997.
19. Andrews RK, Kroll MH, Ward CM, Scarborough RM, Lopez JA, Berndt MC. Binding of a novel 50-kilodalton alboaggregin from Trimeresurus albolabris and related viper venom proteins to the platelet membrane glycoprotein Ib-IX-V complex. Effect on platelet aggregation and glycoprotein Ib-mediated platelet activation. Biochemistry(35):12629-12639, 1996.
20. Wagner CT, Kroll MH, Chow TW, Hellums JD, Schafer AI. Epinephrine and shear stress synergistically induce platelet aggregation via a mechanism that bypasses vWf - Gp Ib interactions. Biorheology(33):209-229, 1996.
21. Razdan K, Kroll MH. Molecular cloning of a novel platelet protein showing homology to the angiotensin II receptor c-terminal domain. J biol Chem(271):2221-2224, 1996.
22. Kroll MH, Hellums JD, McIntire LV, Schafer AI, Moake JL. Platelets and shear stress. Blool(88):1525-1541, 1996.
23. Durante W, Kroll MH, Orloff GJ, Cunningham JM, Scott-Burden TS, Vanhoutte PM, Schafer AI. Specific hemostatic proteins regulate interleukin-1b stimulated inducible nitric oxide synthase expression in cultured vascular smooth muscle cells. Biochemical Pharmacology(51):847-853, 1996.
24. Sullivan R, Kunze DL, Kroll MH. Thrombin receptors activate potassium and chloride channels. Blood(87):648-656, 1996.
25. McCrary JK, Nolasco LH, Hellums JD, Kroll MH, Turner NA, Moake JL. Direct demonstration of radiolabeled von Willebrand factor binding to platelet glycoprotein Ib and IIB-IIIa in the presence of shear stress. Ann Biomed Engineering(23):787-793, 1995.
26. Kamat SG, Michelson AD, Benoit SE, Moake JL, Rajasekhar D, Hellums JD, Kroll MH, Schafer AI. Fibrinolysis inhibits shear stress induced platelet aggregation. Circulation(92):1399-1407, 1995.
27. Christodoulides N, Durante W, Kroll MH, Schafer AI. Vascular smooth muscle cell heme oxygenases generate guanylyl cyclase-stimulatory carbon monoxide. Circulation(91):2306-2309, 1995.
28. Durante W, Schini VB, Kroll MH, Catovsky S, Scott-Burden T, White JG, Vanhoutte PM, Schafer AI. Platelets inhibit the induction of nitric oxide synthesis by interleukin 1-bets in vascular smooth muscle cells. Blood(83):1831-1838, 1994.
29. Razdan K, Hellums JD, Kroll MH. Shear stress-induced von Willebrand factor binding to platelets causes the activation of tyrosine kinase(s). Biochemical Journal(302):681-686, 1994.
30. Michelson AD, Benoit SE, Kroll MH, Li JM, Rohrer MJ, Kestin AS, Barnard MR. The activation-induced decrease in platelet surface expression of the glycoprotein Ib-IX complex is reversible. Blood(83):3562-3573, 1994.
31. Kroll MH, Hellums JD, Guo Z, Durante W, Razdan K, Hrbolich JK, Schafer AI. Protein kinase C is activated in platelets subjected to pathological shear stress. J Biol Chem 268(5):3520-4, 2/15/1993. PMID: 8429027.
32. Durante W, Schini VB, Catovsky S, Kroll MH, Vanhoutte PM, Schafer AI. Plasmin potentiates induction of nitric oxide synthesis by interleukin-1 beta in vascular smooth muscle cells. Am J Physiol 264(2 Pt 2):H617-24, 2/1993. PMID: 8447474.
33. Durante W, Schafer AI, Hrbolich JK, Claure RA, Mendelsohn ME, Kroll MH. Endothelium-derived relaxing factor inhibits shear stress-induced platelet aggregation. Platelets(4):135-140, 1993.
34. Guo Z, Weinstein MJ, Phillips MD, Kroll MH. Mr 6,400 aurin tricarboxylic acid directly activates platelets. Thrombosis Research(71):77-88, 1993.
35. Kroll MH, Mendelsohn ME, Miller JL, Ballen KK, Hrbolich JK, Schafer AI. Monoclonal antibody AG-1 initiates platelet activation by a pathway dependent on glycoprotein IIb-IIIa and extracellular calcium. Biochim Biophys Acta 1137(3):248-56, 11/17/1992. PMID: 1332779.
36. Durante W, Kroll MH, Vanhoutte PM, Schafer AI. Endothelium-derived relaxing factor inhibits thrombin-induced platelet aggregation by inhibiting platelet phospholipase C. Blood 79(1):110-6, 1/1/1992. PMID: 1309423.
37. Kroll MH, Harris TS, Moake JL, Handin RI, Schafer AI. von Willebrand factor binding to platelet GpIb initiates signals for platelet activation. J Clin Invest 88(5):1568-73, 11/1991. PMID: 1939645.
38. Luzzatto G, Kroll MH, Zavoico GB, Schafer AI. Regulation of the phosphoinositide cycle by Na+/H+ exchange and intracellular pH in human platelets. Biochim Biophys Acta 1084(1):78-86, 6/19/1991. PMID: 1647205.
39. Folts JD, Schwartz B, Kroll MH Schafer AI. Streptokinase inhibits platelet thrombus formation in stenosed dog coronary arteries: possible mechanisms. Platelets(1084):78-86, 1991.
40. Hechtman DL, Kroll MH, Gimbrone MA Jr, Schafer AI. Vascular smooth muscle synthesis of prostacyclin from platelet-derived arachidonic acid and prostaglandin endoperoxides. Am J Physiol 260:H1544-H1551, 1991.
41. Kroll MH, Claure RE, Miller JL. The monoclonal antibody AG-1, a potent stimulator of human platelets, interacts with a low molecular weight GTP-binding protein. Biochem Biophys Res Commun 171(3):1252-7, 9/28/1990. PMID: 2121139.
42. Kroll MH, Schafer AI. Biochemical mechanisms of platelet activation. Blood 74(4):1181-95, 9/1989. PMID: 2669994.
43. Kroll MH, Zavoico GB, Schafer AI. Second messenger function of phosphatidic acid in platelet activation. J Cell Physiol 139(3):558-64, 6/1989. PMID: 2738101.
44. Takayama H, Kroll MH, Gimbrone MA, Schafer AI. Turnover of eicosanoid precursor fatty acids among phospholipid classes and subclasses of cultured human umbilical vein endothelial cells. Biochem J 258(2):427-34, 3/1/1989. PMID: 2495792.
45. Kroll MH, Zavoico GB, Schafer AI. Control of platelet protein kinase C activation by cyclic AMP. Biochim Biophys Acta 970(1):61-7, 6/8/1988. PMID: 2835990.
Other Articles
1. Kroll MH, Shandera W. AIDS associated Kaposi's Sarcoma. Hospital Practice(33):85-102, 1998.
2. Shipp M, Kroll MH. Acute leukemias. Medical Knowledge Self-Assessment Program 10, American College of Physicians, 1995.
3. Kroll MH. Bleeding. Medical Knowledge Self-Assessment Program 10, American College of Physicians, 1995.
4. McCarthy PL, Kroll MH. Hemorrhagic and thrombotic complications of bone marrow transplantation. Quarterly Newsletter of the American Red Cross 3, 1994.
5. Rappaport P, Kroll MH, Zarrow L, Colton T. Chemical manipulation of microbes relative to natural desulfurization of coal and water microbiology. Publication No. SM176-08019, National Science Foundation, Student Originated Studies, 1976.

Abstracts

1. Feng S, Lu X, Kroll MH. Filamin binding to glycoprotein Iba signals talin-directed aIIbB3 activation. Blood(106):383A, 2005.
2. Feng S, Lu X, Resendiz JC, Kroll MH. Pathological shear stress directly regulates platelet aIIbB3 signaling. Blood(106):3570A, 2005.
3. Feng S, Lu X, Kroll MH. A contractile cytoskeletal tether modulates signaling between glycoprotein Iba and aIIbB3. Blood(104):1554A, 2004.
4. Feng S, Lu X, Kroll MH. Filamin A binding stabilizes nascent glycoprotein Iba trafficking and thereby enhances its surface expression. Blood(104):3656A, 2004.
5. Martin K, Feng S, Kroll MH Kenny D. The cytoplasmic tail of GPIbB modulates signaling induced by GPIb/V/WF interactions under high shear conditions. Blood(104):1563A, 2004.
6. Resendiz JC, Lassila R, Kroll MH. Tyrosine kinases regulate the activation of phosphatidylionositol 3-kinase in platelets stimulated by the PAR1-activating peptide. Accepted for presentation in the International Society of Haemostasis and Thrombosis Meeting, 7/2003.
7. Resendiz JC, Lassila R, Kroll MH. Distinct mechanisms of protease-activated receptor (PAR) 1 and Par 4-induced phosphatidylinositol 3-kinase activation. Blood(102):2870A, 2003.
8. Feng S, Lu X, Kroll MH. The cytoplasmic domain of GpIba couples von Willebrand factor-dependent cell contact with rolling and stable adhesion. Blood(102):2886A, 2003.
9. Feng A, Lu X, Kroll MH. A peptide from the filamin A binding domain of platelet glycoprotein Iba inhibits ristocetin-and shear-induced platelet aggregation. Blood(100):1842A, 2002.
10. Henry D, Cooley T, Volberding P, Martin F, Tonda M, Kroll MH. Final results of a phase III randomized trial of doxil vs daunoXome in patients with AIDS-related Kaposi's sarcoma. Proceed ASCO(21):1640A, 2002.
11. Feng S, Lu X, Kroll MH. Pathological shear stress stimulates aIIbB3-dependent tyrosine kinase signaling. Blood(100):1841A, 2002.
12. Kroll MH, Resendiz JC, Feng S, Ji G. Purinergic P2Y12 receptor blockade inhibits shear-induced platelet aggregation by inhibiting phosphatidylinositol 3-kinase. Blood(100):959A, 2002.
13. Kroll MH, Resendiz JC, Feng S, Ji G. von Willebrand factor binding to platelet glycoprotein Ib-IX-V stimulates the assembly on an a-actinin based signaling complex. Blood(100):1843A, 2002.
14. Resendiz JC, Feng S, Kroll MH. Tyrosine kinases regulate the activation of phosphatidylinositol 3-kinase in platelet stimulated by pathological shear stress. Thrombosis and Haemostasis Suppl:1860A, 7/2001.
15. Resendiz JC, Feng S, Ji G, Lu X, Kroll MH. Activation of SLP-76 by shear-induced von Willebrand factor binding to platelet aIIbB3. Blood(98):99A, 2001.
16. Feng S, Resendiz JC, Lu X, Ji G, Berndt MC, Kroll MH. Cytoplasmic domains of platelet glycoprotein Iba regulate filamin 1 a binding. Blood(986):1007A, 2001.
17. Feng S, Resendiz JC, Lu X, Ji G, Kroll MH. Pathological Shear Stress Stimulates aIIbB3-Dependent signaling. Blood(98):102A, 2001.
18. Feng S, Resendiz JC, Christodoulides N, Arboleda D, Berndt MC, Kroll MH. Pathological Shear Stress Induces a-Actinin Phosphorylation and its association with platelet glycoprotein Ib/IX. Blood(96):246A, 2000.
19. Resendiz JC, Feng S, Christodoulides N, Arboleda D, Berndt MC, Kroll MH. Phosphoinositide 3-kinase is activated and associated with Glycoprotein Ib/IX in platelets exposed to pathological shear stress. Blood(96):243A, 2000.
20. Vilchez R, Kozinetz C, Kroll MH, Butel JS. The incidence and recent trends of four AIDS-related malignancies in a large urban center. Clin Infect Dis(31):277A, 2000.

Book Chapters

1. Kroll, MH. Platelets in pulmonary vascular biology and pathology. In: Textbook of pulmonary vascular diseases. Hales, Rich, Archer and West Eds. Springer, 2010.
2. Wright JA, Kroll MH. Polycythemia vera. In: Conn's Current Therapy 2009. Eleseiver, 2009.
3. Kroll MH, Hassan AA. Acquired platelet function disorders. In: Platelets in cardiovascular and haematologic disorders: A clinical handbook. Ed(s) P Gresele, B Fuster, JA Lopez, CP Page, J Vermylen. Cambridge Press: London, 2008.
4. Kroll MH, Jac J. Acquired bleeding disorders. In: Manual of Intensive Care Medicine. Ed(s) RS Irwin, JM Rippe. Lippincott Williams and Wilkins: Philadelphia, 2006.
5. Jac J, Kroll MH. Antithrombotic therapy. In: Manual of Intensive Care Medicine. Ed(s) RS Irwin, JM Rippe. Lippincott Williams and Wilkins: Philadelphia, 2006.
6. Kroll MH, Feng S. Determinants of glycoprotein Ib-mediated hemostasis versus thrombosis. In: Microvascular Research: Biology and Pathology. Ed(s) D Shepro. Elsevier: Burlington, 2005.
7. Kroll MH, Resendiz JC. Mechanisms of platelet activation. In: Thrombosis and Hemorrhage, 3rd. Ed(s) J Loscalzo, AI Schafer. Williams and Wilkins: Baltimore, 2002.
8. Baker KA, Kroll MH. Hematology and Oncology Drugs. In: Pocket Guide to Commonly Prescribed Drugs, 3rd. Ed(s) GN Levine. Appleton and Lange: Stamford, 1999.
9. McCarthy PL, Kroll MH. Hemostatic complications of blood and bone marrow transplantation. In: Thrombosis and Hemorrhage, 2nd. Ed(s) J Loscalzo, AI Schafer. Williams and Wilkins: Baltimore, 1998.
10. Sullivan FR, Kroll MH. Mechanisms of platelet activation. In: Thrombosis and Hemorrhage, 2nd. Ed(s) J Loscalzo, AI Schafer. Williams and Wilkins: Baltimore, 1998.
11. Kroll MH, Schafer AI. Analyses of receptor-ligand interactions. In: Immunopharmacology of Platelets. Ed(s) M Joseph. Academic Press: London, 1995.
12. McCarthy PL, Kroll MH. Hemostatic complications of bone marrow transplantation. In: Thrombosis and Hemorrhage. Ed(s) J Loscalzo, AI Schafer. Blackwell Scientific Publications: Cambridge, 1994.
13. Kroll MH. Mechanisms of platelet activation. In: Thrombosis and Hemorrhage. Ed(s) J Loscalzo, AI Schafer. Blackwell Scientific Publications: Cambridge, 1994.
14. Scjafer AI, Kroll MH. Non-atheromatous arterial disease. In: Annual Review of Medicine, 44, 155-170, 1993.
15. Kroll MH, Smith CW, Loscalzo J. In: Vascular Disorders, 49-52, 1991.
16. Arani M, Kroll MH. Platelet toxicology. In: Toxicology of the blood and bone marrow. Ed(s) J Descote. Taylor and Francis: Boca Raton. Submitted.

Books (edited and written)

1. Kroll MH. Manual of Coagulation Disorders. Blackwell Scientific Pulications: Malden, 2001.

Letters to the Editor

1. Franceschi R, Christodoulides N, Kroll MH, Genta RM. Helicobacter pylori and idiopathic thrombocytopenic purpura. Ann Intern Med(140):766-767, 2004.
2. Vilchez RA, Jorgensen JL, Kroll MH. Systemic non-Hodgkin lymphoma in HIV-infected patients in the era of highly active antiretroviral therapy. Blood(99):4250-4251, 2002.
3. Kroll MH. Hemophiliacs and AIDS. New Yorker:6, 7/1997.
4. Rumbaut RR, Kroll MH. Acquired platelet storage pool deficiency due to severe valvular disease corrected by prosthetic valve replacement. Am J Hematol(45):272-274, 1994.

Last updated: 5/29/2014