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Mien-Chie Hung, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor and Chair, Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
Director, Center for Biological Pathways, The University of Texas M. D. Anderson Cancer Center, Houston, TX
Director, Breast Cancer Basic Research Program, Breast Cancer Basic Research Program, The University of Texas M.D. Anderson Cancer Center, Houston, TX
Distinguished Teaching Professor, The University of Texas M. D. Anderson Cancer Center, Houston, TX
Ruth Legett Jones Distinguished Chair, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1983 Brandeis University, Waltham, MA, PHD, Biochemsitry
1977 National Taiwan University, Taipei, MS, Biochemistry
1973 National Taiwan University, Taipei, BS, Chemistry

Postgraduate Training

1/1986-8/1986 Postdoctoral Fellow, Massachusetts Institute of Technology, Cambridge, MA, Dr. Robert A. Weinberg

Experience/Service

Academic Appointments

Professor, Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 9/1996-present

Administrative Appointments/Responsibilities

Administrative Director, Jones BRB, Bates-Freemand and Anderson Central Buildings, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 7/2007-present

Honors and Awards

2006 Member, The University of Texas Academy of Health Science Education
2002 Academician, Academia Sinica
1998 Faculty Achievement Award in Basic Research, The University of Texas M.D. Anderson Cancer Center
1998 John P. McGovern Outstanding Teacher Award, The University of Texas Health Science Center in Houston
1993 Faculty Achievement Award in Education, The University of Texas M.D. Anderson Cancer Center
1989 John P. McGovern Outstanding Teacher Award, The University Texas Health Science Center in Houston

Selected Publications

Peer-Reviewed Original Research Articles
1. Weihua, Z, Tsan, R., Wu, Q., Huang, W-C., Chiu, C-H., *Fidler, I.J. and *Hung, M-C. Survival of cancer cells is maintained by kinase-independent EGFR. Cancer Cell 13:385-393, 5/2008. PMCID: PMC2413063.
2. Yang, J-Y., Zong, C.S., Xia, W., Yamaguchi, H., Ding, Q., Xie, X., Lang, J-Y., Lai, C-C., Chang, C-J., Huang, W-C., Huang, H., Kuo, H-P., Lee, D-F., Li, L-Y., Lien H-C., Cheng, X, Chang, K-J., Hsiao, C-D., Tsai, F-J., Tsai, C-H., Sahin, AA., Muller, WJ., Mills, GB., Yu, D., Hortobagyi, GN. and Hung, M-C. Erk promotes tumorigenesis by inhibiting Foxo3a via MDM2-mediated degradation. Nature Cell Biology 10:138-148, 2/2008. e-Pub 1/2008. PMCID: PMC2376808.
3. Lee, D-F., Kuo, H-P., Chen, C-T., Hsu, J-M., Sun, H-L., Chou, C-K., Wei, Y., Li, L-Y.,Ping, B., Huang, W-C., He, X., Hung, J-Y., Lai, C-C., Ding, Q., Su, J-L., Yang, J-Y., Sahin, A.A., Hortobagyi, G.N., Tsai, F-J., Tsai, C-H. and Hung, M-C. Suppression of TSC1 by IKKβ confers tumor angiogenesis through the mTOR pathway. Cell 130:440-455, 8/2007.
4. Xie, X., Xia, W., Li, Z., Kuo, H-P.,Liu, Y., Li, Z., Ding, Q., Zhang, S., Spohn, W., Yang, Y., Wei, Y., Lang, J-Y., Evans, D.B., Chiao, P.J., Abbruzzese J.L. and Hung, M-C. Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Cancer Cell 12:52-65, 7/2007.
5. Huang, W-C., Ju, T-K., *Hung, M-C. and Chen, C-C. *co-corresponding author. Phosphorylation of CBP by IKKα promotes cell growth by switching the binding preference of CBP from p53 to NF-κB. Mol Cell 26:75-87, 2007. PMCID: PMC2312502.
6. Su, J-L., Yang, P-C., Shih, J-Y., Yang, C-Y., Wei, L-H., Hsieh, C-Y., Chou, C-H., Jeng, Y-M., Wang, M-Y., Chang, K-J., Hung, M-C. and Kuo, M-L. The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell 9:209-223, 2006.
7. Wang, S-C., Nakajima, Y., Yu, Y-L., Xia, W., Chen, C-T, Yang, C-C., McIntush EW., Li, L-Y., Hawke, D., Kobayashi, R. and Hung, M-C. Tyrosine phosphorylation controls protein stability of PCNA. Nat. Cell Biol. 8:1359-1368, 2006.
8. Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3*. Science 310:306-310, 10/2005. PMID: 16224021.
9. Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC. Erk1/2 associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell 19:159-170, 7/2005. PMID: 16039586.
10. Lo HW, Hsu SC, Ali-Seyed M, Gunduz M, Xia W, Wei Y, Bartholomeusz G, Shih JY, Hung MC. Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell 7:575-589, 6/2005. PMID: 15950906.
11. Li YM, Pan Y, Wei Y, Cheng X, Zhou BP, Tan M, Zhou X, Xia W, Hortobagyi GN, Yu D, Hung MC. Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis*. Cancer Cell 6:459-469, 11/2004. PMID: 15542430.
12. Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, Hung MC. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition*. Nat Cell Biol 6:931-940, 10/2004. PMID: 15448698.
13. Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, Ali-Seyed M, Lee DF, Bartholomeusz G, Ou-Yang F, Giri DK, Hung MC. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2*. Cancer Cell 6:251-261, 9/2004. PMID: 15380516.
14. Nagata Y, Lan KH, Zhou X, Tan M, Esteva FJ, Sahin AA, Klos KS, Li P, Monia BP, Nguyen NT, Hortobagyi GN, Hung MC, Yu D. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients*. Cancer Cell 6:117-127, 8/2004. PMID: 15324695.
15. Hu MC, Lee DF, Xia W, Golfman L, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC. IkB kinase promotes tumourigenesis through inhibition of Forkhead transcription factor FOXO3a.*. Cell 117:225-237, 2004.
16. Deng J, Miller SA, Wang HY, Xia W, Wen Y, Zhou BP, Li Y, Lin SY, Hung MC. beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. Cancer Cell 2:323-334, 10/2002. PMID: 12398896.
17. Tan M, Jing T, Lan KH, Neal CL, Li P, Lee S, Fang D, Nagata Y, Liu J, Arlinghaus R, Hung MC, Yu D. Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis. Mol Cell 9:993-1004, 5/2002. PMID: 12049736.
18. Bourguignon, L.Y.W., Lan, K-H., Singleton, P., Lin, S-Y., Yu, D. and Hung, M-C. Localizing the EGF receptor-Reply. Nature Cell Biol. 4:E22-23, 2002.
19. Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol 3:973-982, 11/2001. PMID: 11715018.
20. Lin SY, Makino K, Xia W, Matin A, Wen Y, Kwong KY, Bourguignon L, Hung MC. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 3:802-808, 9/2001. PMID: 11533659.
21. Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 3:245-252, 3/2001. PMID: 11231573.
22. Lin SY, Xia W, Wang JC, Kwong KY, Spohn B, Wen Y, Pestell RG, Hung MC. Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci U S A 97:4262-4266, 4/2000. PMID: 10759547.
23. Xing X, Wang SC, Xia W, Zou Y, Shao R, Kwong KY, Yu Z, Zhang S, Miller S, Huang L, Hung MC. The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. Nat Med 6:189-195, 2/2000. PMID: 10655108.

Last updated: 8/26/2009