Skip to Content

'
Mien-Chie Hung, Ph.D.

Present Title & Affiliation

Primary Appointment

Vice President for Basic Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Department Chair, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Director, Breast Cancer Basic Research Program, Breast Cancer Basic Research Program, The University of Texas MD Anderson Cancer Center, Houston, TX
Director, Center for Biological Pathways, The University of Texas MD Anderson Cancer Center, Houston, TX
Ruth Legett Jones Distinguished Chair, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Surgical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Graduate School of Biomedical Science, The University of Texas Health Science Center, Houston, TX

Education & Training

Degree-Granting Education

1983 Brandeis University, Waltham, MA, PHD, Biochemsitry
1977 National Taiwan University, Taipei, MS, Biochemistry
1973 National Taiwan University, Taipei, BS, Chemistry

Postgraduate Training

1/1986-8/1986 Postdoctoral Fellow, Massachusetts Institute of Technology, Cambridge, MA, Dr. Robert A. Weinberg

Experience/Service

Academic Appointments

Professor, Tumor Biology Department, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 9/1994-8/1998
Associate Professor, Department of Tumor Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 1/1991-9/1994
Assistant Professor, Department of Tumor Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 1/1986-1/1991
Postdoctoral Fellow, Whitehead Institute, Massachusetts Institute of Technology, Cambridge, MA, 1/1984-1/1986
Prepostdoctoral Fellow, Department of Biochemistry, Brandeis University, Waltham, MA, 1/1978-1/1983

Honors and Awards

2010-2012 Full Member of Scientific Advisory Council, Susan G Komen For the Cure
2007-present Distinguished Teaching Professor, The University of Texas M. D. Anderson Cancer Center
2006-present Member, The University of Texas Academy of Health Science Education, The University of Texas
2006 Education Spotlight, Educator of the Month for November 2000 and January 2006, The University of Texas M. D. Anderson Cancer Center
2004-present Honorary Professor, Peking Union Medical College, Chinese Academy of Medical Sciences
2002-present Academician, Academia Sinica
2000 Education Spotlight, Educator of the Month for November 2000 and January 2006, The University of Texas M. D. Anderson Cancer Center
1998 Faculty Achievement Award in Basic Research, The University of Texas M.D. Anderson Cancer Center
1998 John P. McGovern Outstanding Teacher Award, The University of Texas Health Science Center in Houston
1993 Faculty Achievement Award in Education, The University of Texas M.D. Anderson Cancer Center
1992 John P. McGovern Outstanding Teacher Award, The University of Texas Health Science Center in Houston
1989 John P. McGovern Outstanding Teacher Award, The University of Texas Health Science Center in Houston

Selected Publications

Peer-Reviewed Original Research Articles
1. Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Lai CC, Lin AC, Chang YH, Tsai SF, Li LY, Hung MC. KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol Cell 36(1):131-40, 10/2009. PMCID: PMC2770835.
2. Weihua Z, Tsan R, Huang WC, Wu Q, Chiu CH, Fidler IJ, Hung MC. Survival of cancer cells is maintained by kinase-independent EGFR. Cancer Cell 13(5):385-393, 5/2008. PMCID: PMC2413063.
3. Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, Xie X, Lang JY, Lai CC, Chang CJ, Huang WC, Huang H, Kuo HP, Lee DF, Li LY, Lien HC, Cheng X, Chang KJ, Hsiao CD, Tsai FJ, Tsai CH, Sahin AA, Muller WJ, Mills GB, Yu D, Hortobagyi GN, Hung MC. Erk promotes tumorigenesis by inhibiting Foxo3a via MDM2-mediated degradation. Nat Cell Biol 10(2):138-148, 2/2008. e-Pub 1/2008. PMCID: PMC2376808.
4. Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y, Sun HL, Li LY, Ping B, Huang WC, He X, Hung JY, Lai CC, Ding Q, Su JL, Yang JY, Sahin AA, Hortobagyi GN, Tsai FJ, Tsai CH, Hung MC. IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 130(3):440-55, 8/2007. PMID: 17693255.
5. Xie X, Xia W, Li Z, Kuo HP, Liu Y, Li Z, Ding Q, Zhang S, Spohn B, Yang Y, Wei Y, Lang JY, Evans DB, Chiao PJ, Abbruzzese JL, Hung MC. Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Cancer Cell 12(1):52-65, 7/2007. PMID: 17613436.
6. Huang WC, Ju TK, Hung MC, Chen CC. Phosphorylation of CBP by IKKα promotes cell growth by switching the binding preference of CBP from p53 to NF-κB. Mol Cell 26(1):75-87, 4/2007. PMCID: PMC2312502.
7. Wang SC, Nakajima Y, Yu YL, Xia W, Chen CT, Yang CC, McIntush EW, Li LY, Hawke DH, Kobayashi R, Hung MC. Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Biol 8(12):1359-68, 12/2006. e-Pub 11/2006. PMID: 17115032.
8. Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science 310(5746):306-310, 10/2005. PMID: 16224021.
9. Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC. Erk1/2 associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell 19(2):159-170, 7/2005. PMID: 16039586.
10. Lo HW, Hsu SC, Ali-Seyed M, Gunduz M, Xia W, Wei Y, Bartholomeusz G, Shih JY, Hung MC. Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell 7(6):575-589, 6/2005. PMID: 15950906.
11. Li YM, Pan Y, Wei Y, Cheng X, Zhou BP, Tan M, Zhou X, Xia W, Hortobagyi GN, Yu D, Hung MC. Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell 6(5):459-469, 11/2004. PMID: 15542430.
12. Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, Hung MC. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 6(10):931-940, 10/2004. e-Pub 9/2004. PMID: 15448698.
13. Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, Ali-Seyed M, Lee DF, Bartholomeusz G, Ou-Yang F, Giri DK, Hung MC. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. Cancer Cell 6(3):251-261, 9/2004. PMID: 15380516.
14. Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117(2):225-37, 4/2004. PMID: 15084260.
15. Deng J, Miller SA, Wang HY, Xia W, Wen Y, Zhou BP, Li Y, Lin SY, Hung MC. beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. Cancer Cell 2(4):323-334, 10/2002. PMID: 12398896.
16. Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol 3(11):973-982, 11/2001. PMID: 11715018.
17. Lin SY, Makino K, Xia W, Matin A, Wen Y, Kwong KY, Bourguignon L, Hung MC. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 3(9):802-808, 9/2001. PMID: 11533659.
18. Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 3(3):245-252, 3/2001. PMID: 11231573.
19. Lin SY, Xia W, Wang JC, Kwong KY, Spohn B, Wen Y, Pestell RG, Hung MC. Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci U S A 97(8):4262-4266, 4/2000. PMCID: PMC18221.
20. Xing X, Wang SC, Xia W, Zou Y, Shao R, Kwong KY, Yu Z, Zhang S, Miller S, Huang L, Hung MC. The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. Nat Med 6(2):189-195, 2/2000. PMID: 10655108.

Last updated: 4/3/2012