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Mitchell J. Frederick

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Head and Neck Surgery - Research, Division of Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Research Interests

1.  Testing of anti-cancer pharmaceuticals

2.  Mechanisms of drug resistance

3.  Pharmaceutical pathways specific for head and neck cancer

Office Address

The University of Texas M. D. Anderson Cancer Center
1515 Holcombe Blvd. - Unit 123
Unit Number: Unit 123
Houston, TX 77030
Room Number: T5.3908
Phone: 713-792-4708
Fax: 713-745-2234

Education & Training

Degree-Granting Education

1995 The University of Texas Health Science Center, Graduate School of Biomedical Science, Houston, TX, PHD, Cancer Biology
1985 University of Michigan, Ann Arbor, MI, BS, Cellular and Molecular Biology

Postgraduate Training

1/1996 Project Investigator Elizabeth A. Grimm, Ph.D, The University of Texas M.D. Anderson Cancer Center Department of Tumor Biology, Houston, TX

Selected Publications

Peer-Reviewed Original Research Articles
1. Henderson YC, Frederick MJ, Wang MT, Hollier LM, Clayman GL. LBP-1b, LBP-9, and LBP-32/MGR detected in syncytiotrophoblasts from first-trimester human placental tissue and their transcriptional regulation. DNA Cell Biology 27(2):71-9, 2/2008.
2. Henderson YC, Frederick, MJ, Clayman GL. Differential Responses of Human Papillary Thyroid Cancer Cell Lines Carrying the RET/PTC1 Rearrangement or a BRAF Mutation to MEK1/2 Inhibitors. Archives of Otolaryngology 133(8):810-15, 8/2007.
3. Henderson YC, Frederick MJ, Jayakumar A, Choi Y, Wang MT, Kang Y, Evans R, Spring PM, Uesugi M, Clayman GL. Human LBP-32/MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3. Placenta 28:152-60, 3/2007. PMID: 16730372.
4. Shellenberger TD, Mazumdar A, Henderson Y, Briggs K, Wang M, Chattopadhyay C, Jayakumar A, Frederick M, Clayman GL. Headpin: a serpin with endogenous and exogenous suppression of angiogenesis. Cancer Res 65(24):11501-9, 12/2005. PMID: 16357159.
5. Jayakumar A, Kang Y, Henderson Y, Mitsudo K, Liu X, Briggs K, Wang M, Frederick MJ, El-Naggar AK, Bebok Z, Clayman GL. Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distribution. Arch Biochem Biophys 435(1):89-102, 3/2005. PMID: 15680911.

Grant & Contract Support

Title: Effect of AstraZeneca Experimental Drugs on the Growth and Signaling Pathways of Colon Cancer Stem Cells
Funding Source: AstraZeneca
Role: Principal Investigator
Duration: 10/31/2008 - 10/30/2009

Last updated: 9/20/2009