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Mong-Hong Lee, Ph.D.

Present Title & Affiliation

Dual/Joint/Adjunct Appointment

Professor, Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number: Unit 108
Houston, TX 77030
Room Number: Y7.6075
Phone: (713) 794-1323
Fax: (713) 794-3270

Education & Training

Degree-Granting Education

1993 University of Pittsburgh, Pittsburgh, PA, PHD, Molecular, Cellular, & Developmental Biology
1984 National Taiwan University, Taipei, Taiwan, BS, Agricultural Chemistry

Postgraduate Training

1993-1997 Postdoctoral Fellowship, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY, Dr. Joan Massague


Academic Appointments

Associate Professor, Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2004-2010

Other Appointments/Responsibilities

Joint Faculty Member, Texas A&M Health Science Center Graduate School of Biomedical Sciences, Houston, TX, 2010-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Fang L, Yang Z, Zhou J, Tung JY, Hsiao CD, Wang L, Deng Y, Wang P, Wang J, Lee MH. Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal Cancer. Mol Cancer Ther 14(6):1476-87, 6/2015. e-Pub 4/2015. PMCID: PMC4458447.
2. Choi HH, Su CH, Fang L, Zhang J, Yeung SC, Lee MH. CSN6 deregulation impairs genome integrity in a COP1-dependent pathway. Oncotarget 6(14):11779-93, 5/2015. PMID: 25957415.
3. Choi, J., Guma, S., Fang, L., Phan, F., Ivan, C., Baggery, K., Sood, A. & Lee, M. H. Regulating the ubiquitination of CDK inhibitor p27 Kip1 via CSN6-COP1 axis. Cell Cycle, 5/2015. e-Pub 5/2015. PMID: 25945542.
4. Pathiraja, T. N., Thakkar, K. N., Jiang, S., Stratton, S., Liu, Z., Gagea, M., Shi, X., Shah, P. K., Phan, L., Lee, M. H., Andersen, J., Stampfer, M. & Barton, M. C. TRIM24 links glucose metabolism with transformation of human mammary epithelial cells. Oncogene 34(22):2836-45, 5/28/2015, 5/2015. PMCID: PMC4370790.
5. Fuentes-Mattei E, Velazquez-Torres G, Phan L, Zhang F, Chou PC, Shin JH, Choi HH, Chen JS, Zhao R, Chen J, Gully C, Carlock C, Qi Y, Zhang Y, Wu Y, Esteva FJ, Luo Y, McKeehan WL, Ensor J, Hortobagyi GN, Pusztai L, Fraser Symmans W, Lee MH, Yeung SC. Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer. J Natl Cancer Inst 106(7), 7/2014. e-Pub 6/23/2014. PMCID: PMC4110474.
6. 70. Wu, W., Merriman, K., Nabaah, A., Seval, N., Seval, D., Lin, H., Wang, M., Qazilbash, M. H., Baladandayuthapani, V., Berry, D., Orlowski, R. Z., Lee, M. H. & Yeung, S. The association of diabetes and anti-diabetic medications with clinical outcomes in multiple myeloma. British Journal of Cancer 111(3):628-36, 6/2014. e-Pub 6/2014. PMID: 24921909.
7. Phan LM, Yeung SC, Lee MH. Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies. Cancer Biol Med 11(1):1-19, 3/2014. PMCID: PMC3969803.
8. 71. Li, C., Bai, J., Hao, X., Zhang, S., Hu, Y., Zhang, X., Yuan, W., Hu, L., Cheng, T., Zetterberg, A., Lee, M. H. & Zhang, J. Multi-gene fluorescence in situ hybridization to detect cell cycle gene copy number aberrations in young breast cancer patients. Cell Cycle 13(8):1299-305, 2/2014. PMCID: PMC4049966.
9. Chen J, Shin JH, Zhao R, Phan L, Wang H, Xue Y, Post SM, Ho Choi H, Chen JS, Wang E, Zhou Z, Tseng C, Gully C, Velazquez-Torres G, Fuentes-Mattei E, Yeung G, Qiao Y, Chou PC, Su CH, Hsieh YC, Hsu SL, Ohshiro K, Shaikenov T, Wang H, Yeung SC, Lee MH. CSN6 drives carcinogenesis by positively regulating Myc stability. Nat Commun 5:5384, 2014. e-Pub 11/14/2014. PMCID: PMC4234183.
10. Zhao R, Yang HY, Shin J, Phan L, Fang L, Che TF, Su CH, Yeung SC, Lee MH. CDK inhibitor p57 (Kip2) is downregulated by Akt during HER2-mediated tumorigenicity. Cell Cycle 12(6):935-43, 3/2013. e-Pub 2/2013. PMCID: PMC3637352.
11. Esteva FJ, Moulder SL, Gonzalez-Angulo AM, Ensor J, Murray JL, Green MC, Koenig KB, Lee MH, Hortobagyi GN, Yeung SC. Phase I trial of exemestane in combination with metformin and rosiglitazone in nondiabetic obese postmenopausal women with hormone receptor-positive metastatic breast cancer. Cancer Chemother Pharmacol 71(1):63-72, 1/2013. e-Pub 9/2012. PMCID: PMC3536885.
12. Yang C, Lu W, Lin T, You P, Ye M, Huang Y, Jiang X, Wang C, Wang F, Lee MH, Yeung SC, Johnson RL, Wei C, Tsai RY, Frazier ML, McKeehan WL, Luo Y. Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress. BMC Gastroenterol 13:67, 2013. e-Pub 4/2013. PMCID: PMC3637159.
13. Luo Y, Yang C, Ye M, Jin C, Abbruzzese JL, Lee MH, Yeung SC, McKeehan WL. Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations. Cancer Metab 1(1):21, 2013. e-Pub 11/2013. PMID: 24279986.
14. Wen YY, Chou PC, Pham L, Su CH, Chen J, Hsieh YC, Xue Y-W, Qu C-J, Gully C, Parreno K, Teng C, Hsu SL, Yeung SC, Wang HM, Lee MH. DNA damage-mediated c-Myc degradation requires 14-3-3 sigma. Cancer Hallmarks(1, 3-17), 2013.
15. Pérez CM, Ortiz AP, Fuentes-Mattei E, Velázquez-Torres G, Santiago D, Giovannetti K, Bernabe R, Lee MH, Yeung SC. High Prevalence of Cardiometabolic Risk Factors in Hispanic Adolescents: Correlations with Adipocytokines and Markers of Inflammation. J Immigr Minor Health. e-Pub 2013. PMID: 23828626.
16. Chen B, Zhao R, Su CH, Linan M, Tseng C, Phan L, Fang L, Yang HY, Yang H, Wang W, Xu X, Jiang N, Cai S, Jin F, Yeung SC, Lee MH. CDK inhibitor p57 (Kip2) is negatively regulated by COP9 signalosome subunit 6. Cell Cycle 11(24):4633-41, 12/2012. e-Pub 11/2012. PMID: 23187808.
17. Teng CL, Hsieh YC, Phan L, Shin J, Gully C, Velazquez-Torres G, Skerl S, Yeung SC, Hsu SL, Lee MH. FBXW7 is involved in Aurora B degradation. Cell Cycle 11(21):4059-68, 11/2012. e-Pub 10/2012. PMCID: PMC3507501.
18. Xue Y, Chen J, Choi HH, Phan L, Chou PC, Zhao R, Yang H, Santiago J, Liu M, Yeung GE, Yeung SC, Lee MH. HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53. Cell Cycle 11(22):4181-90, 11/2012. e-Pub 10/2012. PMCID: PMC3524214.
19. Wu CC, Yang TY, Yu CT, Phan L, Ivan C, Sood AK, Hsu SL, Lee MH. p53 negatively regulates Aurora A via both transcriptional and posttranslational regulation. Cell Cycle 11(18):3433-42, 9/2012. e-Pub 8/2012. PMCID: PMC3466554.
20. Tu SM, Som A, Tu B, Logothetis CJ, Lee MH, Yeung SC. Effect of Paget's disease of bone (osteitis deformans) on the progression of prostate cancer bone metastasis. Br J Cancer 107(4):646-51, 8/2012. e-Pub 7/2012. PMCID: PMC3419961.
21. Gully CP, Velazquez-Torres G, Shin JH, Fuentes-Mattei E, Wang E, Carlock C, Chen J, Rothenberg D, Adams HP, Choi HH, Guma S, Phan L, Chou PC, Su CH, Zhang F, Chen JS, Yang TY, Yeung SC, Lee MH. Aurora B kinase Phosphorylates and Instigates Degradation of p53. Proc Natl Acad Sci U S A 109(24):E1513-22, 6/2012. e-Pub 5/2012. PMCID: PMC3386093.
22. Pan J, Chen C, Jin Y, Fuentes-Mattei E, Velazquez-Tores G, Benito JM, Konopleva M, Andreeff M, Lee MH, Yeung SC. Differential impact of structurally different anti-diabetic drugs on proliferation and chemosensitivity of acute lymphoblastic leukemia cells. Cell Cycle 11(12):2314-26, 6/2012. e-Pub 6/2012. PMCID: PMC3383592.
23. Qu C, Liang Z, Huang J, Zhao R, Su C, Wang S, Wang X, Zhang R, Lee MH, Yang H. miR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN. Cell Cycle 11(4). e-Pub 2/2012. PMID: 22306986.
24. Matthias N, Lockworth CR, Zhang F, Lee MH, Yeung SC, Tsai KY, Hamir AN. Multiple cystic sweat gland tumors in transgenic mice. Comp Med 62(1):27-30, 2/2012. PMCID: PMC3276389.
25. Choi HH, Gully C, Su CH, Velazquez-Torres G, Chou PC, Tseng C, Zhao R, Phan L, Shaiken T, Chen J, Yeung SC, Lee MH. COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3s. Oncogene 30(48):4791-801, 12/2011. e-Pub 5/2011. PMID: 21625211.
26. He X, Esteva FJ, Ensor J, Hortobagyi GN, Lee MH, Yeung SC. Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer. Ann Oncol. e-Pub 11/2011. PMID: 22112968.
27. Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest 121(3):851-65, 3/2011. e-Pub 2/2011. PMCID: PMC3049400.
28. Su CH, Zhao R, Zhang, F, Qu C, Feng YH, Pham L, Chen J, Wang H, Yeung J, Lee MH,. 14-3-3 sigma exerts tumor suppressor activity mediated by regulation of COP1 stability. Cancer Res 71:884-894, 2011.
29. Zhao R, Fuentes-Mattei E, Velazquez-Torres G, Su CH, Chen J, Lee MH, Yeung SC. Exenatide improves glucocorticoid-induced glucose intolerance in mice. Diabetes Metab Syndr Obes 4:61-5, 2011. e-Pub 1/2011. PMCID: PMC3064408.
30. Gully CP, Zhang F, Chen J, Yeung JA, Velazquez-Torres G, Wang E, Yeung SC, Lee MH. Anti-neoplastic effects of an Aurora B kinase inhibitor in breast cancer. Mol Cancer 9:42, 2010. PMCID: PMC2839967.
31. Jin Q, Yuan LX, Boulbes D, Baek JM, Wang YN, Gomez-Cabello D, Hawke DH, Yeung SC, Lee MH, Hortobagyi GN, Hung MC, Esteva FJ. Fatty acid synthase phosphorylation:a novel therapeutic target in HER2-overexpressing breast cancer cells. Breast Cancer Res 12(6):R96, 2010. e-Pub 11/2010. PMCID: PMC3046439.
32. Su CH, Zhao R, Velazquez-Torres G, Cheng J, Gully C, Yeung SC, Lee MH. Nuclear export regulation of COP1 by 14-3- sigma in response to DNA damage. Mol Cancer 9:243, 2010.
33. Feng YH, Velazquez-Torres G, Gully C, Chen J, Lee MH, Yeung SC. The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth. J Cell Mol Med 15:825-36, 2010. e-Pub 5/2010. PMID: 20455996.
34. Li DQ, Ohshiro K, Reddy SD, Pakala SB, Lee MH, Zhang Y, Rayala SK, Kumar R. E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. Proc Natl Acad Sci U S A 106(41):17493-8, 10/2009. e-Pub 9/2009. PMCID: PMC2762678.
35. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Kondo S, Wang H, Wang H, Yeung SC, Lee MH. Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation. Am J Pathol 175(1):400-11, 7/2009. e-Pub 6/2009. PMCID: PMC2708825.
36. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Yeung SC, Lee MH. Pim-1 plays a pivotal role in hypoxia-induced chemoresistance. Oncogene 28(28):2581-92, 7/2009. e-Pub 6/2009. PMID: 19483729.
37. Lee MH, Yeung SC. Intercepting Akt with DNAzyme: A nasopharyngeal carcinoma story. Cancer Biol Ther 8(4):372-4, 2/2009. e-Pub 2/2009. PMID: 19182540.
38. Pan J, Song E, Cheng C, Lee MH, Yeung SC. Farnesyltransferase inhibitors-induced autophagy: alternative mechanisms? Autophagy 5(1):129-31, 1/2009. e-Pub 1/2009. PMID: 19066466.
39. Yeung SC, Gully C, Lee MH. Aurora B kinase inhibitors for cancer chemotherapy. Mini Rev Med Chem 8(14):1514-25, 12/2008. PMID: 19075809.
40. Yeung SJ, Pan J, Lee MH. Roles of p53, Myc and HIF-1 in Regulating Glycolysis - the Seventh Hallmark of Cancer. Cell Mol Life Sci 65(24):3981-99, 12/2008. PMID: 18766298.
41. Pan J, Chen B, Su CH, Zhao R, Xu ZX, Sun L, Lee MH, Yeung SC. Autophagy induced by farnesyltransferase inhibitors in cancer cells. Cancer Biol Ther 7(10):1679-84, 10/2008. e-Pub 10/2008. PMID: 18769123.
42. Zhang XC, Chen J, Su CH, Yang HY, Lee MH. Roles for CSN5 in control of p53/MDM2 activities. J Cell Biochem 103(4):1219-30, 3/2008. PMID: 17879958.
43. Lee M.H., Yeung, S.J. & Yang, H. 14-3-3 family proteins and checkpoint response. Humana Press, 2008.
44. Yang HY, Wen YY, Lin YI, Pham L, Su CH, Yang H, Chen J, Lee MH. Roles for negative cell regulator 14-3-3sigma in control of MDM2 activities. Oncogene 26(52):7355-62, 11/2007. e-Pub 6/2007. PMID: 17546054.
45. Le XF, Bedrosian I, Mao W, Murray M, Lu Z, Keyomarsi K, Lee MH, Zhao J, Bast RC, Jr. Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway. Cell Cycle 5:1654-61, 8/2006. PMID: 16861913.
46. Yang H, Zhang Y, Zhao R, Wen YY, Fournier K, Wu HB, Yang HY, Diaz J, Laronga C, Lee MH. Negative cell cycle regulator 14-3-3sigma stabilizes p27 Kip1 by inhibiting the activity of PKB/Akt. Oncogene 25:4585-94, 8/2006. PMID: 16532026.
47. Lee MH, Lozano G. Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins. Semin Cancer Biol 16(3):225-34, 6/2006. e-Pub 4/2006. PMID: 16697215.
48. Yang HY, Yang H, Zhao R, Lee MH. Modified p27 Kip1 is efficient in suppressing HER2-mediated tumorigenicity. J Cell Biochem 98:128-38, 5/2006. PMID: 16365885.
49. Yang H, Wen YY, Zhao R, Lin YL, Fournier K, Yang HY, Qiu Y, Diaz J, Laronga C, Lee MH. DNA damage-induced protein 14-3-3 sigma inhibits protein kinase B/Akt activation and suppresses Akt-activated cancer. Cancer Res 66(6):3096-105, 3/2006. PMID: 16540659.
50. Ding Y, Lee JF, Lu H, Lee MH, Yan DH. Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. Mol Cell Biol 26:1979-96, 3/2006. PMID: 16479015.
51. Yang H, Zhao R, Lee MH. 14-3-3sigma, a p53 regulator, suppresses tumor growth of nasopharyngeal carcinoma. Mol Cancer Ther 5:253-60, 2/2006. PMID: 16505098.
52. Yang H, Zhao R, Yang HY, Lee MH. Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity. Oncogene 24:1924-35, 3/2005. PMID: 15688030.
53. Lee MH, Yang HY. Regulators of G1 cyclin-dependent kinases and cancers. Cancer Metastasis Rev 22:435-49, 12/2003. PMID: 12884917.
54. Yang HY, Wen YY, Chen CH, Lozano G, Lee MH. 14-3-3 sigma positively regulates p53 and suppresses tumor growth. Mol Cell Biol 23(20):7096-107, 10/2003. PMCID: PMC230310.
55. Lee MH, Yang HY. Negative regulators of cyclin-dependent kinases and their roles in cancers. Cell Mol Life Sci 58:1907-22, 11/2001. PMID: 11766887.
56. Yang HY, Shao R, Hung MC, Lee MH. p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis. Oncogene 20:3695-702, 6/2001. PMID: 11439332.
57. Newman LA, Sahin AA, Cunningham JE, Bondy ML, Mirza NQ, Vlastos GS, Whitman GJ, Brown H, Buchholz TA, Lee MH, Singletary SE. A case-control study of unilateral and bilateral breast carcinoma patients. Cancer 91:1845-53, 5/2001. PMID: 11346865.
58. Newman L, Xia W, Yang HY, Sahin A, Bondy M, Lukmanji F, Hung MC, Lee MH. Correlation of p27 protein expression with HER-2/neu expression in breast cancer. Mol Carcinog 30:169-75, 3/2001. PMID: 11301477.
59. Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 3:245-52, 3/2001. PMID: 11231573.
60. Yang HY, Zhou BP, Hung MC, Lee MH. Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27. J Biol Chem 275:24735-9, 8/2000. PMID: 10859299.
61. Laronga C, Yang HY, Neal C, Lee MH. Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression. J Biol Chem 275(30):23106-12, 7/2000. PMID: 10767298.
62. Yan Y, Frisen J, Lee MH, Massague J, Barbacia M. The CDK inhibitor P57Kip2 is required for cell differentiation and protection against apoptosis during mouse development. Genes and Development 11:973-982, 1997.
63. Lee MH, Nikolic M, Baptista CA, Lai E, Tsai LH, Massague J. The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons. Proc Natl Acad Sci U S A 93:3259-63, 4/1996. PMID: 8622924.
64. Orlow I, Iavarone A, Crider-Miller SJ, Bonilla F, Latres E, Lee MH, Gerald WL, Massague J, Weissman BE, Cordon-Cardo C. Cyclin-dependent kinase inhibitor p57KIP2 in soft tissue sarcomas and Wilms'tumors. Cancer Res 56:1219-21, 3/1996. PMID: 8640801.
65. Reid LH, Crider-Miller SJ, West A, Lee MH, Massague J, Weissman BE. Genomic organization of the human p57KIP2 gene and its analysis in the G401 Wilms' tumor assay. Cancer Res 56:1214-8, 3/1996. PMID: 8640800.
66. Pedulla, ML, Lee MH, Lever DC, Hatfull GF. A novel non-specific DNA-binding protein of mycobacteria required for phage L5 integration. Proc. Nat. Acad. Sci. USA 93:15411-15416, 1996.
67. Lee MH, Reynisdottir I, Massague J. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev 9(6):639-49, 3/1995. PMID: 7729683.
68. Ponce-Castaneda MV, Lee MH, Latres E, Polyak K, Lacombe L, Montgomery K, Mathew S, Krauter K, Sheinfeld J, Massague J, et al. p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors. Cancer Res 55:1211-4, 3/1995. PMID: 7882310.
69. Nourse J, Firpo E, Flanagan WM, Coats S, Polyak K, Lee MH, Massague J, Crabtree GR, Roberts JM. Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570-3, 12/1994. PMID: 7990932.
70. Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, Massague J. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78(1):59-66, 7/1994. PMID: 8033212.
71. Pascopella L, Collins FM, Martin JM, Lee MH, Hatfull GF, Stover CK, Bloom BR, Jacobs WR, Jr. Use of in vivo complementation in Mycobacterium tuberculosis to identify a genomic fragment associated with virulence. Infect Immun 62(4):1313-9, 4/1994. PMID: 8132338.
72. Hatfull GF, Barsom L, Chang L, Donnelly-Wu M, Lee MH, Levin M, Nesbit C, Sarkis GJ. Bacteriophages as tools for vaccine development. Dev Biol Stand 82:43-7, 1994. PMID: 7958482.
73. Lee MH, Hatfull GF. Mycobacteriophage L5 integrase-mediated site-specific integration in vitro. J Bacteriol 175(21):6836-41, 11/1993. PMID: 8226625.
74. Lee MH, Pascopella L, Jacobs WR, Jr, Hatfull GF. Site-specific integration of mycobacteriophage L5: integration-proficient vectors for Mycobacterium smegmatis, Mycobacterium tuberculosis, and bacille Calmette-Guerin. Proc Natl Acad Sci U S A 88(8):3111-5, 4/1991. PMID: 1901654.
75. Wen YY, Su CH, Chen J, Yeung SC, Lee MH. 14-3-3 and c-Myc degradation in response to DNA damage. Science Signaling. Submitted.
76. Chou, P. C., Zhao, R., Phan, L., Fuentes-Mattei, E., Velazquez-Torres, G., Choi, H. H., Zhang, F., Wu, Y., Yeung, S. C. & Lee, M. H. Anti-Insulin Resistance Treatments Suppress ErbB+ Breast Cancer Growth and Alter Cancer Metabolism Status. Cell Metabolism. Submitted.
77. Chen J, Zhao J, Shin JH, Wang H, xue Y, Post S, Zhou Z, Gully C, Phan L, Velazquez-Torres G, Fuentes-Mattei E, Yeung G, Ohshiro K, Qiao Y, Shaikenov T, Su CH, Wang H, Yeung J, Lee MH. COP9 signalosome governs Cullin neddylation in Myc-induced lymphomagenesis. Cancer Cell. Submitted.
78. Esteva FJ, Hortobagyi GN, Lee MH, Yeung SC. Safety and pharmaconkinetic study of exemestane in combination with metformin and rosiglitazone in overweight and obese postmenopausal women with hormone reptor-positive metastatic breast cancer. Eur J Cancer. Submitted.
79. He XX, Tu SM, Zhou ZG, Qu CJ, Xue YW, Guma S, Lee MH, Yeung SC. Thizaolidinediones and metformin associated with inproved survival of diabetic prostate cancer patients. Annals Oncol. Submitted.

Invited Articles

1. Lee MH, Zhao R, Phan L, Yeung SC. Roles of COP9 signalosome in cancer. Cell Cycle 10(18):3057-66, 9/2011. e-Pub 9/2011. PMCID: PMC3218617.
2. Lee MH, Yang HY. Molecular targets for cell cycle inhibition and cancer therapy. (peer reviewed). Expert Opinion on Therapeutic Patents 13:1-18, 2003.
3. Lee M and Yang HY. Negative regulators of cyclin-dependent kinases and their roles in cancer. Cellular and Molecular Life Sciences 58:1907-1922, 2001.


1. Yang HY, Shao RP, Xia W, Newman L, Hung MC, Lee MH. Enhanced ubiquitin-mediated degradation of p27 kip1 in Her2/neu overexpressing cancer. The First International Conference of Ubiquitin, Ubiquitin-like proteins, and Cancer meeting, 2002.
2. Yang, HY, Shou R P, Hung MC, Lee MH. Cyclin-dependent kinase inhibitor p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis. SCBA international meeting, Taipei, Taiwan, 2001.
3. Yang, HY, Shou R P, Hung MC, Lee MH. Inhibitory roles of p27 kip1 in HER2/neu-mediated cell growth and tumorigenesis. IIAR International Conference on Invasion and Metastasis, Athens, Greece, 2001.
4. Yang, HY, Shou R P, Hung MC, Lee MH. p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis. American Association for Cancer Research (AACR) 92nd Annual Meeting,, 2001.
5. Newman, LA, Vlastos G, Mirza NQ, Brown E, Sahin A, Bondy M, Whitman G, Lee MH, Yu D, Buccholz T, Singletary SE. Case-Control Study of Bilateral Breast Cancer (BBC) and Unilateral Breast Cancer (UBC). American Society of Clinical Oncology meeting, 2000.
6. Newman,LA, Vlastos G, Mirza NQ, Brown E, Sahin A, Bondy M, Whitman G, Lee MH, Yu D, Buccholz T, Singletary SE. Case-Control Study of Bilateral Breast Cancer (BBC) and Unilateral Breast Cancer (UBC). American Society of Clinical Oncology meeting, 2000.
7. Yang, HY, Lee MH. Oncogenic signals in regulating p27 stability. Era of Hope, Department of Defense Breast Cancer Research Meeting, the section of Cell Cycle and Breast Cancer, 2000.
8. Laronga, C, Yang HY, Neal C, Lee MH. Association Of The Cyclin-Dependent Kinases And 14-3-3 Sigma Negatively Regulates Cell Cycle Progression. American Association for Cancer Research (AACR) 91st Annual Meeting, 1999.
9. Yang, HY, Zhou BP, Hung MC, Lee MH. Oncogenic signals of HER-2/neu in regulating the stability of Cyclin-dependent kinase inhibitors p27. . Progression. American Association for Cancer Research (AACR) 91st Annual Meeting, 1999.

Book Chapters

1. Lee, M.H., Yang, H., Zhao, R. & Yeung, S.C. Roles of negative and positive growth regulators in nasopharyngeal carcinoma. In: Apoptosis in Carcinogenesis and Chemotherapy. Ed(s) Chen, G.G. Springer, 1-31, 2008.
2. Lee MH, Zhao Ruiying. Functional Regulation of Cip/Kip CDK inhibitors. In: Development of Inhibitors of Cyclin dependent Kinases as Antitumour Agents . 3. Ed(s) Smith, J.P. & Yue, E. CRC Press [as part of the enzyme inhibitor series], 2006.
3. Stover, CK, Burlein JE, Bennett LT, de la Cruz VF, Young JF, Furest TR, Hatfull G F, Lee MH, Jacobs Jr WR, Bloom B. Modern Approaches to New Vaccines Including Prevention of AIDS. Development of BCG as A Live Recombinant Vaccine Vehicle. In: Vaccine. 91. Cold Spring Harbor Press, 393-398, 1991.
4. Hatfull, G F; Donnelly, M; Lee, M H ; Nesbit, C; Peterson, L. Mycobacteriophage L5 : A Model for Genetic Analysis of the Mycobacteria. In: Twenty-Sixth US-Japan Joint Conference on Tuberculosis and Leprosy Research, 83-87, 1991.
5. Hatful, GF, Donnely M, Lee M, Peterson L; Oyaski M. Molecular Genetics of Mycobacteriophage L5. In: The Twenty-Fifth US-Japan Joint Conference on Leprosy Research, 38-42, 1990.

Last updated: 6/29/2015