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Morris D. Groves

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Neuro-Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1991 South Texas College of Law, Houston, TX, JD, Law
1986 Baylor College of Medicine, Houston, TX, MD, Medicine
1982 Baylor University, Waco, TX, BS, Biology

Postgraduate Training

1/1996-1998 Fellowship (Neuro Oncology), Neuro-Oncology, UT M.D. Anderson Cancer Center, Houston, TX
1993-1995 Resident (Neurology), Neurology, UT Health Science Center, Houston, TX
1986-1987 Intern (General Surgery), Baylor College of Medicine, Houston, TX

Board Certifications

American Board of Psychiatry and Neurology

Selected Publications

Peer-Reviewed Original Research Articles

1. Groves MD, Hess KR, Puduvalli VK, Colman H, Conrad CA, Gilbert MR, Weinberg J, Cristofanilli M, Yung WK, Liu TJ. Biomarkers of disease: cerebrospinal fluid vascular endothelial growth factor (VEGF) and stromal cell derived factor (SDF)-1 levels in patients with neoplastic meningitis (NM) due to breast cancer, lung cancer and melanoma. J Neurooncol 94(2):229-234, 9/2009. e-Pub 3/7/2009. PMID: 19267183.
2. Groves MD, Puduvalli VK, Gilbert MR, Levin VA, Conrad CA, Liu VH, Hunter K, Meyers, CA, Hess KR, Yung WK. Two Phase II Trials of Temozolomide with Interferon-a2b (Pegylated and non-pegylated) in Patients with Recurrent Glioblastoma Multiforme. Br J Cancer 101(4):615-620, 8/18/2009. PMID: 19672263.
3. Suki D, Hatiboglu MA, Patel AJ, Weinberg JS, Groves MD, Mahajan A, Sawaya R. Comparative Risk of Leptomeningeal Dissemination of Cancer after Surgery or Stereotactic Radiosurgery for Supratentorial Solid Tumor Metastases. Neurosurgery 64(4):664-74; discussion 674-6, 4/2009. e-Pub 2/2009. PMID: 19197219.
4. de Groot JF, Gilbert MR, Aldape K, Hess KR, Hanna TA, Ictech S, Groves MD, Conrad C, Colman H, Puduvalli VK, Levin V, Yung WK. Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma. J Neurooncol 90(1):89-97, 10/2008. e-Pub 6/26/2008. PMID: 18581057.
5. Groves MD, Katz RL. Low Grade Astrocytoma Presenting with Visual Loss. J Neurooncol 89(1):49-50, 8/2008. e-Pub 4/9/2008. PMID: 18398571.
6. Groves MD, Glantz MJ, Chamberlain MC, Baumgartner KE, Conrad CA, Hsu S, Wefel JS, Gilbert MR, Ictech S, Hunter KU, Forman AD, Puduvalli VK, Colman H, Hess KR, Yung WK. A Multicenter Phase II Trial of Intrathecal Topotecan in Patients with Meningeal Malignancies. Neuro Oncol 10(10):208-215, 4/2008. e-Pub 3/3/2008. PMCID: PMC2613823.
7. Puduvalli VK,Pierre G,Groves MD,Hess K,Gilbert MR,Mahankali S,Jackson E,Levin V,Conrad CA,Hsu S,Colman H,DeGroot J,Ritterhouse M,Ictech S,Yung WK. Phase II Trial of Irinotecan and Thalidomide in Adults with Recurrent Glioblastoma Multiforme. Neuro Oncol 10(2):216-222, 4/2008. e-Pub 2/26/2008. PMCID: PMC2613824.
8. Groves MD, Puduvalli VK, Chang SM, Conrad CA, Gilbert MR, Tremont-Lukats IW, Liu TJ, Peterson P, Schiff D, Cloughesy TF, Wen PY, Greenberg H, Abrey LE, Deangelis LM, Hess KR, Lamborn KR, Prados MD, Yung WK. A North American brain tumor consortium (NABTC 99-04) phase II trial of temozolomide plus thalidomide for recurrent glioblastoma multiforme. J Neurooncol 81(3):271-7, 2/2007. e-Pub 9/22/2006. PMID: 17031561.
9. Colman H, Berkey BA, Maor MH, Groves MD, Schultz CJ, Vermeulen S, Nelson DF, Mehta MP, Yung WK. Phase II Radiation Therapy Oncology Group trial of conventional radiation therapy followed by treatment with recombinant interferon-beta for supratentorial glioblastoma: results of RTOG 9710. Int J Radiat Oncol Biol Phys 66(3):818-24, 11/2006. e-Pub 8/2006. PMID: 16887285.
10. Groves MD, Puduvalli VK, Conrad CA, Gilbert MR, Yung WK, Jaeckle K, Liu V, Hess KR, Aldape KD, Levin VA. Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: A relationship among efficacy, joint toxicity and anticonvulsant status. J Neurooncol 80(1):83-90, 10/2006. e-Pub 4/2006. PMID: 16639492.
11. Wen PY, Yung WK, Lamborn KR, Dahia PL, Wang Y, Peng B, Abrey LE, Raizer J, Cloughesy TF, Fink K, Gilbert M, Chang S, Junck L, Schiff D, Lieberman F, Fine HA, Mehta M, Robins HI, DeAngelis LM, Groves MD, Puduvalli VK, Levin V, Conrad C, Maher EA, Aldape K, Hayes M, Letvak L, Egorin MJ, Capdeville R, Kaplan R, Murgo AJ, Stiles C, Prados MD. Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin Cancer Res 12(16):4899-907, 8/2006. PMID: 16914578.
12. Cloughesy TF, Wen PY, Robins HI, Chang SM, Groves MD, Fink KL, Junck L, Schiff D, Abrey L, Gilbert MR, Lieberman F, Kuhn J, DeAngelis LM, Mehta M, Raizer JJ, Yung WK, Aldape K, Wright J, Lamborn KR, Prados MD. Phase II trial of tipifarnib in patients with recurrent malignant glioma either receiving or not receiving enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study. J Clin Oncol 24(22):3651-6, 8/2006. PMID: 16877733.
13. Rivera E,Meyers C,Groves M,Valero V,Francis D,Arun B,Broglio K,Yin G,Hortobagyi GN,Buchholz T. Phase I Study of Capecitabine in Combination with Temozolomide in the Treatment of Patients with Brain Metastases From Breast Carcinoma. Cancer 107(6):1348-54, 2006. PMID: 16909414.
14. Levin VA, Giglio P, Puduvalli VK, Jochec J, Groves MD, Yung WK, Hess K. Combination chemotherapy with 13-cis-retinoic acid and celecoxib in the treatment of glioblastoma multiforme. J Neurooncol 78(1):1-6, 11/2005. e-Pub 11/29/2005. PMID: 16391896.
15. Giglio P, Weinberg JS, Forman AD, Wolff R, Groves MD. Neoplastic meningitis in patients with adenocarcinoma of the gastrointestinal tract. Cancer 103(11):2355-62, 6/2005. PMID: 15856426.
16. Puduvalli VK, Yung WK, Hess KR, Kuhn JG, Groves MD, Levin VA, Zwiebel J, Chang SM, Cloughesy TF, Junck L, Wen P, Lieberman F, Conrad CA, Gilbert MR, Meyers CA, Liu V, Mehta MP, Nicholas MK, Prados M. Phase II study of fenretinide (NSC 374551) in adults with recurrent malignant gliomas: A North American Brain Tumor Consortium study. J Clin Oncol 22(21):4282-9, 11/2004. PMID: 15514370.
17. See SJ, Levin VA, Yung WK, Hess KR, Groves MD. 13-cis-retinoic acid in the treatment of recurrent glioblastoma multiforme. Neuro-oncol 6(3):253-8, 7/2004. PMCID: PMC1871997.

Invited Articles

1. Groves MD. Leptomeningeal Metastases: Still a Challenge. Educational book for the American Society of Clinical Oncology Meeting 2008:1-8, 2008.
2. Groves MD. The Pathogenesis of Neoplastic Meningitis. Current Oncology Reports 5:15-23, 2003.

Grant & Contract Support

Title: A Pilot Study of Bevacizumab for Meningeal Malignancies
Funding Source: Genentech, Inc.
Role: Principal Investigator
Duration: 7/2008
 
Title: A Phase I, Open-Label, Dose Escalation Study of ANG1005 in Patients with Malignant Glioma
Funding Source: AngioChem, Inc.
Role: Principal Investigator
Duration: 4/8/2008 - 3/25/2013
 
Title: Phase I/II Open-Label Multi-Center Trials of Pazopanib in Combination with Lapatinib in Adult Patients with Relapsed Malignant Glioma
Funding Source: GlaxoSmithKline
Role: Principal Investigator
Duration: 10/12/2006 - 10/31/2011
 
Title: A Phase I Safety and Pharmacokinetic Study of Intravenous RTA 744 Injection in Patients with Recurrent, Progressive or Refractory Neoplastic Meningitis
Funding Source: Institutional Research Grant, MDACC
Role: Principal Investigator
Duration: 8/31/2006 - 8/31/2011
 
Title: Phase II Study of Temozolomide and Intrathecal DepoCyte in Patients with Neoplastic Meningitis
Funding Source: Schering Plough, Enzon
Role: Principal Investigator
Duration: 1/1/2006 - 1/24/2010
 
Title: Determination of Cerebrospinal Fluid Levels of Vascular Endothelial Growth Factor as a Predictor of Malignant Meningitis
Funding Source: Enzon, Inc.
Role: Principal Investigator
Duration: 10/27/2003 - 12/31/2009
 
Title: Phase II Evaluation of Pegylated Interferon Alfa-2b and Temozolomide for the Treatment of Recurrent and Progressive Malignant Gliomas
Funding Source: Schering-Plough/Integrated Therapeutics, Inc.
Role: Principal Investigator
Duration: 8/22/2003 - 2/23/2011

Last updated: 9/18/2009