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Nicholas B. Levine, M.D.

Present Title & Affiliation

Primary Appointment

Director, Department of Neurosurgery, Nicholson Microsurgical and Endoscopic Center for Clinical Applications Laboratory, Division of Surgery, The University of Texas MD Anderson Cancer Center and Baylor College of Medicine, Houston, TX
Assistant Professor, Department of Neurosurgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
Co-Director of Education, MINTOS (Minimally Invasive and New Technology in Oncologic Surgery), Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Assistant Professor, Department of Neurosurgery, Division of Surgery, Baylor College of Medicine, Houston, TX

Bio Statement

Dr. Nicholas Levine is an Assistant Professor in the Department of Neurosurgery at MD Anderson Cancer Center, with subspecialty interests in open and endoscopic skull base surgery and complex intracranial neurosurgery. Surgical interest include tumors of the skull base, vestibular schwannomas, intraventricular tumors, pineal region tumors and craniopharyngiomas. Dr. Levine is also the Director of the Microsurgical and Endoscopic Center for Clinical Applications Laboratory. He has taught at national skull base courses on surgical approaches and anatomy.  He is fellowship trained in skull base surgery and cerebrovascular surgery.

Education & Training

Degree-Granting Education

2000 University of Michigan Medical School, Ann Arbor, MI, MD, Medicine
1996 University of California at Los Angeles, Los Angeles, CA, BS, Neuroscience

Postgraduate Training

7/2007-7/2008 Fellowship, Skull Base/Cerebrovascular, University of South Florida, Department of Neurosurgery, Tampa, FL
1/2005-12/2005 Fellowship, Cerebrovascular, University of Cincinnati, College of Medicine, Department of Neurosurgery, Cincinnati, OH
7/2000-7/2007 Residency, Neurosurgery, University of Cincinnati, College of Medicine, Department of Neurosurgery, Cincinnati, OH

Board Certifications

11/2012 American Board of Neurological Surgery

Honors and Awards

1996 Cum Laude, BS Neuroscience, University of California at Los Angeles

Selected Publications

Peer-Reviewed Original Research Articles

1. Levine NB, Kurokawa R, Fichtenbaum CJ, Howington JA, Kuntz C. An immunocompetent patient with primary Scedosporium apiospermum vertebral osteomyelitis. J Spinal Disord Tech 15(5):425-30, 10/2002. PMID: 12394669.
2. Levine NB, Tanaka T, Jones BV, Crone KR. Minimally invasive management of a traumatic artery aneurysm resulting from shaken baby syndrome. Pediatr Neurosurg 40(3):128-31, May-Jun, 5/2004. PMID: 15367803.
3. Kuntz C, Maher PC, Levine NB, Kurokawa R. Prospective evaluation of thoracic pedicle screw placement using fluoroscopic imaging. J Spinal Disord Tech 17(3):206-14, 6/2004. PMID: 15167336.
4. Levine NB, Collins J, Franz DN, Crone KR. Gradual formation of an operative corridor by balloon dilation for resection of subependymal giant cell astrocytomas in children with tuberous sclerosis: specialized minimal access technique of balloon dilation. Minim Invasive Neurosurg 49(5):317-20, 10/2006. PMID: 17163349.
5. Froelich SC, Aziz KM, Levine NB, Theodosopoulos PV, van Loveren HR, Keller JT. Refinement of the extradural anterior clinoidectomy: surgical anatomy of the orbitotemporal periosteal fold. Neurosurgery 61(5 Suppl 2):179-85; discussion 185-6, 11/2007. PMID: 18091231.
6. Levine NB, Miller MN, Crone KR. Endoscopic resection of colloid cysts: indications, technique, and results during a 13-year period. Minim Invasive Neurosurg 50(6):313-7, 12/2007. PMID: 18210351.
7. Froelich SC, Aziz KM, Levine NB, Pensak ML, Theodosopoulos PV, Keller JT. Exposure of the distal cervical segment of the internal carotid artery using the trans-spinosum corridor: cadaveric study of surgical anatomy. Neurosurgery 62(ONS Suppl 2):ONS354-ONS362, 5/2008. PMID: 18596515.
8. Froelich SC, Aziz KA, Levine NB, Tew JM, Keller JT, Theodosopoulos PV. Extension of the one-piece orbitozygomatic frontotemporal approach to the glenoid fossa: cadaveric study. Neurosurgery 62(ONS Suppl 2):ONS312-ONS317, 5/2008. PMID: 18596509.
9. Prabhu SS, Levine NB, Rao G, Shah K, Weinberg J. Report of Negative Diffusion-Weighted MR Imaging during Tumor Resections Using Intraoperative MRI. Stereotact Funct Neurosurg 87(5):304-308, 7/2009. PMID: 19641341.
10. Ringer AJ, Matern E, Parikh S, Levine NB. Screening for blunt cerebrovascular injury: selection criteria for use of angiography. J Neurosurg, 7/2009. PMID: 19645535.
11. Hanna E, DeMonte F, Ibrahim S, Roberts D, Levine N, Kupferman M. Endoscopic resection of sinonasal cancers with and without craniotomy: oncologic results. Arch Otolaryngol Head Neck Surg 135(12):1219-24, 12/2009. PMID: 20026819.
12. Hassaneen W, Cahill DP, Fuller GN, Levine NB. Immunohistochemical detection of somatostatin receptor subtype 5 (SSTR-5) in cushing adenoma. J Neurooncol 98(1):151-2, 5/2010. PMID: 19894022.
13. Levine NB, Demonte F. Functional outcome in the neurosurgical patient and its impact on quality of life. Skull Base 20(1):19-22, 1/2010. PMCID: PMC2853064.
14. Giliberti FM, Shinder R, Bell D, Savar AM, Sacks JM, Levine NB, Esmaeli B. Malignant mixed tumor of the lacrimal gland in a teenager. J Pediatr Ophthalmol Strabismus. e-Pub 2/2010. PMID: 20210279.
15. Uribe JS, Ramos E, Youssef AS, Levine N, Turner AW, Johnson WM, Vale FL. Craniocervical fixation with occipital condyle screws: biomechanical analysis of a novel technique. Spine (Phila Pa 1976) 35(9):931-8, 4/2010. PMID: 20375778.
16. Hassaneen W, Suki D, Salaskar AL, Levine NB, DeMonte F, Lang FF, McCutcheon IE, Dorai Z, Feiz-Erfan I, Wildrick DM, Sawaya R. Immediate morbidity and mortality associated with transcallosal resection of tumors of the third ventricle. J Clin Neurosci 17(7):830-6, 7/2010. PMID: 20478709.
17. Hassaneen W, Levine NB, Suki D, Salaskar AL, de Moura Lima A, McCutcheon IE, Prabhu SS, Lang FF, DeMonte F, Rao G, Weinberg JS, Wildrick DM, Aldape KD, Sawaya R. Multiple craniotomies in the management of multifocal and multicentric glioblastoma. J Neurosurg 114(3):576-84, 3/2011. PMID: 20690813.
18. Kupferman ME, Demonte F, Levine N, Hanna E. Feasibility of a robotic surgical approach to reconstruct the skull base. Skull Base 21(2):79-82, 3/2011. PMCID: PMC3312597.
19. Bell D, Gidley P, Levine N, Fuller GN. Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): sine qua non radiology-pathology and the University of Texas MD Anderson Cancer Center experience. Ann Diagn Pathol 15(2):117-23, 4/2011. PMID: 21167761.
20. Dziurzynski K, Wei J, Qiao W, Hatiboglu MA, Kong LY, Wu A, Wang Y, Cahill D, Levine N, Prabhu S, Rao G, Sawaya R, Heimberger AB. Glioma-associated cytomegalovirus mediates subversion of the monocyte lineage to a tumor propagating phenotype. Clin Cancer Res 17(14):4642-9, 7/2011. e-Pub 4/2011. PMCID: PMC3139801.
21. Khan MI, Habra MA, McCutcheon IE, Nogueras-González GM, Devin JK, Busaidy NL, Levine NB, Lindstrom W, Kagan D, Jimenez C, Waguespack SG. Random postoperative day 3 cortisol as a predictor of hypothalamic-pituitary-adrenal axis integrity after transsphenoidal surgery. Endocr Pract 17(5):1-25, 9/1/2011. e-Pub 3/2011. PMID: 21454228.
22. Dziurzynski K, Blas-Boria D, Suki D, Cahill DP, Prabhu SS, Puduvalli V, Levine N. Butterfly glioblastomas: a retrospective review and qualitative assessment of outcomes. J Neurooncol 109(3):555-63, 9/2012. e-Pub 7/2012. PMID: 22806339.
23. Mitchell EH, Diaz A, Yilmaz T, Roberts D, Levine N, DeMonte F, Hanna EY, Kupferman ME. Multimodality treatment for sinonasal neuroendocrine carcinoma. Head Neck 34(10):1372-6, 10/2012. e-Pub 11/2011. PMID: 22052583.
24. Bhayani MK, Yilmaz T, Sweeney A, Calzada G, Roberts DB, Levine NB, DeMonte F, Hanna EY, Kupferman ME. Sinonasal adenocarcinoma: A 16-year experience at a single institution. Head Neck 36(10):1490-6, 10/2014. e-Pub 1/29/2014. PMID: 23996784.
25. Ow TJ, Hanna EY, Roberts DB, Levine NB, El-Naggar AK, Rosenthal DI, DeMonte F, Kupferman ME. Optimization of long-term outcomes for patients with esthesioneuroblastoma. Head Neck 36(4):524-30, 4/2014. e-Pub 6/2013. PMID: 23780581.
26. Su SY, Kupferman ME, DeMonte F, Levine NB, Raza SM, Hanna EY. Endoscopic resection of sinonasal cancers. Curr Oncol Rep 16(2):369, 2/2014. PMID: 24445501.
27. Farnia B, Allen PK, Brown PD, Khatua S, Levine NB, Li J, Penas-Prado M, Mahajan A, Ghia AJ. Clinical Outcomes and Patterns of Failure in Pineoblastoma: A 30-year Single Institution Retrospective Review. World Neurosurg. e-Pub 7/2014. PMID: 25045788.
28. Maldaun MV, Khawja SN, Levine NB, Rao G, Lang FF, Weinberg JS, Tummala S, Cowles CE, Ferson D, Nguyen AT, Sawaya R, Suki D, Prabhu SS. Awake craniotomy for gliomas in a high-field intraoperative magnetic resonance imaging suite: analysis of 42 cases. J Neurosurg 121(4):1-8, 10/2014. e-Pub 8/2014. PMID: 25105702.
29. Alves MV, Roberts D, Levine NB, DeMonte F, Hanna EY, Kupferman ME. Impact of Chemoradiotherapy on CSF Leak Repair after Skull Base Surgery. J Neurol Surg B Skull Base 75(5):354-7, 10/2014. e-Pub 6/2014. PMCID: PMC4176540.


1. Effendi ST, Suki D, Levine NB, Lang FF. Stryker neuro-oncology award 199 insular glioma resection: the MD anderson experience. Neurosurgery 61 Suppl 1:226, 8/2014. PMID: 25032650.

Last updated: 10/22/2014