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Olga Y. Gorlova, PhD

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Epidemiology, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Professor, Department of Statistics, Rice University, Houston, TX

Bio Statement

 

I have a substantial experience in genetic epidemiology of scleroderma and have been collaborating with Dr. Mayes since 2007 on the genome wide study of scleroderma and on the effects of smoking in scleroderma susceptibility, and with Dr. Assassi in predicting scleroderma outcomes and clinical features based on patients’ genetic profile. My experience and qualifications, as evidenced by the publications below, make me well-suited to perform statistical analysis as a co-inverstigator on this project

Office Address

The University of Texas MD Anderson Cancer Center
1155 Pressler Street
Department of Epidemiology
Unit Number: Unit 1340
Houston, TX 77030
Phone: 713-792-5805

Education & Training

Degree-Granting Education

2000 Institute of Cytology and Genetics, Novosibirsk, Russian Federation, PHD, Genetics
1992 Novosibirsk University, Department of Sciences, Novosibirsk, Russian Federation, MS, Summa Cum Laude, Biology

Postgraduate Training

8/2000-1/2002 Postdoctoral Fellow, Genetic Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, Dr. Chris Amos

Honors and Awards

2010 Nominee, 6th Annual Robert M. Chamberlain Distinguished Mentor Award, The University of Texas MD Anderson Cancer Center
2008 Business and Professional Women of Texas Award, Business and Professional Women
1992 Second Prize at 30th International Student Scientific Conference, Novosibirsk University, Novosibirsk, Russia

Selected Publications

Peer-Reviewed Original Research Articles
1. Kalinina (Gorlova) OY, Gorlov IP. Effect of recombination on population fitness and density: a comparison of models with free recombination and without recombination. Dokl Biol Sci (Proceedings of Russian Academy of Sciences). 332:532-535 (In Russian), 1993.
2. Gorlov IP, Chepkasov IL, Kalinina (Gorlova) OY. Meiotic crossing over is not the only source of recombinants in human. Genetika 29(12):2000-2010. (In Russian), 12/1993. PMID: 8119579.
3. Gorlov IP, Zhelezova AI, Gorlova OYu. Sex differences in chiasma distribution along two marked mouse chromosomes: differences in chiasma distribution as a reason for sex differences in recombination frequency. Genet Res 64(3):161-6, 12/1994. PMID: 7698640.
4. Gorlov IP, Gorlova OY, Logunov DV. Cytogenetic studies on Siberian spiders. Hereditas 122:211-220, 1995.
5. Gorlova OY, Gorlov IP, Nevo E, Logunov DV. Cytogenetic studies on seventeen spider species from Israel. Bulletin of the British Arachnological Society 10:249-252, 1997.
6. Nevo E, Filippucci GM, Pavlicek T, Gorlova OY, Shenbrot G, Ivanitskaya E, Beiles A. Genotypic and phenotypic divergence of rodents (Acomys cahirinus and Apodemus mystacinus) at “Evolution Canyon”: Micro- and macroscale parallelism. Acta Theriologica Suppl. 5:9-34, 1998.
7. Gorlov I, Gorlova OY, Ivanitskaya E, Korol A, Nevo E. Recombination in subterranean mole rat Spalax ehrenbergi superspecies: ecological and cytogenetic determinants. Israel Journal of Zoology 45:306-307, 1999.
8. Gorlova OYu. Do mammalian karyotypes evolve towards equalization of relative chromosome lengths? Dokl Biol Sci 373:389-90, Jul-Aug, 7/2000. PMID: 11013840.
9. Gorlova OIu, Gorlov IP. Variation in the relative length of chromosomes in mammalian karyotypes. Hypothesis of equalizing selection. Genetika 36(6):725-39, 6/2000. PMID: 10923254.
10. Gorlov IP, Gorlova OY. Cost-benefit analysis of recombination and its application for understanding of chiasma interference. J Theor Biol 213(1):1-8, 11/2001. PMID: 11708850.
11. Gorlova OY, Kimmel M, Henschke C. Modeling of long-term screening for lung carcinoma. Cancer 92(6):1531-40, 9/2001. PMID: 11745232.
12. Gorlova OY, Amos CI, Zhu DK, Wang W, Turner S, Boerwinkle E. Power of a simplified multivariate test for genetic linkage. Ann Hum Genet 66(Pt 5-6):407-17, 11/2002. PMID: 12485473.
13. Gorlova OY, Amos CI, Wang NW, Shete S, Turner ST, Boerwinkle E. Genetic linkage and imprinting effects on body mass index in children and young adults. Eur J Hum Genet 11(6):425-32, 6/2003. PMID: 12774034.
14. Kimmel M, Gorlova OY. Stochastic models of progression of cancer and their use in controlling cancer-related mortality. Journal of Applied Mathematics and Computer Science 13(3):101-109, 2003.
15. Gorlov IP, Gorlova OY, Frazier ML, Amos CI. Missense mutations in hMLH1 and hMSH2 are associated with exonic splicing enhancers. Am J Hum Genet 73(5):1157-61, 11/2003. e-Pub 10/2003. PMCID: PMC1180494.
16. Gorlova OY, Amos C, Henschke C, Lei L, Spitz M, Wei Q, Wu X, Kimmel M. Genetic susceptibility for lung cancer: interactions with gender and smoking history and impact on early detection policies. Hum Hered 56(1-3):139-45, 2003. PMID: 14614248.
17. Gorlov IP, Gorlova OY, Frazier ML, Amos CI. Missense mutations in cancer suppressor gene TP53 are colocalized with exonic splicing enhancers (ESEs). Mutat Res 554(1-2):175-83, 10/2004. PMID: 15450416.
18. Gorlova OY, Peng B, Yankelevitz D, Henschke C, Kimmel M. Estimating the growth rates of primary lung tumours from samples with missing measurements. Stat Med 24(7):1117-34, 4/2005. PMID: 15568189.
19. Dong C, Li WD, Geller F, Lei L, Li D, Gorlova OY, Hebebrand J, Amos CI, Nicholls RD, Price RA. Possible genomic imprinting of three human obesity-related genetic loci. Am J Hum Genet 76(3):427-37, 3/2005. e-Pub 1/2005. PMCID: PMC1196395.
20. Gorlov IP, Gorlova OY, Amos CI. Predicting the oncogenicity of missense mutations reported in the International Agency for Cancer Research (IARC) mutation database on p53. Hum Mutat 26(5):446-54, 11/2005. PMID: 16173033.
21. Gorlova OY, Zhang Y, Schabath MB, Lei L, Zhang Q, Amos CI, Spitz MR. Never smokers and lung cancer risk: a case-control study of epidemiological factors. Int J Cancer 118(7):1798-804, 4/2006. PMID: 16217766.
22. Gorlova OY, Weng SF, Zhang Y, Amos CI, Spitz MR. Aggregation of cancer among relatives of never-smoking lung cancer patients. Int J Cancer 121(1):111-8, 7/2007. PMID: 17304511.
23. Wu X, Lin J, Etzel CJ, Dong Q, Gorlova OY, Zhang Q, Amos CI, Spitz MR. Interplay between mutagen sensitivity and epidemiological factors in modulating lung cancer risk. Int J Cancer 120(12):2687-95, 6/2007. PMID: 17290394.
24. Gorlova OY, Lei L, Zhu D, Weng SF, Shete S, Zhang Y, Li WD, Price RA, Amos CI. Imprinting detection by extending a regression-based QTL analysis method. Hum Genet 122(2):159-174, 9/2007. e-Pub 6/2007. PMID: 17562082.
25. Gorlov IP, Gorlova OY, Sunyaev SR, Spitz MR, Amos CI. Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms. Am J Hum Genet 82(1):100-12, 1/2008. PMCID: PMC2253956.
26. Gorlova OY, Weng SF, Zhang Y, Amos CI, Spitz MR, Wei Q. DNA repair capacity and lung cancer risk in never smokers. Cancer Epidemiol Biomarkers Prev 17(6):1322-8, 6/2008. PMID: 18559546.
27. Gorlov IP, Gorlova OY, Amos CI. Relative effects of mutability and selection on single nucleotide polymorphisms in transcribed regions of the human genome. BMC Genomics 9:292, 2008. PMCID: PMC2442617.
28. Deng L, Kimmel M, Foy M, Spitz M, Wei Q, Gorlova OY. Estimation of effects of smoking and DNA-repair capacity on coefficients of a carcinogenesis model for lung cancer. Int J Cancer 124(9):2152-8, 5/2009. e-Pub 11/2008. PMCID: PMC2749693.
29. Gorlov IP, Gallick GE, Gorlova OY, Amos C, Logothetis CJ. GWAS meets microarray: are the results of genome-wide association studies and gene-expression profiling consistent? Prostate cancer as an example. PLoS One 4(8):e6511, 2009. e-Pub 8/4/2009. PMCID: PMC2714961.
30. Gorlov IP, Byun J, Gorlova OY, Aparicio AM, Efstathiou E, Logothetis CJ. Candidate pathways and genes for prostate cancer: a meta-analysis of gene expression data. BMC Med Genomics 2(1):48, 2009. e-Pub 8/4/2009. PMCID: PMC2731785.

Grant & Contract Support

Title: Topography and genetics of smoking and nicotine dependence in American Indians
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Buchwald
Duration: 5/1/2010 - 4/30/2015
 
Title: A genome-wide study of lung cancer in never smokers
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 5/1/2010 - 2/28/2015
 
Title: Two stage genome-wide association study in systemic sclerosis
Funding Source: NIH/NIAMS
Role: Principal Investigator-MDACC
Principal Investigator: Dr. Maureen Mayes (UT-H Medical School)
Duration: 9/1/2008 - 8/31/2013

Last updated: 2/15/2013