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Patricia J. Eifel, M.D., F.A.C.R., FASTRO

Present Title & Affiliation

Primary Appointment

Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1977 Stanford University School of Medicine, Stanford, CA, MD, Medicine
1973 Stanford University, Stanford, CA, BS, Biology

Postgraduate Training

1981-1982 Post Doctoral Research Fellow, Post Doctoral Division of Radiation Biology, Stanford University, Stanford, CA, Dr. Brown
1980 Chief Resident, Radiation Therapy Division, Stanford University Hospital, Stanford, CA, Dr. Hoppe
1978-1981 Resident, Radiation Therapy Division, Stanford University Hospital, Stanford, CA, Dr. Hoppe
1977-1978 Intern, Department of Pediatrics, Stanford University Hospital, Stanford, CA, Dr. Hoppe

Board Certifications

1982 American Board of Radiology (Therapeutic Radiology)

Experience/Service

Administrative Appointments/Responsibilities

Program Director, Department of Radiation Oncology, Division of Radiation Oncology, Radiation Therapy Residency Program, Houston, TX, 1991-1998

Honors and Awards

2010 America's Top Doctors, Castle Connolly Guide
2009 America's Top Doctors, Castle Connolly Guide
2009 America's Top Doctors for Cancer, Castle Connolly Medical, LTD
2007 America's Top Doctors, Castle Connolly Guide
2006 America's Top Doctors, Castle Connolly Guide
2005 America's Top Doctors, Castle Connolly Guide
2004 America's Top Doctors, Castle Connolly Guide
2003 America's Top Doctors, Castle Connolly Guide
2002 America's Top Doctors, Castle Connolly Guide

Professional Memberships

American Association for Women Radiologists, Houston, TX
Member, 2007-present
American Board of Radiology, Tucson, AZ
Member, 1995-present
American Brachytherapy Society
Member, 1994-present
American College of Radiation Oncology, Bethesda, MD
Board of Chancellors, 1995-1997
Member, 1994-present
Chair, Resident Scholarship Program Committee, 1994-1999
American College of Surgeons, American Joint Committee on Cancer, Chicago, IL
Member, Gynecologic Task Force, 2006-present
American Society for Radiation Oncology
Chair, ASTRO Nominating Committee, Standing Committee, 11/2009-10/2010
Immediate Past Chair, ASTRO Board of Directors, 11/2009-10/2010
Past Chair, ASTRO Gold Medal Awards Committee, Standing Committee, 11/2009-10/2010
Member, ASTRO Finance/Audit Committee of the Society, 9/2008-present
Chair, ASTRO Executive Committee of the Society, 9/2008-11/2009
Chair, ASTRO Gold Medal Awards Committee of the Society, 9/2008-11/2009
President, 9/2007-9/2008
President-Elect, 9/2006-9/2007
Member, 1983-present
Society of Gynecologic Oncologists, Chicago, IL
Vice-Chair, International Committee, 2012-2014

Selected Publications

Peer-Reviewed Original Research Articles
1. Mikell JK, Klopp AH, Gonzalez GM, Kisling KD, Price MJ, Berner PA, Eifel PJ, Mourtada F. Impact of heterogeneity-based dose calculation using a deterministic grid-based boltzmann equation solver for intracavitary brachytherapy. Int J Radiat Oncol Biol Phys 83(3):e417-22, 7/1/2012. e-Pub 3/19/2012. PMID: 22436788.
2. Costales AB, Eifel PJ, Deavers MT, Frumovitz M, Schmeler KM. Metastatic adenocarcinoma found in inguinal, pelvic and para-aortic lymph nodes 14 years following hysterectomy for adenocarcinoma in situ of the cervix. Gynecol Oncol Reports 2. e-Pub 5/2012.
3. Klopp AH, Mourtada F, Yu H, Beadle B, Munsell M, Jhingran A, Eifel P. Pilot study of a computed tomography-compatible shielded intracavitary barchytherapy applicator for treatment of cervical cancer. Practical Radiation Oncology. e-Pub 5/2012.
4. Klopp AH, Eifel PJ. Biological predictors of cervical cancer response to radiation therapy. Semin Radiat Oncol 22(2):143-150, 4/2012. PMID: 22385921.
5. Kelly P, Das P, Varadhachary GR, Fontanilla HP, Krishnan S, Delclos ME, Jhingran A, Eifel PJ, Crane CH. Role of Definitive Radiation Therapy in Carcinoma of Unknown Primary in the Abdomen and Pelvis. Int J Radiat Oncol Biol Phys 82(5):2012-7, 4/2012. e-Pub 6/2011. PMID: 21640510.
6. Jhingran A, Salehpour M, Sam M, Levy L, Eifel PJ. Vaginal motion and bladder and rectal volumes during pelvic intensity-modulated radiation therapy after hysterectomy. Int J Radiat Oncol Biol Phys 82(1):256-62, 1/2012. e-Pub 11/2010. PMID: 21093170.
7. Greer BE, Koh WJ, Abu-Rustum NR, Apte SM, Campos SM, Chan J, Cho KR, Copeland L, Crispens MA, Dupont N, Eifel PJ, Gaffney DK, Huh WK, Kapp DS, Lurain JR, Martin L, Morgan MA, Morgan RJ, Mutch D, Remmenga SW, Reynolds RK, Small W, Teng N, Valea FA. Cervical cancer. J Natl Compr Canc Netw 8(12):1388-416, 12/2010. PMID: 21147903.
8. Eifel PJ. Radiotherapy: Intermediate-risk endometrial cancer--adjuvant treatment. Nat Rev Clin Oncol 7(10):553-4, 10/2010. PMID: 20877416.
9. Beadle BM, Jhingran A, Yom SS, Ramirez PT, Eifel PJ. Patterns of Regional Recurrence After Definitive Radiotherapy for Cervical Cancer. Int J Radiat Oncol Biol Phys 76(5):1396-403, 4/2010. e-Pub 7/2009. PMID: 19581056.
10. Klopp AH, Jhingran A, Ramondetta L, Lu K, Gershenson DM, Eifel PJ. Node-positive adenocarcinoma of the endometrium: outcome and patterns of recurrence with and without external beam irradiation. Gynecol Oncol 115(1):6-11, 10/2009. e-Pub 7/2009. PMID: 19632709.
11. Torres MA, Jhingran A, Thames HD, Levenback CF, Bodurka DC, Ramondetta LM, Eifel PJ. Concurrent chemoradiation in the routine management of patients with cervical cancer: does marital status matter? Int J Gynecol Cancer 19(6):1107-12, 8/2009. PMID: 19820377.
12. Beadle BM, Jhingran A, Salehpour M, Sam M, Iyer RB, Eifel PJ. Cervix regression and motion during the course of external beam chemoradiation for cervical cancer. Int J Radiat Oncol Biol Phys 73(1):235-41, 1/1/2009. e-Pub 5/29/2008. PMID: 18513882.
13. Eifel PJ, Jhingran A, Levenback CF, Tucker S. Predictive value of a proposed subclassification of Stages I and II cervical cancer based on clinical tumor diameter. Int J Gynecol Cancer 19(1):2-7, 1/2009. PMID: 19258933.
14. Tripuraneni P, Watson RL, Ang KK, Harrison L, Eifel P, Zietman A, Haffty B, Thevenot LI, Willett CG, Schomberg PJ, Pickles T, Halberg FE, Devlin PM. Intersociety Radiation Oncology Summit-SCOPE II. Int J Radiat Oncol Biol Phys 72(2):323-6, 10/2008. PMID: 18793951.
15. McGuire SE, Frank SJ, Eifel PJ. Treatment of recurrent vaginal melanoma with external beam radiation therapy and palladium-103 brachytherapy. Brachytherapy 7(4):359-63, Oct-Dec, 10/2008. e-Pub 9/2008. PMID: 18778972.
16. Klopp AH, Jhingran A, Ramdas L, Story MD, Broadus RR, Lu KH, Eifel PJ, Buchholz TA. Gene Expression Changes in Cervical Squamous Cell Carcinoma after Initiation of Chemoradiation and Correlation with Clinical Outcome. Int J Radiat Oncol Biol Phys 71(1):226-36, 5/2008. PMID: 18406887.
17. Wolfson AH, Winter K, Crook W, Krishan A, Grigsby PW, Markoe AM, Morris M, Gaffney DK, Eifel PJ, Lucci JA. Are increased tumor sneuploidy and heightened Cell Proliferation Along With Heterogeneity Associated With Patient Outcome for Carcinomas of the Uterine Cervix? A combined analysis of subjects treated in RTOG 9001 and a single-institution trial. Int J Radiat Oncol Biol Phys 70(1):111-117, 1/2008. e-Pub 10/2007. PMID: 17919835.
18. Torres MA, Jhingran A, Thames HD, Levenback CF, Bodurka DC, Ramondetta LM, Eifel PJ. Comparison of treatment tolerance and outcomes in patients with cervical cancer treated with concurrent chemoradiotherapy in a prospective randomized trial or with standard treatment. Int J Radiat Oncol Biol Phys 70(1):118-125, 1/2008. e-Pub 9/2007. PMID: 17869451.
19. Gaffney DK, Winter K, Dicker AP, Miller B, Eifel PJ, Ryu J, Avizonis V, Fromm M, Small W, Greven K. Efficacy and patterns of failure for locally advanced cancer of the cervix treated with celebrex (celecoxib) and chemoradiotherapy in RTOG 0128. Int J Radiat Oncol Biol Phys 69(1):111-7, 9/2007. e-Pub 5/2007. PMID: 17482376.
20. Gaffney DK, Winter K, Dicker AP, Miller B, Eifel PJ, Ryu J, Avizonis V, Fromm M, Greven K. A Phase II study of acute toxicity for Celebrex (celecoxib) and chemoradiation in patients with locally advanced cervical cancer: primary endpoint analysis of RTOG 0128. Int J Radiat Oncol Biol Phys 67(1):104-9, 2007. e-Pub 11/2006. PMID: 17084549.
21. Frank SJ, Deavers MT, Jhingran A, Bodurka DC, Eifel PJ. Primary adenocarcinoma of the vagina not associated with diethylstilbestrol (DES) exposure. Gynecol Oncol 105(2):470-474, 2007. e-Pub 2/2007. PMID: 17292459.
22. Mourtada F, Gifford KA, Berner PA, Horton JL, Price MJ, Lawyer AA, Eifel PJ. Retrospective dosimetric comparison of low-dose-rate and pulsed-dose-rate intracavitary brachytherapy using a tandem and mini-ovoids. Med Dosim 32(3):181-187, 2007. PMID: 17707197.
23. Pothuri B, Ramondetta L, Eifel P, Deavers MT, Wilton A, Alektiar K, Barakat R, Soslow RA. Radiation-associated endometrial cancers are prognostically unfavorable tumors: a clinicopathologic comparison with 527 sporadic endometrial cancers. Gynecol Oncol 103(3):948-51, 12/2006. e-Pub 7/2006. PMID: 16870239.
24. Price MJ, Gifford KA, Horton J, Lawyer A, Eifel P, Mourtada F. Comparison of dose distributions around the pulsed-dose-rate Fletcher-Williamson and the low-dose-rate Fletcher-Suit-Delclos ovoids: a Monte Carlo study. Phys Med Biol 51(16):4083-94, 8/2006. e-Pub 8/2006. PMID: 16885626.
25. Klopp AH, Eifel PJ. Gene expression profiling in cervical cancer: state of the art and future directions. Cancer J 12(3):170-174, May-Jun, 5/2006. PMID: 16803672.
26. Eifel PJ, Jhingran A, Brown J, Levenback C, Thames H. Time course and outcome of central recurrence after radiation therapy for carcinoma of the cervix. Int J Gynecol Cancer 16(3):1106-11, May-Jun, 5/2006. PMID: 16803493.
27. Greer BE, Koh WJ, Abu-Rustum N, Bookman MA, Bristow RE, Campos S, Cho KR, Copeland L, Eifel P, Jaggernauth W, Jhingran A, Kapp DS, Kavanagh J, Lipscomb GH, Lurain JR, 3rd, Morgan RJ, Jr, Nag S, Partridge EE, Powell CB, Remmenga SW, Reynolds RK, Small W, Jr, Soper J, Teng N. Uterine cancers. J Natl Compr Canc Netw 4(5):438-62, 5/2006. PMID: 16687093.
28. Eifel PJ. Chemoradiotherapy for cervical cancer: what next? J Clin Oncol 23(33):8277-9, 11/2005. e-Pub 10/2005. PMID: 16230671.
29. Price MJ, Horton JL, Gifford KA, Eifel PJ, Jhingran A, Lawyer AA, Berner PA, Mourtada F. Dosimetric evaluation of the Fletcher-Williamson ovoid for pulsed-dose-rate brachytherapy: a Monte Carlo study. Phys Med Biol 50(21):5075-87, 11/2005. e-Pub 10/2005. PMID: 16237242.
30. Gifford KA, Horton JL, Pelloski CE, Jhingran A, Court LE, Mourtada F, Eifel PJ. A three-dimensional computed tomography-assisted Monte Carlo evaluation of ovoid shielding on the dose to the bladder and rectum in intracavitary radiotherapy for cervical cancer. Int J Radiat Oncol Biol Phys 63(2):615-21, 10/2005. PMID: 16168853.
31. Frumovitz M, Sun CC, Schover LR, Munsell MF, Jhingran A, Wharton JT, Eifel P, Bevers TB, Levenback CF, Gershenson DM, Bodurka DC. Quality of life and sexual functioning in cervical cancer survivors. J Clin Oncol 23(30):7428-36, 10/2005. PMID: 16234510.
32. Ahamad A, D'Souza W, Salehpour M, Iyer R, Tucker SL, Jhingran A, Eifel PJ. Intensity-modulated radiation therapy after hysterectomy: comparison with conventional treatment and sensitivity of the normal-tissue-sparing effect to margin size. Int J Radiat Oncol Biol Phys 62(4):1117-24, 7/2005. PMID: 15990017.
33. Bristol I, Brown J, Slomovitz BM, Shannon VR, Eifel PJ. Methemoglobinemia induced by topical vaginal sulfanilamide cream in a patient with cervical cancer: a case report. Gynecol Oncol 97(3):953-6, 6/2005. PMID: 15907987.
34. Pelloski CE, Palmer M, Chronowski GM, Jhingran A, Horton J, Eifel PJ. Comparison between CT-based volumetric calculations and ICRU reference-point estimates of radiation doses delivered to bladder and rectum during intracavitary radiotherapy for cervical cancer. Int J Radiat Oncol Biol Phys 62(1):131-7, 5/2005. PMID: 15850913.
35. Frank SJ, Jhingran A, Levenback C, Eifel PJ. Definitive radiation therapy for squamous cell carcinoma of the vagina. Int J Radiat Oncol Biol Phys 62(1):138-47, 5/2005. PMID: 15850914.
36. Slomovitz BM, Ramondetta LM, Lee CM, Oh JC, Eifel PJ, Jhingran A, Burke TW, Gershenson DM, Lu KH. Heterogeneity of stage IIIA endometrial carcinomas: implications for adjuvant therapy. Int J Gynecol Cancer 15(3):510-6, May-Jun, 5/2005. PMID: 15882178.
37. D'Souza WD, Ahamad AA, Iyer RB, Salehpour MR, Jhingran A, Eifel PJ. Feasibility of dose escalation using intensity-modulated radiotherapy in posthysterectomy cervical carcinoma. Int J Radiat Oncol Biol Phys 61(4):1062-70, 3/2005. PMID: 15752885.
38. Erickson B, Eifel P, Moughan J, Rownd J, Iarocci T, Owen J.. Patterns of brachytherapy practice for patients with carcinoma of the cervix (1996-1999): A patterns of care study. Int J Radiat Oncol Biol Phys 63(4):1083-92, 2005. e-Pub 8/2005. PMID: 16099599.
39. Eifel PJ, Moughan J, Erickson B, Iarocci T, Grant D, Owen J. Patterns of radiotherapy practice for patients with carcinoma of the uterine cervix: a patterns of care study. Int J Radiat Oncol Biol Phys 60(4):1144-53, 11/2004. PMID: 15519786.
40. Soliman PT, Slomovitz BM, Broaddus RR, Sun CC, Oh JC, Eifel PJ, Gershenson DM, Lu KH. Synchronous primary cancers of the endometrium and ovary: A single institution review of 84 cases. Gynecol Oncol 94(2):456-62, 8/2004. PMID: 15297188.
41. Viswanathan AN, Deavers MT, Jhingran A, Ramirez PT, Levenback C, Eifel PJ. Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence. Gynecol Oncol 93(1):27-33, 4/2004. PMID: 15047210.
42. Callister M, Ramondetta LM, Jhingran A, Burke TW, Eifel PJ. Malignant mixed Müllerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome. Int J Radiat Oncol Biol Phys 58(3):786-96, 3/2004. PMID: 14967435.
43. Eifel PJ, Winter K, Morris M, Levenback C, Grigsby PW, Cooper J, Rotman M, Gershenson D, Mutch DG. Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01. J Clin Oncol 22(5):872-80, 3/2004. PMID: 14990643.
44. Frumovitz M, Ramirez PT, Tortolero-Luna G, Malpica A, Eifel P, Burke TW, Levenback C. Characteristics of recurrence in patients who underwent lymphatic mapping for vulvar cancer. Gynecol Oncol 92:205-10, 2004. PMID: 14751159.

Invited Articles
1. Eifel PJ. Chemoradiotherapy in the treatment of cervical cancer. Semin Radiat Oncol 16(3):177-86, 2006. PMID: 16814159.
2. Eifel PJ. Concurrent chemotherapy and radiation therapy as the standard of care for cervical cancer. Nat Clin Pract Oncol 3(5):248-55, 2006. PMID: 16683003.

Book Chapters
1. Eifel PJ, Levenback C. Cervical Cancer. In: 60 Years of Survival Outcomes at the University of Texas MD Anderson Cancer Center. Ed(s) Rodriguez MA, Walters RS, Burke TW. Springer: New York, 97-107, 2013.
2. Eifel PJ. A multidisciplinary approach to cancer: A radiation oncologist’s view. In: Oncologic Imaging. Ed(s) Silverman P. Elsevier: Philadelphia, PA, 17-24, 2012. ISBN: 978-1-4377-2232-1.
3. Bhosale P, Kamat A, Eifel PJ. Ovarian Cancer. In: Oncologic Imaging. Ed(s) PM Silverman. Elsevier: New York, 455-478, 2012. ISBN: 978-1-4377-2232-1.
4. Eifel PJ, Berek JS, Markman MA. Cancer of the Cervix, Vagina, and Vulva. In: DeVita, Hellman, and Rosenberg’s Cancer: Principles and Practices of Oncology, 9th. Ed(s) VT DeVita, Jr., TS Lawrence, SA Rosenberg. Lippincott, Williams & Wilkins: Philadelphia, PA, 1311-1344, 2011. ISBN: 1-4511-0545-2.
5. Jhingran A, Eifel P. The Endometrium. In: Radiation Oncology, 9th. Mosby: St. Louis, 774-797, 2010. ISBN: 978-0-323-04791-9.
6. Eifel PJ. The Uterine Cervix. In: Radiation Oncology, 9th. Ed(s) JD Cox and KK Ang. Mosby: St. Louis, MO, 733-797, 2010. ISBN: 978-0-323-04791-9.
7. Eifel PJ. The Vulva and Vagina. In: Radiation Oncology, 9th. Ed(s) JD Cox and KK Ang. Mosby: St. Louis, MO, 798-811, 2010. ISBN: 978-0-323-04971-9.
8. Choi S, Eifel PJ. Cervical Cancer. In: J Natl Compr Canc Netw. 6, 1. Ed(s) B Haffty, L Wilson. Jones Bartlett Publishers: Sudbury, MA, 14-36, 2008. ISBN: 18267056.
9. Eifel PJ. Integration of chemotherapy & radiation for cancer of the cervix. In: Choices in Advanced Radiotherapy, 1. Ed(s) Richard F. Mould. Nucletron B.V. The Netherlands, 99-103, 2007. ISBN: 978-90-5353-046-7.
10. Karlan B, Markman M, Eifel PJ. Ovarian cancer, fallopian tube carcinoma, and peritoneal carcinoma. In: Cancer. Principles and Practice of Oncology, 7th Edition, 7. Ed(s) VT DeVita Jr., S Hellman, SA Rosenberg. Lippincott Williams & Wilkins: Philadelphia, PA, 1295-1341, 2007. ISBN: 0-781-74450-4.
11. Eifel PJ Burke TW. Contemporary treatment of vaginal and vulvar cancers. In: MD Anderson Cancer Care Series. Gynecologic Cancer. Ed(s) AU Buzdar and FS Freedman. Springer-Verlag: New York, 64, 2006.
12. Gershenson DM, Kavanagh JJ, Eifel PJ, Silva EG. Multidisciplinary care of patients with gynecologic cancers. In: MD Anderson Cancer Care Series. Gynecologic Cancer. Ed(s) AA Buzdar and RS Freedman. Springer-Verlag: New York, 2006.
13. Jhingran A, Eifel PJ, Wharton JT, Tortolero-Luna G. Neoplasms of the cervix. In: Cancer Medicine 7. Ed(s) Holland and Frei. B.C. Decker, Inc. London, 1497, 2006.
14. Jhingran A, Eifel PJ, Ramirez P. Treatment of locally advanced cervical cancer. In: MD Anderson Cancer Care Series. Gynecologic Cancer. Ed(s) AA Buzdar and RS Freedman. Springer-Verlag: New York, 102, 2006.
15. Eifel PJ, Berek JS, Markman MA. Cancer of the cervix, vagina, and vulva. In: Cancer. Principles and Practice of Oncology, 7th. Ed(s) VT DeVita Jr., S Hellman and SA Rosenberg. Lippincott, Williams & Wilkins: Philadelphia, PA, 1295, 2005.
16. Eifel PJ. Intensity-modulated radiation therapy for carcinomas of the uterine cervix and endometrium. In: Image-Guided IMRT. Ed(s) T Bortfeld, R Schmidt-Ullrich, W DeNeve, and DE Wazer. Springer-Verlag: Berlin Heidelberg, 411, 2005.
17. Karlan BY, Markman MA, Eifel PJ. Ovarian cancer, peritoneal carcinoma, and fallopian tube carcinoma. In: Cancer. Principles & Practice of Oncology, 7th. Ed(s) VT DeVita Jr., S Hellman, and SA Rosenberg. Lippincott, Williams & Wilkins: Philadelphia, PA, 1364, 2005.
18. Eifel PJ. Radiation Therapy. In: Practical Gynecologic Oncology, 4th. Ed(s) JS Berek and NF Hacker. Lippincott, Williams & Wilkins: Philadelphia, PA, 119-16, 2005.
19. Eifel PJ Curtin J. Early-Stage Cervical Cancer. In: Gynecologic Cancer: Controversies in Management. Elsevier Science: Philadelphia, PA, 161-174, 2004.
20. Jhingran A Eifel PJ. Radiation Therapy. In: Handbook of Gynecologic Oncology, 2nd. Ed(s) RR Barakat, MW Bevers, DM Gershenson, WJ Hoskins. Martin Dunitz Ltd. London, 77-90, 2002. ISBN: 1-84184-166-8.

Books (edited and written)
1. PJ Eifel, DM Gershenson, JJ Kavanaugh, EG Silva. Ed(s) PJ Eifel, DM Gershenson, JJ Kavanaugh, EG Silva. Gynecologic Cancer. In: MD Anderson Cancer Care Series. Series Ed(s) AU Buzdar and FS Freedman, 5. Springer: New York, 2006.

Grant & Contract Support

Title: Quality Research in Radiation Oncology (QRRO)
Funding Source: NIH/NCI
Role: Gynecologic Committee Chair
Principal Investigator: Wilson, J
Duration: 6/15/2006 - 4/30/2010

Last updated: 3/7/2013