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Patrick M. Lynch, J.D., M.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Gastroenterology, Hepat,& Nutr, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1400 Pressler
Unit Number: Unit 1466
Houston, TX 77030
Phone: (713) 794-5073
Fax: (713) 794-5398
Email: plynch@mdanderson.org

Education & Training

Degree-Granting Education

1983 Creighton University School of Medicine, Omaha, NE, MD, Medicine
1975 Creighton University School of Law, Omaha, NE, JD, Law

Postgraduate Training

7/1986-6/1988 Clinical Fellowship, Gastroenterology, Baylor College of Medicine, Houston, TX
7/1984-6/1986 Clinical Residency, University of Arkansas for Medical Sciences, Little Rock, AR
7/1983-6/1984 Clinical Internship, University of Arkansas for Medical Sciences, Little Rock, AR

Board Certifications

1/1988 Gastroenterology, Board Eligible
1/1986 American Board of Internal Medicine

Experience/Service

Academic Appointments

Associate Professor, Department of Gastroenterology, Hepat,& Nutr, Division of Internal Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 1/1996-8/2009

Institutional Committee Activities

Member, Executive Committee of Prevention Faculty, 1/1997-1/1999
Member, Criteria for Advancement Committee (ad hoc), 1/1995
Member, Quality Assurance Committee, Gastroenterology, 1/1993-1/1999
Member, Program Committee: "Advances in Biology and Therapy of Colorectal Cancer", 1/1993

Professional Memberships

Alpha Omega Alpha Honorary Medical Society
Member, 1/1983-present
American Gastroenterological Association
Member, 1/1992-present
Chairman, Subcommittee on Colorectal Cancer, Clinical Teaching Program (CTP) Committee, 1/1992-1/1998
American Society for Gastrointestinal Endoscopy
member, 1989-present
American Society of Clinical Oncology
Member, Task Force on Cancer Genetics Education, 1/1997-1/2000
Member, 1/1995-1/2000
Member, Subcommittee on Cancer Genetic Testing, 1/1995-1/2000
Cancer Studies Consortium Task Force on Preventive Recommendations
Member, 1/1995-1/2000
Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA)
Council Member, 1/2001-present
President, 1/2000-1/2001
Cooperative Family Registry for Colorectal Cancer Studies
Member, Advisory Committee, 1/1997-present
International Society for Gastrointestinal Hereditary Tumors
Governing Council and Member, 1/2003-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Lynch PM. Tumor-Based Screening for Hereditary Nonpolyposis Colorectal Cancer: Does Age-Based Selection Optimize Yield? Journal of Oncology Practice. e-Pub 1/2013.
2. Lynch PM. Current approaches in hereditary nonpolyposis colorectal cancer. J Natl Compr Canc Netw 10(8):961-7, 8/2012. PMID: 22878821.
3. Lynch PM. Hyperplastic polyposis: semantics, biology, and endoscopy. Gut 59(8):1019-21, 8/2010. PMID: 20639248.
4. Lynch PM. Eicosapentaenoic acid and chemoprevention of FAP. Gut 59(7):871-3, 7/2010. PMID: 20581233.
5. Lynch PM, Ayers GD, Hawk E, Richmond E, Eagle C, Woloj M, Church J, Hasson H, Patterson S, Half E, Burke CA. The safety and efficacy of celecoxib in children with familial adenomatous polyposis. Am J Gastroenterol 105(6):1437-1443, 6/2010. e-Pub 3/2010. PMID: 20234350.
6. Lynch PM. Pharmacotherapy for inherited colorectal cancer. Expert Opinion Pharmacotherapy 11(7):1101-1108, 5/2010. PMID: 20345333.
7. Zhang L, Ren X, Alt E, Bai X, Huang S, Xu Z, Lynch PM, Moyer MP, Wen XF, Wu X. Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis. Nature, 4/2010. PMID: 20348907.
8. Burton AM, Peterson SK, Marani SK, Vernon SW, Amos CI, Frazier ML, Lynch PM, Gritz Er. Health and lifestyle behaviors among persons at risk of Lynch syndrome. Cancer Causes Control 21(4):513-521, 4/2010. e-Pub 12/2009. PMID: 20012181.
9. Coolbaugh-Murphy MI, Xu JP, Ramagli LS, Ramagli BC, Brown BW, Lynch PM, Hamilton SR, Frazier ML, Siciliano MJ. Microsatellit instability in the peripheral blood leukocytes of HNPCC patients. Human Mutation 31(3):317-24, 3/2010. PMID: 20052760.
10. Pande M, Lynch PM, Hopper JL, Jenkins MA, Gallinger S, Haile RW, Lemarchand L, Lindor NM, Campbell PT, Newcomb PA, Potter JD, Baron JA, Frazier ML, Amos CI. Smoking and Colorectal Cancer in Lynch Syndrome: Results from the Colon Cancer Family Registry and The University of Texas M.D. Anderson Cancer Center. Clin Cancer Res 16(4):1331-1339, 2/2010. e-Pub 2/2010. PMCID: PMC2822883.
11. Burt RW, Barthel JS, Dunn KB, David DS, Drelichman E, Ford JM, Giardiello FM, Gruber SB, Halverson AL, Hamilton SR, Ismail MK, Jasperson K, Lazenby AJ, Lynch PM, Martin EW Jr, Mayer RJ, Ness RM, Provenzale D, Rao MS, Shike M, Stein bach G, Terdiman JP, Weinberg D. NCCN clinical practice guidelines in oncology. Colorectal cancer screening. J Natl Compr Canc Netw 8(1):8-61, 1/2010. PMID: 20064289.
12. Chen J, Etzel CJ, Amos CI, Zhang Q, Viscofsky N, Lindor NM, Lynch PM, Frazier ML. Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome. Cancer Causes Control 20(9):1769-77, 11/2009. e-Pub 8/2009. PMID: 19690970.
13. Lynch PM. The hMSH2 and hMLH1 genes in hereditary nonpolyposis colorectal cancer. Surg Oncol Clin N Am 18(4):611-24, 10/2009. PMID: 19793569.
14. HT Lynch, PM LYnch, SJ Lanspa, CL Snyder, JF Lynch, CR Boland. Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications. Clin Genet 76:1-18, 2009.
15. Pande M, Amos CI, Osterwisch DR, Chen J, Lynch PM, Broaddus R, Frazier ML. Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome. Cancer Epidemiol Biomarkers Prev 17(9):2393-401, 9/2008. PMID: 18768509.
16. Lynch PM. Chemoprevention with special reference to inherited colorectal cancer. Fam Cancer 7(1):59-64, 2008. PMID: 17680350.
17. Lynch PM. Standards of care in diagnosis and testing for hereditary colon cancer. Fam Cancer 7(1):65-72, 2008. PMID: 17701450.

Invited Articles
1. Lynch HT, Lynch PM. Molecular screening for the Lynch syndrome-better than family history? N Engl Med 352(18):1920-22, 5/2005.

Editorials
1. Lynch, PM. How Helpful is Age at Colorectal Cancer Onset in Finding HNPCC. Disease of Colon & Rectum. In Press.
2. Lynch, PM. Immunohistochemistry to detect Hereditary Nonpolyposis Colorectal Cancer in young patients: the seven-year Auckland experience. Disease of Colon & Rectum. In Press.

Abstracts
1. Chen J, Pande M, Huang Y, Wei C, Amos C, Talseth-Palmer B, Meldrum C, Chen W, Gorlov I, Lynch P, Scott R, Frazier M. Cell cycle–related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients. Carcinogenisis, 11/2012.
2. Mala Pande, Marsha L. Frazier, Patrick M. Lynch, Russell Broaddus, Christopher Amos. Genome wide association identified colorectal cancer susceptibility loci and colorectal cancer risk in Lynch syndrome. Hereditary Cancer in Clinical Practice 1(Suppl 1):16, 5/2010. PMCID: PMCPMC2876288.
3. Sinicrope F, Joshi N, Gerner E, Morlan W, Lynch PM, Kirsch I, Broaddus R. Effects of α-Difluoromethylornithine (DFMO) on Histopathology, Mucosal Polyamines, and Gene Expression Profiles in Patients with Dysplastic Barrett's Epithelium. Gastroenterology:A-635, 2008.
4. Lynch PM, Saraiya DS. Non-surgical management of Attenuated Familial Adenomatous Polyposis: Results of a long-term surveillance program. Gastroenterology(A-162), 2008.

Last updated: 2/14/2013