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Paul D. Brown, MD

Present Title & Affiliation

Primary Appointment

Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1995 North Dakota School of Medicine, Grand Forks, ND, MD, Magna Cum Laude, Medical
1991 North Dakota State University, Fargo, ND, BS, Magna Cum Laude, BS in Zoology

Postgraduate Training

1996-2000 Clinical Residency, MN Radiation Oncology, Mayo Clinic, Rochester, MN
1995-1996 Clinical Internship, MN Preliminary Medicine, Mayo Clinic, Rochester, MN

Board Certifications

5/2000 The American Board of Radiology


Academic Appointments

Professor, Department of Radiation Oncology, Division of Radiation Oncology, Mayo Clinic, Rochester, MN, 3/2009-6/2010

Honors and Awards

1992-1995 Dr. Wontat Memorial Award

Selected Publications

Peer-Reviewed Original Research Articles

1. Jensen AW, Laack NN, Buckner JC, Schomberg PJ, Wetmore CJ, Brown PD. Long-Term Follow-Up of Dose-Adapted and Reduced-Field Radiotherapy With or Without Chemotherapy for Central Nervous System Germinoma. Int J Radiat Oncol Biol Phys 77(5):1449-1456, 8/2010. e-Pub 1/2010. PMID: 20045266.
2. Jaeckle KA, Ballman KV, Giannini C, Schomberg PJ, Ames MM, Reid JM, McGovern RM, Safgren SL, Galanis E, Uhm JH, Brown PD, Hammack JE, Arusell R, Nikcevich DA, Morton RF, Wender DB, Buckner JC. Phase II NCCTG trial of RT + irinotecan and adjuvant BCNU plus irinotecan for newly diagnosed GBM. J Neurooncol 99(1):73-80, 8/2010. e-Pub 1/2010. PMCID: PMC2897141.
3. Sperduto PW, Chao ST, Sneed PK, Luo X, Suh J, Roberge D, Bhatt A, Jensen AW, Brown PD, Shih H, Kirkpatrick J, Schwer A, Gaspar LE, Fiveash JB, Chiang V, Knisely J, Sperduto CM, Mehta M. Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients. Int J Radiat Oncol Biol Phys 77(3):655-661, 7/2010. e-Pub 11/2009. PMID: 19942357.
4. Lageman SK, Cerhan JH, Locke DE, Anderson SK, Wu W, Brown PD. Comparing neuropsychological tasks to optimize brief cognitive batteries for brain tumor clinical trials. J Neurooncol 96(2):271-286, 1/2010. e-Pub 7/2009. PMID: 19618121.
5. Macdonald OK, Kruse JJ, Miller JM, Garces YI, Brown PD, Miller RC, Foote RL. Proton beam radiotherapy versus three-dimensional conformal stereotactic body radiotherapy in primary peripheral, early-stage non-small-cell lung carcinoma: a comparative dosimetric analysis. Int J Radiat Oncol Biol Phys 75(3):950-958, 11/2009. PMID: 19801106.
6. Schomas DA, Laack NN, Brown PD. Low-grade gliomas in older patients: Long-Term Follow-Up From Mayo Clinic. Cancer 115(17):3968-78, 9/2009. PMCID: PMC2789453.
7. Brown PD, Cerhan JH. Same, better, or worse? Neurocognitive effects of radiotherapy for low-grade gliomas remain unknown. Lancet Neurol 8(9):779-81, 9/2009. e-Pub 8/2009. PMID: 19665932.
8. Daniels TB, Pollock BE, Miller RC, Lucchinetti CF, Leavitt JA, Brown PD. Radiation-induced optic neuritis after pituitary adenoma radiosurgery in a patient with multiple sclerosis: case report. J Neurooncol 93(2):263-7, 6/2009. e-Pub 12/2008. PMCID: PMC2724634.
9. Vogelbaum MA, Berkey B, Peereboom D, Macdonald D, Giannini C, Suh JH, Jenkins R, Herman J, Brown P, Blumenthal DT, Biggs C, Schultz C, Mehta M. Phase II trial of preirradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: RTOG BR0131. Neuro Oncol 11(2):167-175, 4/2009. e-Pub 9/2008. PMCID: PMC2718988.
10. Minehan KJ, Brown PD, Scheithauer BW, Krauss WE, Wright MP. Prognosis and Treatment of Spinal Cord Astrocytoma. Int J Radiat Oncol Biol Phys 73(3):727-733, 3/2009. e-Pub 8/2008. PMID: 18687533.
11. Brown PD, Krishnan S, Sarkaria JN, Wu W, Jaeckle KA, Uhm JH, Geoffroy FJ, Arusell R, Kitange G, Jenkins RB, Kugler JW, Morton RF, Rowland KM, Mischel P, Yong WH, Scheithauer BW, Schiff D, Giannini C, Buckner JC, North Central Cancer Treatment Group Study N0177. Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. J Clin Oncol 26(34):5603-5609, 12/2008. e-Pub 10/2008. PMCID: PMC2651097.
12. Locke DE, Cerhan JH, Wu W, Malec JF, Clark MM, Rummans TA, Brown PD. Cognitive rehabilitation and problem-solving to improve quality of life of patients with primary brain tumors: a pilot study. J Support Oncol 6(8):383-391, Nov-Dec, 11/2008. PMID: 19149323.
13. Shaw EG, Berkey B, Coons SW, Bullard D, Brachman D, Buckner JC, Stelzer KJ, Barger GR, Brown PD, Gilbert MR, Mehta M. Recurrence following neurosurgeon-determined gross-total resection of adult supratentorial low-grade glioma: results of a prospective clinical trial. J Neurosurg 5(743-755):835-41, 11/2008. PMID: 18976072.
14. Schomas D, Laack N, Schomberg P, Brown P. Pathologically diagnosed optic low-grade gliomas in children: Long-term follow-up of the Mayo Clinic experience. Neuro-Oncology 10(3):449-450, 2008, 6/2008.
15. Pollock BE, Brown PD, Nippoldt TB, Young WF. Pituitary tumor type affects the chance of biochemical remission after radiosurgery of hormone-secreting pituitary adenomas. Neurosurgery 62(6):1271-1276, 6/2008. PMID: 18824993.
16. Pinn ME, Gold DG, Petersen IA, Osborn TG, Brown PD, Miller RC. Systemic lupus erythematosus, radiotherapy, and the risk of acute and chronic toxicity: the Mayo Clinic Experience. Int J Radiat Oncol Biol Phys 71(2):498-506, 6/2008. e-Pub 12/2007. PMID: 18164848.
17. McWilliams RR, Rao RD, Buckner JC, Link MJ, Markovic S, Brown PD. Melanoma-induced brain metastases. Expert Rev Anticancer Ther 8(5):743-755, 5/2008. PMID: 18471047.
18. Brown PD, Decker PA, Rummans TA, Clark MM, Frost MH, Ballman KV, Arusell RM, Buckner JC. A prospective study of quality of life in adults with newly diagnosed high-grade gliomas: comparison of patient and caregiver ratings of quality of life. Am J Clin Oncol 31(2):163-168, 4/2008. PMID: 18391601.
19. Brown PD, Asher AL, Farace E. Adjuvant whole brain radiotherapy: strong emotions decide but rational studies are needed. Int J Radiat Oncol Biol Phys 70(5):1325-1329, 4/2008. e-Pub 1/2008. PMID: 18234426.
20. Gold DG, Miller RC, Pinn ME, Osborn TG, Petersen IA, Brown PD. Chronic toxicity risk after radiotherapy for patients with systemic sclerosis (systemic scleroderma) or systemic lupus erythematosus: association with connective tissue disorder severity. Radiother Oncol 87(1):127-131, 4/2008. e-Pub 12/2007. PMID: 18158195.
21. Pollock BE, Cochran J, Natt N, Brown PD, Erickson D, Link MJ, Garces YI, Foote RL, Stafford SL, Schomberg PJ. Gamma knife radiosurgery for patients with nonfunctioning pituitary adenomas: results from a 15-year experience. Int J Radiat Oncol Biol Phys 70(5):1325-1329, 4/2008. e-Pub 10/2007. PMID: 18029107.
22. Brown PD, Brown CA, Pollock BE, Gorman DA, Foote RL. Stereotactic radiosurgery for patients with radioresistant brain metastases. Neurosurgery 51(3):656-667, 2/2008. PMID: 18596426.
23. Shintani SA, Foote RL, Lowe VJ, Brown PD, Garces YI, Kasperbauer JL. Utility of PET/CT imaging performed early after surgical resection in the adjuvant treatment planning for head and neck cancer. Int J Radiat Oncol Biol Phys 70(2):322-329, 2/2008. e-Pub 9/2007. PMID: 17889447.
24. Locke DE, Decker PA, Sloan JA, Brown PD, Malec JF, Clark MM, Rummans TA, Ballman KV, Schaefer PL, Buckner JC. Validation of single-item linear analog scale assessment of quality of life in neuro-oncology patients. J Pain Symptom Manage 34(6):628-638, 12/2007. e-Pub 8/2007. PMCID: PMC2732111.
25. Olivier KR, Schild SE, Morris CG, Brown PD, Markovic SN. A higher radiotherapy dose is associated with more durable palliation and longer survival in patients with metastatic melanoma. Cancer 110(8):1791-1795, 10/2007. PMID: 17721993.
26. Buckner JC, Brown PD, O'Neill BP, Meyer FB, Wetmore CJ, Uhm JH. Central nervous system tumors. Mayo Clin Proc 82(10):1271-1286, 10/2007. PMID: 17908533.
27. Johnson ME, Piderman KM, Sloan JA, Huschka M, Atherton PJ, Hanson JM, Brown PD, Rummans TA, Clark MM, Frost MH. Measuring spiritual quality of life in patients with cancer. J Support Oncol 5(9):437-442, 10/2007. PMID: 18019851.
28. Schiff D, Brown PD, Giannini C. Outcome in adult low-grade glioma: the impact of prognostic factors and treatment. Neurology 69(13):1366-1373, 9/2007. PMID: 17893297.
29. Lapid MI, Rummans TA, Brown PD, Frost MH, Johnson ME, Huschka MM, Sloan JA, Richardson JW, Hanson JM, Clark MM. Improving the quality of life of geriatric cancer patients with a structured multidisciplinary intervention: a randomized controlled trial. Palliat Support Care 5(2):107-114, 6/2007. PMID: 17578061.
30. Pollock BE, Jacob JT, Brown PD, Nippoldt TB. Radiosurgery of growth hormone-producing pituitary adenomas: factors associated with biochemical remission. J Neurosurg 111((Suppl S)):170-5, 5/2007. PMID: 17542527.
31. Rao RD, Brown PD, Buckner JC. Innovation in the management of brain metastases. Oncology (Williston Park) 21(4):473-481, 4/2007. PMID: 17474347.
32. Leenstra JL, Rodriguez FJ, Frechette CM, Giannini C, Stafford SL, Pollock BE, Schild SE, Scheithauer BW, Jenkins RB, Buckner JC, Brown PD. Central neurocytoma: management recommendations based on a 35-year experience. Int J Radiat Oncol Biol Phys 67(4):1145-1154, 3/2007. e-Pub 12/2006. PMID: 17187939.
33. Foote RL, Brown PD, Garces YI, Okuno SH, Miller RC, Strome SE. Informed consent in advanced laryngeal cancer. Head Neck 29(3):230-235, 3/2007. PMID: 17230562.
34. Hussain A, Brown PD, Stafford SL, Pollock BE. Stereotactic radiosurgery for brainstem metastases: Survival, tumor control, and patient outcomes. Int J Radiat Oncol Biol Phys 67(2):521-524, 2/2007. e-Pub 11/2006. PMID: 17097830.
35. Ballman KV, Buckner JC, Brown PD, Giannini C, Flynn PJ, LaPlant BR, Jaeckle KA. The relationship between six-month progression-free survival and 12-month overall survival end points for phase II trials in patients with glioblastoma multiforme. Neuro Oncol 9(1):29-38, 1/2007. e-Pub 11/2006. PMCID: PMC1828103.
36. Miller JJ, Frost MH, Rummans TA, Huschka M, Atherton P, Brown P, Gamble G, Richardson J, Hanson J, Sloan JA, Clark MM. Role of a medical social worker in improving quality of life for patients with advanced cancer with a structured multidisciplinary intervention. J Psychosoc Oncol 25(4):105-119, 2007. PMID: 18032268.
37. Brown PD. Low-grade Gliomas: The debate continues. Curr Oncol Rep 8(1):71-77, 1/2006. PMID: 16566078.
38. Brown PD, Buckner JC, O'Fallon JR, Iturria NL, Brown CA, O'Neill BP, Scheithauer BW, Dinapoli RP, Arusell RM, Curran WJ, Abrams R, Shaw EG. Effects of Radiotherapy on Cognitive Function in Patients With Low-Grade Glioma Measured by the Folstein Mini-Mental State Examination. J Clin Oncol 56(4):1067-1072, 7/2003. PMID: 12829670.
39. Foote RL, Brown PD, Garces YI, McIver B, Kasperbauer JL. Is there a role for radiation therapy in the management of Hürthle cell carcinoma? Int J Radiat Oncol Biol Phys 5(3):161-167, 7/2003. PMID: 12829143.
40. Stafford SL, Pollock BE, Leavitt JA, Foote RL, Brown PD, Link MJ, Gorman DA, Schomberg PJ. A study on the radiation tolerance of the optic nerves and chiasm after stereotactic radiosurgery. Int J Radiat Oncol Biol Phys 55(5):1177-1181, 4/2003. PMID: 12654424.
41. Bartleson JD, Krecke KN, O'Neill BP, Brown PD. Reversible, strokelike migraine attacks in patients with previous radiation therapy. Neuro Oncol 5(2):121-127, 4/2003. PMCID: PMC1920675.
42. Buckner JC, Gesme D, O'Fallon JR, Hammack JE, Stafford S, Brown PD, Hawkins R, Scheithauer BW, Erickson BJ, Levitt R, Shaw EG, Jenkins R. Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities. J Clin Oncol 21(2):251-5, 1/2003. PMID: 12525516.
43. Pollock BE, Brown PD, Foote RL, Stafford SL, Schomberg PJ. Properly Selected Patients with Multiple Brain Metastases May Benefit from Aggressive Treatment of their Intracranial Disease. J Neurooncol 61(1):73-80, 1/2003. PMID: 12587798.
44. Sarkar A, Pollock BE, Brown PD, Gorman DA. Evaluation of gamma knife radiosurgery in the treatment of oligodendrogliomas and mixed oligodendroastrocytomas. J Neurosurg 97(S5):653-656, 12/2002. PMID: 12507114.
45. Brown PD, Bonner JA, Foote RL, Frytak S, Marks RS, Richardson RL, Creagan ET. Long-term results of a phase I/II study of high-dose thoracic radiotherapy with concomitant cisplatin and etoposide in limited stage small-cell lung cancer. Am J Clin Oncol 24(6):556-61, 12/2001. PMID: 11801753.
46. Brown PD, Eshleman JS, Foote RL, Strome SE. An analysis of facial nerve function in irradiated and unirradiated facial nerve grafts. Int J Radiat Oncol Biol Phys 48(3):737-743, 10/2000. PMID: 11020570.
47. Brown PD, Stafford SL, Schild SE, Martenson JA, Schiff D. Metastatic spinal cord compression in patients with colorectal cancer. J Neurooncol 44(2):175-180, 9/1999. PMID: 10619502.
48. Schild SE, Stafford SL, Brown PD, Wood CP, Scheithauer BW, Schomberg PJ, Wong WW, Lyons MK, Shaw EG. The results of radiotherapy for brainstem tumors. J Neurooncol 40(2):171-177, 11/1998. PMID: 9892099.

Grant & Contract Support

Title: Optimizing Proton Radiation Therapy- Project 2 Improving the Therapeutic Ratio of Proton Radiation Therapy in Challenging Clinical Sites
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Thomas DeLaney
Duration: 9/25/2008 - 7/31/2014
Funding Source: Brain Tumor Network
Role: Co-Investigator
Principal Investigator: Cragar-Locke, D
Funding Source: NIH/NCI
Role: Co-Shared Resource Director
Principal Investigator: Brian O'Neill

Last updated: 8/20/2013