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Paul K. Wong, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Molecular Carcinogenesis, Science Park-Research Division, The University of Texas MD Anderson Cancer Center, Smithville, TX

Dual/Joint/Adjunct Appointment

Adjunct Professor, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX
Adjunct Professor, Department of Microbiology, University of Texas at Austin, Austin, TX

Education & Training

Degree-Granting Education

1972 University of Manitoba, Winnepeg, Manitoba, Canada, PHD, Viral Genetics
1969 University of Manitoba, Winnipeg, Manitoba, Canada, MsSc, Animal Virology/Genetics
1968 University of Manitoba, Winnipeg, Manitoba, Canada, BSc(Hons), Microbiology

Postgraduate Training

1974 Retrovirology, Cancer Research, University of Western Ontario, Ontario, Ontario, Canada

Experience/Service

Academic Appointments

Adjunct Professor, Institute for Neuroscience, University of Texas at Austin, Austin, TX, 1995-present
Associate Professor (with tenure), Microbiology, School of Basic Medical Sciences, University of Illinois, Urbana, IL, 1980-1986
Assistant Professor, Microbiology, School of Basic Medical Sciences, University of Illinois, Urbana, IL, 1974-1980

Selected Publications

Peer-Reviewed Original Research Articles
1. Kim J, Hwangbo J, Wong PKY. p38 MAPK-Mediated Bmi-1 Down-Regulation and Defective Proliferation in ATM-Deficient Neural Stem Cells can be Restored by Akt Activation. PLoS ONE 28(6(1)):e16615, 1/2011. PMID: 21305053.
2. Kuang X, Wenhui H, Yan M, Wong PKY. Phenylbutyric acid suppresses protein accumulation-mediated ER stress in retrovirus-infected astrocytes and delays onset of paralysis in infected mice. Neurochem Int 57(7):738-48, 12/2010. PMID: 20813146.
3. Reddy PV, Lungu G, Kuang X, Stoica G, Wong PK. Neuroprotective effects of the drug GVT (monosodium luminol) are mediated by the stabiolization of Nrf2 in astrocytes. Neurochem Int 56(6-7):780-8, 2010.
4. Kuang X, Shen J, Wong PK, Yan M. Deregulation of mTOR signaling is involved in thymic lymphoma development in Atm-/- mice. Biochem Biophys Res Commun 383(3):368-72, 6/2009. PMID: 19364503.
5. Kim J, Wong PK. Oxidative stress is linked to ERK-P16 signaling-mediated growth defect in ATM-deficient astrocytes. J Biol Chem 284(21):14396-404, 5/2009. PMCID: PMC2682888.
6. Scofield VL, Yan M, Kuang X, Kim SJ, Crunk D, Wong PK. The drug monosodium luminol (GVT) preserves thymic epithelial cell cytoarchitecture and allows thymocyte survival in mice infected with the T cell-tropic, cytopathic retrovirus ts. Immunol Lett 122(2):159-69, 2/2009. PMID: 19183564.
7. Kuang X, Scofield VL, Yan M, Stoica G, Liu N, Wong PKY. Attenuation of oxidative stress, inflammation and apoptosis by minocycline prevents retrovirus-induced neurodegeneration in mice. Brain Res 1286:174-184, 2009. PMID: 19523933.
8. Kim J, Wong PKY. Loss of ATM impairs proliferation of neural stem cells through oxidative stress-mediated p38 MAPK signaling. Stem Cells 27:1987-1998, 2009.
9. Yan M, Shen J, Person MD, Kuang X, Lynn WS, Atlas D, Wong PK. Endoplasmic reticulum stress and unfolded protein response in Atm-deficient thymocytes and thymic lymphoma cells are attributable to oxidateive stress. Neoplasia 10(2):160-7, 2/2008. PMCID: PMC2244691.
10. Jiang Y, Scofield VL, Yan M, Qiang W, Liu N, Reid AJ, Lynn WS, Wong PK. Retrovirus-induced oxidative stress with neuroimmunodegeneration is suppressed by antioxidant treatment with a refined monosodium alpha-luminol (Galavit). J Virol 80(9):4557-69, 5/2006. PMCID: PMC1472001.
11. Yan M, Kuang X, Qiang W, Shen J, Claypool K, Lynn WS, Wong PK. Prevention of thymic lymphoma development in Atm-/- mice by dexamethasone. Cancer Res 62(18):5153-7, 9/2002. PMID: 12234978.

Grant & Contract Support

Title: Mitochondria as a key target of the neuroprotective effects of Monosodium Luminol (MSL or GVT)
Funding Source: Yale University
Role: Principal Investigator-MDACC
Principal Investigator: Gerald Shadel

Last updated: 6/10/2011