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Paul K. Wong, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Carcinogenesis, Science Park-Research Division, The University of Texas M.D. Anderson Cancer Center, Smithville, TX

Dual/Joint/Adjunct Appointment

Adjunct Professor, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX

Education & Training

Degree-Granting Education

1972 University of Manitoba, Winnepeg, Manitoba, Canada, PHD, Viral Genetics
1969 University of Manitoba, Winnipeg, Manitoba, Canada, MsSc, Animal Virology/Genetics
1968 University of Manitoba, Winnipeg, Manitoba, Canada, BSc(Hons), Microbiology

Postgraduate Training

1974 Retrovirology, Cancer Research, University of Western Ontario, Ontario, Ontario, Canada

Experience/Service

Academic Appointments

Adjunct Professor, Institute for Neuroscience, University of Texas at Austin, Austin, TX, 1995-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Kuang X, Shen J, Wong PK, Yan M. Deregulation of mTOR signaling is involved in thymic lymphoma development in Atm-/- mice. Biochem Biophys Res Commun 383(3):368-72, 6/2009. PMID: 19364503.
2. Kim J, Wong PK. Oxidative stress is linked to ERK-P16 signaling-mediated growth defect in ATM-deficient astrocytes. J Biol Chem 284(21):14396-404, 5/2009. PMCID: PMC2682888.
3. Scofield VL, Yan M, Kuang X, Kim SJ, Crunk D, Wong PK. The drug monosodium luminol (GVT) preserves thymic epithelial cell cytoarchitecture and allows thymocyte survival in mice infected with the T cell-tropic, cytopathic retrovirus ts. Immunol Lett 122(2):159-69, 2/2009. PMID: 19183564.
4. Kuang X, Scofield VL, Yan M, Stoica G, Liu N, Wong PKY. Attenuation of oxidative stress, inflammation and apoptosis by minocycline prevents retrovirus-induced neurodegeneration in mice. Brain Res 1286:174-184, 2009. PMID: 19523933.
5. Kim J, Wong PKY. Loss of ATM impairs proliferation of neural stem cells through oxidative stress-mediated p38 MAPK signaling. Stem Cells 27:1987-1998, 2009.
6. Lungu GG, Stoica G, Wong PK. Down-regulation of Jab1, HIF-1alpha, and VEGF by Moloney murine leukemia virus-ts1 infection: a possible cause of neurodegeneration. J Neurovirol 14(3):239-51, 5/2008. PMID: 18569458.
7. Yan M, Shen J, Person MD, Kuang X, Lynn WS, Atlas D, Wong PK. Endoplasmic reticulum stress and unfolded protein response in Atm-deficient thymocytes and thymic lymphoma cells are attributable to oxidateive stress. Neoplasia 10(2):160-7, 2/2008. PMCID: PMC2244691.
8. Jiang Y, Scofield VL, Yan M, Qiang W, Liu N, Reid AJ, Lynn WS, Wong PK. Retrovirus-induced oxidative stress with neuroimmunodegeneration is suppressed by antioxidant treatment with a refined monosodium alpha-luminol (Galavit). J Virol 80(9):4557-69, 5/2006. PMCID: PMC1472001.
9. Yan M, Kuang X, Qiang W, Shen J, Claypool K, Lynn WS, Wong PK. Prevention of thymic lymphoma development in Atm-/- mice by dexamethasone. Cancer Res 62(18):5153-7, 9/2002. PMID: 12234978.
10. Szurek PF, Yuen PH, Ball JK, Wong PK. A Val-25-to-Ile substitution in the envelope precursor polyprotein, gPr80env, is responsible for the temperature sensitivity, inefficient processing of gPr80env, and neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB. J Virol 64(2):467-75, 2/1990. PMCID: PMC249133.

Last updated: 10/14/2009