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Peter Friedl, MD, PhD

Present Title & Affiliation

Dual/Joint/Adjunct Appointment

Professor, Department of Genitourinary Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor, Radboud University Nijmegen, Nijmegen, Netherlands

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number: 18-2
Houston, TX 77030
Room Number: T7.3908
Phone: 713-792-2260
Fax: 713-792-6589

Education & Training

Degree-Granting Education

2003 University of Wurzburg, Wurzburg, Germany, Allergologist, Department of Allergology
2002 University of Wurzburg, Wurzburg, Germany, Dermotologist, Department of Dermatology
1996 McGill University, Montreal, Canada, Canada, PHD, Department of Immunology and Cell Biology
1992 Ruhr-University of Bochum, Bochum, Germany, MD, magna cum laude, Department of Medical Microbiology and Immunology

Postgraduate Training

1996-2003 Clinical Residency, University of Wurzburg, Wurzburg, Germany
1991-1996 Physician in training and research group leader, University of Witten/Herdecke, Witten, Germany

Board Certifications

9/2003 Allergologist
8/2002 Dermatologist


Academic Appointments

Associate Professor, Department of Dermatology, Rudolf-Virchow Center and Department of Dermatology, Wurzburg, Germany, 2003-2007
Clinical and Scientific Assistant - Clinical Residency, University of Wurzburg, Wurzburg, Germany, 1996-2003
PhD Student, McGill University, Montreal, Canada, 1992-1996
Research Associate, University of Witten/Herdecke, Witten, Germany, 1991-1996

Other Appointments/Responsibilities

Professor, Interdisciplinary Center for Clinical Research, Wurzburg, Germany, 2002-2003

Military or Other Governmental Service

Civil Service, Germany, 1983-1984

Institutional Committee Activities

Advisor, Koch Center for Urogenital Cancer Research, 2009-present
Speaker, Graduate Program, Target Proteins, Graduate School for Life Sciences, University of Wurzburg, 2004-2007

Honors and Awards

2010 Vici Award, Netherlands Science Foundation
2008 German Cancer Award, German Cancer Society
2005 Oscar-Gans Award, German Dermatological Society
2004 German Skin Cancer Award
2002 Award of the Foundation, 400 Years University of Wurzburg
2001 Grunenthal Award "Skin and Environment"
1997 Hermal Early Career Award
1996 Dean's Honour List, McGill University, Montreal, Canada
1994 Felix-Wankel Animal Protection Award

Professional Memberships

American Association for Cancer Research (AACR), Germany
Member, 1996
American Association of Immunologists
Member, 1995-2007
Arbeitsgemeinschaft Dermatologische Forschung, Germany
Member, 1996
Deutsche Gesellschaft fur Immunologie (DGI), Germany
Member, 1993
Deutsche Krebsgesellschaft, Arbeitsgemeinschaft Dermatologische Onkologie, Germany
Member, 1998
European Association for Cancer Research (EACR)
Member, 2005
European Institute for Biomedical Imaging Research
Member, 2007
European Society for Molecular Imaging (Founding Member)
Member, 2006
German Association of Immunologists, Germany
Member, 1994
Rudolf-Virchow Center, Wurzburg, Germany
Member, 2007

Selected Publications

Peer-Reviewed Original Research Articles

1. Chatterji T, Varkaris AS, Parikh NU, Song JH, Cheng CJ, Schweppe RE, Alexander S, Davis JW, Troncoso P, Friedl P, Kuang J, Lin SH, Gallick GE. Yes-mediated phosphorylation of focal adhesion kinase at tyrosine 861 increases metastatic potential of prostate cancer cells. Oncotarget 6(12):10175-94, 4/30/2015. e-Pub 3/2015. PMID: 25868388.
2. Masuzzo P, Martens L, 2014 Cell Migration Workshop Participants, Ampe C, Anderson KI, Barry J, De Wever O, Debeir O, Decaestecker C, Dolznig H, Friedl P, Gaggioli C, Geiger B, Goldberg IG, Horn E, Horwitz R, Kam Z, Le Dévédec SE, Vignjevic DM, Moore J, Olivo-Marin JC, Sahai E, Sansone SA, Sanz-Moreno V, Strömblad S, Swedlow J, Textor J, Van Troys M, Zantl R. An open data ecosystem for cell migration research. Trends Cell Biol 25(2):55-8, 2/2015. e-Pub 12/5/2014. PMID: 25484346.
3. Hoogenkamp HR, Bakker GJ, Wolf L, Suurs P, Dunnewind B, Barbut S, Friedl P, van Kuppevelt TH, Daamen WF. Directing collagen fibers using counter-rotating cone extrusion. Acta Biomater 12:pii: S1742-7061, 1/2015. e-Pub 10/16/2014. PMID: 25462525.
4. Friedl P, Weigelin B. A Swiss Army Knife for CTLs. Immunity 41(6):873-5, 12/18/2014. PMID: 25526299.
5. Starke J, Wehrle-Haller B, Friedl P. Plasticity of the actin cytoskeleton in response to extracellular matrix nanostructure and dimensionality. Biochem Soc Trans 42(5):1356-1366, 10/2014. PMID: 25233415.
6. Haeger A, Krause M, Wolf K, Friedl P. Cell jamming: collective invasion of mesenchymal tumor cells imposed by tissue confinement. Biochim Biophys Acta 1840(8):2386-95, 8/2014. e-Pub 4/8/2014. PMID: 24721714.
7. Friedl P, Wolf K, Zegers MM. Rho-directed forces in collective migration. Nat Cell Biol 16(3):208-10, 3/2014. PMID: 24576897.
8. Zegers MM, Friedl P. Rho GTPases in collective cell migration. Small GTPases 5:e28997, 2014. e-Pub 5/9/2014. PMCID: PMC4114924.
9. Starke J, Maaser K, Wehrle-Haller B, Friedl P . Mechanotransduction of mesenchymal melanoma cell invasion into 3D collagen lattices: Filopod-mediated extension-relaxation cycles and force anisotropy. Exp Cell Res 19(16):2424-33, 10/2013. e-Pub 7/2013. PMID: 23830878.
10. Alexander S, Weigelin B, Winkler F, Friedl P. Preclinical Intravital microscopy of the tumor-stroma interface: invasion, metastasis and therapy response. Curr Opin Cell Biol 25(5):659-71, 10/2013. e-Pub 7/2013. PMID: 23896198.
11. Wolf K, Te Lindert M, Krause M, Alexander S, Te Riet J, Willis AL, Hoffman RM, Figdor CG, Weiss SJ, Friedl P. Physical limits of cell migration: Control by ECM space and nucler deformation and tuning by proteolysis and traction force. J Cell Biol 201(7):1069-84, 6/2013. PMCID: PMC3691458.
12. Friedl P, Hubbell J, Livingston D, Mihich E. Twenty-Third Annual Pezcoller Symposium: Engineering influences in cancer research. Cancer Res 72(4):841-4, 2/2012. PMID: 22237623.
13. Alexander S, Friedl P. Cancer invasion and resistance: interconnected processes of disease progression and therapy failure. Trends Mol Med 18(1):13-26, 1/2012. PMID: 22177734.
14. Gritsenko PG, Ilina O, Friedl P. Interstitial guidance of cancer invasion. J Pathol 226(2):185-99, 1/2012. PMID: 22006671.
15. Bonetto F, Srinivas M, Weigelin B, Cruz LJ, Heerschap A, Friedl, P, Figdor, CG, de Vries IJ. A large-scale (19) F MRI-based cell migration assay to optimize cell therapy. NMR Biomed 25:1095-1103, 2012.
16. Friedl P, Locker J, Sahai E, Segall JE. Classifying Collective Cancer Cell Invasion. Nat. Cell Biol. 14:777-783, 2012.
17. Bakker GJ, Andresen V, Hoffman RM, Friedl P. Fluorescence lifetime microscopy of tumor cell invasion, drug delivery, and cytotoxicity. Methods Enzymol 503:109-25, 2012. PMID: 22264531.
18. Weigelin B, Bakker, GJ, Friedl P. Intravital third harmonic generation microscopy of collective melanoma cell invasion: principles of interface guidance and microvesicle dynamics. Intravital 1:32-43, 2012.
19. Friedl P, Sahai SJ, Weiss KM, Yamada. New dimensions in cell migration. Nat. Rev. Mol. Cell Biol. 13:743-747, 2012 Oct 17, 2012. e-Pub 10/2012. PMID: 23072889.
20. Wolf K, Friedl P. Extracellular matrix determinants of proteolytic and non-proteolytic cell migration. Trends Cell Biol 21(12):736-44, 12/2011. PMID: 22036198.
21. Friedl P, Alexander S. Cancer invasion and the microenvironment: plasticity and reciprocity. Cell 147(5):992-1009, 11/2011. PMID: 22118458.
22. Weigelin B, Krause M, Friedl P. Cytotoxic T lymphocyte migration and effector function in the tumor microenvironment. Immunol Lett 138(1):19-21, 7/2011. PMID: 21333682.
23. Friedl P, Wolf K, Lammerding J. Nuclear mechanics during cell migration. Curr Opin Cell Biol 23(1):55-64, 2/2011. PMCID: PMC3073574.
24. Ilina O, Bakker GJ, Vasaturo A, Hofmann RM, Friedl P. Two-photon laser-generated microtracks in 3D collagen lattices: principles of MMP-dependent and -independent collective cancer cell invasion. Phys Biol 8(1):015010, 2/2011. e-Pub 2/2011. PMID: 21301056.
25. Weigelin B, Friedl P. A three-dimensional organotypic assay to measure target cell killing by cytotoxic T lymphocytes. Biochem Pharmacol 80(12):2087-91, 12/2010. PMID: 20849829.
26. Dommerholt J, Schmidt S, Temming R, Hendriks LJ, Rutjes FP, van Hest JC, Lefeber DJ,Friedl P, van Delft FL. Readily accessible bicyclononynes for bioorthogonal labeling and three-dimensional imaging of living cells. Angew Chem Int Ed Engl 49(49):9422-5, 12/2010. PMCID: PMC3021724.
27. Khalil AA, Friedl P. Determinants of leader cells in collective cell migration. Integr Biol (Camb) 2(11-12):568-74, 11/2010. PMID: 20886167.
28. Storim J, Brocker EB, Friedl P. A dynamic immunological synapse mediates homeostatic TCR-dependent and -independent signaling. Eur J Immunol 40(10):2741-50, 10/2010. PMID: 20821730.
29. Friedl P, Zallen JA. Dynamics of cell-cell and cell-matrix interactions in morphogenesis, regeneration and cancer. Curr Opin Cell Biol 22(5):557-9, 10/2010. PMID: 20850290.
30. Kampik D, Ralla B, Keller S, Hirschberg M, Friedl P, Geerling G. Influence of corneal collagen crosslinking with riboflavin and ultraviolet-a irradiation on excimer laser surgery. Invest Ophthalmol Vis Sci 51(8):3929-34, 8/2010. PMID: 20207972.
31. Belletti B, Pellizzari I, Berton S, Fabris L, Wolf K, Lovat F, Schiappacassi M, D'Andrea S, Nicoloso MS, Lovisa S, Sonego M, Defilippi P, Vecchione A, Colombatti A, Friedl P, Baldassarre G. p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling. Mol Cell Biol 30(9):2229-40, 5/2010. PMCID: PMC2863592.
32. Schmidt S, Friedl P. Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms. Cell Tissue Res 339(1):83-92, 1/2010. PMCID: PMC2784868.
33. Friedl P, Wolf K. Plasticity of cell migration: a multiscale tuning model. J Cell Biol 188(1):11-9, 1/2010. PMCID: PMC2812848.
34. Friedl P. To adhere or not to adhere? Nat Rev Mol Cell Biol 11(1):3, 1/2010. PMID: 20050305.
35. Meierjohann S, Hufnagel A, Wende E, Kleinschmidt MA, Wolf K, Friedl P, Gaubatz S, Schartl M. MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation. Mol Cancer 9:201, 2010. e-Pub 7/2010. PMCID: PMC2915980.
36. Wolf K, Alexander S, Schacht V, Coussens LM, von Andrian UH, van Rheenen J, Deryugina E, Friedl P. Collagen-based cell migration models in vitro and in vivo. Semin Cell Dev Biol 20(8):931-41, 10/2009. PMID: 19682592.
37. Ilina O, Friedl P. Mechanisms of collective cell migration at a glance. J Cell Sci 122(Pt 18):3203-8, 9/2009. PMID: 19726629.
38. Friedl P, Gilmour D. Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol 10(7):445-57, 7/2009. PMID: 19546857.
39. Imle A, Polzer B, Alexander S, Klein CA, Friedl P. Genomic instability of micronucleated cells revealed by single-cell comparative genomic hybridization. Cytometry A 75(7):562-8, 7/2009. PMID: 19405114.
40. Friedl P, Wolf K. Proteolytic interstitial cell migration: a five-step process. Cancer Metastasis Rev 28(1-2):129-35, 6/2009. PMID: 19153672.
41. Friedl P. Painting a picture of cancer immunology. Interview by Caitlin Sedwick. J Cell Biol 185(2):180-1, 4/2009. PMCID: PMC2673549.
42. Andresen V, Alexander S, Heupel WM, Hirschberg M, Hoffman RM, Friedl P. Infrared multiphoton microscopy: subcellular-resolved deep tissue imaging. Curr Opin Biotechnol 20(1):54-62, 2/2009. PMID: 19324541.
43. Friedl P. Dynamic imaging of cancer invasion and metastasis: principles and preclinical applications. Clin Exp Metastasis 26(4):269-271, 2009. PMID: 19229643.
44. Wolf K, Friedl P. Mapping proteolytic cancer cell-extracellular matrix interfaces. Clin Exp Metastasis 26(4):289-98, 2009. PMID: 18600304.
45. Friedl P,. p27kip1 Affects cell migration and invasion by regulating the switch from mesenchymal to amoeboid motility. Clin Ep Metastasis 26:867, 2009.
46. Berton S, Belletti B, Wolf K, Canzonieeri V, Lovat F, Vecchione A, Colombatti A,Friedl P, Baldassarre G. The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition. Mol Cell Biol 29:5031-45, doi: 10.11, 2009. PMCID: PMC2738297.
47. Alexander S, Koehl GE, Hirschberg M, Geissler EK, Friedl P. Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model. Histochem Cell Biol 130(6):1147-54, 12/2008. PMID: 18987875.
48. Friedl P, Weigelin B. Interstitial leukocyte migration and immune function. Nat Immunol 9(9):960-9, 9/2008. PMID: 18711433.
49. Friedl P, Wolf K. Tube travel: the role of proteases in individual and collective cancer cell invasion. Cancer Res 68(18):7247-9, 9/2008. PMID: 18794108.
50. Hartmann A, Quist J, Hamm H, Brocker EB, Friedl P. Transplantation of autologous keratinocyte suspension in fibrin matrix to chronic venous leg ulcers: improved long-term healing after removal of the fibrin carrier. Dermatol Surg 34(7):922-9, 7/2008. PMID: 18384617.
51. Muessel MJ, Scott KS, Friedl P, Bradding P, Wardlaw AJ. CCL11 and GM-CSF differentially use the Rho GTPase pathway to regulate motility of human eosinophils in a three-dimensional microenvironment. J Immunol 180(12):8354-60, 6/2008. PMID: 18523302.
52. Belletti B, Nicoloso MS, Schiappacassi M, Berton S, Lovat F, Wolf K, Canzonieri V, D'Andrea S, Zucchetto A, Friedl P, Colombatti A, Baldassarre G. Stathmin activity influences sarcoma cell shape, motility, and metastatic potential. Mol Biol Cell 19(5):2003-13, 5/2008. PMCID: PMC2366875.
53. Wolf K, Wu YI, Liu Y, Geiger J, Tam E, Overall C, Stack MS, Friedl P. Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat Cell Biol 9(8):893-904, 8/2007. PMID: 17618273.
54. Fischer A, Steidl C, Wagner TU, Lang E, Jakob PM, Friedl P, Knobeloch KP, Gessler M. Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res 100(6):856-63, 3/2007. PMID: 17303760.
55. Cam H, Griesmann H, Beitzinger M, Hofmann L, Beinoraviciute-Kellner R, Sauer M, Huttinger-Kirchhof N, Oswald C, Friedl P, Gattenlohner S, Burek C, Rosenwald A, Stiewe T. p53 family members in myogenic differentiation and rhabdomyosarcoma development. Cancer Cell 10(4):281-93, 10/2006. PMID: 17045206.
56. Wolf K, Friedl P. Molecular mechanisms of cancer cell invasion and plasticity. Br J Dermatol 154 Suppl 1:11-5, 5/2006. PMID: 16712711.
57. Hartmann A, Boukamp P, Friedl P. Confocal reflection imaging of 3D fibrin polymers. Blood Cells Mol Dis 36(2):191-3, Mar-Apr, 3/2006. PMID: 16488165.
58. Friedl P. Cell fusion: new mechanisms for plasticity in cancer? Lancet Oncol 6(12):916-918, 12/2005. PMID: 16321755.
59. Friedl P, den Boer AT, Gunzer M. Tuning immune responses: diversity and adaptation of the immunological synapse. Nat Rev Immunol 5(7):532-45, 7/2005. PMID: 15999094.
60. Wolf K, Friedl P. Functional imaging of pericellular proteolysis in cancer cell invasion. Biochimie 87(3-4):315-20, Mar-Apr, 3/2005. PMID: 15781318.
61. Mayer C, Maaser K, Daryab N, Zänker KS, Bröcker EB, Friedl P. Release of cell fragments by invading melanoma cells. Eur J Cell Biol 83(11-12):709-15, 12/2004. PMID: 15679115.
62. Gunzer M, Weishaupt C, Hillmer A, Basoglu Y, Friedl P, Dittmar KE, Kolanus W, Varga G, Grabbe S. A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivo. Blood 104(9):2801-9, 11/2004. e-Pub 7/2004. PMID: 15256430.
63. Friedl P, Storim J. Diversity in immune-cell interactions: states and functions of the immunological synapse. Trends Cell Biol 14(10):557-67, 10/2004. PMID: 15450978.
64. Friedl P. Dynamic imaging of cellular interactions with extracellular matrix. Histochem Cell Biol 122(3):183-90, 9/2004. e-Pub 7/2004. PMID: 15258769.
65. Uhlenbrock K, Eberth A, Herbrand U, Daryab N, Stege P, Meier F, Friedl P, Collard JG, Ahmadian MR. The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism. J Cell Sci 117(Pt 20):4863-71, 9/2004. e-Pub 8/2004. PMID: 15340013.
66. Friedl P. Dynamic imaging of the immune system. Curr Opin Immunol 16(4):389-93, 8/2004. PMID: 15245730.
67. Vanier G, Segura M,Friedl P, Lacouture S, Gottschalk M. Invasion of porcine brain microvascular endothelial cells by Streptococcus suis serotype 2. Infect Immun 72(3):1441-9, 3/2004. PMCID: PMC356020.
68. Schröder M, Matischak K, Friedl P. Serum- and protein-free media formulations for the Chinese hamster ovary cell line DUKXB11. J Biotechnol 108(3):279-92, 3/2004. PMID: 15006429.
69. Lauer R, Bauer R, Linz B, Pittner F, Peschek GA, Ecker Friedl P, Noe CR. Development of an in vitro blood-brain barrier model based on immortalized porcine brain microvascular endothelial cells. Farmaco 59(2):133-7, 2/2004. PMID: 14871505.
70. Friedl P. Prespecification and plasticity: shifting mechanisms of cell migration. Curr Opin Cell Biol 16(1):14-23, 2/2004. PMID: 15037300.
71. Friedl P, Hegerfeldt Y, Tusch M. Collective cell migration in morphogenesis and cancer. Int J Dev Biol 48(5-6):441-9, 2004. PMID: 15349818.
72. Friedl P, Bröcker EB. Reconstructing leukocyte migration in 3D extracellular matrix by time-lapse videomicroscopy and computer-assisted tracking. Methods Mol Biol 239:77-90, 2004. PMID: 14573911.
73. Wolf K, Müller R, Borgmann S, Bröcker EB, Friedl P. Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases. Blood 102(9):3262-9, 11/2003. e-Pub 7/2003. PMID: 12855577.
74. Friedl P, Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3(5):362-74, 5/2003. PMID: 12724734.
75. Wolf K, Mazo I, Leung H, Engelke K, von Andrian UH, Deryugina EI, Strongin AY, Bröcker EB, Friedl P. Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol 160(2):267-77, 1/2003. e-Pub 1/2003. PMCID: PMC2172637.
76. Friedl P, Wolf K. Proteolytic and non-proteolytic migration of tumour cells and leucocytes. Biochem Soc Symp(70):277-85, 2003. PMID: 14587300.
77. Zielasek J, Bender G, Schlesinger S, Friedl P, Kenn W, Allolio B, Lauer M. A woman who gained weight and became schizophrenic. Lancet 360(9343):1392, 11/2002. PMID: 12423986.
78. Friedl P, Bröcker EB. TCR triggering on the move: diversity of T-cell interactions with antigen-presenting cells. Immunol Rev 186:83-9, 8/2002. PMID: 12234364.
79. Hegerfeldt Y, Tusch M, Bröcker EB, Friedl P. Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies. Cancer Res 62(7):2125-30, 4/2002. PMID: 11929834.
80. Friedl P, Borgmann S, Brocker EB. Amoeboid leukocyte crawling through extracellular matrix: lessons from the Dictyostelium paradigm of cell movement. J Leukoc Biol 70(4):491-509, 10/2001. PMID: 11590185.
81. Storim J, Friedl P, Schaefer BM, Bechtel M, Wallich R, Kramer MD, Reinartz J. Molecular and functional characterization of the four-transmembrane molecule l6 in epidermal keratinocytes. Exp Cell Res 267(2):233-42, 7/2001. PMID: 11426942.
82. Friedl P, Gunzer M. Interaction of T cells with APCs: the serial encounter model. Trends Immunol 22(4):187-91, 4/2001. PMID: 11274922.
83. Gunzer M, Schafer A, Borgmann S, Grabbe S, Zanker KS, Brocker EB, Kampgen E, Friedl P. Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 13(3):323-32, 9/2000. PMID: 11021530.
84. Gunzer M, Friedl P, Niggemann B, Brocker EB, Kampgen E, Zanker KS. Migration of dendritic cells within 3-D collagen lattices is dependent on tissue origin, state of maturation, and matrix structure and is maintained by proinflammatory cytokines. J Leukoc Biol 67(5):622-9, 5/2000. PMID: 10811001.
85. Friedl P, Brocker EB. The biology of cell locomotion within three-dimensional extracellular matrix. Cell Mol Life Sci 57(1):41-64, 1/2000. PMID: 10949580.
86. Friedl P, Brocker EB. T cell migration in three-dimensional extracellular matrix: guidance by polarity and sensations. Dev Immunol 7(2-4):249-66, 2000. PMCID: PMC2276041.
87. Maaser K, Wolf K, Klein CE, Niggemann B, Zanker KS, Brocker EB, Friedl P. Functional hierarchy of simultaneously expressed adhesion receptors: integrin alpha2beta1 but not CD44 mediates MV3 melanoma cell migration and matrix reorganization within three-dimensional hyaluronan-containing collagen matrices. Mol Biol Cell 10(10):3067-79, 10/1999. PMCID: PMC25559.
88. Friedl P, Zanker KS, Brocker EB. Cell migration strategies in 3-D extracellular matrix: differences in morphology, cell matrix interactions, and integrin function. Microsc Res Tech 43(5):369-78, 12/1998. PMID: 9858334.
89. Nikolai G, Niggemann B, Werner M, Zanker KS, Friedl P. Direct and rapid induction of migration in human CD4+ T lymphocytes within three-dimensional collagen matrices mediated by signalling via CD3 and/or CD2. Immunology 95(1):62-8, 9/1998. PMCID: PMC1364377.
90. Friedl P, Entschladen F, Conrad C, Niggemann B, Zanker KS. CD4+ T lymphocytes migrating in three-dimensional collagen lattices lack focal adhesions and utilize beta1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotion. Eur J Immunol 28(8):2331-43, 8/1998. PMID: 9710211.
91. Friedl P, Brocker EB, Zanker KS. Integrins, cell matrix interactions and cell migration strategies: fundamental differences in leukocytes and tumor cells. Cell Adhes Commun 6(2-3):225-36, 1998. PMID: 9823473.
92. Entschladen F, Niggemann B, Zanker KS, Friedl P. Differential requirement of protein tyrosine kinases and protein kinase C in the regulation of T cell locomotion in three-dimensional collagen matrices. J Immunol 159(7):3203-10, 10/1997. PMID: 9317118.
93. Nikolai G, Friedl P, Werner M, Niggemann B, Zanker KS. Effect of a mistletoe extract (Iscador QuFrF) on viability and migratory behavior of human peripheral CD4+ and CD8+ T lymphocytes in three-dimensional collagen lattices. In Vitro Cell Dev Biol Anim 33(9):710-6, 10/1997. PMID: 9358287.
94. Niggemann B, Maaser K, Lu H, Kroczek R, Zanker KS, Friedl P. Locomotory phenotypes of human tumor cell lines and T lymphocytes in a three-dimensional collagen lattice. Cancer Lett 118(2):173-80, 10/1997. PMID: 9459207.
95. Friedl P, Maaser K, Klein CE, Niggemann B, Krohne G, Zanker KS. Migration of highly aggressive MV3 melanoma cells in 3-dimensional collagen lattices results in local matrix reorganization and shedding of alpha2 and beta1 integrins and CD44. Cancer Res 57(10):2061-70, 5/1997. PMID: 9158006.
96. Nikolai G, Friedl P, Werner M, Zanker KS. Donor-dependent and dose-dependent variation in the induction of T lymphocyte locomotion in a three-dimensional collagen matrix system by a mistletoe preparation (Iscador). Anticancer Drugs 8 Suppl (1):S61-4, 4/1997. PMID: 9179371.
97. Dorner B, Muller S, Entschladen F, Schroder JM, Franke P, Kraft R, Friedl P, Clark-Lewis I, Kroczek RA. Purification, structural analysis, and function of natural ATAC, a cytokine secreted by CD8(+) T cells. J Biol Chem 272(13):8817-23, 3/1997. PMID: 9079718.
98. Gunzer M, Kampgen E, Brocker EB, Zanker KS, Friedl P. Migration of dendritic cells in 3D-collagen lattices. Visualisation of dynamic interactions with the substratum and the distribution of surface structures via a novel confocal reflection imaging technique. Adv Exp Med Biol 417:97-103, 1997. PMID: 9286344.
99. Friedl P, Noble PB, Walton PA, Laird DW, Chauvin PJ, Tabah RJ, Black M, Zanker KS. Migration of coordinated cell clusters in mesenchymal and epithelial cancer explants in vitro. Cancer Res 55(20):4557-60, 10/1995. PMID: 7553628.
100. Friedl P, Noble PB, Zanker KS. T lymphocyte locomotion in a three-dimensional collagen matrix. Expression and function of cell adhesion molecules. J Immunol 154(10):4973-85, 5/1995. PMID: 7537296.
101. Friedl P, Noble PB, Shields ED, Zanker KS. Locomotor phenotypes of unstimulated CD45RAhigh and CD45ROhigh CD4+ and CD8+ lymphocytes in three-dimensional collagen lattices. Immunology 82(4):617-24, 8/1994. PMCID: PMC1414901.
102. Friedl P|, Noble PB, Zanker KS. Lymphocyte locomotion in three-dimensional collagen gels. Comparison of three quantitative methods for analysing cell trajectories. J Immunol Methods 165(2):157-65, 10/1993. PMID: 7901283.
103. Friedl P, Konig B, Konig W. Effects of mucoid and non-mucoid pseudomonas aeruginosa isolates from cystic fibrosis patients on inflammatory mediator release from human polymorphonuclear granulocytes and rat mast cells. Immunology 76(1):86-94, 5/1992. PMCID: PMC1421756.
104. Konig B, Friedl P, Pedersen SS, Konig W. Alginate--its role in neutrophil responses and signal transduction towards mucoid Pseudomonas aeruginosa bacteria. Int Arch Allergy Immunol 99(1):98-106, 1992. PMID: 1336422.
Other Articles
1. Friedl P, Wolf K. Fast Moving Front article selection from the field of Molecular Biology & Genetics for the month of March 2011: "Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion":893-904, 2007.

Book Chapters

1. Friedl P. In: At the tumor-stroma interface: imaging collective cancer cell invasion and resistance, 2009.
2. Friedl P, Wolf K, von Andrian UH, Harms G. Curr Protoc Cell Biol. In: Biological second and third harmonic generation microscopy. Chapter 4, Unit 4.15, 2007. ISBN: 18228516.
3. Rimke I, Buttner E, Andresen V, Friedl P. In: Infrared multiphoton microscopy beyond 1 micon: system design and biomedical applications: Washington, 2006.
4. Friedl P, Wolf K. In: Diversite cellulaire et moleculaire des strategies de migration cellulaires: Paris, 1-6, 2003.
5. Friedl P. In: Extrazellulare Matris und Immuneregularion: Springer, 55-59, 2002.
6. Friedl P, Masser K, Brocker EB. In: Molecular mechanisms of melanoma cell motility and tissue invasion: Netherlands, 2002.
7. Friedl P, Brocker EB. In: Biological confocal reflection microscopy: reconstruction of three-dimensional extracellular matrix, cell migration, and matrix reorganization: Florida, 9-21, 2001.
8. Friedl P, Brocker EB. In: Cancer cell interaction with the extracellular matrix involved in tissue invasion and cancer cell migration: Motility mechanisms beyond the single cell paradign: Heidelberg, 7-18, 1997.
9. Friedl P, Niggemann B, Brocker EB, Zanker KS. In: Konfrontation humaner T Lymphozyten mit autologen Tymorexplataten in 3-D Kollagenmatrices in vitro: Heidelberg, 237-242, 1997.
10. Nikolai G, Friedl P, Nobel PB, Wener M, Niggemann B, Zanker KS. In: Eine Methode zur Untersuchung des Einflusses von Mistelpraparaten auf die Motilitat humaner T-Lymphozyten in einem in vitro 3-D Kollagenmatrixsystem: Stuttgart, 1996.


1. Video Publication.

Friedl P, Zanker KS.  Krebs und Metastasierung (Cancer and Metastasis). Spektrum Videothek, Spektrum Akademischer Verlag, Heidelberg, 1995


Grant & Contract Support

Title: Preclinical micro-endoscopy in tumors: Targeting metastatic intravasation and resistance
Funding Source: ERC - CoG Deepinsight
Role: Principal Investigator
Duration: 8/1/2014 - 7/31/2019
Title: Molecules in motion: Microscopy-based quantification of reaction-diffusion systems in immunity, cancer metabolism and drug delivery
Funding Source: Netherlands Science Foundation (NWO)
Role: Co-Principal Investigator
Principal Investigator: Roland Brock
Duration: 2013 - 2016
Title: Project No: 302067. CCinG-Cadherin control of invasive growth in morphogeneis and cancer
Funding Source: Marie Curie Actions
Role: Principal Investigator
Duration: 1/2013 - 12/2015
Title: Intravital imaging of patient-derived tumor organoids; in vivo imaging of combination therapy identified by
Funding Source: Netherlands Science Foundation (NWO)
Role: Co-Principal Investigator
Duration: 1/1/2012 - 12/31/2016
Title: Individual-cell and collective cancer invasion and metastasis: paths, mechanisms and therapeutic implications
Funding Source: Netherlands' Science Foundation (NWO)
Role: Principal Investigator
Duration: 9/1/2011 - 8/31/2016
Title: Chemokine functions in collective cancer cell invasion: induction, guidance and systemic dissemination. Marie Curie Actions
Funding Source: CICCI
Role: Principal Investigator
Duration: 6/1/2011 - 5/31/2013
Title: Intravital imaging of tumor growth and gression during angiogenesis inhibition therapy
Funding Source: Bayer Healthcare
Role: Principal Investigator
Duration: 3/2010 - 12/2010
Title: Healthy Aging: Small Molecule Inhibitors Against Chronic Disease
Funding Source: Pieken in the Delta Oest Nederland (PIDON)
Role: Principal Investigator
Duration: 7/1/2009 - 6/30/2013
Title: Tissue Transmigration Training Network (T3 Net)
Funding Source: FP7 European
Role: Principal Investigator
Duration: 4/1/2009 - 3/31/2012
Title: European Network for Cell Imaging and Tracking Expertise; FP7 Project ENCITE HEALTH
Funding Source: European Community, Encite Health
Role: Principal Investigator
Duration: 7/1/2008 - 12/31/2012
Title: Serial killing in vitro and in vivo: modulation by the tumor microenvironment
Funding Source: Dutch Cancer Foundation
Role: Principal Investigator
Duration: 1/1/2008 - 12/31/2012
Title: Biological multiphoton-excited fluorescence life-time microscopy. Construction of a FLIM detector
Funding Source: Deutsche Forschungsgemeinschaft (German research council)
Role: Principal Investigator
Duration: 1/2007 - 12/2007
Title: Vessel-guided collective cancer invasion in vivo: molecular mechanisms and fate
Funding Source: Deutsche Forschungsgemeinschaft (German research council)
Role: Principal Investigator
Duration: 1/2006 - 12/2011
Title: Dynamic imaging of tumor invasion: patterns and molecular mechanisms of collective dissemination. Invasion and Metastasis Consortium AZ
Funding Source: Deutsche Forschungsgemeinschaft (German research council)
Role: Principal Investigator
Duration: 1/2006 - 12/2009
Title: Visualization of the effector function of cytotoxic T lymphocytes in 3D collagen lattices: cellular and molecular interaction strategies, serial target cell killing, and identification of novel escape strategies. Project within the Clinical Research Group Immunology of the Tumor Microenvironment
Funding Source: Deutsche Forschungsgemeinschaft (German research council)
Role: Principal Investigator
Duration: 9/2004 - 8/2010
Title: In vivo detection of small tumor load by multiphoton microscopy
Funding Source: European Community
Role: Principal Investigator
Duration: 7/2004 - 6/2009
Title: Plasticity of cell migration through oncogenic transformation. DFG Transregio SFB"Oncogenic ras pathways"
Funding Source: Deutsche Forschungsgemeinschaft (German research council)
Role: Principal Investigator
Duration: 7/2004 - 6/2008
Title: Plasticity of tumor cell migration by mesenchymal-amoeboid transition (MAT): functional and molecular analysis of the amoeboid phenotype.
Funding Source: Deutsche Forschungsgemeinschaft (German research council)
Role: Principal Investigator
Duration: 6/2004 - 5/2007
Title: Regulation of angiogenesis in multicellular fibrin and collagen matrices: implications for chronic wounds and tumor invasion
Funding Source: Interdisciplinary Center for Clinical Research (IZKF), Wurzburg
Role: Principal Investigator
Duration: 5/2004 - 12/2006
Title: Events in immunological synapse formation in CD8+ T cell induction and effector phase, Queen-Wilhelmina-Fellowship to Dr. Annemieke T. den Boer
Funding Source: Dutch Cancer Foundation
Role: Principal Investigator
Duration: 5/2003 - 4/2006
Title: Interdisciplinary Center for Clinical Research (IZKF Wurzburg): Rotation position for research for 9 months (IZKF-rotation support, 1 physician for 9 months).
Funding Source: Interdisciplinary Center for Clinical Research (IZKF), Wurzburg
Role: Principal Investigator
Duration: 7/2002 - 6/2009
Title: Plasticity of tumor cell migration - functional and molecular characterization of mesenchymal-amoeboid transition in HT-1080 fibrosarcoma and MV3 melanoma cells (FR 1155/2-3)
Funding Source: Deutsche Forschungsgemeinschaft (German research council)
Role: Principal Investigator
Duration: 2/2002 - 1/2004
Title: Tissue Engineering: Establishment and validation of a dermo-epidermal composite graft
Funding Source: Ministry for Research and Education, Germany
Role: Principal Investigator
Duration: 1/2002 - 12/2003
Title: Dynamic interactions of T cells with dendritic cells in 3-D collagen matrices: structure of the interaction plane, function of accessory receptors and efficiency of interaction
Funding Source: Deutsche Forschungsgemeinschaft (German research council)
Role: Principal Investigator
Duration: 5/2001 - 8/2003
Title: Dominant-negative inhibition of integrin-cytoskeleton interactions
Funding Source: Foundation of the University Wurzburg
Role: Principal Investigator
Duration: 4/2001 - 8/2001
Title: Trojan peptides for inhibition of melanoma cell invasion
Funding Source: Erna-Graff Foundation for animal protection
Role: Principal Investigator
Duration: 11/2000 - 6/2001
Title: Cell migration in 3D collagen matrices: Parameter definition and software evaluation for an automated cell tracking device for pharmacological substance screening in vitro
Funding Source: Ministry for Research and Education, Germany
Role: Principal Investigator
Duration: 11/1999 - 10/2001
Title: Function of fibroblast-activation protein (FAP) for cell migration in collagen: functional characterization of FAP inhibitor compounds
Funding Source: Boehringer Ingelheim Pharma KG
Role: Principal Investigator
Duration: 12/1998 - 7/2000
Title: T cell migration in extracellular matrices
Funding Source: Deutsche Forschungsgemeinschaft (German research council)
Role: Principal Investigator
Duration: 9/1998 - 1/2002
Title: Function and redistribution of matrix metalloproteinases in the migration of different cell types
Funding Source: Deutsche Forschungsgemeinschaft (German research council)
Role: Principal Investigator
Duration: 9/1998 - 1/2002
Title: Migrating cell clusters in primary melanoma explants-function of B1 integrins
Funding Source: Society for Biological Cancer Defense
Role: Principal Investigator
Duration: 1/1998 - 12/1998
Title: Comparison of cellular and molecular migration strategies in T cells, dendritic cells and melanoma cells in 3D collagen matrices
Funding Source: Wilhelm-Sander Foundation
Role: Principal Investigator
Duration: 1/1997 - 7/2007
Title: Transendothelial Migration of Tumor Cells in vitro
Funding Source: Felix-Wankel Foundation
Role: Principal Investigator
Duration: - 1999

Last updated: 9/9/2016