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Pradeep Chaluvally Raghavan, PhD

Present Title & Affiliation

Primary Appointment

Instructor, Department of Systems Biology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2006 University of Calicut, Kerala, India, PHD, Chemoprevention and Cancer Biology
2001 University of Bharathiar, Tamil Nadu, India, MS, Microbiology
1998 University of Calicut, Kerala, India, BS, Life Science/Zoology

Postgraduate Training

9/2010-2/2014 Research Fellowship, Ovarian and Breast Cancer Research, microRNA and RNAi Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, Gordon Mills
10/2006-6/2010 Research Fellowship, Cancer Biology, HER2 and EFGR family, Weizmann Institute of Sciences, Rehovot, Israel, Professor Yosef Yarden
9/2005-10/2006 Scientist, Avestha Gengrainse Technologies Pvt. Ltd, Bangalore, India

Honors and Awards

2014 Scientific Scholar Award, Marsha Rivkin Centre for Ovarian Cancer Research
2013 AACR-Millennium Scholar in Training Award, American Association of Cancer Research Annual Symposium
2013 Ann Schreiber Program of Excellence Fellowship Award Ovarian Cancer Research Fund
2013 Young Investigator Award, American Association of Indian Scientists in Cancer Research
2012 AMGEN Basic Science Poster Winner Award Trainee and Alumni Association, MD Anderson Cancer Center
2012 Judges Choice Annual Postdoctoral Symposium Award, MD Anderson Cancer Center
2012 Trainee Excellence Award, MD Anderson Alumni and Faculty Association Education Fund
2009 AACR-Avon Foundation International Scholar in Training Travel Aaward, San Antonio Breast Cancer Symposium
2004 Fr. Gabriel Jubilee Award, Amala Institute of Medical Sciences

Selected Publications

Peer-Reviewed Original Research Articles

1. Chaluvally-Raghavan P, Zhang F, Pradeep S, Zhao X, Yu S, Pecot CV, Aure M, Peuget S, Rodriguez-Aguayo C, Han H-D, Zhang D, Venkatanarayan A, Lu Y, Lopez-Berestein G , Kristensen V, Børresen-Dale A-L, Chin K, Gray J, Dusetti NJ, Flores ER, Sood AK and Mills GB. Genomic amplification of has-miR-569 at 3q26.2 Leads to Loss of TP53INP1 and Aggressiveness of Epithelial Cancers. Cancer Cell. In Press.
2. Pradeep S, Kim SW, Wu SY, Nishimura M, Chaluvally-Raghavan P, Miyake T, Pecot CV, Kim SJ, Choi HJ, Bischoff FZ, Mayer JA, Huang L, Nick AM, Hall CS, Rodriguez-Aguayo C, Zand B, Dalton HJ, Arumugam T, Lee HJ, Han HD, Cho MS, Rupaimoole R, Mangala LS, Sehgal V, Oh SC, Liu J, Lee JS, Coleman RL, Ram P, Lopez-Berestein G, Fidler IJ, Sood AK. Hematogenous metastasis of ovarian cancer: rethinking mode of spread. Cancer Cell 26(1):77-91, 7/14/2014. PMCID: PMC4100212.
3. Pradeep CR, Zeisel A, Köstler WJ, Lauriola M, Jacob-Hirsch J, Haibe-Kains B, Amariglio N, Ben-Chetrit N, Emde A, Solomonov I, Neufeld G, Piccart M, Sagi I, Sotiriou C, Rechavi G, Domany E, Desmedt C, Yarden Y. Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions. Oncogene 31(31):3569-83, 8/2/2012. e-Pub 12/5/2011. PMCID: PMC3616212.
4. Lindzen M, Carvalho S, Starr A, Ben-Chetrit N, Pradeep CR, Köstler WJ, Rabinkov A, Lavi S, Bacus SS, Yarden Y. A recombinant decoy comprising EGFR and ErbB-4 inhibits tumor growth and metastasis. Oncogene 31(30):3505-15, 7/26/2012. e-Pub 11/21/2011. PMCID: PMC3290749.
5. Pradeep CR, Köstler WJ, Lauriola M, Granit RZ, Zhang F, Jacob-Hirsch J, Rechavi G, Nair HB, Hennessy BT, Gonzalez-Angulo AM, Tekmal RR, Ben-Porath I, Mills GB, Domany E, Yarden Y. Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling. Oncogene 31(7):907-17, 2/16/2012. e-Pub 7/11/2011. PMCID: PMC3193899.
6. Emde A, Pradeep CR, Ferraro DA, Ben-Chetrit N, Sela M, Ribba B, Kam Z, Yarden Y. Combining epitope-distinct antibodies to HER2: cooperative inhibitory effects on invasive growth. Oncogene 30(14):1631-42, 4/7/2011. e-Pub 12/6/2010. PMCID: PMC3632784.
7. Guruvayoorappan C, Pradeep CR, Kuttan G. 13-cis-retinoic acid induces apoptosis by modulating caspase-3, bcl-2, and p53 gene expression and regulates the activation of transcription factors in B16F-10 melanoma cells. J Environ Pathol Toxicol Oncol 27(3):197-207, 2008. PMID: 18652567.
8. Guruvayoorappan C, Pradeep CR, Kuttan G. 13 Cis-retinoic acid mediates apoptosis in Dalton's lymphoma ascites cells by regulating gene expression. J Basic Clin Physiol Pharmacol 18(4):267-76, 2007. PMID: 18380168.
9. Pradeep CR, Kuttan G. Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells. International Immunopharmacol 4(14):1795-803, 2004.
10. Pradeep CR, Kuttan G. Effect of beta-carotene on the inhibition of lung metastasis in mice. Phytomedicine 10(2-3):159-64, 2003.
11. Pradeep CR and Kuttan G. Effect of piperine on the inhibition of nitric oxide (NO) and TNF-alpha production. Immunopharmacol Immunotoxicol 25(3):337-46, 2003.
12. Pradeep CR and Kuttan G. Effect of piperine on the inhibition of lung metastasis induced B16F-10 melanoma cells in mice. Clin Exp Metastasis 19(8):703-8, 2002.

Grant & Contract Support

Title: Unravelling the oncogenic effects of amplified miRNAs in High Grade Serous Epithelial Ovarian Cancer
Funding Source: The Marsha Rivkin Center for Ovarian Cancer
Role: Principal Investigator
Duration: 4/1/2014 - 3/31/2015
Title: Role of MicroRNAs in the 3Q26 Amplicon in Ovarian Cancer Pathophysiology and Therapy
Funding Source: Ann Schreiber Program of Excellence Training Grant from Ovarian Cancer Research Fund
Role: Principal Investigator
Duration: 3/1/2013 - 2/28/2014

Last updated: 4/7/2015