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Raymond N. DuBois, Jr., M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Provost & Executive Vice President, The University of Texas MD Anderson Cancer Center, Houston, TX
Professor of Cancer Biology & Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

The DuBois Laboratory goals are to advance the understanding, diagnosis, treatment and prevention of colorectal cancer. We actively seek to understand the molecular mechanisms and biology that drive the development and progression of colon cancer. We have learned that bioactive lipids and inflammation play central roles in this process. We were among the first labs to recognize that cyclooxygenase (COX) plays a key role in the formation of adenomatous polyps and colorectal cancer. We were also among the first to appreciate that prostaglandin E2 (PGE2) exhibits most of the cancer promoting activity of the PGs. These exciting discoveries led to successful clinical translational studies applying the use of non-steroidal anti-inflammatory drugs (NSAIDs) that include cyclooxygenase-2 selective inhibitors (COXIBs) in the treatment of high-risk colorectal cancer patients.

We are heavily engaged in identifying important molecular targets downstream of COX-2 to improve the treatment and prevention of colorectal cancer. This is to eliminate the cardiovascular risk associated with the long-term use of COXIBs. These efforts include identifying the molecules involved in tissue inflammation that cause the progression of colorectal cancer. They also involve uncovering the role of nuclear receptor signaling through peroxisome proliferator activated receptors in colorectal cancer. Furthermore, we are learning about other arachidonic acid based molecules such as endocannabinoids that act through cannabinoid receptors to inhibit colon cancer.

These are very exciting times to be involved in the basic and clinical translational research of cancer. We have pioneered many concepts regarding the role of eicosanoids in cancer through the development of robust collaborations that integrate our extensive clinical and basic science expertise. The ultimate goal of our work is to meet the long-term objective of reducing the local and global cancer burden.

Office Address

Email: rdubois@mdanderson.org

Education & Training

Degree-Granting Education

1985 University of Texas Health Science Center at San Antonio, San Antonio, TX, MD, Medicine
1981 University of Texas Health Science Center at Dallas, Dallas, TX, PHD, Biochemistry
1977 Texas A&M University, College Station, TX, BS, Biochemistry

Postgraduate Training

1988-1991 Gastroenterology Fellowship, The Johns Hopkins Hospital, Baltimore, MD
1985-1988 Osler Medicine Internship & Residency, The Johns Hopkins Hospital, Baltimore, MD

Experience/Service

Institutional Committee Activities

Ex Officio Member, Graduate Education Committee, 2008-present
Member, Executive Committee, 2007-present
Chair, Research Council, 2007-present

Honors and Awards

2009-present Ellen F. Knisely Distinguished Chair in Colon Cancer Research
2008-2009 President, AACR
2007 Johns Hopkins Society of Scholars, Johns Hopkins
2006 Anthony Dipple Carcinogenesis Award, Oxford University Press
2004 Distinguished Achievement Award, American Gastroenterological Association (AGA)
2004 Dorothy P. Landon Cancer Research Prize, AACR
2004 Fellow, American Association for the Advancement of Science
2003 Board of Directors, American Association for Cancer Research
2002 Richard and Hinda Rosenthal Foundation Cancer Research Award, AACR
2000 E.V. Newman Research Prize, Vanderbilt University Department of Medicine
2000 Outstanding Investigator Award, American Federation for Medical Research
2000 President, Gastroenterology Research Group of the AGA
2000 President, Southern Society for Clinical Investigation

Selected Publications

Peer-Reviewed Original Research Articles
1. Kim SH, Xia D, Kim SW, Holla V, Menter DG, Dubois RN. Human enhancer of filamentation 1 Is a mediator of hypoxia-inducible factor-1alpha-mediated migration in colorectal carcinoma cells. Cancer Res 70(10):4054-63, 5/2010. e-Pub 5/2010. PMCID: PMC2871069.
2. Menter DG, Schilsky RL, DuBois RN. Cyclooxygenase-2 and cancer treatment: understanding the risk should be worth the reward. Clin Cancer Res 16(5):1384-90, 3/1/2010. e-Pub 2/23/2010. PMID: 20179228.
3. Wang D, Dubois RN. Eicosanoids and cancer. Nat Rev Cancer 10(3):181-93, 3/2010. e-Pub 2/2010. PMID: 20168319.
4. Wang D, Dubois RN. The role of COX-2 in intestinal inflammation and colorectal cancer. Oncogene 29(6):781-8, 2/2010. PMID: 19946329.
5. Xia D, Holla VR, Wang D, Menter DG, DuBois RN. HEF1 is a crucial mediator of the proliferative effects of prostaglandin E(2) on colon cancer cells. Cancer Res 70(2):824-31, 1/15/2010. e-Pub 1/12/2010. PMID: 20068165.
6. Wang D, Dubois RN, Richmond A. The role of chemokines in intestinal inflammation and cancer. Curr Opin Pharmacol, 9/2009. e-Pub 9/2009. PMID: 19734090.
7. Dubois RN. New, long-term insights from the Adenoma Prevention with Celecoxib Trial on a promising but troubled class of drugs. Cancer Prev Res (Phila Pa) 2(4). e-Pub 3/2009. PMID: 19336723.
8. Backlund MG, Mann JR, Holla VR, Shi Q, Daikoku T, Dey SK, DuBois RN. Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Cancer Res 68(22):9331-7, 11/2008. PMID: 19010907.
9. Wang D, Wang H, Ning W, Backlund MG, Dey SK, DuBois RN. Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res 68(15):6468-76, 8/2008. PMID: 18676872.
10. Holla VR, Backlund MG, Yang P, Newman RA, DuBois RN. Regulation of prostaglandin transporters in colorectal neoplasia. Cancer Prev Res (Phila Pa) 1(2). e-Pub 3/2008. PMID: 19138942.
11. Wang D, Dubois RN. Peroxisome proliferator-activated receptors and progression of colorectal cancer. PPAR Res 2008:931074, 2008. PMID: 18551185.
12. Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, DuBois RN, Dey SK. Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success. J Biol Chem 282(52):37770-82, 12/2007. PMID: 17965409.
13. Lee SH, Rangiah K, Williams MV, Wehr AY, DuBois RN, Blair IA. Cyclooxygenase-2-mediated metabolism of arachidonic acid to 15-oxo-eicosatetraenoic acid by rat intestinal epithelial cells. Chem Res Toxicol 20(11):1665-75, 11/2007. PMID: 17910482.
14. Horikawa Y, Otaka M, Komatsu K, Jin M, Odashima M, Wada I, Matsuhashi T, Ohba R, Oyake J, Hatakeyama N, Dubois RN, Watanabe S. MEK activation suppresses CPT11-induced apoptosis in rat intestinal epithelial cells through a COX-2-dependent mechanism. Dig Dis Sci 52(10):2757-65, 10/2007. PMID: 17393318.
15. Buchanan FG, Holla V, Katkuri S, Matta P, DuBois RN. Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer. Cancer Res 67(19):9380-8, 10/2007. PMID: 17909047.
16. Daikoku T, Tranguch S, Chakrabarty A, Wang D, Khabele D, Orsulic S, Morrow JD, Dubois RN, Dey SK. Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer. Cancer Res 67(11):5285-92, 6/2007. PMID: 17545608.
17. Mann JR, Backlund MG, Buchanan FG, Daikoku T, Holla VR, Rosenberg DW, Dey SK, DuBois RN. Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression. Cancer Res 66(13):6649-56, 7/2006. PMID: 16818638.
18. Wang D, Wang H, Brown J, Daikoku T, Ning W, Shi Q, Richmond A, Strieter R, Dey SK, DuBois RN. CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. J Exp Med 203(4):941-51, 4/2006. PMID: 16567391.
19. Holla VR, Mann JR, Shi Q, DuBois RN. Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer. J Biol Chem 281(5):2676-82, 2/2006. PMID: 16293616.
20. Cha YI, Kim SH, Sepich D, Buchanan FG, Solnica-Krezel L, DuBois RN. Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation. Genes Dev 20(1):77-86, 1/2006. PMID: 16391234.
21. Wang D, Dubois RN. Prostaglandins and cancer. Gut 55(1):115-22, 1/2006. PMID: 16118353.
22. Buchanan FG, Gorden DL, Matta P, Shi Q, Matrisian LM, DuBois RN. Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. Proc Natl Acad Sci U S A 103(5):1492-7, 1/2006. PMID: 16432186.
23. Batts LE, Polk DB, Dubois RN, Kulessa H. Bmp signaling is required for intestinal growth and morphogenesis. Dev Dyn 235(6):1563-1570, 2006. e-Pub 3/2006. PMID: 16538672.
24. Peek RM, Mohla S, DuBois RN. Inflammation in the genesis and perpetuation of cancer: summary and recommendations from a national cancer institute-sponsored meeting. Cancer Res 65(19):8583-6, 10/2005. PMID: 16204020.
25. Lee SH, Williams MV, Dubois RN, Blair IA. Cyclooxygenase-2-mediated DNA damage. J Biol Chem 280(31):28337-46, 8/2005. PMID: 15964853.
26. Mann JR, Backlund MG, DuBois RN. Mechanisms of disease: Inflammatory mediators and cancer prevention. Nat Clin Pract Oncol 2(4):202-10, 4/2005. PMID: 16264935.
27. Holla VR, Wang D, Brown JR, Mann JR, Katkuri S, DuBois RN. Prostaglandin E2 regulates the complement inhibitor CD55/decay-accelerating factor in colorectal cancer. J Biol Chem 280(1):476-83, 1/2005. PMID: 15520008.
28. Backlund MG, Mann JR, Holla VR, Buchanan FG, Tai HH, Musiek ES, Milne GL, Katkuri S, DuBois RN. 15-hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer. J Biol Chem 280(5):3217-3223, 2005. e-Pub 11/2004. PMID: 15542609.
29. Daikoku T, Wang D, Tranguch S, Morrow JD, Orsulic S, DuBois RN, Dey SK. Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res 65(9):3735-3744, 2005. PMID: 15867369.
30. Musiek ES, Gao L, Milne GL, Han W, Everhart MB, Wang D, Backlund MG, DuBois RN, Zanoni G, Vidari G, Blackwell TS, Morrow JD. Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages. J Biol Chem 280(42):35562-35570, 2005. PMID: 16100121.
31. Buchanan FG, McReynolds M, Couvillon A, Kam Y, Holla VR, DuBois RN, Exton JH. Requirement of phospholipase D1 activity in H-RasV-12 induced transformation. Proc Natl Acad Sci USA 102:1638-1642, 2005.
32. Buchanan FG, Chang W, Sheng H, Shao J, Morrow JD, DuBois RN. Up-regulation of the enzymes involved in prostacyclin synthesis via Ras induces vascular endothelial growth factor. Gastroenterology 127(5):1391-400, 11/2004. PMID: 15521009.
33. Wang D, Wang H, Shi Q, Katkuri S, Walhi W, Desvergne B, Das SK, Dey SK, DuBois RN. Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell 6(3):285-95, 9/2004. PMID: 15380519.
34. Organ EL, Nalbantyan CD, Nanney LB, Woodward SC, Sheng J, Dubois RN, Price J, Sutcliffe M, Coffey RJ, Rubin DH. Effects of transforming growth factor-alpha (TGF-alpha) in vitro and in vivo on reovirus replication. DNA Cell Biol 23(7):430-41, 7/2004. PMID: 15294092.
35. Gupta RA, Wang D, Katkuri S, Wang H, Dey SK, DuBois RN. Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat Med 10(3):245-7, 3/2004. PMID: 14758356.
36. Yoshinaga M, Buchanan FG, DuBois RN. 15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells. Prostaglandins Other Lipid Mediat 73(1-2):111-22, 1/2004. PMID: 15165036.
37. Wang H, Guo Y, Wang D, Kingsley PJ, Marnett LJ, Das SK, DuBois RN, Dey SK. Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nat Med 10(10):1074-1080, 2004. PMID: 15378054.
38. Gupta RA, Wang D, Katkuri S, Wang H, Dey SK, DuBois RN. Activation of the nuclear hormone receptor PPARδ accelerates intestinal adenoma growth. Nature Medicine 10:245-247, 2004.
39. Blot WJ, Fischer T, Nielson GL, Friis S, Mumma M, Lipworth L, DuBois RN, McLaughlin JK, Sorensen HT. Outcome of upper gastrointestinal bleeding and use of ibuprofen versus paracetamol. Pharm World Sci 26:319-323, 2004.
40. Wang D, Wang H, Shi Q, Katkuri S, Walhi W, Desvergne B, Das SK, Dey SK, DuBois RN. Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear hormone receptor PPRAδ. Cancer Cell 6:285-295, 2004.
41. Gupta RA, Sarraf P, Mueller E, Brockman JA, Prusakiewicz JJ, Eng C, Willson TM, DuBois RN. Peroxisome proliferator-activated receptor gamma-mediated differentiation: a mutation in colon cancer cells reveals divergent and cell type-specific mechanisms. J Biol Chem 278(25):22669-77, 6/2003. PMID: 12591919.
42. Crosby CG, DuBois RN. The cyclooxygenase-2 pathway as a target for treatment or prevention of cancer. Expert Opin Emerg Drugs 8(1):1-7, 5/2003. PMID: 14610907.
43. Daikoku T, Matsumoto H, Gupta RA, Das SK, Gassmann M, DuBois RN, Dey SK. Expression of hypoxia-inducible factors in the peri-implantation mouse uterus is regulated in a cell-specific and ovarian steroid hormone-dependent manner. Evidence for differential function of HIFs during early pregnancy. J Biol Chem 278(9):7683-91, 2/2003. PMID: 12482866.
44. Gupta RA, Sarraf P, Brockman JA, Shappell SB, Raftery LA, Willson TM, DuBois RN. Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22. J Biol Chem 278(9):7431-8, 2/2003. PMID: 12468551.
45. Wagenaar-Miller RA, Hanley G, Shattuck-Brandt R, DuBois RN, Bell RL, Matrisian LM, Morgan DW. Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction. Br J Cancer 88(9):1445-1452, 2003. PMID: 12778076.
46. Gupta RA, Sarraf P, Mueller E, Brockman JA, Prusakiewicz JJ, Eng C, Willson TM and DuBois RN. PPARγ mediated differentiation: A mutation in colon cancer cells reveals divergent and cell-type specific mechanisms. J Biol Chem 278:22669-22677, 2003.
47. Buchanan FG, Wang D, Bargiacchi F, DuBois RN. Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor. J Biol Chem 278(37):35451-35457, 2003. PMID: 12824187.
48. Lee SH, Williams MV, DuBois RN, Blair IA. Targeted lipidomics using electron capture atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom 17(19):2168-2176, 2003. PMID: 14515314.
49. Gupta RA, Dubois RN. Controversy: PPARgamma as a target for treatment of colorectal cancer. Am J Physiol Gastrointest Liver Physiol 283(2):G266-9, 8/2002. PMID: 12121872.
50. Kozak KR, Gupta RA, Moody JS, Ji C, Boeglin WE, DuBois RN, Brash AR, Marnett LJ. 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist. J Biol Chem 277(26):23278-86, 6/2002. PMID: 11956198.
51. Hawk ET, Viner JL, Dannenberg A, DuBois RN. COX-2 in cancer--a player that's defining the rules. J Natl Cancer Inst 94(8):545-6, 4/2002. PMID: 11959883.
52. Kawai N, Tsuji S, Tsujii M, Ito T, Yasumaru M, Kakiuchi Y, Kimura A, Komori M, Sasaki Y, Hayashi N, Kawano S, DuBois RN, Hori M. Tumor necrosis factor alpha stimulates invasion of Src-activated intestinal cells. Gastroenterology 122:331-339, 2002.
53. Pyo H, Choy H, Amorino GP, Kim JS, Cao Q, Hercules SK, DuBois RN. A selective cyclooxygenase-2 inhibitor, NS-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2. Clin Cancer Res 7(10):2998-3005, 10/2001. PMID: 11595687.
54. Mann M, Sheng H, Shao J, Williams CS, Pisacane PI, Sliwkowski MX, DuBois RN. Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth. Gastroenterology 120(7):1713-9, 6/2001. PMID: 11375952.
55. Souto EO, Miyoshi H, Dubois RN, Gores GJ. Kupffer cell-derived cyclooxygenase-2 regulates hepatocyte Bcl-2 expression in choledocho-venous fistula rats. Am J Physiol Gastrointest Liver Physiol 280(5):G805-11, 5/2001. PMID: 11292587.
56. Sheng H, Shao J, Washington MK, DuBois RN. Prostaglandin E2 increases growth and motility of colorectal carcinoma cells. J Biol Chem 276(21):18075-81, 5/2001. PMID: 11278548.
57. Sheng H, Shao J, DuBois RN. Akt/PKB activity is required for Ha-Ras-mediated transformation of intestinal epithelial cells. J Biol Chem 276(17):14498-504, 4/2001. PMID: 11278613.
58. Dubois RN. Nonsteroidal antiinflammatory drugs, cyclooxygenase-2, and colorectal cancer prevention. Curr Opin Gastroenterol 17(1):65-71, 1/2001. PMID: 17031153.
59. Williams CS, Sheng H, Brockman JA, Armandla R, Shao J, Washington MK, Elkahloun AG, DuBois RN. A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. Neoplasia 3(5):428-436, Sep-Oct, 2001. PMID: 11687954.
60. Kobayashi O, Miwa H, Watanabe S, Tsujii M, Dubois RN, Sato N. Cyclooxygenase-2 downregulates inducible nitric oxide synthase in rat intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 281(3):G688-G696, 2001. PMID: 11518681.
61. Reese J, Das SK, Paria BC, Lim H, Song H, Matsumoto H, Knudtson KL, DuBois RN, Dey SK. Global gene expression analysis to identify molecular markers of uterine receptivity and embryo implantation. J Biol Chem 276(47):44137-44145, 2001. PMID: 11551965.
62. Sheng H, Shao J, Dubois RN. K-Ras-mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B1. Cancer Res 61(6):2670-2675, 2001. PMID: 11289146.
63. Gupta RA, Brockman JA, Sarraf P, Willson TM, DuBois RN. Target genes of peroxisome proliferator-activated receptor gamma in colorectal cancer cells. J Biol Chem 276(32):29681-29687, 2001. PMID: 11397807.
64. Gupta RA, Tan J, Krause WF, Geraci MW, Willson TM, Dey SK, DuBois RN. Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. Proc Natl Acad Sci U S A 97(24):13275-80, 11/2000. PMID: 11087869.
65. Shao J, Sheng H, DuBois RN, Beauchamp RD. Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation. J Biol Chem 275(30):22916-24, 7/2000. PMID: 10781597.
66. Zhang Z, DuBois RN. Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells. Gastroenterology 118(6):1012-7, 6/2000. PMID: 10833474.
67. Gupta RA, DuBois RN. Translational studies on COX-2 inhibitors in the prevention and treatment of colon cancer. Ann N Y Acad Sci 910:196-204, 6/2000. PMID: 10911914.
68. Sheng H, Shao J, Dixon DA, Williams CS, Prescott SM, DuBois RN, Beauchamp RD. Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. J Biol Chem 275(9):6628-35, 3/2000. PMID: 10692471.
69. Shattuck-Brandt RL, Varilek GW, Radhika A, Yang F, Washington MK, DuBois RN. Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice. Gastroenterology 118(2):337-45, 2/2000. PMID: 10648462.
70. Williams CS, Watson AJ, Sheng H, Helou R, Shao J, DuBois RN. Celecoxib prevents tumor growth in vivo without toxicity to normal gut: lack of correlation between in vitro and in vivo models. Cancer Res 60(21):6045-6051, 2000. PMID: 11085526.
71. Shattuck-Brandt RL, Varilek GW, Radhika A, Yang F, Washington MK, DuBois RN. Cyclooxygenase-2 expression is increased in the subepithelial myofibroblasts of colon and cecal carcinomas from IL-10 (-/-) mice. Gastroenterlogy 118:337-345, 2000.
72. Williams CS, Tsujii M, Reese J, Dey SK, DuBois RN. Host cyclooxygenase-2 modulates carcinoma growth. J Clin Invest 105(11):1589-1594, 2000. PMID: 10841517.
73. Shao J, Sheng H, Inoue H, Morrow JD, DuBois RN. Regulation of Constitutive Cyclooxygenase-2 Expression in Colon Carcinoma Cells. J Biol Chem 275(43):33951-33956, 2000. PMID: 10930401.
74. Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, Gordon GB, Wakabayashi N, Saunders B, Shen Y, Fujimura T, Su L, Levin B, Godio L, Patterson S, Rodriguez-Bigas MA, Jester SL, King KL, Schumacher M, Abbruzzese J, DuBois RN , Hittelman WH, Zimmerman S, Sherman JW, Kelloff G. The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis. N Engl J Med 342:1946-1952, 2000.
75. O'Mahony CA, Beauchamp RD, Albo D, Tsujii M, Sheng HM, Shao J, Dubois RN, Berger DH. Cyclooxygenase-2 alters transforming growth factor-beta 1 response during intestinal tumorigenesis. Surgery 126(2):364-70, 8/1999. PMID: 10455907.
76. Kamitani H, Ikawa H, Hsi LC, Watanabe T, DuBois RN, Eling TE. Regulation of 12-lipoxygenase in rat intestinal epithelial cells during differentiation and apoptosis induced by sodium butyrate. Arch Biochem Biophys 368(1):45-55, 8/1999. PMID: 10415110.
77. Williams CS, Goldman AP, Sheng H, Morrow JD, DuBois RN. Sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growth. Neoplasia 1(2):170-6, 6/1999. PMID: 10933052.
78. Kamitani H, Ikawa H, Hsi LC, Watanabe T, DuBois RN, Eling TE. Regulation of 12-Lipoxygenase in rat intestinal epithelial cells during differentiation and apoptosis by butyrate. Arch Biochem & Biophys 368:45-55, 1999.
79. Ethridge RT, Hellmich MR, DuBois RN, Evers BM. Inhibition of heat-shock protein 70 induction in intestinal cells overexpressing cyclooxygenase 2. Gastroenterology 115(6):1454-63, 12/1998. PMID: 9834273.
80. Brockman JA, Gupta RA, Dubois RN. Activation of PPARgamma leads to inhibition of anchorage-independent growth of human colorectal cancer cells. Gastroenterology 115(5):1049-55, 11/1998. PMID: 9797355.
81. Sheng H, Williams CS, Shao J, Liang P, DuBois RN, Beauchamp RD. Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway. J Biol Chem 273(34):22120-7, 8/1998. PMID: 9705357.
82. Sheng H, Shao J, Williams CS, Pereira MA, Taketo MM, Oshima M, Reynolds AB, Washington MK, DuBois RN, Beauchamp RD. Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas. Carcinogenesis 19(4):543-9, 4/1998. PMID: 9600336.
83. Giardiello FM, Spannhake EW, DuBois RN, Hylind LM, Robinson CR, Hubbard WC, Hamilton SR, Yang VW. Prostaglandin levels in human colorectal mucosa: effects of sulindac in patients with familial adenomatous polyposis. Dig Dis Sci 43(2):311-6, 2/1998. PMID: 9512123.
84. Sheng H, Shao J, Morrow JD, Beauchamp RD, DuBois RN. Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res 58(2):362-6, 1/1998. PMID: 9443418.
85. DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA. The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers. Carcinogenesis 19(1):49-53, 1/1998. PMID: 9472692.
86. Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN. Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells. Cell 93(5):705-716, 1998. PMID: 9630216.
87. Karnes WE, Shattuck-Brandt R, Burgart LJ, DuBois RN, Tester DJ, Cunningham JM, Kim CY, McDonnell SK, Schaid DJ, Thibodeau SN. Reduced COX-2 protein in colorectal cancer with defective mismatch repair. Cancer Res 58(23):5473-5477, 1998. PMID: 9850081.
88. Sheng GG, Shao J, Sheng H, Hooton EB, Isakson PC, Morrow JD, Coffey RJ, DuBois RN, Beauchamp RD. A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells. Gastroenterology 113(6):1883-91, 12/1997. PMID: 9394727.
89. Chang MS, Tsai JC, Yang R, DuBois RN, Breyer MD, O'Day DM. Induction of rabbit cyclooxygenase 2 in the anterior uvea following glaucoma filtration surgery. Curr Eye Res 16(11):1147-51, 11/1997. PMID: 9395775.
90. Zhang T, Nanney LB, Peeler MO, Williams CS, Lamps L, Heppner KJ, DuBois RN, Beauchamp RD. Decreased transforming growth factor beta type II receptor expression in intestinal adenomas from Min/+ mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression. Cancer Res 57(9):1638-43, 5/1997. PMID: 9134999.
91. Sheng H, Shao J, Kirkland SC, Isakson P, Coffey RJ, Morrow J, Beauchamp RD, DuBois RN. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest 99(9):2254-9, 5/1997. PMID: 9151799.
92. Sheng H, Shao J, Hooton EB, Tsujii M, DuBois RN, Beauchamp RD. Cyclooxygenase-2 induction and transforming growth factor beta growth inhibition in rat intestinal epithelial cells. Cell Growth Differ 8(4):463-70, 4/1997. PMID: 9101092.
93. Coffey RJ, Hawkey CJ, Damstrup L, Graves-Deal R, Daniel VC, Dempsey PJ, Chinery R, Kirkland SC, DuBois RN, Jetton TL, Morrow JD. Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells. Proc Natl Acad Sci U S A 94(2):657-62, 1/1997. PMID: 9012840.
94. Schmedtje JF, Ji YS, Liu WL, DuBois RN, Runge MS. Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells. J Biol Chem 272(1):601-8, 1/1997. PMID: 8995303.
95. Guan Y, Chang M, Cho W, Zhang Y, Redha R, Davis L, Chang S, DuBois RN, Hao CM, Breyer M. Cloning, expression, and regulation of rabbit cyclooxygenase-2 in renal medullary interstitial cells. Am J Physiol 273(1 Pt 2):F18-F26, 1997. PMID: 9249588.
96. Zhang T, Nanney LB, Luongo C, Lamps L, Heppner KJ, DuBois RN, Beauchamp RD. Concurrent Overexpression of Cyclin D1 and Cyclin-dependent Kinase 4 (Cdk4) in Intestinal Adenomas from Multiple Intestinal Neoplasia (Min) Mice and Human Familial Adenomatous Polyposis Patients. Cancer Res 57(1):169-175, 1997. PMID: 8988060.
97. Sheng H, Shao J, Hooton EB, Tsujii M, DuBois RN, Beauchamp RD. Cyclooxygenase-2 induction by TGFβ growth inhibition in rat intestinal epithelial cells. Cell Growth and Differentiation 8:463-470, 1997.
98. Sheng H, Shao J, Kirkland S, Isakson P, Coffey R, Morrow J, Beauchamp RD, DuBois RN. Inhibition of Human Colon Cancer Cell Growth by Selective Inhibition of Cyclooxygenase- 2. J Clin Invest 99:2254-2259, 1997.
99. Watson AJ, Dubois RN. Lipid metabolism and APC: implications for colorectal cancer prevention. Lancet 349(9050):444-445, 1997. PMID: 9040567.
100. DuBois RN, Shao J, Tsujii M, Sheng H, Beauchamp RD. G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2. Cancer Res 56(4):733-7, 2/1996. PMID: 8631005.
101. Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, Carver-Moore K, DuBois RN, Clark R, Aguet M, Schreiber RD. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84(3):431-442, 1996. PMID: 8608597.
102. Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83(3):493-501, 11/1995. PMID: 8521479.
103. Giardiello FM, Offerhaus GJ, DuBois RN. The role of nonsteroidal anti-inflammatory drugs in colorectal cancer prevention. Eur J Cancer 31A(7-8):1071-6, Jul-Aug, 7/1995. PMID: 7576994.
104. DuBois RN, Bishop PR, Graves-Deal R, Coffey RJ. Transforming growth factor alpha regulation of two zinc finger-containing immediate early response genes in intestine. Cell Growth Differ 6(5):523-9, 5/1995. PMID: 7647035.
105. Capdevila JH, Morrow JD, Belosludtsev YY, Beauchamp DR, DuBois RN, Falck JR. The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s). Biochemistry 34(10):3325-37, 3/1995. PMID: 7880828.
106. Zeldin DC, DuBois RN, Falck JR, Capdevila JH. Molecular Cloning, Expression and Characterization of an Endogenous Human Cytochrome P450 Arachidonic Acid Epoxygenase Isoform. Arch Biochem Biophys 322(1):76-86, 1995. PMID: 7574697.
107. Barnard JA, Graves-Deal R, Pittelkow MR, DuBois RN, Cook P, Ramsey GW, Bishop PR, Damstrup L, Coffey RJ. Auto- and Cross-induction within the Mammalian Epidermal Growth Factor-related Peptide Family. J Biol Chem 269:22817-22822, 1994.
108. DuBois RN, Tsujii M, Bishop P, Awad JA, Makita K, Lanahan A. Cloning and Characterization of a Growth Factor-Inducible Cyclooxygenase Gene from Rat Intestinal Epithelial Cells. Am J Physiol 226(5 Pt 1):G6822-G6827, 1994. PMID: 8203528.
109. Harris RC, McKanna JA, Akai Y, Jacobson HR, Dubois RN, Breyer MD. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J Clin Invest 94(6):2504-2510, 1994. PMID: 7989609.
110. Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, DuBois RN. Upregulation of Cyclooxygenase-2 Gene Expression in Human Colorectal Adenomas and Adenocarcinomas. Gastroenterology 107:1183-1188, 1994.
111. Karara A, Makita K, Jacobson HR, Falck JR, Guengerich FP, DuBois RN, Capdevila JH. Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase. J Biol Chem 268(18):13565-70, 6/1993. PMID: 8514789.
112. Collins JF, Honda T, Knobel S, Bulus NM, Conary J, DuBois RN, Ghishan FK. Molecular Cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ Exchanger (NHE-2). Proc Natl Acad Sci USA 90:3938-3942, 1993.
113. Capdevila JH, Wei S, Yan J, Karara A, Jacobson HR, Falck JR, Guengerich FP, DuBois RN. Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading. J Biol Chem 267(30):21720-6, 10/1992. PMID: 1400482.
114. Holt PR, DuBois RN. In vivo immediate early gene expression induced in intestinal and colonic mucosa by feeding. FEBS Lett 287(1-2):102-4, 8/1991. PMID: 1715281.
115. DuBois RN, McLane MW, Ryder K, Lau LF, Nathans D. A Growth Factor-Inducible Nuclear Protein with a Novel Cysteine/Histidine Repetitive Sequence. J Biol Chem 265(31):19185-19191, 1990. PMID: 1699942.
116. DuBois RN, Lazenby AJ, Yardley JH, Hendrix TR, Bayless TM, Giardiello FM. Lymphocytic enterocolitis in patients with 'refractory sprue'. JAMA 262(7):935-7, 8/1989. PMID: 2754795.
117. DuBois RN, Hill KE, Burk RF. Antioxidant effect of acetaminophen in rat liver. Biochem Pharmacol 32(17):2621-2, 9/1983. PMID: 6615558.
118. Kramer RE, DuBois RN, Simpson ER, Anderson EM, Kashiwagi K, Lambeth JD, Jefcoate CR, and Waterman MR. Cell-Free Synthesis of Precursor Forms of Mitochondrial Steroid Hydroxylase Enzymes of the Bovine Adrenal Cortex. Archives of Bioch & Biophys 215:478-485, 1982.
119. DuBois RN, Simpson ER, Tuckey J, Lambeth JD, Waterman MR. Evidence for a higher molecular weight precursor of cholesterol side-chain-cleavage cytochrome P-450 and induction of mitochondrial and cytosolic proteins by corticotropin in adult bovine adrenal cells. Proc Natl Acad Sci U S A 78(2):1028-32, 2/1981. PMID: 6262752.
120. John ME, DuBois RN, Waterman MR. Altered Heme Environments in Opossum and Rabbit Methemoglobins. Z Naturforsch [C] 36(11-12):964-967, Nov-Dec, 1981. PMID: 6275619.
121. Dubois RN, Waterman MR. Effect of phenobarbital administration to rats on the level of the in vitro synthesis of cytochrome P-450 directed by total rat liver RNA. Biochem Biophys Res Commun 90(1):150-7, 9/1979. PMID: 496967.

Invited Articles
1. Gupta RA, Dubois RN. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer 1(1):11-21, 10/2001. PMID: 11900248.
2. Wang D, DuBois RN. Cyclooxygenase 2-derived prostaglandin E2 regulates the angiogenic switch. Proc Natl Acad Sci U S A 101(2):415-6, 1/2004. PMID: 14707264.

Grant & Contract Support

Title: Prostaglandins and Inflammation in Colorectal Cancer
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Principal Investigator
Duration: 4/1/2010 - 4/1/2013
 
Title: Cancer Center Support Grant
Funding Source: NIH/NCI
Role: Investigator
Principal Investigator: Ronald DePinho
Duration: 7/1/2008 - 6/30/2013
 
Funding Source: American Cancer Society (ACS)
Role: Principal Investigator
Duration: 1/1/2008 - 12/31/2010
 
Title: Mechanisms for Chemoprevention of Cancer
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 6/22/2004 - 4/30/2010
 
Title: Partnership for Excellence in Cancer Research
Funding Source: NIH/NCI
Role: Contact PI for MD Anderson
Principal Investigator: multiple
Duration: 8/16/2002 - 8/30/2013
 
Title: Nuclear Hormone Receptors and Intestinal Epithelial Biology
Funding Source: NIH/NIDDK
Role: Principal Investigator
Duration: 7/2002 - 6/30/2012
 
Title: Role of Eicosanoids in Intestinal Epithelial Growth and Function
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 8/1/1994 - 7/31/2013

Last updated: 11/30/2012