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Renata Pasqualini, PhD

Present Title & Affiliation

Primary Appointment

Helen Buchanan & Stanley Seeger Professor of Medicine and Experimental Diagnostic Imaging, Department of Genitourinary Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Distinguished Faculty, Department of Genitourinary Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center Trust, Houston, TX
Helen Buchanan & Stanley Seeger Professor of Medicine and Experimental Diagnostic Imaging, Department of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Boulevard, Unit 0018-1
P.O. Box 301439
Houston, TX 77230-1439
Room Number: T7.3904

Education & Training

Degree-Granting Education

1990 Ludwig Institute for Cancer Research, São Paulo Branch, Institute of Chemistry, University of São Paulo, São Paulo, Brazil, PHD, Biochemistry

Postgraduate Training

1/1994-1996 Senior Research Fellow, Cellular and Molecular Biology, The Burnham Institute, La Jolla, CA, Dr. Errki Ruoslahti
1/1991-1994 Postdoctoral Research Fellow, Cellular and Molecular Biology, Cellular and Molecular Biology, Harvard Medical School, Dana Farber Cancer Institute, Tumor Virology Division, Boston, MA, Dr. Martin Hemler
1/1990-1991 Postdoctoral Research Fellow, Cell Biology, Cell Biology, Harvard Medical School, Boston, MA, Dr. Merton Bernfield

Honors and Awards

2011 Sergio Lombroso Award in Cancer Research, Weizmann Institute of Science
2010 Celebrating Women in Science, BioHouston's 2010 Women in Science
2010 Prostate Cancer Foundation Creativity Award
2009 Edith and Peter O'Donnell Award, The Academy of Medicine Engineering and Science of Texas
2009 Potu N. Rao Award for Excellence in Basic Science, Division of Cancer Medicine Faculty Awards, The University of Texas MD Anderson Cancer Center
2007 The Top 400 Inventors for 99% of patents filed since 1946
2006-2010 Marcus Foundation Award, Marcus Foundation
2006 Fellows of the MD Anderson Research Trust Award, The University of Texas MD Anderson Cancer Center
2005-2006 Living Legend Faculty Achievement Award, The University of Texas MD Anderson Cancer Center
2004-2007 Prostate Cancer Research Foundation (CaP CURE) Award
2003 Golfers Against Cancer Foundation Award, Golfers Against Cancer Foundation
2002-2003 Randall-Downey Foundation Award
2001 The V Foundation Award on Translational Cancer Research
2000-2010 The Gillson-Longenbaugh Foundation Award
2000 Angel Works Award
1999 Susan G. Komen Career Development Award in Basic Cancer Research, AACR
1996-1997 Research Fellowship, The Susan Komen Foundation
1993-1996 Research Fellowship, Arthritis Foundation
1990 Research Fellowship, International Agency for Research on Cancer (IARC)

Selected Publications

Peer-Reviewed Original Research Articles
1. Rotolo JA, Stancevic B, Zhang J, Hua G, Fuller JD, Yin X, Haimovitz-Friedman A, Kim K, Qian MD, Cardo-Vila M, Fuks Z, Pasqualini R, Arap W, Kolesnick R. Anti-ceramide antibody prevents the radiation GI syndrome in mice. J Clin Invest 122(5), 5/2012. e-Pub 4/2012. PMID: 22466649.
2. Guzman-Rojas L, Rangel R, Salameh A, Edwards JK, Dondossola E, Kim YG, Saghatelian A, Giordano RJ, Kolonin MG, Staquicini FI, Koivunen E, Sidman RL, Arap W, Pasqualini R. Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment. Proc Natl Acad Sci U S A 109(5):1637-42, 1/2012. PMID: 22307623.
3. Barnhart KF, Christianson DR, Hanley PW, Driessen WH, Bernacky BJ, Baze WB, Wen S, Tian M, Ma J, Kolonin MG, Saha PK, Do KA, Hulvat JF, Gelovani JG, Chan L, Arap W, Pasqualini R. Targeting white adipose tissue in obese monkeys results in weight loss and improved insulin resistance. Sci Transl Med 3(108):108ra112, 11/2011.
4. Staquicini FI, Cardó-Vila M, Kolonin MG, Trepel M, Edwards JK, Nunes DN, Sergeeva A, Efstathiou E, Sun J, Almeida NF, Tu S-M, Botz GH, Wallace MJ, O'Connell D, Krajewski S, Gershenwald JE, Molldrem JJ, Flamm AL, Koivunen E, Pentz RD, Dias-Neto E, Setubal JC, Cahill DJ, Troncoso P, Do K-A, Logothetis CJ, Sidman RL, Pasqualini R, Arap W. Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients. Proc Natl Acad Sci U S A 108(46):18637-42, 11/2011.
5. Arias CA, Panesso D, McGrath DM, Qin X, Mojica MF, Miller C, Diaz L, Tran TT, Rincon S, Barbu EM, Reyes J, Roh JH, Lobos E, Sodergren E, Pasqualini R, Arap W, Quinn JP, Shamoo Y, Murray BE, Weinstock GM. Genetic basis for in vivo daptomycin resistance in enterococci. N Engl J Med 365(10):892-900, 9/2011. PMID: 21899450.
6. Carraro DM, Ferreira EN, de Campos-Molina G, Puga RD, Abrantes EF, Trape AP, Eckhardt BL, Nunes DN, Brentani MM, Arap W, Pasqualini R, Brentani H, Dias-Neto E, Brentani RR. Poly (A)+ transcriptome assessment of ERBB2-induced alterations in breast cell lines. PLoS ONE 6(6):e21022, 7/2011. PMID: 21822460.
7. Binder M, Müller F, Jackst A, Léchenne B, Pantic M, Bacher U, Zu Eulenburg C, Veelken H, Mertelsmann R, Pasqualini R, Arap W, Trepel M. B-cell receptor epitope recognition correlates with the clinical course of chronic lymphocytic leukemia. Cancer 117(9):1891-900, 5/2011. PMID: 21509766.
8. Polf JC, Bronk LF, Driessen WHP, Arap W, Pasqualini R, Gillin M. Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles. Appl Phys Lett 98(19):193702, 5/2011. PMCID: PMCPMC3170386.
9. Moeller BJ, Sidman RL, Pasqualini R, Arap W.. Discovery of DNA repair inhibitors by combinatorial library profiling. Cancer Res 71(5):1816-24, 3/2011. PMID: 21343400.
10. Gesteira TF, Coulson-Thomas VJ, Taunay-Rodrigues A, Oliveira V, Thacker BE, Juliano MA, Pasqualini R, Arap W, Tersariol IL, Nader HB, Esko JD, Pinhal MA. Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1. J Biol Chem 286(7):5338-46, 2/2011. PMID: 20129923.
11. Corti A, Pastorino F, Curnis F, Arap W, Ponzoni M, Pasqualini R. Targeted drug delivery and penetration into solid tumors. Med Res Rev, 2/2011. PMID: 21287572.
12. Staquicini, FI, Ozawa MG, Moya CA, Driessen WHP, Barbu EM, Nishimori H, Soghomonyan S, Flores LG II, Liang X, Paolillo V, Alauddin MM, Basilion JP, Furnari FB, Bogler O, Lang FF, Aldape KD, Fuller GN, Hook M, Gelovani JG, Sidman RL, Cavenee WK, Pasqualini R, Arap W. Systematic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma. J Clin Invest 121(1):161-73, 1/2011. PMID: 21183793.
13. Karjalainen K, Jaalouk DE, Bueso-Ramos CE, Zurita AJ, Kuniyasu A, Eckhardt BL, Marini FC, Lichtiger B, O'Brien S, Kantarjian HM, Cortes JE, Koivunen E, Arap W, Pasqualini R. Targeting neuropilin-1 in human leukemia and lymphoma. Blood 117(3):920-7, 1/2011. PMID: 21063027.
14. Tonelli RR, Giordano RJ, Barbu EM, Torrecilhas AC, Kobayashi GS, Langley RR, Arap W, Pasqualini R, Colli W, Alves MJ. Role of the gp85/trans-sialidases in Trypanosoma cruzi tissue tropism: preferential binding of a conserved peptide motif to the vasculature in vivo. PLoS Negl Trop Dis 4(11):e864, 11/2010. PMID: 21072227.
15. Li J, Gu X, Ma Y, Calicchio ML, Kong D, Teng YD, Yu L, Crain AM, Vartanian TK, Pasqualini R, Arap W, Libermann TA, Snyder EY, Sidman RL. Nna1 mediates purkinje cell dendritic development via lysyl oxidase propeptide and NF-кB signaling. Neuron 68(1):45-60, 10/2010. PMID: 20920790.
16. Moeller BJ, Arap W, Pasqualini R. Targeting synthetic lethality in DNA damage repair pathways as an anti-cancer strategy. Curr Drug Targets 11(10):1336-40, 10/2010. PMID: 20840076.
17. Staquicini FI, Sidman RL, Arap W, Pasqualini R. Phage display technology for stem cell delivery and systemic therapy. Adv Drug Deliv Rev 62(12):1213-6, 9/2010. PMID: 20932865.
18. Staquicini FI, Moeller BJ, Arap W, Pasqualini R. Combinatorial vascular targeting in translational medicine. Proteomics Clin Appl 4(6-7):626-32, 7/2010. PMID: 21137081.
19. Loi M, Marchiò S, Becherini P, Di Paolo D, Soster M, Curnis F, Brignole C, Pagnan G, Perri P, Caffa I, Longhi R, Nico B, Bussolino F, Gambini C, Ribatti D, Cilli M, Arap W, Pasqualini R, Allen TM, Corti A, Ponzoni M, Pastorino F. Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma. J Control Release 145(1):66-73, 7/2010. PMID: 20346382.
20. Edwards JK, Pasqualini R, Arap W, Calin GA. MicroRNAs and ultraconserved genes as diagnostic markers and therapeutic targets in cancer and cardiovascular diseases. J Cardiovasc Transl Res 3(3):271-9, 6/2010. PMID: 20560048.
21. Souza GR, Molina JR, Raphael RM, Ozawa MG, Stark DJ, Levin CS, Bronk LF, Ananta JS, Mandelin J, Georgescu MM, Bankson JA, Gelovani JG, Killian TC, Arap W, Pasqualini R. Three-dimensional tissue culture based on magnetic cell levitation. Nature Nanotechnol 5(4):291-6, 4/2010. PMID: 20228788.
22. Cardó-Vila M, Giordano RJ, Sidman RL, Fan Z, Mendelsohn J, Arap W, Pasqualini R. From combinatorial peptide selection to drug prototype: (II) Targeting the epidermal growth factor receptor pathway. Proc Natl Acad Sci U S A 107(11):5118-23, 3/2010. PMID: 20190183.
23. Giordano RJ, Cardó-Vila M, Salameh A, Anobom CD, Zeitlin BD, Hawke DH, Valente AP, Almeida FC, Nör JE, Sidman RL, Pasqualini R, Arap W. From combinatorial peptide selection to drug prototype (I): Targeting the vascular endothelial growth factor receptor pathway. Proc Natl Acad Sci U S A 107(11):5112-7, 3/2010. PMID: 20190181.
24. Weaver MS, Workman G, Cardó-Vila M, Arap W, Pasqualini R, Sage EH. Processing of the matricellular protein hevin in mouse brain is dependent on ADAMTS4. J Biol Chem 285(8):5868-77, 2/2010. PMID: 20018883.
25. Ardelt PU, Kneitz B, Adam P, Reiss C, Kocot A, Fensterle J, Chen L, Pasqualini R, Arap W, Gerharz EW, Riedmiller H. Reactive antibdodies against bacillus calmette-guerin heat shock protein-65 potentially predict the outcome of immunotherapy for high grade transitional cell carcinoma of the bladder. Cancer 116(3):600-9, 2/2010. PMID: 19957324.
26. Ozawa MG, Cardó-Vila M, Mintz PJ, Arap W, Pasqualini R. Cracking the code of compartment-specific dual functionality proteins in cancer: the case for CRKL. Cell Cycle 9(1):8-9, 1/2010. PMID: 20009577.
27. Dias-Neto E, Nunes DN, Giordano, RJ, Sun J, Botz GH, Yang K, Setubal JC, Pasqualini R, Arap W. Next-generation phage display: integrating and comparing available molecular tools to enable cost-effective high-throughput analysis. PLoS One 4(12):e8338, 12/2009. PMID: 20020040.
28. Stefanidakis M, Karjalainen K, Jaalouk DE, Gahmberg CG, O'Brien S, Pasqualini R, Arap W, Koivunen EA. Role of leukemia cell invadosome in extramedullary infiltration. Blood 114(14):3008-17, 10/2009. PMID: 19636064.
29. Trepel M, Stoneham CA, Eleftherohorinou H, Mazarakis ND, Pasqualini R, Arap W, Hajitou A. A heterotypic bystander effect for tumor cell killing after AAVP-mediated vascular-targeted suicide gene transfer. Mol Cancer Ther 8(8):2383-91, 8/2009. PMID: 19671758.
30. Giordano RJ, Edwards JK, Tuder RM, Arap W, Pasqualini R. Combinatorial ligand-directed lung targeting. Proc Am Thorac Soc 6(5):411-5, 8/2009. PMID: 19687212.
31. Moeller BJ, Pasqualini R, Arap W. Targeting cancer-specific synthetic lethality in double-strand DNA break repair. Cell Cycle 8(12):1872-6, 6/2009. PMID: 19440052.
32. Zhang Y, Daquinag A, Traktuev DO, Amaya-Manzanares F, Simmons PJ, March KL, Pasqualini R, Arap W, Kolonin MG. White adipose tissue cells are recruited by experimental tumors and promote cancer progression in mouse models. Can Res 69(12):5259-66, 6/2009. PMID: 19491274.
33. Paoloni MC, Tandle A, Mazcko C, Hanna E, Kachala S, LeBlanc A, Newman S, Vail D, Henry C, Thamm D, Sorenmo K, Hajitou A, Pasqualini R, Arap W, Khanna C, Libutti SK. Launching a novel preclinical infrastructure: comparative oncology trials consortium directed therapeutic targeting of TNFalpha to cancer vasculature. PLoS ONE 4(3):e4972, 3/2009. PMID: 19330034.
34. Marchiò S, Pasqualini R, Arap W. Targeting the extracellular signature of metastatic colorectal cancers. Expert Opin Ther Targets 13(3):363-79, 3/2009. PMID: 19236157.
35. Lewis VO, Ozawa MG, Beavers MT, Want G, Shintani T, Arap W, Pasqualini R. The interleukin-11 receptor alpha as a candidate ligand-directed target in osteosarcoma: consistent data from cell lines, orthotopic models, and human tumor samples. Cancer Res 69(5):1995-9, 3/2009. PMID: 19244100.
36. Mintz PJ, Cardó-Vila M, Ozawa MG, Hajitou A, Rangel R, Guzman-Rojas L, Christianson DR, Arap MA, Giordano RJ, Souza GR, Easley J, Salameh A, Oliviero S, Brentani RR, Koivunen E, Arap W, Pasqualini R. An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment. Proc Natl Acad Sci U S A 106(7):2182-7, 2/2009. PMID: 19168626.
37. Staquicini FI, Dias-Neto E, Li J, Snyder EY, Sidman RL, Arap W, Pasqualini R. Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells. Proc Natl Acad Sci U S A 106(8):2903-8, 2/2009. PMID: 19193855.
38. Decuzzi P, Pasqualini R, Arap W, Ferrari M. Intravascular delivery of particulate systems: does geometry really matter? Pharm Res 26(1):235-43, 1/2009. PMID: 18712584.
39. Staquicini F, Pasqualini R, Arap W. Ligand-directed profiling: applications to target drug discovery in cancer. Expert Opinion on Drug Discovery (EODC) 4(1):51-9, 1/2009. PMID: Not currently indexed for MEDLINE.
40. Tagore DM, Notle WM, Neveu JM, Rangel R, Guzman-Rojas L, Pasqualini R, Arap W, Lane WS, Saghatelian A. Peptidase substrates via global peptide profiling. Nat Chem Biol 5(1):23-5, 1/2009. PMID: 19011639.
41. Khakoo AY, Sidman RL, Pasqualini R, Arap W. Does the renin-angiotensin system participate in regulation of human vasculogenesis and angiogenesis? Cancer Res 68(22):9112-5, 11/2008. PMID: 1901089.
42. Cardó-Vila M, Zurita AJ, Giordano RJ, Sun J, Rangel R, Guzman-Rojas L, Anobom CD, Valenta AP, Almeida FCL, Lahdenranta J, Kolonin MG, Arap W, Pasqualini R. A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11. PLoS ONE 3(10):e3452, 10/2008. PMID: 18941632.
43. Staquicini FI, Tandle A, Libutti SK, Sun J, Zigler M, Bar-Eli M, Aliperti F, Perez, EC, Gershenwald JE, Mariano M, Pasqualini R, Arap W, Lopes JD. A subset of host B-lymphocytes control melanoma metastasis through a MCAM/MUC18-dependent interaction: evidence from mice and humans. Cancer Res 68(20):8419-28, 10/2008. PMID: 18922915.
44. Nie J, Chang B, Traktuev D, Sun J, March KL, Chan L, Sage EH, Pasqualini R, Arap W, Kolonin MG. Combinatorial peptides identify a5B1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cells. Stem Cells 26(10):2735-45, 10/2008. PMID: 18583538.
45. Giordano RJ, Lahdenranta J, Zhen L, Chukwueke U, Petrache I, Langley RR, Fidler IJ, Pasqualini R, Tuder RM, Arap W. Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse. J Biol Chem 283(43):29447-60, 10/2008. PMID: 18718906.
46. Corti A, Curnis F, Arap W, Pasqualini R. The neovasculature-homing motif NGR: more than meets the eye. Blood 112(7):2628-35, 10/2008. PMID: 18574027.
47. Lin SH, Cheng CJ, Lee YC, Ye X, Tsai WW, Kim J, Pasqualini R, Arap W, Navone NM, Tu SM, Hu M, Yu-Lee LY Logothetis CJ. A 45-kDa ErbB3 secreted by prostate cancer cells promotes bone formation. Oncogene 27(39):5195-203, 9/2008. PMID: 18490922.
48. Ozawa MG, Zurita A, Dias-Neto E, Nunes DN, Sidman RL, Gelovani JG, Arap W, Pasqualini R. Beyond receptor expression levels: the relevance of target accessibility in ligand-directed pharmacodelivery systems. Trends Cardiovasc Med 18(4):126-32, 5/2008.
49. Hajitou A, Lev DC, Hannay J, Korchin B, Staquicini FI, Soghomonyan S, Alauddin MM, Benjamin RS, Pollock RE, Gelovani JG, Arap W, Pasqualini R. A preclinical model for predicting drug response in soft tissue sarcoma with targeted AAVP molecular imaging. Proc Natl Acad Sci U S A 105(11):4471-6, 3/2008.
50. Hajitou A, Rangel R, Trepel M, Soghomonyan S, Gelovani JG, Alauddin MM, Pasqualini R, Arap W. Design and construction of targeted AAVP vectors for mammalian cell transduction. Nat Protoc 2(3):523-31, 3/2007.
51. Rangel R, Sun Y, Guzman-Rojas L, Ozawa MG, Sun J, Giordano RJ, Van Pelt CS, Tinkey PT, Behringer RR, Sidman RL, Arap W, Pasqualini R. Impaired angiogenesis in aminopeptidase N-null mice. Proc Natl Acad Sci U S A 104(11):4588-93, 3/2007. PMID: 17360568.
52. Souza GR, Levin CS, Hajitou A, Pasqualini R, Arap W, Miller JH. In vivo detection of gold-imidazole self-assembly complexes: NIR-SERS signal reporters. Anal Chem 78(17):6232-7, 9/2006. PMID: 16944906.
53. Hajitou A, Trepel M, Lilley CE, Soghomonyan S, Alauddin MM, Marini FC III, Restel BH, Ozawa MG, Moya CA, Rangel R, Sun Y, Zaoui K, Schmidt M, von Kalle C, Weitzman MD, Gelovani JG, Pasqualini R, Arap W. A hybrid vector for ligand-directed tumor targeting and molecular imaging. Cell 125(2):385-98, 4/2006. PMID: 16630824.
54. Kolonin MG, Bover L, Sun J, Zurita AJ, Do Kim-Anh, Lahdenranta J, Cardó-Vila M, Giordano RJ, Jaalouk DE, Ozawa MG, Moya CA, Souza GR, Staquicini FI, Kunyiasu A, Scudiero DA, Holbeck SL, Sausville EA, Arap W, Pasqualini R. Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries. Cancer Res 66(1):34-40, 1/2006. PMID: 16397212.
55. Souza GR, Christianson DR, Staquicini FI, Ozawa MG, Snyder EY, Sidman RL, Miller JH, Arap W, Pasqualini R. Networks of gold nanoparticles and bacteriophage as biological sensors and cell-targeting agents. Proc Natl Acad Sci U S A 103(5):1215-20, 1/2006. PMID: 16434473.
56. Lionakis MS, Lahdenranta J, Sun J, Liu W, Lewis RE, Albert ND, Pasqualini R, Arap W, Kontoannis DP. Development of a ligand-directed approach to study the pathogenesis of invasive aspergillosis. Infect Immun 73(11):7747-58, 11/2005.
57. Giordano RJ, Anobom CD, Cardó-Vila M, Kalil J, Valente AP, Pasqualini R, Almeida FC, Arap W. Structural basis for the interaction of a vascular endothelial growth factor mimic peptide motif and its corresponding receptors. Chem Biol 12(10):1075-83, 10/2005. PMID: 16242650.
58. Yao VJ, Ozawa MG, Trepel M, Arap W, McDonald DM, Pasqualini R. Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection. Am J Pathol 166(2):625-36, 2/2005. PMID: 15681844.
59. Arap MA, Lahdenranta J, Mintz PJ, Hajitou A, Sarkis AS, Arap W, Pasqualini R. Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands. Cancer Cell 6(3):275-84, 9/2004. PMID: 15380518.
60. Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W. Reversal of obesity by targeted ablation of adipose tissue. Nat Med 10(6):625-32, 6/2004. PMID: 15133506.
61. Marchiò S, Lahdenranta J, Schlingemann RO, Valdembri D, Wesseling P, Arap MA, Hajitou A, Ozawa MG, Trepel M, Giordano RJ, Nanus DM, Dijkman HB, Oosterwijk E, Sidman RL, Cooper MD, Bussolino F, Pasqualini R, Arap W. Aminopeptidase A is a functional target in angiogenic blood vessels. Cancer Cell 5(2):151-62, 2/2004. PMID: 14998491.
62. Pasqualini R, Arap W. Hybridoma-free generation of monoclonal antibodies. Proc Natl Acad Sci U S A 101(1):257-9, 1/2004. PMID: 14688405.
63. Ellerby HM, Lee S, Ellerby LM, Chen S, Kiyota T, del Rio G, Sugihara G, Sun Y, Bredesen DE, Arap W, Pasqualini R. An artificially designed pore-forming protein with anti-tumor effects. J Biol Chem 278(37):35311-6, 9/2003. PMID: 12750379.
64. Cardó-Vila M, Arap W, Pasqualini R. Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V. Mol Cell 11(5):1151-62, 5/2003. PMID: 12769841.
65. Mintz PJ, Kim J, Do KA, Wang X, Zinner RG, Cristofanilli M, Arap MA, Hong WK, Troncoso P, Logothetis CJ, Pasqualini R, Arap W. Fingerprinting the circulating repertoire of antibodies from cancer patients. Nat Biotechnol 21(1):57-63, 1/2003. PMID: 12496764.
66. Kolonin MG, Pasqualini R, Arap W. Teratogenicity induced by targeting a placental immunoglobulin transporter. Proc Natl Acad Sci U S A 99(20):13055-60, 10/2002. PMID: 12242328.
67. Arap W, Kolonin MG, Trepel M, Lahdenranta J, Cardó-Vila M, Giordano RJ, Mintz PJ, Ardelt PU, Yao VJ, Vidal CI, Chen L, Flamm A, Valtanen H, Weavind LM, Hicks ME, Pollock RE, Botz GH, Bucana CD, Koivunen E, Cahill D, Troncoso P, Baggerly KA, Pentz RD, Do KA, Logothetis CJ, Pasqualini R. Steps toward mapping the human vasculature by phage display. Nat Med 8(2):121-7, 2/2002. PMID: 11821895.
68. Arap W, Haedicke W, Bernasconi M, Kain R, Rajotte D, Krajewski S, Ellerby HM, Bredesen DE, Pasqualini R, Ruoslahti E. Targeting the prostate for destruction through a vascular address. Proc Natl Acad Sci U S A 99(3):1527-31, 2/2002. PMID: 11830668.
69. Giordano RJ, Cardó-Vila M, Lahdenranta J, Pasqualini R, Arap W. Biopanning and rapid analysis of selective interactive ligands. Nat Med 7(11):1249-53, 11/2001. PMID: 11689892.
70. Lahdenranta J, Pasqualini R, Schlingemann RO, Hagedorn M, Stallcup WB, Bucana CD, Sidman RL, Arap W. An anti-angiogenic state in mice and humans with retinal photoreceptor cell degeneration. Proc Natl Acad Sci U S A 98(18):10368-73, 8/2001. PMID: 11526242.
71. Pasqualini R, Koivunen E, Kain R, Lahdenranta J, Sakamoto M, Stryhn A, Ashmun RA, Shapiro LH, Arap W, Ruoslahti E. Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Cancer Res 60(3):722-7, 2/2000. PMID: 10676659.
72. Ellerby HM, Arap W, Ellerby LM, Kain R, Andrusiak R, Rio GD, Krajewski S, Lombardo CR, Rao R, Ruoslahti E, Bredesen DE, Pasqualini R. Anti-cancer activity of targeted pro-apoptotic peptides. Nat Med 5(9):1032-8, 9/1999. PMID: 10470080.

Invited Articles
1. Arap W, Trepel M, Zetter BR, Pasqualini R. Meeting report: innovations in prostate cancer research. Cancer Res 68(3):635-8, 2/2008.
2. Sergeeva A, Kolonin MG, Molldrem JJ, Pasqualini R, Arap W. Display technologies: application for the discovery of drug and gene delivery agents. Adv Drug Deliv Rev 58(15):1622-54, 12/2006. PMID: 17123658.
3. Hajitou A, Pasqualini R, Arap W. Vascular targeting: recent advances and therapeutic perspectives. Trends Cardiovasc Med 16(3):80-8, 4/2006. PMID: 16546688.
4. Trepel M, Arap W, Pasqualini R. In vivo phage display and vascular heterogeneity: implications for targeted medicine. Curr Opin Chem Biol 6(3):399-404, 6/2002. PMID: 12023122.
5. Kolonin MG, Pasqualini R, Arap W. Molecular addresses in blood vessels as targets for therapy. Curr Opin Chem Biol 5(3):308-13, 6/2001. PMID: 11479123.

Editorials
1. Moeller BJ, Pasqualini R, Arap W. Ceramide-mediated apoptosis following ionizing radiation in human prostate cancer cells: PKC-alpha joins the fray. Cancer Biol Ther 8(1):64-5, 1/2009. PMID: 19127120.
2. Arap W, Pasqualini R. Engineered embryonic endothelial progenitor cells as therapeutic Trojan horses. Cancer Cell 5(5):406-8, 5/2004. PMID: 15144946.
3. Pasqualini R, Barbas CF III, Arap W. Vessel maneuvers: zinc fingers promote angiogenesis. Nat Med 8(12):1353-4, 12/2002. PMID: 12457173.
4. Pasqualini R, McDonald DM, Arap W. Vascular targeting and antigen presentation. Nat Immunol 2(7):567-8, 7/2001. PMID: 11429533.

Book Chapters
1. Sato M, Yao VJ, Arap W, Pasqualini R. GRP78 Signaling hub: a receptor for targeted tumor therapy. In: Advances in Genetics. 69. Ed(s) Goodwin ST, Dunlap JC, Friedmann T. Associated Press: London, 97-110, 2010.
2. Driessen WHP, Bronk LF, Edwards JK, Proneth B, Souza GR, Decuzzi P, Pasqualini R, Arap W. On the synergistic effects of ligand-mediated and phage-intrinsic properties during in vivo selection. In: Advances in Genetics. 69. Ed(s) Goodwin SF, Dunlap JC, Friedmann T. Associated Press: London, 115-130, 2010.
3. Pasqualini R, Arap W. Combinatorial mapping of vascular zip codes by in vivo phage display. In: Protein Discovery Technologies, Principles, Methods and Applications. Marcel Dekker/CRC Press: Boca Raton, FL, 99-112, 2009.
4. Driessen WH, Ozawa MG, Arap W, Pasqualini R. Ligand-directed cancer gene therapy to angiogenic vasculature. In: Adv Genet. 67, 103-21, 2009. ISBN: 19914451.
5. Zurita AJ, Arap W, Pasqualini R. Molecular Characterization of the Endothelium: A Phage Display Perspective The Endothelium: a phage display perspective the endothelium. In: A Comprehensive Reference, The Endothelial Cell as Input-Output Device/Output/Proteome. Ed(s) W.C. Aird. Marcel Dekker, Inc., 2007.
6. Trepel M, Arap W, Pasqualini R. Selection, isolation, and identification of targeting peptides for ligand-directed gene delivery. In: Gene Transfer, Delivery, and Expression of DNA and RNA: A Laboratory Manual. Ed(s) Friedman and Rossi. Cold Spring Harbor Laboratory Press: New York, 359-369, 2007.
7. Christianson DR, Ozawa MG, Pasqualini R, Arap W. Techniques to Decipher Molecular Diversity by Phage Display. In: Cardiovascular Proteomics book in Methods in Molecular Biology. 357. Humana Press, 385-406, 2006.
8. Vidal C, Cardó-Vila M, Lahdenranta J, Arap W, Pasqualini R. Targeting blood vessels in vivo by using phage display libraries. In: Targeted Therapy for Cancer. Ed(s) Syrigo, Harrington, 250-255, 2003.
9. Pasqualini R, Arap W, Rajotte D, Ruoslahti E. A Laboratory Manual. In: Phage Display. Ed(s) C. F. Barbas III, D.R. Burton, J.K. Scott, and G.J. Silverman. Cold Spring Harbor Laboratory Press: New York, 1-24, 2000.

Books (edited and written)
1. Pasqualini R. Ed(s) Pasqualini R. Advances in Genetics. In: Tissue-specific vascular endothelial signals and vector targeting, Part B. Series Ed(s) SF Goodwin, JC Dunlap, T Friedmann. 69. Academic Press is an imprint of Elsevier: London, 2010.

Letters to the Editor
1. Kontoyiannis DP, Pasqualini R, Arap W. Aminopeptidase N inhibitors and SARS. Lancet 361:1558, 5/2003. PMID: 12737884.

Last updated: 3/12/2013