Skip to Content

'
Richard Castillo, M.S., Ph.D.

Present Title & Affiliation

Primary Appointment

Instructor, Department of Radiation Physics - Patient Care, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Faculty Member, Department of Radiation Physics - Patient Care, Division of Radiation Oncology, The University of Texas Graduate School of Biomedical Sciences, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd
Unit Number: 94
Houston, TX 77030
Room Number: Y2.5308
Phone: 713-563-2544
Fax: 713-563-2545

Education & Training

Degree-Granting Education

2011 UT Graduate School of Biomedical Sciences, Houston, TX, PHD, Medical Physics
2007 UT Graduate School of Biomedical Sciences, Houston, TX, MS, Medical Physics
2004 Trinity University, San Antonio, TX, BS, Physics, Mathematics

Honors and Awards

2012 Aaron M. Blanchard Research Award in Medical Physics, The University of Texas Graduate School of Biomedical Sciences

Selected Publications

Peer-Reviewed Original Research Articles

1. Castillo S, Castillo R, Balter P, Pan T, Ibbott G, Hobbs B, Yuan Y, Guerrero T. Assessment of a quantitative metric for 4D CT artifact evaluation by observer consensus. Journal of Applied Clinical Medical Physics. In Press.
2. Li M, Zheng XL, Luo HY, Castillo R, Zhang SX, Tan LW, Castillo E, Guerrero T. Automated segmentation of brain tissue and white matter in cryosection images from the Chinese Visible Human dataset. Journal of Medical and Biological Engineering. In Press.
3. Li M, Zheng X, Luo H, Castillo R, Zhang S, Tan L, Castillo E, Guerrero T. Automated segmentation of brian tissue and white matter in cryosection images from the Chinese Visible Human dataset. JMBE. In Press.
4. Vinogradskiy Y, Koo PJ, Castillo R, Castillo E, Guerrero T, Gaspar L, Miften M, Kavanagh B. Comparison of 4DCT-ventilation with nuclear medicine ventilation-perfusion (VQ) imaging: a clinical validation study. Int J Radiat Oncol Biol Phys. In Press.
5. Castillo E, Castillo R, Fuentes D, Guerrero T. Computing global minimizers to a constrained B-spine image registration problem from Optimal L1 perturbations to block match data. Medical Physics. In Press.
6. Li M, Castillo E, Luo HY, Zheng XL, Castillo R, Meshkov D, Guerrero T. Deformable image registration for temporal substraction of chest radiographs. International Journal of Computer Assisted Radiology and Surgery. In Press.
7. Liu S, Yuan Y, Castillo R, Guerrero T, Johnson V. Evaluation of image registration spatial accuracy using a Bayesian Hierarchical model. Biometrics. In Press.
8. Castillo R, Pham N, Ansari S, Meshkov D, Castillo S, Li M, Olanrewaju A, Hobbs B, Castillo E, Guerrero T. Pre-radiotherapy FDG PET predicts radiation pneumonitis in lung cancer. Radiation Oncology. In Press.
9. Li M, Castillo E, Luo HY, Zheng XL, Castillo R, Meshkov D, Guerrero T. Deformable image registration for temporal subtraction of chest radiographs. Int J Comput Assist Radiol Surg. e-Pub 9/28/2013. PMID: 24078349.
10. Li M, Castillo E, Zheng XL, Luo HY, Castillo R, Wu Y, Guerrero T. Modeling lung deformation: a combined deformable image registration method with spatially varying Young's modulus estimates. Med Phys 40(8):081902, 8/2013. PMCID: PMC3716779.
11. McCurdy M, Bergsma DP, Hyun E, Kim T, Choi E, Castillo R, Castillo E, Guerrero T. The Role of Lung Lobes in Radiation Pneumonitis and Radiation-Induced Inflammation in the Lung: A Retrospective Study. J Radiat Oncol 2(2):203-208, 6/2013. PMCID: PMC3697156.
12. Vinogradskiy Y, Castillo R, Castillo E, Tucker SL, Liao Z, Guerrero T, Martel MK. Use of 4-dimensional computed tomography-based ventilation imaging to correlate lung dose and function with clinical outcomes. Int J Radiat Oncol Biol Phys 86(2):366-71, 6/2013. e-Pub 3/2013. PMID: 23474113.
13. Echeverria AE, McCurdy M, Castillo R, Bernard V, Ramos NV, Buckley W, Castillo E, Liu P, Martinez J, Guerrero T. Proton therapy radiation pneumonitis local dose-response in esophagus cancer patients. Radiother Oncol 106(1):124-9, 1/2013. e-Pub 11/2/2012. PMCID: PMC3696882.
14. Castillo R, Castillo E, Fuentes D, Ahmad M, Wood, A, Ludwig M, Guerrero T. A reference dataset for deformable image registration spatial accuracy evaluation using the COPDgene study archive. Phys Med Biol 58:2861-2877, 2013.
15. Vinogradskiy Y, Castillo R, Castillo E, Tucker SL, Liao Z, Guerrero T, Martel MK. Using 4DCT-based ventilation imaging to correlate lung dose and function with clinical outcomes. Int J Radiat Oncol Biol Phys 86:366-371, 2013.
16. Mathew L, Wheatley A, Castillo R, Castillo E, Rodrigues G, Guerrero T, Parraga G. Hyperpolarized (3)He Magnetic Resonance Imaging: Comparison with Four-dimensional X-ray Computed Tomography Imaging in Lung Cancer. Acad Radiol 19(12):1546-53, 12/2012. e-Pub 9/2012. PMID: 22999648.
17. Castillo E, Castillo R, White B, Rojo J, Guerrero T. Least median of squares filtering of locally optimal point matches for compressible flow image registration. Phys Med Biol 57(15):4827-33, 8/2012. e-Pub 7/2012. PMCID: PMC3448271.
18. McCurdy MR, Castillo R, Martinez J, Al Hallack MN, Lichter J, Zouain N, Guerrero T. [18F]-FDG Uptake Dose Response Correlates with Radiation Pneumonitis in Lung Cancer Patients. Radiother Oncol 104(1):52-57, 7/2012. e-Pub 5/2012. PMID: 22578806.
19. Castillo R, Castillo E, McCurdy M, Gomez DR, Block AM, Bergsma D, Joy S, Guerrero T. Spatial correspondence of 4D CT ventilation and SPECT pulmonary perfusion defects in patients with malignant airway stenosis. Phys Med Biol 57(7):1855-71, 4/2012. e-Pub 3/2012. PMID: 22411124.
20. Vinogradskiy YY, Castillo R, Castillo E, Chandler A, Martel MK, Guerrero T. Use of weekly 4DCT-based ventilation maps to quantify changes in lung function for patients undergoing radiation therapy. Med Phys 39(1):289-98, 1/2012. PMID: 22225299.
21. Castillo R, Castillo E, Martinez J, Guerrero T. Ventilation from four-dimensional computed tomography: density versus Jacobian methods. Phys Med Biol 55(16):4661-85, 8/2010. e-Pub 7/2010. PMID: 20671351.
22. Castillo E, Castillo R, Martinez J, Shenoy M, Guerrero T. Four-dimensional deformable image registration using trajectory modeling. Phys Med Biol 55(1):305-27, 2010. PMID: 20009196.
23. Gu X, Pan H, Liang Y, Castillo R, Yang D, Choi D, Castillo E, Majumdar A, Guerrero T, Jiang SB. Implementation and evaluation of various demons deformable image registration algorithms on a GPU. Phys Med Biol 55(1):207-19, 2010. PMID: 20009197.
24. Castillo R, Castillo E, Guerra R, Johnson VE, McPhail T, Garg AK, Guerrero T. A framework for evaluation of deformable image registration spatial accuracy using large landmark point sets. Phys Med Biol 54(7):1849-70, 4/2009. e-Pub 3/2009. PMID: 19265208.
25. Castillo E, Castillo R, Zhang Y, Guerrero T. Compressible image registration for thoracic computed tomography images. JMBE 29:222-233, 2009.
26. Guerrero T, Castillo R, Noyola-Martinez J, Torres M, Zhou X, Guerra R, Cody D, Komaki R, Travis E. Reduction of pulmonary compliance found with high-resolution computed tomography in irradiated mice. Int J Radiat Oncol Biol Phys 67(3):879-87, 3/2007. PMID: 17293238.
27. Guerrero T, Castillo R, Sanders K, Price R, Komaki R, Cody D. Novel method to calculate pulmonary compliance images in rodents from computed tomography acquired at constant pressures. Phys Med Biol 51(5):1101-12, 3/2006. e-Pub 2/2006. PMID: 16481680.
28. Pan T, Mawlawi O, Nehmeh SA, Erdi YE, Luo D, Liu HH, Castillo R, Mohan R, Liao Z, Macapinlac HA. Attenuation correction of PET images with respiration-averaged CT images in PET/CT. J Nucl Med 46(9):1481-7, 9/2005. PMID: 16157531.
29. Castillo E, Castillo R, Guerrero T. Moving Least Squares Guided Local Optimization (MILO) Method for Deformable Image Registration. Phys Med Biol. Submitted.
30. McCurdy M, Bergsma DP, Kim T, Choi E, Castillo E, Castillo R, Hyun E, Guerrero T. Radiation Pneumonitis and Anatomic Variation of 18F-FDG PET Radiation Dose Response in Lung: A Retrospective Study. Int J Radiat Oncol Biol Phys. Submitted.

Abstracts

1. Mathew L, Castillo R, Castillo E, Yaremko B, Rodrigues G, Etemad-Rezai R, Guerrero T, Parraga G. Four-dimensional x-ray computed tomography and hyperpolarized (3)He magnetic resonance imaging of gas distribution in lung cancer. AAPM Annual Meeting, Charlotte, NC, 7/2012.
2. Choi E, Kim T, Bergsma D, McCurdy MR, Castillo R, Castillo E, Block A, Guerrero T. Comparing Effects of Radiation Therapy on Upper versus Lower Lung Lobes. American Radium Society 94th Annual Meeting, Las Vegas, NV, 5/2012.
3. McCurdy MR, Bernard V, Echeverria AE, Velez-Ramos N, Castillo R, Castillo E, Buckley W, Bergsma D, Block A, Hyun E, Ahmed F, Guerrero T. Effect of End Range Protons on Metabolic Radiation Dose Response of the Lung. American Radium Society 94th Annual Meeting, Las Vegas, NV, 5/2012.
4. Echeverria AE, McCurdy M, Castillo R, Bernard V, Velez-Ramos N, Buckley W, Castillo E, Liu P, Hyun E, Guerrero T. Radiation Pneumonitis: Proton Therapy Local Dose Response and Clinical Symptoms. American Radium Society 94th Annual Meeting, Las Vegas, NM, 5/2012.
5. Vinogradskiy Y, Castillo R, Castillo E, Tucker S, Liao Z, Guerrero T, Martel M. Using 4DCT-Based Ventilation Imaging to Correlate Lung Dose and Function with Clinical Outcomes. AAPM Annual Meeting, Charlotte, NC, 5/2012.
6. McCurdy M, Wazni M, Martinez J, Castillo R, Guerrero T. Post-Radiation Normalized FDG-PET Versus Radiation Dose Correlates with Radiation Pneumonitis Symptoms and the Nitric Oxide Ratio. AAPM Annual Meeting, Vancouver, BC, 7/2011.
7. Castillo R, Castillo E, Gomez D, Lopez J, Guerrero T. Spatial Correlation of 4DCT Ventilation and SPECT Pulmonary Perfusion Defects in Patients with Malignant Airway Stenosis. AAPM Annual Meeting, Vancouver, BC, John R. Cunningham Young Investigator Competition Finalist, 7/2011.
8. Vinogradskiy Y, Castillo R, Castillo E, Chandler A, Martel M, Guerrero T. Use of Weekly 4DCT-Based Ventilation Maps to Quantify Changes in Lung Function for Patients Undergoing Radiation Therapy. AAPM Annual Meeting, Vancouver, BC, 7/2011.
9. Castillo R, Castillo E, Martinez J, Guerrero T. Ventilation from Four Dimensional Computed Tomography: Density versus Jacobian Methods. AAPM Annual Meeting, Philadelphia, PA, 7/2010.
10. McCurdy M, Shenoy M, Martinez J, Castillo R, Castillo E, Guerrero T. Radiation Pneumonitis Response of the Upper versus Lower Lung Lobes. American Radium Society Annual Meeting, Cancun, Mexico, 5/2010.
11. McCurdy M, Martinez J, Castillo R, Zouain N, Guerrero T. Radiation Pneumonitis: Pulmonary Metabolic Response to Radiation in Lung Cancer Patients. ASTRO Annual Meeting, Chicago, IL, 11/2009.
12. Guerrero T, McCurdy M, Greene I, Pagilagan J, Castillo R. Validation of the Pulmonary Metabolic Radiation Response as An Imaging Biomarker. National Cancer Institute (NCI) Translational Science Annual Meeting, Vienna, VA, 11/2009.
13. Castillo R, McPhail T, Guerra R, Castillo E, Warren J, Garg AK, Guerrero T. Interior Landmark Point Pairs Improve Deformable Image Registration Spatial Accuracy within the Lung. ASTRO Annual Meeting, Boston, MA, 9/2008.

Grant & Contract Support

Title: Bayesian framework for inter-modality deformable image registration evaluation
Funding Source: NIH/NCI
Role: Principal Investigator-MDACC
Duration: 9/1/2013 - 8/31/2016
 
Title: Magnetic Resonance Imaging Biomarkers of Radiotherapy-Associated Organ at Risk Injury for Patients enrolled on a Randomized Trial of Photon/Proton Radiotherapy for Oropharyngeal Cancer
Funding Source: Center for Radiation Oncology Research
Role: Collaborator
Principal Investigator: Clifton Fuller
Duration: 7/1/2013 - 6/30/2014
 
Title: A Robust Quality Control Framework for Clinical 4D CT Ventilation Imaging
Funding Source: NIH/NIBIB
Role: Principal Investigator-MDACC
Duration: 7/17/2012 - present
 
Title: Medical Physics Training Grant for Image-Guided Therapy Research
Funding Source: NIH/NIAID
Role: Postdoctoral Fellow
Principal Investigator: Edward Jackson

Last updated: 3/10/2014