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Richard D. Wood, PhD

Present Title & Affiliation

Primary Appointment

Grady F. Saunders Distinguished Professor in Molecular Biology, The University of Texas MD Anderson Cancer Center, Smithville, TX

Research Interests

Many enzymes and regulatory proteins are devoted to the repair of DNA damage arising from agents inside cells and from the environment. DNA repair is a front-line defense against the mutations that can accumulate to cause cancer. Research in my laboratory includes exploration of the biochemical mechanism of the DNA nucleotide excision repair pathway in human cells. We have reconstituted the process with purified proteins and can dissect intermediates in the reaction. In one study we are examining how this repair process participates in resolving cross-links between DNA strands. We also investigate several DNA polymerases that help cells tolerate DNA damage. Some of the work is with a mouse model deficient in DNA polymerase zeta, to understand the role of this enzyme in chromosome instability, skin carcinogenesis and mammary carcinogenesis. In addition, we are determining the biochemical and cellular functions of two other specialized DNA polymerases which were identified in our laboratory, POLQ and POLN. These are nuclear enzymes present only in higher eukaryotes and both have an unusual ability to bypass specific lesions in DNA templates. This research will provide insights into how DNA damage is tolerated in cells before it is repaired.

Office Address

The University of Texas MD Anderson Cancer Center
1808 Park Road 1C
PO Box 389
Unit Number: Unit 116
Smithville, TX 78957
Room Number: SRD1.106
Phone: 512.237.9431
Fax: 512.237.6532
Email: rwood@mdanderson.org

Education & Training

Degree-Granting Education

1981 University of California, Berkeley, Berkeley, CA, PHD, Biophysics
1977 Westminster College, Salt Lake City, UT, BS, Biology, Mathematics

Postgraduate Training

1985-1988 Research Fellowship, Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, United Kingdom
1982-1985 Research Fellowship, Yale University, New Haven, CT

Experience/Service

Academic Appointments

Richard Cyert Professor of Molecular Oncology, Pharmacology, University of Pittsburgh, Pittsburgh, PA, 2001-2008
Adjunct Professor, Department of Biological Sciences, Biological Sciences, University of Pittsburgh, Pittsburgh, PA, 2001-2008
Principal Scientist, Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, United Kingdom, 1995-2001
Honorary Professor, Department of Biochemistry and Molecular Biology, University College, London, United Kingdom, 1995-2001
Senior Scientist, Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, United Kingdom, 1992-1995
Research Scientist, Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, United Kingdom, 1988-1992

Honors and Awards

2006 Pfizer Visiting Professor in Oncology, The University of Texas M.D. Anderson Cancer Center
1999 Distinguished Alumnus Medal, Westminster College
1998 EMBO, Elected Member, European Molecular Biology Organization
1998 Meyenburg Prize for Cancer Research, Deutsches Krebsforschungszentrum
1997 Fellow of the Royal Society (F.R.S.), UK/Commonwealth Academy of Sciences

Selected Publications

Peer-Reviewed Original Research Articles

1. Takata K. Reh S, Tomida J, Person MD, Wood RD. Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs. Nature Communications 4(2338), 9/2013. PMCID: PMCPMC3778836.
2. Lange SS, Bedford E, Reh S, Wittschieben JP, Carbajal S, Kusewitt DF, DiGiovanni J, Wood RD. Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses. Proc Natl Acad Sci U S A 110(8):E687-96, 2/19/2013. e-Pub 2/5/2013. PMCID: PMC3581960.
3. Christov PP, Yamanaka K, Choi JY, Takata K, Wood RD, Guengerich FP, Lloyd RS, Rizzo CJ. Replication of the 2,6-Diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) Adduct by Eukaryotic DNA Polymerases. Chem Res Toxicol 25(8):1652-61, 8/20/2012. e-Pub 7/6/2012. PMID: 22721435.
4. Lange SS, Wittschieben JP, Wood RD. DNA polymerase zeta is required for proliferation of normal mammalian cells. Nucleic Acids Res 40(10):4473-82, 5/2012. e-Pub 2/7/2012. PMCID: PMC3378892.
5. Hogg M, Seki M, Wood RD, Doublié S, Wallace SS. Lesion Bypass Activity of DNA Polymerase θ (POLQ) Is an Intrinsic Property of the Pol Domain and Depends on Unique Sequence Inserts. J Mol Biol 405(3):642-52, 1/21/2011. e-Pub 11/2/2010. PMCID: PMC3025778.
6. Lemee F, Bergoglio V, Fernandez-Vidal A, Machado-Silva A, Pillaire MJ, Bieth A, Gentil C, Baker L, Martin AL, Leduc C, Lam E, Magdeleine E, Filleron T, Oumouhou N, Kaina B, Seki M, Grimal F, Lacroix-Triki M, Thompson A, Roche H, Bourdon JC, Wood RD, Hoffmann JS, Cazaux C. DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability. Proc Natl Acad Sci U S A 107(30):13390-13395, 7/2010. e-Pub 7/2010. PMCID: PMC2922118.
7. Takata K, Arana ME, Seki M, Kunkel TA, Wood RD. Evolutionary conservation of residues in vertebrate POLN conferring low fidelity and bypass activity. Nucleic Acids Res 38(10):3233-44, 6/2010. e-Pub 2/9/2010. PMCID: PMC2879524.
8. Wittschieben JP, Patil V, Glushets V, Robinson LJ, Kusewitt DF, Wood RD. Loss of DNA polymerase zeta enhances spontaneous tumorigenesis. Cancer Res 70(7):2770-8, 4/1/2010. e-Pub 3/9/2010. PMCID: PMC3008348.
9. Yamanaka K, Minko IG, Takata K, Kolbanovskiy A, Kozekov ID, Wood RD, Rizzo CJ, Lloyd RS. Novel enzymatic function of DNA polymerase ν in translesion DNA synthesis past major groove DNA−peptide and DNA −DNA cross-links. Chem Res Toxicol 23(3):689-95, 3/15/2010. e-Pub 1/2010. PMCID: PMC2838406.
10. Bhagwat NR, Roginskaya VY, Acquafondata MB, Dhir R, Wood RD, Niedernhofer LJ. Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue. Cancer Res 69(17):6831-8, 9/1/2009. PMCID: PMC2739111.
11. Goff JP, Shields DS, Seki M, Choi S, Epperly MW, Dixon T, Wang H, Bakkenist CJ, Dertinger SD, Torous DK, Wittschieben J, Wood RD, Greenberger JS. Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation. Radiat Res 172(2):165-74, 8/2009. PMCID: PMC2742993.
12. Koberle B, Roginskaya V, Zima KS, Masters JR, Wood RD. Elevation of XPA protein level in testis tumor cells without increasing resistance to cisplatin or UV radiation. Mol Carcinog 47(8):580-6, 8/2008. PMID: 18240296.
13. Arana ME, Seki M, Wood RD, Rogozin IB, Kunkel TA. Low-fidelity DNA synthesis by human DNA polymerase theta. Nucleic Acids Res 36(11):3847-56, 6/2008. e-Pub 5/24/2008. PMCID: PMC2441791.
14. Seki M, Wood RD. DNA polymerase theta (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct. DNA Repair (Amst) 7(1):119-27, 1/1/2008. e-Pub 10/24/2007. PMCID: PMC2185714.
15. Masuda K, Ouchida R, Hikida M, Kurosaki T, Yokoi M, Masutani C, Seki M, Wood RD, Hanaoka F, O-Wang J. DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes. J Biol Chem 282(24):17387-94, 6/15/2007. e-Pub 4/20/2007. PMID: 17449470.
16. Niedernhofer LJ, Bhagwat N, Wood RD. ERCC1 and non-small-cell lung cancer. N Engl J Med 356(24):2538-40; author reply 2540-1, 6/14/2007. PMID: 17568038.
17. Arana ME, Takata K, Garcia-Diaz M, Wood RD, Kunkel TA. A unique error signature for human DNA polymerase nu. DNA Repair (Amst) 6(2):213-23, 2/4/2007. e-Pub 11/21/2006. PMCID: PMC1950682.
18. Yoshimura M, Kohzaki M, Nakamura J, Asagoshi K, Sonoda E, Hou E, Prasad R, Wilson SH, Tano K, Yasui A, Lan L, Seki M, Wood RD, Arakawa H, Buerstedde JM, Hochegger H, Okada T, Hiraoka M, Takeda S. Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage. Mol Cell 24(1):115-25, 10/2006. PMCID: PMC1868411.
19. Takata K, Shimizu T, Iwai S, Wood RD. Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol. J Biol Chem 281(33):23445-55, 8/2006. PMID: 16787914.
20. Koberle B, Roginskaya V, Wood RD. XPA protein as a limiting factor for nucleotide excision repair and UV sensitivity in human cells. DNA Repair (Amst) 5(5):641-8, 5/2006. PMID: 16413230.
21. Wittschieben JP, Reshmi SC, Gollin SM, Wood RD. Loss of DNA polymerase zeta causes chromosomal instability in mammalian cells. Cancer Res 66(1):134-42, 1/2006. PMID: 16397225.
22. Wittschieben BO, Iwai S, Wood RD. DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA. J Biol Chem 280(48):39982-9, 12/2005. PMID: 16223728.
23. Seki M, Gearhart PJ, Wood RD. DNA polymerases and somatic hypermutation of immunoglobulin genes. EMBO Rep 6(12):1143-8, 12/2005. PMCID: PMC1369213.
24. Clarkson SG, Wood RD. Polymorphisms in the human XPD (ERCC2) gene, DNA repair capacity and cancer susceptibility: an appraisal. DNA Repair (Amst) 4(10):1068-74, 9/2005. PMID: 16054878.
25. Thorel F, Constantinou A, Dunand-Sauthier I, Nouspikel T, Lalle P, Raams A, Jaspers NG, Vermeulen W, Shivji MK, Wood RD, Clarkson SG. Definition of a short region of XPG necessary for TFIIH interaction and stable recruitment to sites of UV damage. Mol Cell Biol 24(24):10670-80, 12/2004. PMCID: PMC533987.
26. Seki M, Masutani C, Yang LW, Schuffert A, Iwai S, Bahar I, Wood RD. High-efficiency bypass of DNA damage by human DNA polymerase Q. EMBO J 23(22):4484-94, 11/2004. PMCID: PMC526458.
27. Welsh C, Day R, McGurk C, Masters JR, Wood RD, Köberle B. Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines. Int J Cancer 110(3):352-61, 6/2004. PMID: 15095299.
28. Seki M, Marini F, Wood RD. POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells. Nucleic Acids Res 31(21):6117-26, 11/2003. PMCID: PMC275456.
29. Marini F, Kim N, Schuffert A, Wood RD. POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308. J Biol Chem 278(34):32014-9, 8/2003. PMID: 12794064.
30. Marini F, Wood RD. A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308. J Biol Chem 277(10):8716-23, 3/2002. PMID: 11751861.
31. Kuraoka I, Robins P, Masutani C, Hanaoka F, Gasparutto D, Cadet J, Wood RD, Lindahl T. Oxygen free radical damage to DNA. Translesion synthesis by human DNA polymerase eta and resistance to exonuclease action at cyclopurine deoxynucleoside residues. J Biol Chem 276(52):49283-8, 12/2001. PMID: 11677235.
32. Araujo SJ, Nigg EA, Wood RD. Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome. Mol Cell Biol 21(7):2281-91, 4/2001. PMCID: PMC86862.
33. Yang H, Phan IT, Fitz-Gibbon S, Shivji MK, Wood RD, Clendenin WM, Hyman EC, Miller JH. A thermostable endonuclease III homolog from the archaeon Pyrobaculum aerophilum. Nucleic Acids Res 29(3):604-13, 2/2001. PMCID: PMC30402.
34. Gaillard PH, Wood RD. Activity of individual ERCC1 and XPF subunits in DNA nucleotide excision repair. Nucleic Acids Res 29(4):872-9, 2/2001. PMCID: PMC29621.
35. Wittschieben J, Shivji MK, Lalani E, Jacobs MA, Marini F, Gearhart PJ, Rosewell I, Stamp G, Wood RD. Disruption of the developmentally regulated Rev3l gene causes embryonic lethality. Curr Biol 10(19):1217-20, 10/2000. PMID: 11050392.
36. Kuraoka I, Kobertz WR, Ariza RR, Biggerstaff M, Essigmann JM, Wood RD. Repair of an interstrand DNA cross-link initiated by ERCC1-XPF repair/recombination nuclease. J Biol Chem 275(34):26632-6, 8/2000. PMID: 10882712.
37. Batty D, Rapic'-Otrin V, Levine AS, Wood RD. Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites. J Mol Biol 300(2):275-90, 7/2000. PMID: 10873465.
38. Kuraoka I, Bender C, Romieu A, Cadet J, Wood RD, Lindahl T. Removal of oxygen free-radical-induced 5',8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells. Proc Natl Acad Sci U S A 97(8):3832-7, 4/2000. PMCID: PMC18102.
39. Winter DB, Phung QH, Wood RD, Gearhart PJ. Differential expression of DNA polymerase epsilon in resting and activated B lymphocytes is consistent with an in vivo role in replication and not repair. Mol Immunol 37(3-4):125-31, Feb-Mar, 3/2000. PMID: 10865111.
40. Berneburg M, Lowe JE, Nardo T, Araujo S, Fousteri MI, Green MH, Krutmann J, Wood RD, Stefanini M, Lehmann AR. UV damage causes uncontrolled DNA breakage in cells from patients with combined features of XP-D and Cockayne syndrome. EMBO J 19(5):1157-66, 3/2000. PMCID: PMC305654.
41. Araujo SJ, Tirode F, Coin F, Pospiech H, Syvaoja JE, Stucki M, Hubscher U, Egly JM, Wood RD. Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK. Genes Dev 14(3):349-59, 2/2000. PMCID: PMC316364.
42. Winkler GS, Araujo SJ, Fiedler U, Vermeulen W, Coin F, Egly JM, Hoeijmakers JH, Wood RD, Timmers HT, Weeda G. TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair. J Biol Chem 275(6):4258-66, 2/2000. PMID: 10660593.
43. George H, Kuraoka I, Nauman DA, Kobertz WR, Wood RD, West SC. RuvAB-mediated branch migration does not involve extensive DNA opening within the RuvB hexamer. Curr Biol 10(2):103-6, 1/2000. PMID: 10662672.
44. Araujo SJ, Wood RD. Protein complexes in nucleotide excision repair. Mutat Res 435(1):23-33, 9/1999. PMID: 10526214.
45. Sgouros J, Gaillard PH, Wood RD. A relationship betweena DNA-repair/recombination nuclease family and archaeal helicases. Trends Biochem Sci 24(3):95-7, 3/1999. PMID: 10203755.
46. Koberle B, Masters JR, Hartley JA, Wood RD. Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours. Curr Biol 9(5):273-6, 3/1999. PMID: 10074455.
47. Constantinou A, Gunz D, Evans E, Lalle P, Bates PA, Wood RD, Clarkson SG. Conserved residues of human XPG protein important for nuclease activity and function in nucleotide excision repair. J Biol Chem 274(9):5637-48, 2/1999. PMID: 10026181.
48. Klungland A, Hoss M, Gunz D, Constantinou A, Clarkson SG, Doetsch PW, Bolton PH, Wood RD, Lindahl T. Base excision repair of oxidative DNA damage activated by XPG protein. Mol Cell 3(1):33-42, 1/1999. PMID: 10024877.
49. Shivji MK, Ferrari E, Ball K, Hubscher U, Wood RD. Resistance of human nucleotide excision repair synthesis in vitro to p21Cdn1. Oncogene 17(22):2827-38, 12/1998. PMID: 9879989.
50. Rapic Otrin V, Kuraoka I, Nardo T, McLenigan M, Eker AP, Stefanini M, Levine AS, Wood RD. Relationship of the xeroderma pigmentosum group E DNA repair defect to the chromatin and DNA binding proteins UV-DDB and replication protein A. Mol Cell Biol 18(6):3182-90, 6/1998. PMCID: PMC108900.
51. Lin YL, Shivji MK, Chen C, Kolodner R, Wood RD, Dutta A. The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair. J Biol Chem 273(3):1453-61, 1/1998. PMID: 9430682.
52. Sugasawa K, Ng JM, Masutani C, Maekawa T, Uchida A, van der Spek PJ, Eker AP, Rademakers S, Visser C, Aboussekhra A, Wood RD, Hanaoka F, Bootsma D, Hoeijmakers JH. Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity. Mol Cell Biol 17(12):6924-31, 12/1997. PMCID: PMC232549.
53. Evans E, Moggs JG, Hwang JR, Egly JM, Wood RD. Mechanism of open complex and dual incision formation by human nucleotide excision repair factors. EMBO J 16(21):6559-73, 11/1997. PMCID: PMC1170260.
54. Gaillard PH, Moggs JG, Roche DM, Quivy JP, Becker PB, Wood RD, Almouzni G. Initiation and bidirectional propagation of chromatin assembly from a target site for nucleotide excision repair. EMBO J 16(20):6281-9, 10/1997. PMCID: PMC1326312.
55. Moggs JG, Szymkowski DE, Yamada M, Karran P, Wood RD. Differential human nucleotide excision repair of paired and mispaired cisplatin-DNA adducts. Nucleic Acids Res 25(3):480-91, 2/1997. PMCID: PMC146461.
56. Evans E, Fellows J, Coffer A, Wood RD. Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG protein. EMBO J 16(3):625-38, 2/1997. PMCID: PMC1169665.
57. Yagi T, Wood RD, Takebe H. A low content of ERCC1 and a 120 kDa protein is a frequent feature of group F xeroderma pigmentosum fibroblast cells. Mutagenesis 12(1):41-4, 1/1997. PMID: 9025096.
58. Moggs JG, Yarema KJ, Essigmann JM, Wood RD. Analysis of incision sites produced by human cell extracts and purified proteins during nucleotide excision repair of a 1,3-intrastrand d(GpTpG)-cisplatin adduct. J Biol Chem 271(12):7177-86, 10/1996. PMID: 8636155.
59. Sijbers AM, de Laat WL, Ariza RR, Biggerstaff M, Wei YF, Moggs JG, Carter KC, Shell BK, Evans E, de Jong MC, Rademakers S, de Rooij J, Jaspers NG, Hoeijmakers JH, Wood RD. Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease. Cell 86(5):811-22, 9/1996. PMID: 8797827.
60. Ariza RR, Keyse SM, Moggs JG, Wood RD. Reversible protein phosphorylation modulates nucleotide excision repair of damaged DNA by human cell extracts. Nucleic Acids Res 24(3):433-40, 2/1996. PMCID: PMC145647.
61. Aboussekhra A, Wood RD. Detection of nucleotide excision repair incisions in human fibroblasts by immunostaining for PCNA. Exp Cell Res 221(2):326-32, 12/1995. PMID: 7493631.
62. Kearsey JM, Shivji MK, Hall PA, Wood RD. Does the p53 up-regulated Gadd45 protein have a role in excision repair? Science 270(5238):1004-5; author reply 1005-6, 11/1995. PMID: 7481777.
63. Davies AA, Friedberg EC, Tomkinson AE, Wood RD, West SC. Role of the Rad1 and Rad10 proteins in nucleotide excision repair and recombination. J Biol Chem 270(42):24638-41, 10/1995. PMID: 7559571.
64. Nagai A, Saijo M, Kuraoka I, Matsuda T, Kodo N, Nakatsu Y, Mimaki T, Mino M, Biggerstaff M, Wood RD. Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein. Biochem Biophys Res Commun 211(3):960-6, 6/1995. PMID: 7598728.
65. Shivji MK, Podust VN, Hubscher U, Wood RD. Nucleotide excision repair DNA synthesis by DNA polymerase epsilon in the presence of PCNA, RFC, and RPA. Biochemistry 34(15):5011-7, 4/1995. PMID: 7711023.
66. Aboussekhra A, Biggerstaff M, Shivji MK, Vilpo JA, Moncollin V, Podust VN, Protic M, Hubscher U, Egly JM, Wood RD. Mammalian DNA nucleotide excision repair reconstituted with purified protein components. Cell 80(6):859-68, 3/1995. PMID: 7697716.
67. Vilpo JA, Vilpo LM, Szymkowski DE, O'Donovan A, Wood RD. An XPG DNA repair defect causing mutagen hypersensitivity in mouse leukemia L1210 cells. Mol Cell Biol 15(1):290-7, 1/1995. PMCID: PMC231955.
68. Shivji MK, Grey SJ, Strausfeld UP, Wood RD, Blow JJ. Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair. Curr Biol 4(12):1062-8, 12/1994. PMID: 7704570.
69. Robins P, Pappin DJ, Wood RD, Lindahl T. Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I. J Biol Chem 269(46):28535-8, 11/1994. PMID: 7961795.
70. Shivji MK, Eker AP, Wood RD. DNA repair defect in xeroderma pigmentosum group C and complementing factor from HeLa cells. J Biol Chem 269(36):22749-57, 9/1994. PMID: 8077226.
71. Jones CJ, Lloyd RS, Wood RD. Analysis of cells harboring a putative DNA repair gene reveals a lack of evidence for a second independent xeroderma pigmentosum group A correcting gene. Mutat Res 324(4):159-64, 8/1994. PMID: 7519740.
72. Cleaver JE, McDowell M, Jones C, Wood R, Karentz D. Mutation and expression of the XPA gene in revertants and hybrids of a xeroderma pigmentosum cell line. Somat Cell Mol Genet 20(4):327-37, 7/1994. PMID: 7974007.
73. Lehmann AR, Bootsma D, Clarkson SG, Cleaver JE, McAlpine PJ, Tanaka K, Thompson LH, Wood RD. Nomenclature of human DNA repair genes. Mutat Res 315(1):41-2, 7/1994. PMID: 7517009.
74. O'Donovan A, Scherly D, Clarkson SG, Wood RD. Isolation of active recombinant XPG protein, a human DNA repair endonuclease. J Biol Chem 269(23):15965-8, 6/1994. PMID: 8206890.
75. Samec S, Jones TA, Corlet J, Scherly D, Sheer D, Wood RD, Clarkson SG. The human gene for xeroderma pigmentosum complementation group G (XPG) maps to 13q33 by fluorescence in situ hybridization. Genomics 21(1):283-5, 5/1994. PMID: 8088806.
76. O'Donovan A, Davies AA, Moggs JG, West SC, Wood RD. XPG endonuclease makes the 3' incision in human DNA nucleotide excision repair. Nature 371(6496):432-5, 1994. PMID: 8090225.
77. Jones CJ, Wood RD. Preferential binding of the xeroderma pigmentosum group A complementing protein to damaged DNA. Biochemistry 32(45):12096-104, 11/1993. PMID: 8218288.
78. Szymkowski DE, Lawrence CW, Wood RD. Repair by human cell extracts of single (6-4) and cyclobutane thymine-thymine photoproducts in DNA. Proc Natl Acad Sci U S A 90(21):9823-7, 11/1993. PMCID: PMC47664.
79. Biggerstaff M, Szymkowski DE, Wood RD. Co-correction of the ERCC1, ERCC4 and xeroderma pigmentosum group F DNA repair defects in vitro. EMBO J 12(9):3685-92, 9/1993. PMCID: PMC413645.
80. Satoh MS, Jones CJ, Wood RD, Lindahl T. DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions. Proc Natl Acad Sci U S A 90(13):6335-9, 7/1993. PMCID: PMC46923.
81. Szymkowski DE, Hajibagheri MA, Wood RD. Electron microscopy of DNA excision repair patches produced by human cell extracts. J Mol Biol 231(2):251-60, 5/1993. PMID: 8510146.
82. O'Donovan A, Wood RD. Identical defects in DNA repair in xeroderma pigmentosum group G and rodent ERCC group 5. Nature 363(6425):185-8, 5/1993. PMID: 8483505.
83. Szymkowski DE, Yarema K, Essigmann JM, Lippard SJ, Wood RD. An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts. Proc Natl Acad Sci U S A 89(22):10772-6, 11/1992. PMCID: PMC50424.
84. Coverley D, Kenny MK, Lane DP, Wood RD. A role for the human single-stranded DNA binding protein HSSB/RPA in an early stage of nucleotide excision repair. Nucleic Acids Res 20(15):3873-80, 8/1992. PMCID: PMC334061.
85. Shivji KK, Kenny MK, Wood RD. Proliferating cell nuclear antigen is required for DNA excision repair. Cell 69(2):367-74, 4/1992. PMID: 1348971.
86. Biggerstaff M, Wood RD. Requirement for ERCC-1 and ERCC-3 gene products in DNA excision repair in vitro. Complementation using rodent and human cell extracts. J Biol Chem 267(10):6879-85, 4/1992. PMID: 1551896.
87. Jones CJ, Cleaver JE, Wood RD. Repair of damaged DNA by extracts from a xeroderma pigmentosum complementation group A revertant and expression of a protein absent in its parental cell line. Nucleic Acids Res 20(5):991-5, 3/1992. PMCID: PMC312081.
88. Robins P, Jones CJ, Biggerstaff M, Lindahl T, Wood RD. Complementation of DNA repair in xeroderma pigmentosum group A cell extracts by a protein with affinity for damaged DNA. EMBO J 10(12):3913-21, 12/1991. PMCID: PMC453130.
89. Hansson J, Keyse SM, Lindahl T, Wood RD. DNA excision repair in cell extracts from human cell lines exhibiting hypersensitivity to DNA-damaging agents. Cancer Res 51(13):3384-90, 7/1991. PMID: 2054778.
90. Biggerstaff M, Robins P, Coverley D, Wood RD. Effect of exogenous DNA fragments on human cell extract-mediated DNA repair synthesis. Mutat Res 254(3):217-24, 5/1991. PMID: 2052011.
91. Coverley D, Kenny MK, Munn M, Rupp WD, Lane DP, Wood RD. Requirement for the replication protein SSB in human DNA excision repair. Nature 349(6309):538-41, 2/1991. PMID: 1992355.
92. Frosina G, Wood RD. Influence of RNA synthesis on DNA-repair replication in human cell extracts. Mutat Res 244(4):287-93, 8/1990. PMID: 1696681.
93. Hansson J, Grossman L, Lindahl T, Wood RD. Complementation of the xeroderma pigmentosum DNA repair synthesis defect with Escherichia coli UvrABC proteins in a cell-free system. Nucleic Acids Res 18(1):35-40, 1/1990. PMCID: PMC330200.
94. Hansson J, Munn M, Rupp WD, Kahn R, Wood RD. Localization of DNA repair synthesis by human cell extracts to a short region at the site of a lesion. J Biol Chem 264(36):21788-92, 12/1989. PMID: 2557339.
95. Gough G, Wood RD. Inhibition of in vitro SV40 DNA replication by ultraviolet light. Mutat Res 227(3):193-7, 11/1989. PMID: 2478885.
96. Wood RD. Repair of pyrimidine dimer ultraviolet light photoproducts by human cell extracts. Biochemistry 28(21):8287-92, 10/1989. PMID: 2605185.
97. Hansson J, Wood RD. Repair synthesis by human cell extracts in DNA damaged by cis- and trans-diamminedichloroplatinum(II). Nucleic Acids Res 17(20):8073-91, 10/1989. PMCID: PMC334948.
98. Wood RD, Robins P. DNA repair replication by soluble extracts from human lymphoid cell lines. Genome 31(2):601-4, 1989. PMID: 2632347.
99. Hutchinson F, Yamamoto K, Stein J, Wood RD. Effect of photoreactivation on mutagenesis of lambda phage by ultraviolet light. J Mol Biol 202(3):593-601, 8/1988. PMID: 2971813.
100. Wood RD, Robins P, Lindahl T. Complementation of the xeroderma pigmentosum DNA repair defect in cell-free extracts. Cell 53(1):97-106, 4/1988. PMID: 3349527.
101. Wood RD, Hutchinson F. Ultraviolet light-induced mutagenesis in the Escherichia coli chromosome. Sequences of mutants in the cI gene of a lambda lysogen. J Mol Biol 193(4):637-41, 2/1987. PMID: 3302271.
102. Wood RD. DNA sequence changes induced by ultraviolet light: targeting of transition mutations at photoproducts. Photobiochem Photobiophys Suppl:317-24, 1987.
103. Wood RD, Stein J. Role of the RecF gene product in UV mutagenesis of lambda phage. Mol Gen Genet 204(1):82-4, 7/1986. PMID: 3018447.
104. Hutchinson F, Wood RD. Mechanisms of mutagenesis of E. coli by ultraviolet light. Basic Life Sci 38:377-83, 1986. PMID: 2943265.
105. Wood RD, Hutchinson F. The role of pyrimidine dimers in mutagenesis by ultraviolet light. Prog Clin Biol Res 209A:191-8, 1986. PMID: 2944122.
106. Skopek TR, Wood RD, Hutchinson F. Sequence specificity of mutagenesis in the cI gene of bacteriophage lambda. Environ Health Perspect 62:157-61, 10/1985. PMCID: PMC1568688.
107. Wood RD. Pyrimidine dimers are not the principal pre-mutagenic lesions induced in lambda phage DNA by ultraviolet light. J Mol Biol 184(4):577-85, 8/1985. PMID: 2931533.
108. Westerveld A, Hoeijmakers JH, van Duin M, de Wit J, Odijk H, Pastink A, Wood RD, Bootsma D. Molecular cloning of a human DNA repair gene. Nature 310(5976):425-9, Aug 2-8, 8/1984. PMID: 6462228.
109. Wood RD, Skopek TR, Hutchinson F. Changes in DNA base sequence induced by targeted mutagenesis of lambda phage by ultraviolet light. J Mol Biol 173(3):273-91, 3/1984. PMID: 6230458.
110. Wood RD, Hutchinson F. Non-targeted mutagenesis of unirradiated lambda phage in Escherichia coli host cells irradiated with ultraviolet light. J Mol Biol 173(3):293-305, 3/1984. PMID: 6230459.
111. Wood RD, Burki HJ, Hughes M, Poley A. Radiation-induced lethality and mutation in a repair-deficient CHO cell line. Int J Radiat Biol Relat Stud Phys Chem Med 43(2):207-13, 2/1983. PMID: 6600735.
112. Wood RD, de Veciana M, Presson-Tincknell B. Postirradiation properties of a UV-sensitive variant of CHO. Photochem Photobiol 36(2):169-74, 8/1982. PMID: 7122711.
113. Wood RD, Burki HJ. Repair capability and the cellular age response for killing and mutation induction after UV. Mutat Res 95(2-3):505-14, 8/1982. PMID: 6889678.
114. Burki HJ, Lam CK, Wood RD. UV-light-induced mutations in synchronous CHO cells. Mutat Res 69(2):347-56, 2/1980. PMID: 7360150.

Invited Articles

1. Wood RD, Lange SS. Break for a Break-Preventer. Proc Natl Acad Sci USA, 2/2014.
2. Wood RD. DNA damage tolerance and a web of connections with DNA repair at Yale. Yale Journal of Biology and Medicine 86(4):507-516, 12/2013. PMCID: PMC3848105.
3. Yousefzadeh MJ, Wood RD. DNA polymerase POLQ and cellular defense against DNA damage. DNA Repair (Amst) 12(1):1-9, 1/1/2013. e-Pub 12/4/2012. PMCID: PMC3534860.
4. Lange SS, Takata K, Wood RD. DNA polymerases and cancer. Nat Rev Cancer 11(2):96-110, 2/2011. PMID: 21258395.
5. Wood RD. Mammalian nucleotide excision repair proteins and interstrand crosslink repair. Environ Mol Mutagen 51(6):520-526, 7/2010. PMCID: PMC3017513.
6. Gan GN, Wittschieben JP, Wittschieben BO, Wood RD. DNA polymerase zeta (pol zeta) in higher eukaryotes. Cell Res 18(1):174-83, 1/2008. PMID: 18157155.
7. Wood RD, Mitchell M, Lindahl T. Human DNA repair genes, 2005. Mutat Res 577(1-2):275-83, 9/2005. PMID: 15922366.
8. Wittschieben BO, Wood RD. DDB complexities. DNA Repair (Amst) 2(9):1065-9, 9/2003. PMID: 12967661.
9. Gearhart PJ, Wood RD. Emerging links between hypermutation of antibody genes and DNA polymerases. Nat Rev Immunol 1(3):187-92, 12/2001. PMID: 11905827.
10. Wood RD, Mitchell M, Sgouros J, Lindahl T. Human DNA repair genes. Science 291(5507):1284-9, 2/2001. PMID: 11181991.
11. Batty DP, Wood RD. Damage recognition in nucleotide excision repair of DNA. Gene 241(2):193-204, 11/2000. PMID: 10675030.
12. Wood RD, Araujo SJ, Ariza RR, Batty DP, Biggerstaff M, Evans E, Gaillard PH, Gunz D, Köberle B, Kuraoka I, Moggs JG, Sandall JK, Shivji MK. DNA damage recognition and nucleotide excision repair in mammalian cells. Cold Spring Harb Symp Quant Biol 65:173-82, 2000. PMID: 12760031.
13. Lindahl T, Wood RD. Quality control by DNA repair. Science 286(5446):1897-905, 12/1999. PMID: 10583946.
14. Wood RD. DNA damage recognition during nucleotide excision repair in mammalian cells. Biochimie 81(1-2):39-44, Jan-Feb, 2/1999. PMID: 10214908.
15. Biggerstaff M, Wood RD. Assay for nucleotide excision repair protein activity using fractionated cell extracts and UV-damaged plasmid DNA. Methods Mol Biol 113:357-72, 1999. PMID: 10443434.
16. Shivji MK, Moggs JG, Kuraoka I, Wood RD. Dual-incision assays for nucleotide excision repair using DNA with a lesion at a specific site. Methods Mol Biol 113:373-92, 1999. PMID: 10443435.
17. Wood RD. Nucleotide excision repair in mammalian cells. J Biol Chem 272(38):23465-8, 9/1997. PMID: 9295277.
18. Lindahl T, Karran P, Wood RD. DNA excision repair pathways. Curr Opin Genet Dev 7(2):158-69, 4/1997. PMID: 9115419.
19. Wood RD, Shivji MK. Which DNA polymerases are used for DNA-repair in eukaryotes? Carcinogenesis 18(4):605-10, 4/1997. PMID: 9111189.
20. Wood RD. DNA repair in eukaryotes. Annu Rev Biochem 65:135-67, 1996. PMID: 8811177.
21. Wood RD. Proteins that participate in nucleotide excision repair of DNA in mammalian cells. Philos Trans R Soc Lond B Biol Sci 347(1319):69-74, 1/1995. PMID: 7746857.
22. Wood RD. Studying nucleotide excision repair of mammalian DNA in a cell-free system. Ann N Y Acad Sci 726:274-9; discussion 279-80, 7/1994. PMID: 8092683.
23. Aboussekhra A, Wood RD. Repair of UV-damaged DNA by mammalian cells and Saccharomyces cerevisiae. Curr Opin Genet Dev 4(2):212-20, 4/1994. PMID: 8032198.
24. Tanaka K, Wood RD. Xeroderma pigmentosum and nucleotide excision repair of DNA. Trends Biochem Sci 19(2):83-6, 2/1994. PMID: 8160271.
25. Wood RD, Aboussekhra A, Biggerstaff M, Jones CJ, O'Donovan A, Shivji MK, Szymkowski DE. Nucleotide excision repair of DNA by mammalian cell extracts and purified proteins. Cold Spring Harb Symp Quant Biol 58:625-32, 1993. PMID: 7956077.
26. Wood RD. Human diseases associated with defective DNA excision repair. J R Coll Physicians Lond 25(4):300-3, 10/1991. PMID: 1960684.
27. Wood RD, Coverley D. DNA excision repair in mammalian cell extracts. Bioessays 13(9):447-53, 9/1991. PMID: 1796907.
28. Hoeijmakers JH, Eker AP, Wood RD, Robins P. Use of in vivo and in vitro assays for the characterization of mammalian excision repair and isolation of repair proteins. Mutat Res 236(2-3):223-38, Sep-Nov, 11/1990. PMID: 2204826.
29. Lindahl T, Wood RD. DNA repair and recombination. Curr Opin Cell Biol 1(3):475-80, 6/1989. PMID: 2697266.
30. Wood RD, Sedgwick SG. Molecular aspects of mutagenesis. Mutagenesis 1(6):399-405, 11/1986. PMID: 2842577.
Other Articles
1. Takata K, Wood RD. Bypass specialists operate together. EMBO J 28(4):313-4, 2/18/2009. PMCID: PMC2646159.
2. Friedberg EC, Wood RD. New insights into the combined Cockayne/xeroderma pigmentosum complex: human XPG protein can function in transcription factor stability. Mol Cell 26(2):162-4, 4/27/2007. PMID: 17466619.
3. Friedberg EC, Aguilera A, Gellert M, Hanawalt PC, Hays JB, Lehmann AR, Lindahl T, Lowndes N, Sarasin A, Wood RD. DNA repair: from molecular mechanism to human disease. DNA Repair (Amst) 5(8):986-96, 2006. PMID: 16955546.
4. Wood RD. The Writing Life of James D. Watson. DNA Repair (Amst) 4(10):1213-4, 2005.
5. Wood RD, Gearhart PJ, Neuberger MS. Hypermutation in antibody genes: preface. Philos Trans R Soc Lond B Biol Sci 356(1405):3-4, 1/2001.
6. Wood RD. DNA repair. Variants on a theme. Nature 399(6737):639-40, 1999. PMID: 10385109.
7. Wood RD. DNA repair: knockouts still mutating after first round. Curr Biol 8(21):R757-60, 10/1998. PMID: 9799728.
8. Wood, R. D. No hedging on DNA repair. Trends Genet 14(10):433-4, 1998.
9. Wood RD. Reliable recipes. Nature 390(6660):573-4, 1997.
10. Wood RD. Introduction. Seminars in Cancer Biology 4(2), 1993.
11. Wood RD. DNA repair. Seven genes for three diseases. Nature 350(6315):190, 1991. PMID: 2005975.
12. Wood RD, Lindahl T. Xeroderma pigmentosum. A gene for tumour prevention. Nature 348(6296):13-4, 11/1990. PMID: 2234052.

Book Chapters

1. Shivji MK, Moggs JG, Kuraoka I, Wood RD. Assaying for the dual incisions of nucleotide excision repair using DNA with a lesion at a specific site. In: Methods Mol Biol. 314, 435-56, 2006. ISBN: 16673898.
2. Biggerstaff M, Wood RD. Repair synthesis assay for nucleotide excision repair activity using fractionated cell extracts and UV-damaged plasmid DNA. In: Methods Mol Biol. 314, 417-34, 2006. ISBN: 16673897.
3. Koberle B, Wittschieben J, Wood, RD. DNA repair and cancer. In: Cellular and Molecular Biology of Cancer. Ed(s) Knowles M, and Selby PJ. Oxford University Press: Oxford, 2005.
4. Friedberg EC, Wood RD. DNA excision repair pathways in eukaryotes. In: DNA replication in eukaryotic cells. Ed(s) De Pamphilis M. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, 249-69, 1996.
5. Wood RD, Vilpo JA, Vilpo LM, Szymkowski DE, O'Donovan A, Moggs JG. Hypersensitivity to cisplatin in mouse leukemia L1210/0 cells: an XPG DNA repair defect. In: Platinum and other metal coordination compounds in cancer chemotherapy 2. Ed(s) Pinedo HM, Schornagel JH. Plenum Press: New York, 317-26, 1996.
6. Wood RD, Biggerstaff M, Shivji MKK. Detection and measurement of nucleotide excision repair synthesis by mammalian cell extracts in vitro. In: Methods-A Companion to Methods in Enzymology, 163-75, 1995.
7. Wood RD. DNA repair. In: The Encyclopaedia of Molecular Biology. Ed(s) Kendrew J. Blackwell Scientific Publications: Oxford, 277-281, 1994.
8. Wood RD, Szymkowski DE. A system to dissect nucleotide excision repair in vitro and its use to study repair of DNA modified by cisplatin. In: DNA Repair Mechanisms. Ed(s) Bohr V, Kraemer K, Wasserman K, Hess-Thaysen J. Munksgaard: Copenhagen, 314-24, 1993.
9. Jones CJ, Wood RD. Recent biochemical studies of the xeroderma pigmentosum group A complemnting protein involved in nucleotide excision repair of DNA. In: Frontiers of Photobiology. Proceedings, 11th International Congress on Photobiology, Kyoto, Japan. Ed(s) Shima A, Ichihashi M, Fujiwara Y, Takebe H. Elsevier: Amsterdam, 309-14, 1992.
10. Lindahl T, Wood RD, Karran P. Molecular deficiencies in human cancer-prone syndromes associated with hypersensitivity to DNA damaging agents. In: Origins of Human Cancer: A Comprehensive Review. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, 163-70, 1991.
11. Wood RD. Repair of damaged DNA in vitro by extracts from human cell lines. In: Platinum and other metal coordination compounds in cancer chemotherapy. Ed(s) Howell SB. Plenum Publishing Corporation: New York, 1991.
12. Wood RD. Parallels between nucleotide excision repair in human cells and E. coli. In: DNA Repair Mechanisms and their Biological Implications in Mammalian Cells. Ed(s) Lambert MW, Laval J. Plenum Publishing Corporation: New York, 483-8, 1989.
13. Wood RD, Lindahl T, Robins P. Isolation of ultraviolet-irradiated DNA lacking pyrimidine hydrates. In: Mechanisms and consequences of DNA damage processing. 83. Ed(s) Friedberg EC, Hanawalt PC. A.R. Liss: New York, 57-61, 1988.
14. Hutchinson F, Wood RD. The determination of sequence changes induced by mutagenesis of the cI gene of lambda phage. In: DNA Repair: A Laboratory Manual of Research Procedures. 3. Ed(s) Friedberg EC, Hanawalt PC. M Dekker Inc. New York, 219-33, 1987.
15. Hutchinson F, Skopek TR, Wood RD. Mechanisms of mutagenesis for lambda phage. In: Cellular Responses to DNA Damage. Ed(s) Friedberg EC, Bridges B. A R Liss: New York, 501-10, 1983.

Books (edited and written)

1. Friedberg EC, Walker GC, Siede W, Wood RD, Schultz RA, Ellenberger T. DNA Repair and Mutagenesis, 2nd edition. ASM Press: Washington DC, 2006.

Letters to the Editor

1. Wood RD. Polymorphisms, not disease alleles. Science(316/5822/222), 2007.

Last updated: 5/30/2014